| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J G Pires, S R Silva, H A Futuro-Net. Dorsal raphe nucleus lesions have no effect on neuroleptic-induced catalepsy and on the anticataleptic activity of buspirone. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 24. issue 6. 1992-09-22. PMID:1823280. |
the dorsal raphe nucleus (drn) is reported to be an important source of serotonergic projections to the basal ganglia, the site of neuroleptic action. |
1992-09-22 |
2023-08-11 |
rat |
| M Steriad. Basic mechanisms of sleep generation. Neurology. vol 42. issue 7 Suppl 6. 1992-08-20. PMID:1630645. |
the generation of rem sleep signs is probably caused, at least partially, by the disinhibition of mesopontine cholinergic cells, the executive elements of tonic and phasic events during dreaming sleep, following cessation of firing of inhibitory serotonergic dorsal raphe neurons. |
1992-08-20 |
2023-08-11 |
Not clear |
| N J Penington, J S Kelly, A P Fo. Action potential waveforms reveal simultaneous changes in ICa and IK produced by 5-HT in rat dorsal raphe neurons. Proceedings. Biological sciences. vol 248. issue 1322. 1992-08-19. PMID:1352892. |
action potentials were recorded from serotonergic dorsal raphe (dr) neurons acutely isolated from the adult rat brain. |
1992-08-19 |
2023-08-11 |
rat |
| K A Jellinger, W Paulu. Clinico-pathological correlations in Parkinson's disease. Clinical neurology and neurosurgery. vol 94 Suppl. 1992-08-12. PMID:1320531. |
more severe cell loss in the serotonergic dorsal raphe nucleus was observed in pd patients with depression than in non-depressed ones. |
1992-08-12 |
2023-08-11 |
human |
| K C Corley, V B Singh, T H Phan, M C Boadle-Bibe. Effect of gepirone on increases in tryptophan hydroxylase in response to sound stress. European journal of pharmacology. vol 213. issue 3. 1992-08-06. PMID:1377631. |
gepirone may block the sound stress-induced biochemical increases by its inhibition of serotonergic neuronal firing in the dorsal raphe nucleus that is mediated by its agonist action at the somatodendritic (5-ht1a) autoreceptors. |
1992-08-06 |
2023-08-11 |
rat |
| L P Morin, J Blanchar. Depletion of brain serotonin by 5,7-DHT modifies hamster circadian rhythm response to light. Brain research. vol 566. issue 1-2. 1992-06-23. PMID:1814534. |
serotonin immunohistochemistry showed an approximate 90% loss of cells from the dorsal raphe nucleus and decreased density of the serotonergic terminal field in the scn and igl. |
1992-06-23 |
2023-08-11 |
Not clear |
| M Banay-Schwartz, T DeGuzman, A Kenessey, M Palkovits, A Lajth. The distribution of cathepsin D activity in adult and aging human brain regions. Journal of neurochemistry. vol 58. issue 6. 1992-06-04. PMID:1573400. |
in the ventrolateral medulla, which contains the major portion of the cerebral noradrenergic cells, the cathepsin d levels increased with age; in the dorsal raphe area, which contains the major portion of the cerebral serotonergic cells, the enzyme levels decreased. |
1992-06-04 |
2023-08-11 |
human |
| J S Sprous. Inhibition of dorsal raphe cell firing by MDL 73005EF, a novel 5-HT1A receptor ligand. European journal of pharmacology. vol 201. issue 2-3. 1992-04-16. PMID:1839146. |
the effect of a novel ligand for the 5-ht1a receptor subtype, mdl 73005ef, on the firing rate of serotonergic dorsal raphe neurons was assessed in rat midbrain slices maintained in vitro. |
1992-04-16 |
2023-08-11 |
rat |
| D Jackson, E D Abercrombi. In vivo neurochemical evaluation of striatal serotonergic hyperinnervation in rats depleted of dopamine at infancy. Journal of neurochemistry. vol 58. issue 3. 1992-03-13. PMID:1371152. |
destruction of nigrostriatal dopamine (da) neurons with 6-hydroxydopamine (6-ohda) early in development results in hyperinnervation of striatum by the serotonergic afferents deriving from the dorsal raphe nucleus. |
1992-03-13 |
2023-08-11 |
rat |
| T Koh, M Nakazawa, K Kani, T Maed. Investigations of origins of serotonergic projection to developing rat visual cortex: a combined retrograde tracing and immunohistochemical study. Brain research bulletin. vol 27. issue 5. 1992-02-06. PMID:1721860. |
in the first experiment, the animals were examined after 2 days; retrogradely labeled cells were observed in the dorsal raphe nucleus (dr), the median raphe nucleus (mr), and in the b9 and b6 cell groups; the majority (82.5%) of the cells was serotonergic. |
1992-02-06 |
2023-08-11 |
rat |
| J S Kelly, P Larkman, N J Penington, D G Rainnie, H McAllister-Williams, J Hodgkis. Serotonin receptor heterogeneity and the role of potassium channels in neuronal excitability. Advances in experimental medicine and biology. vol 287. 1992-02-06. PMID:1759607. |
our studies have confirmed the 5-ht evoked depolarisation of rat facial motorneurones (fm's) and the hyperpolarisation seen in presumed serotonergic neurones of the dorsal raphe nucleus (drn) to be the result of opposite effects on k+ ion permeability. |
1992-02-06 |
2023-08-11 |
rat |
| M A Wilson, M E Mollive. The organization of serotonergic projections to cerebral cortex in primates: retrograde transport studies. Neuroscience. vol 44. issue 3. 1992-01-24. PMID:1721683. |
the present observations support the hypothesis that the dorsal raphe nucleus is comprised of distinct sets of neurons whose output is distributed to multiple, interconnected cortical areas; these serotonergic projections may play a role in the coordination of excitability in functionally related areas of cortex. |
1992-01-24 |
2023-08-11 |
monkey |
| A Klepper, H Herber. Distribution and origin of noradrenergic and serotonergic fibers in the cochlear nucleus and inferior colliculus of the rat. Brain research. vol 557. issue 1-2. 1992-01-22. PMID:1747753. |
the serotonergic innervation of the cn and ic originated largely in the b7 serotonergic cell group (dorsal raphe nucleus). |
1992-01-22 |
2023-08-11 |
rat |
| D Saphie. Paraventricular nucleus magnocellular neuronal responses following electrical stimulation of the midbrain dorsal raphe. Experimental brain research. vol 85. issue 2. 1991-10-21. PMID:1893984. |
in order to determine the responses of paraventricular nucleus magnocellular neurones following activation of central serotonergic pathways, single unit activity was recorded and responses following electrical stimulation of the midbrain dorsal raphe nucleus were examined. |
1991-10-21 |
2023-08-11 |
Not clear |
| S Haj-Dahmane, M Hamon, L Lanfume. K+ channel and 5-hydroxytryptamine1A autoreceptor interactions in the rat dorsal raphe nucleus: an in vitro electrophysiological study. Neuroscience. vol 41. issue 2-3. 1991-09-13. PMID:1714550. |
extracellular recordings were made from serotonergic neurons of the rat dorsal raphe nucleus in a slice preparation. |
1991-09-13 |
2023-08-11 |
rat |
| S Haj-Dahmane, M Hamon, L Lanfume. K+ channel and 5-hydroxytryptamine1A autoreceptor interactions in the rat dorsal raphe nucleus: an in vitro electrophysiological study. Neuroscience. vol 41. issue 2-3. 1991-09-13. PMID:1714550. |
these results indicate that, in serotonergic neurons within the dorsal raphe nucleus, the k+ channel opened through the stimulation of 5-hydroxytryptamine1a autoreceptors is 4-aminopyridine-sensitive. |
1991-09-13 |
2023-08-11 |
rat |
| A Adell, F Artiga. Differential effects of clomipramine given locally or systemically on extracellular 5-hydroxytryptamine in raphe nuclei and frontal cortex. An in vivo brain microdialysis study. Naunyn-Schmiedeberg's archives of pharmacology. vol 343. issue 3. 1991-09-12. PMID:1714040. |
electrophysiological studies have shown that cim also reduces the firing of serotonergic neurons in the dorsal raphe nucleus. |
1991-09-12 |
2023-08-11 |
Not clear |
| C P VanderMaelen, J P Braselto. Acute administration of the antidepressant trazodone increases noradrenergic locus coeruleus neuronal firing in rats. Archives internationales de pharmacodynamie et de therapie. vol 308. 1991-07-26. PMID:2099132. |
these findings, in combination with previous work showing that trazodone inhibits the firing of serotonergic dorsal raphe neurons indicate that trazodone modulates monoaminergic neuronal activity in the brain and suggest a unique electrophysiological profile for this drug among antidepressants. |
1991-07-26 |
2023-08-11 |
rat |
| K S Kim, T C Wessel, D M Stone, C H Carver, T H Joh, D H Par. Molecular cloning and characterization of cDNA encoding tryptophan hydroxylase from rat central serotonergic neurons. Brain research. Molecular brain research. vol 9. issue 4. 1991-06-28. PMID:1645430. |
tryptophan hydroxylase (tph) from central serotonergic neurons in the dorsal raphe nucleus (drn) and that from the endocrine pineal gland (pg) have been shown to exhibit difference biochemical characteristics. |
1991-06-28 |
2023-08-11 |
rat |
| P M Thompson, G Zebrowski, R S Neuma. Alteration of neocortical activity in response to noxious stimulation: participation of the dorsal raphe. Neuropharmacology. vol 30. issue 2. 1991-06-20. PMID:1827661. |
as a large forebrain projection of serotonergic fibres originates from the dorsal raphe nucleus, involvement of this nucleus in altering cortical activity was investigated. |
1991-06-20 |
2023-08-11 |
Not clear |