| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cindy V Ly, Chi-Kuang Yao, Patrik Verstreken, Tomoko Ohyama, Hugo J Belle. straightjacket is required for the synaptic stabilization of cacophony, a voltage-gated calcium channel alpha1 subunit. The Journal of cell biology. vol 181. issue 1. 2008-04-22. PMID:18391075. |
in a screen to identify genes involved in synaptic function, we isolated mutations in drosophila melanogaster straightjacket (stj), an alpha(2)delta subunit of the voltage-gated calcium channel. |
2008-04-22 |
2023-08-12 |
drosophila_melanogaster |
| Cindy V Ly, Chi-Kuang Yao, Patrik Verstreken, Tomoko Ohyama, Hugo J Belle. straightjacket is required for the synaptic stabilization of cacophony, a voltage-gated calcium channel alpha1 subunit. The Journal of cell biology. vol 181. issue 1. 2008-04-22. PMID:18391075. |
interestingly, neuronal overexpression of cac partially rescues the viability and physiological defects in stj mutants, indicating a role for the alpha(2)delta ca(2+) channel subunit in mediating the proper localization of an alpha(1) subunit at synapses. |
2008-04-22 |
2023-08-12 |
drosophila_melanogaster |
| Jan Hendrich, Alexandra Tran Van Minh, Fay Heblich, Manuela Nieto-Rostro, Katrin Watschinger, Jörg Striessnig, Jack Wratten, Anthony Davies, Annette C Dolphi. Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 9. 2008-04-18. PMID:18299583. |
we formulated the hypothesis that gbp impairs the ability of alpha(2)delta subunits to enhance voltage-gated ca(2+)channel plasma membrane density by means of an effect on trafficking. |
2008-04-18 |
2023-08-12 |
Not clear |
| Jan Hendrich, Alexandra Tran Van Minh, Fay Heblich, Manuela Nieto-Rostro, Katrin Watschinger, Jörg Striessnig, Jack Wratten, Anthony Davies, Annette C Dolphi. Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 9. 2008-04-18. PMID:18299583. |
our results conclusively demonstrate that gbp inhibits calcium currents, mimicking a lack of alpha(2)delta only when applied chronically, but not acutely, both in heterologous expression systems and in dorsal root-ganglion neurons. |
2008-04-18 |
2023-08-12 |
Not clear |
| Jan Hendrich, Alexandra Tran Van Minh, Fay Heblich, Manuela Nieto-Rostro, Katrin Watschinger, Jörg Striessnig, Jack Wratten, Anthony Davies, Annette C Dolphi. Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 9. 2008-04-18. PMID:18299583. |
however, it is mediated by alpha(2)delta subunits, being prevented by mutations in either alpha(2)delta-1 or alpha(2)delta-2 that abolish gbp binding, and is not observed for alpha(2)delta-3, which does not bind gbp. |
2008-04-18 |
2023-08-12 |
Not clear |
| Jan Hendrich, Alexandra Tran Van Minh, Fay Heblich, Manuela Nieto-Rostro, Katrin Watschinger, Jörg Striessnig, Jack Wratten, Anthony Davies, Annette C Dolphi. Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 9. 2008-04-18. PMID:18299583. |
our evidence indicates that gbp may act chronically by displacing an endogenous ligand that is normally a positive modulator of alpha(2)delta subunit function, thereby impairing the trafficking function of the alpha(2)delta subunits to which it binds. |
2008-04-18 |
2023-08-12 |
Not clear |
| T Thomaides, T Karapanayiotides, E Kerezoudi, T Avramidis, C Haeropoulos, Y Zoukos, A Spantidea. Intravenous valproate aborts glyceryl trinitrate-induced migraine attacks: a clinical and quantitative EEG study. Cephalalgia : an international journal of headache. vol 28. issue 3. 2008-04-08. PMID:18201252. |
during attacks in msp there was an increase of theta [16.6% (14.8-19.3) to 19.4% (17.4-22.1), p = 0.02] and delta activity [3.6% (3.1-4.4) to 5.4% (3.9-6.5), p = 0.009], whereas there was no decrease in alpha [41.4% (36.2-45.1) to 39.7% (34.7-44.8)] or beta activity [37.6% (34.7-40.3) to 35.1% (33.5-38.8)]. |
2008-04-08 |
2023-08-12 |
Not clear |
| Nelson P Barrera, Jill Betts, Haitao You, Robert M Henderson, Ian L Martin, Susan M J Dunn, J Michael Edwardso. Atomic force microscopy reveals the stoichiometry and subunit arrangement of the alpha4beta3delta GABA(A) receptor. Molecular pharmacology. vol 73. issue 3. 2008-04-07. PMID:18079275. |
here we addressed the subunit arrangement within the alpha(4)beta(3)delta form of the receptor. |
2008-04-07 |
2023-08-12 |
Not clear |
| M Dupuis, E Houdeau, S Mhaouty-Kodj. Increased potency of alpha 1-adrenergic receptors to induce inositol phosphates production correlates with the up-regulation of alpha 1d/Gh alpha/phospholipase C delta 1 signaling pathway in term rat myometrium. Reproduction (Cambridge, England). vol 135. issue 1. 2008-04-07. PMID:18159083. |
increased potency of alpha 1-adrenergic receptors to induce inositol phosphates production correlates with the up-regulation of alpha 1d/gh alpha/phospholipase c delta 1 signaling pathway in term rat myometrium. |
2008-04-07 |
2023-08-12 |
rat |
| M Dupuis, E Houdeau, S Mhaouty-Kodj. Increased potency of alpha 1-adrenergic receptors to induce inositol phosphates production correlates with the up-regulation of alpha 1d/Gh alpha/phospholipase C delta 1 signaling pathway in term rat myometrium. Reproduction (Cambridge, England). vol 135. issue 1. 2008-04-07. PMID:18159083. |
in the present study, we studied the potential regulation by rat myometrial alpha1-adrenergic receptors (alpha1-ar) of the newly identified gh alpha protein/phospholipase c delta 1 (plc delta 1) signaling pathway and compared myometrial inositol phosphates (insp) production and activity of the uterine circular muscle in response to alpha1-ar activation between mid-pregnancy and term. |
2008-04-07 |
2023-08-12 |
rat |
| M Dupuis, E Houdeau, S Mhaouty-Kodj. Increased potency of alpha 1-adrenergic receptors to induce inositol phosphates production correlates with the up-regulation of alpha 1d/Gh alpha/phospholipase C delta 1 signaling pathway in term rat myometrium. Reproduction (Cambridge, England). vol 135. issue 1. 2008-04-07. PMID:18159083. |
for this, we quantified the level of rat myometrial alpha1-ar coupling to gh alpha protein by photoaffinity-labeling, the cytosolic amount of plc delta 1 enzyme by immunoblotting, and the expression level of alpha1-ar subtypes by rt-pcr. |
2008-04-07 |
2023-08-12 |
rat |
| M Dupuis, E Houdeau, S Mhaouty-Kodj. Increased potency of alpha 1-adrenergic receptors to induce inositol phosphates production correlates with the up-regulation of alpha 1d/Gh alpha/phospholipase C delta 1 signaling pathway in term rat myometrium. Reproduction (Cambridge, England). vol 135. issue 1. 2008-04-07. PMID:18159083. |
the results showed an increased level of alpha1-ar/gh alpha protein coupling and the amount of plc delta 1 at term (+147 and +65% respectively, versus mid-pregnancy). |
2008-04-07 |
2023-08-12 |
rat |
| M Dupuis, E Houdeau, S Mhaouty-Kodj. Increased potency of alpha 1-adrenergic receptors to induce inositol phosphates production correlates with the up-regulation of alpha 1d/Gh alpha/phospholipase C delta 1 signaling pathway in term rat myometrium. Reproduction (Cambridge, England). vol 135. issue 1. 2008-04-07. PMID:18159083. |
our results show, for the first time, that rat myometrial alpha 1d-ar/gh alpha/plc delta 1 signaling pathway is up-regulated at term. |
2008-04-07 |
2023-08-12 |
rat |
| Victoria L Haller, Marissa A Bernstein, Sandra P Welc. Chronic morphine treatment decreases the Cav1.3 subunit of the L-type calcium channel. European journal of pharmacology. vol 578. issue 2-3. 2008-04-03. PMID:18048029. |
l- and n-type vocs are heteropentamers of alpha(1), alpha(2)delta, beta, and gamma subunits. |
2008-04-03 |
2023-08-12 |
Not clear |
| B Brawek, M Löffler, D J Dooley, A Weyerbrock, T J Feuerstei. Differential modulation of K(+)-evoked (3)H-neurotransmitter release from human neocortex by gabapentin and pregabalin. Naunyn-Schmiedeberg's archives of pharmacology. vol 376. issue 5. 2008-04-03. PMID:18074120. |
these drugs appear to act by binding to the alpha(2)delta subunit of voltage-sensitive ca(2+) channels (vscc), resulting in the inhibition of neurotransmitter release. |
2008-04-03 |
2023-08-12 |
human |
| B Brawek, M Löffler, D J Dooley, A Weyerbrock, T J Feuerstei. Differential modulation of K(+)-evoked (3)H-neurotransmitter release from human neocortex by gabapentin and pregabalin. Naunyn-Schmiedeberg's archives of pharmacology. vol 376. issue 5. 2008-04-03. PMID:18074120. |
the alpha(2)delta ligands produced significant inhibitions of k(+)-evoked (3)h-ach, (3)h-na, and (3)h-5-ht release between 22% and 56% without affecting (3)h-da release. |
2008-04-03 |
2023-08-12 |
human |
| B Brawek, M Löffler, D J Dooley, A Weyerbrock, T J Feuerstei. Differential modulation of K(+)-evoked (3)H-neurotransmitter release from human neocortex by gabapentin and pregabalin. Naunyn-Schmiedeberg's archives of pharmacology. vol 376. issue 5. 2008-04-03. PMID:18074120. |
neither drug reduced (3)h-na release in the presence of l: -isoleucine, a putative alpha(2)delta antagonist. |
2008-04-03 |
2023-08-12 |
human |
| B Brawek, M Löffler, D J Dooley, A Weyerbrock, T J Feuerstei. Differential modulation of K(+)-evoked (3)H-neurotransmitter release from human neocortex by gabapentin and pregabalin. Naunyn-Schmiedeberg's archives of pharmacology. vol 376. issue 5. 2008-04-03. PMID:18074120. |
such alpha(2)delta ligands appear to be selective modulators of the release of certain, but not all, neurotransmitters. |
2008-04-03 |
2023-08-12 |
human |
| Adam R Clarke, Robert J Barry, Patrick C L Heaven, Rory McCarthy, Mark Selikowitz, Mitchell K Byrn. EEG coherence in adults with attention-deficit/hyperactivity disorder. International journal of psychophysiology : official journal of the International Organization of Psychophysiology. vol 67. issue 1. 2008-04-01. PMID:18029040. |
waveshape coherence was calculated for 8 intrahemispheric electrode pairs (4 in each hemisphere), and 8 interhemispheric electrode pairs, within each of the delta, theta, alpha and beta bands. |
2008-04-01 |
2023-08-12 |
Not clear |
| Priya Xavier, Khosrow Behbehani, Donald Watenpaugh, John R Bur. Detecting electroencephalography variations due to sleep disordered breathing events. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. vol 2007. 2008-03-28. PMID:18003406. |
the normalized power changes between the frequency bands delta, theta, alpha and sigma were calculated using the welch averaging periodogram method between 10 s of eeg data before the event termination and 10 s of eeg data after event termination. |
2008-03-28 |
2023-08-12 |
human |