| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dianne R Peden, Caroline M Petitjean, Murray B Herd, Murat S Durakoglugil, Thomas W Rosahl, Keith Wafford, Gregg E Homanics, Delia Belelli, Jean-Marc Fritschy, Jeremy J Lamber. Developmental maturation of synaptic and extrasynaptic GABAA receptors in mouse thalamic ventrobasal neurones. The Journal of physiology. vol 586. issue 4. 2008-05-29. PMID:18063661. |
in immature brain, rapid (p8/9-p10/11) developmental change to mipsc kinetics and increased expression of extrasynaptic receptors (p8-27) formed by the alpha(4) and delta subunit occurred independently of the alpha(1) subunit. |
2008-05-29 |
2023-08-12 |
mouse |
| Murray B Herd, Alison R Haythornthwaite, Thomas W Rosahl, Keith A Wafford, Gregg E Homanics, Jeremy J Lambert, Delia Belell. The expression of GABAA beta subunit isoforms in synaptic and extrasynaptic receptor populations of mouse dentate gyrus granule cells. The Journal of physiology. vol 586. issue 4. 2008-05-29. PMID:18079158. |
to investigate the subcellular distribution of the beta subunits we have utilized the patch-clamp technique to compare the properties of 'tonic' and miniature inhibitory postsynaptic currents (mipscs) recorded from dggcs of hippocampal slices of p20-26 wild-type (wt), beta(2)(-/-), beta(2n265s) (etomidate-insensitive), alpha(1)(-/-) and delta(-/-) mice. |
2008-05-29 |
2023-08-12 |
mouse |
| Murray B Herd, Alison R Haythornthwaite, Thomas W Rosahl, Keith A Wafford, Gregg E Homanics, Jeremy J Lambert, Delia Belell. The expression of GABAA beta subunit isoforms in synaptic and extrasynaptic receptor populations of mouse dentate gyrus granule cells. The Journal of physiology. vol 586. issue 4. 2008-05-29. PMID:18079158. |
collectively, these observations, together with previous studies on alpha(4)(-/-) mice, identify a population of extrasynaptic alpha(4)beta(2)delta receptors, whereas synaptic gaba(a) receptors appear to primarily incorporate the beta(3) subunit. |
2008-05-29 |
2023-08-12 |
mouse |
| Marina D Jeyasingham, Antonio Artigues, Owen W Nadeau, Gerald M Carlso. Structural evidence for co-evolution of the regulation of contraction and energy production in skeletal muscle. Journal of molecular biology. vol 377. issue 3. 2008-05-27. PMID:18281058. |
skeletal muscle phosphorylase kinase (phk) is a ca(2+)-dependent enzyme complex, (alpha beta gamma delta)(4), with the delta subunit being tightly bound endogenous calmodulin (cam). |
2008-05-27 |
2023-08-12 |
Not clear |
| Brian S Plosky, Ekaterina G Frank, David A Berry, Graham P Vennall, John P McDonald, Roger Woodgat. Eukaryotic Y-family polymerases bypass a 3-methyl-2'-deoxyadenosine analog in vitro and methyl methanesulfonate-induced DNA damage in vivo. Nucleic acids research. vol 36. issue 7. 2008-05-19. PMID:18281311. |
as expected, the 3dmea lesion blocked both human dna polymerases alpha and delta. |
2008-05-19 |
2023-08-12 |
human |
| Jolanda K Brons, Jan Dirk van Elsa. Analysis of bacterial communities in soil by use of denaturing gradient gel electrophoresis and clone libraries, as influenced by different reverse primers. Applied and environmental microbiology. vol 74. issue 9. 2008-05-19. PMID:18310425. |
within proteobacteria, the majority of the clones fell into the alpha or gamma subgroup whereas a few were delta and beta proteobacteria. |
2008-05-19 |
2023-08-12 |
Not clear |
| M P Lefran. Nomenclature of the human T cell receptor genes. Current protocols in immunology. vol Appendix 1. 2008-05-19. PMID:18432649. |
the human t cell receptors (tcr) alpha-beta and gamma-delta are the products of four sets of genes on two chromosomes: t cell receptors alpha (tra) and delta (trd) on chromosome 14 at 14q11.2, t cell receptor beta (trb) on chromosome 7 at 7q35, and t cell receptor gamma (trg) on chromosome 7 at 7p15-p14. |
2008-05-19 |
2023-08-12 |
human |
| N Zheleznova, A Sedelnikova, D S Weis. alpha1beta2delta, a silent GABAA receptor: recruitment by tracazolate and neurosteroids. British journal of pharmacology. vol 153. issue 5. 2008-05-15. PMID:18204487. |
this study investigated the alpha(1)beta(2)delta isoform of the gaba(a) receptor that is presumably expressed in the forebrain. |
2008-05-15 |
2023-08-12 |
Not clear |
| Marcin P Gach, Gennady Cherednichenko, Claudia Haarmann, Jose R Lopez, Kurt G Beam, Isaac N Pessah, Clara Franzini-Armstrong, Paul D Alle. Alpha2delta1 dihydropyridine receptor subunit is a critical element for excitation-coupled calcium entry but not for formation of tetrads in skeletal myotubes. Biophysical journal. vol 94. issue 8. 2008-05-12. PMID:18192372. |
it has been shown that small interfering rna (sirna) partial knockdown of the alpha(2)delta(1) dihydropyridine receptor subunits cause a significant increase in the rate of activation of the l-type ca(2+) current in myotubes but have little or no effect on skeletal excitation-contraction coupling. |
2008-05-12 |
2023-08-12 |
Not clear |
| Marcin P Gach, Gennady Cherednichenko, Claudia Haarmann, Jose R Lopez, Kurt G Beam, Isaac N Pessah, Clara Franzini-Armstrong, Paul D Alle. Alpha2delta1 dihydropyridine receptor subunit is a critical element for excitation-coupled calcium entry but not for formation of tetrads in skeletal myotubes. Biophysical journal. vol 94. issue 8. 2008-05-12. PMID:18192372. |
this study used permanent sirna knockdown of alpha(2)delta(1) to address two important unaddressed questions. |
2008-05-12 |
2023-08-12 |
Not clear |
| Marcin P Gach, Gennady Cherednichenko, Claudia Haarmann, Jose R Lopez, Kurt G Beam, Isaac N Pessah, Clara Franzini-Armstrong, Paul D Alle. Alpha2delta1 dihydropyridine receptor subunit is a critical element for excitation-coupled calcium entry but not for formation of tetrads in skeletal myotubes. Biophysical journal. vol 94. issue 8. 2008-05-12. PMID:18192372. |
first, does the alpha(2)delta(1) subunit contribute to the size and/or spacing of tetradic particles? |
2008-05-12 |
2023-08-12 |
Not clear |
| Marcin P Gach, Gennady Cherednichenko, Claudia Haarmann, Jose R Lopez, Kurt G Beam, Isaac N Pessah, Clara Franzini-Armstrong, Paul D Alle. Alpha2delta1 dihydropyridine receptor subunit is a critical element for excitation-coupled calcium entry but not for formation of tetrads in skeletal myotubes. Biophysical journal. vol 94. issue 8. 2008-05-12. PMID:18192372. |
second, is the alpha(2)delta(1) subunit important for excitation-coupled calcium entry? |
2008-05-12 |
2023-08-12 |
Not clear |
| Marcin P Gach, Gennady Cherednichenko, Claudia Haarmann, Jose R Lopez, Kurt G Beam, Isaac N Pessah, Clara Franzini-Armstrong, Paul D Alle. Alpha2delta1 dihydropyridine receptor subunit is a critical element for excitation-coupled calcium entry but not for formation of tetrads in skeletal myotubes. Biophysical journal. vol 94. issue 8. 2008-05-12. PMID:18192372. |
we found that the size and spacing of tetradic particles is unaffected by sirna knockdown of alpha(2)delta(1), indicating that the visible particle represents the alpha(1s) subunit. |
2008-05-12 |
2023-08-12 |
Not clear |
| Marcin P Gach, Gennady Cherednichenko, Claudia Haarmann, Jose R Lopez, Kurt G Beam, Isaac N Pessah, Clara Franzini-Armstrong, Paul D Alle. Alpha2delta1 dihydropyridine receptor subunit is a critical element for excitation-coupled calcium entry but not for formation of tetrads in skeletal myotubes. Biophysical journal. vol 94. issue 8. 2008-05-12. PMID:18192372. |
strikingly, >97% knockdown of alpha(2)delta(1) leads to a complete loss of excitation-coupled calcium entry during kcl depolarization and a more rapid decay of ca(2+) transients during bouts of repetitive electrical stimulation like those occurring during normal muscle activation in vivo. |
2008-05-12 |
2023-08-12 |
Not clear |
| Marcin P Gach, Gennady Cherednichenko, Claudia Haarmann, Jose R Lopez, Kurt G Beam, Isaac N Pessah, Clara Franzini-Armstrong, Paul D Alle. Alpha2delta1 dihydropyridine receptor subunit is a critical element for excitation-coupled calcium entry but not for formation of tetrads in skeletal myotubes. Biophysical journal. vol 94. issue 8. 2008-05-12. PMID:18192372. |
thus, we conclude that the alpha(2)delta(1) dihydropyridine receptor subunit is physiologically necessary for sustaining ca(2+) transients in response to prolonged depolarization or repeated trains of action potentials. |
2008-05-12 |
2023-08-12 |
Not clear |
| Zuly E Parra, Michelle L Baker, Jennifer Hathaway, April M Lopez, Jonathan Trujillo, Alana Sharp, Robert D Mille. Comparative genomic analysis and evolution of the T cell receptor loci in the opossum Monodelphis domestica. BMC genomics. vol 9. 2008-05-06. PMID:18312668. |
all jawed-vertebrates have four t cell receptor (tcr) chains: alpha (tra), beta (trb), gamma (trg) and delta (trd). |
2008-05-06 |
2023-08-12 |
Not clear |
| Xuefeng Li, Huijun Wang, Pingming Qiu, Hong Lu. Proteomic profiling of proteins associated with methamphetamine-induced neurotoxicity in different regions of rat brain. Neurochemistry international. vol 52. issue 1-2. 2008-05-05. PMID:17904249. |
the proteins identified by tandem mass spectrometry were cu, zn superoxide dismutase, dimethylarginine dimethylaminohydrolase 1, alpha synuclein, ubiquitin-conjugating enzyme e2n, stathmin 1, calcineurin b, cystatin b, subunit of mitochondrial h-atp synthase, atp synthase d chain, mitochondrial, nadh dehydrogenase(ubiquinone) fe-s protein 8, glia maturation factor, beta, ash-m, neurocalcin delta, myotrophin, profiling iia, d-dopachrome tautomerase, and brain lipid binding protein. |
2008-05-05 |
2023-08-12 |
rat |
| Theresa J Kannanayakal, Jerry R Mendell, Jeff Kure. Casein kinase 1 alpha associates with the tau-bearing lesions of inclusion body myositis. Neuroscience letters. vol 431. issue 2. 2008-05-02. PMID:18191026. |
results showed that the alpha isoform of casein kinase 1, but not the delta or epsilon isoforms, stained degenerating muscle fibers in all eight inclusion body myositis cases examined. |
2008-05-02 |
2023-08-12 |
Not clear |
| Ryosuke Yazawa, Glenn A Cooper, Peter Hunt, Marianne Beetz-Sargent, Adrienne Robb, Melanie Conrad, Linda McKinnel, Stacy So, Stuart Jantzen, Ruth B Phillips, William S Davidson, Ben F Koo. Striking antigen recognition diversity in the Atlantic salmon T-cell receptor alpha/delta locus. Developmental and comparative immunology. vol 32. issue 3. 2008-04-29. PMID:17604101. |
at least 99 valpha, 13 vdelta 86 jalpha, 1 jdelta, and 2 ddelta segments were used in tcr alpha or delta transcription, and 652 unique genes were identified from a sample of 759 tcralpha cdna clones. |
2008-04-29 |
2023-08-12 |
Not clear |
| Nieves Márquez, Marco A Calzado, Gonzalo Sánchez-Duffhues, Moisés Pérez, Alberto Minassi, Alberto Pagani, Giovanni Appendino, Laura Diaz, Maria Angeles Muñoz-Fernández, Eduardo Muño. Differential effects of phorbol-13-monoesters on human immunodeficiency virus reactivation. Biochemical pharmacology. vol 75. issue 6. 2008-04-29. PMID:18241838. |
nevertheless, this compound induces a translocation pattern of the pkc isotypes alpha and delta to cellular compartments distinctly different from that elicited by prostratin and pma. |
2008-04-29 |
2023-08-12 |
human |