| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Niraj Kumar Singh, Pranjul Singh, Prachi Varshney, Ashini Singh, Bharat Bhusha. Multimodal action of phosphodiesterase 5 inhibitors against neurodegenerative disorders: An update review. Journal of biochemical and molecular toxicology. vol 38. issue 11. 2024-10-19. PMID:39425458. |
phosphodiesterase type 5 (pde5) is an enzyme primarily found in the smooth muscle of the corpus cavernosum and also highly expressed in the substantia nigra, cerebellum, caudate, hippocampal regions and cerebellar purkinje cells, responsible for selectively breaking down cyclic guanosine monophosphate (cgmp) into 5'-gmp and regulate intracellular cgmp levels. |
2024-10-19 |
2024-10-21 |
Not clear |
| Yuki Yonenobu, Goichi Beck, Kansuke Kido, Norihisa Maeda, Rika Yamashita, Kimiko Inoue, Yuko Saito, Masato Hasegawa, Hidefumi Ito, Kazuko Hasegawa, Eiichi Morii, Toru Iwaki, Shigeo Murayama, Hideki Mochizuk. Neuropathology of spinocerebellar ataxia type 8: Common features and unique tauopathy. Neuropathology : official journal of the Japanese Society of Neuropathology. 2023-01-27. PMID:36703300. |
severe neuronal loss in the substantia nigra and prominent loss of purkinje cells, atrophy of the molecular layer, and proliferation of bergmann glia in the cerebellum were common features. |
2023-01-27 |
2023-08-14 |
Not clear |
| Aifeng Zhang, Hong Yu, Youji He, Yuqing Shen, Ying Zhang, Jiane Liu, Bo Fu, Dan Lv, Fengqin Miao, Jianqiong Zhan. Developmental expression and localization of MHC class I molecules in the human central nervous system. Experimental brain research. vol 233. issue 9. 2016-10-28. PMID:26169100. |
between the age of 20-33 gestational weeks (gw), mhc class i expression was relatively absent in the cerebral cortex with the exception of a few neurons; however, expression increased rapidly in the cochlear nuclei and in the cerebellar cortical purkinje cells while increasing slowly in the substantia nigra. |
2016-10-28 |
2023-08-13 |
human |
| Xuejing Wang, Mingming Ma, Junfang Teng, Jiewen Zhang, Shuang Zhou, Ying Zhang, Erxi Wu, Xuebing Din. Chronic exposure to cerebrospinal fluid of multiple system atrophy in neuroblastoma and glioblastoma cells induces cytotoxicity via ER stress and autophagy activation. Oncotarget. vol 6. issue 15. 2016-04-07. PMID:25965819. |
specifically, dopamine neurons in substantia nigra and purkinje cells in cerebellum cortex were degenerated in msa-csf-injected mice. |
2016-04-07 |
2023-08-13 |
mouse |
| Kirsten Ridder, Sascha Keller, Maria Dams, Anne-Kathleen Rupp, Jessica Schlaudraff, Domenico Del Turco, Julia Starmann, Jadranka Macas, Darja Karpova, Kavi Devraj, Candan Depboylu, Britta Landfried, Bernd Arnold, Karl H Plate, Günter Höglinger, Holger Sültmann, Peter Altevogt, Stefan Momm. Extracellular vesicle-mediated transfer of genetic information between the hematopoietic system and the brain in response to inflammation. PLoS biology. vol 12. issue 6. 2015-08-05. PMID:24893313. |
although cre-mediated recombination events in the brain occur very rarely in healthy animals, their number increases considerably in different injury models, particularly under inflammatory conditions, and extend beyond purkinje neurons to other neuronal populations in cortex, hippocampus, and substantia nigra. |
2015-08-05 |
2023-08-13 |
mouse |
| Y Zhao, J Xiao, S Gong, J A Clara, M S Ledou. Neural expression of the transcription factor THAP1 during development in rat. Neuroscience. vol 231. 2013-07-25. PMID:23219941. |
in addition to purkinje cells in the cerebellum, thap1-ir was also localized to pyramidal neurons in the cerebral cortex, relay neurons in the thalamus, medium spiny and cholinergic neurons in the striatum, dopaminergic neurons in the substantia nigra, and pyramidal and interneurons in the hippocampus. |
2013-07-25 |
2023-08-12 |
rat |
| Dongmei Zhang, Qiang Guo, Chen Bian, Jiqiang Zhang, Sen Lin, Bingyin S. Alterations of steroid receptor coactivator-1 (SRC-1) immunoreactivities in specific brain regions of young and middle-aged female Sprague-Dawley rats. Brain research. vol 1382. 2011-11-15. PMID:21241680. |
the results showed that striking age-related decreases of src-1 were noticed in those regions related to central regulation of motor (substantia nigra, pontine nuclei, lateral reticular nucleus and purkinje cells, etc. |
2011-11-15 |
2023-08-12 |
rat |
| W Guo, X Xu, X Gao, G Burnstock, C He, Z Xian. Expression of P2X5 receptors in the mouse CNS. Neuroscience. vol 156. issue 3. 2009-04-14. PMID:18773945. |
heavy p2x5 receptor immunostaining was observed in the mitral cells of the olfactory bulb; cerebral cortex; globus pallidum, anterior cortical amygdaloid nucleus, amygdalohippocampal area of subcortical telencephalon; anterior nuclei, anteroventral nucleus, ventrolateral nucleus of thalamus; supraoptic nucleus, ventromedial nucleus, arcuate nucleus of hypothalamus; substantia nigra of midbrain; pontine nuclei, mesencephalic trigeminal nucleus, motor trigeminal nucleus, ambiguous nucleus, inferior olive, hypoglossal nucleus, dorsal motor vagus nucleus, area postrema of hindbrain; purkinje cells of cerebellum; and spinal cord. |
2009-04-14 |
2023-08-12 |
mouse |
| Y Honjo, Y Shirakashi, Y Kawamoto, I Akiguch. Anti-DARPP32 antibody-immunopositive inclusions in the brain of patients with multiple system atrophy. Clinical neuropathology. vol 27. issue 5. 2008-10-21. PMID:18808062. |
neurons in the caudate, globus pallidus, substantia nigra, hypothalamus, neocortex layers ii and iii, and cerebellar purkinje cells were all immunopositive for darpp32 in the normal control brains, and the immunostaining patterns were very similar to those observed in patients with msa. |
2008-10-21 |
2023-08-12 |
human |
| Hugh E Criswell, Zhen Ming, M Katherine Kelm, George R Brees. Brain regional differences in the effect of ethanol on GABA release from presynaptic terminals. The Journal of pharmacology and experimental therapeutics. vol 326. issue 2. 2008-08-12. PMID:18502983. |
ethanol produced a concentration-dependent increase in the frequency of sipscs recorded from mechanically dissociated cerebellar purkinje neurons and mipscs from substantia nigra neurons without having an effect on sipscs recorded from lateral septal or cerebrocortical neurons. |
2008-08-12 |
2023-08-12 |
Not clear |
| Jeff G Blackinton, Anna Anvret, Alexandra Beilina, Lars Olson, Mark R Cookson, Dagmar Galte. Expression of PINK1 mRNA in human and rodent brain and in Parkinson's disease. Brain research. vol 1184. 2008-04-08. PMID:17950257. |
highest levels of expression were observed in hippocampus, substantia nigra and cerebellar purkinje cells. |
2008-04-08 |
2023-08-12 |
mouse |
| Ghazal Banisadr, Romain-Daniel Gosselin, Patricia Mechighel, Patrick Kitabgi, William Rostène, Stéphane Mélik Parsadaniant. Highly regionalized neuronal expression of monocyte chemoattractant protein-1 (MCP-1/CCL2) in rat brain: evidence for its colocalization with neurotransmitters and neuropeptides. The Journal of comparative neurology. vol 489. issue 3. 2008-03-26. PMID:16025454. |
neuronal expression of mcp-1/ccl2 is mainly found in the cerebral cortex, globus pallidus, hippocampus, paraventricular and supraoptic hypothalamic nuclei, lateral hypothalamus, substantia nigra, facial nuclei, motor and spinal trigeminal nuclei, and gigantocellular reticular nucleus and in purkinje cells in the cerebellum. |
2008-03-26 |
2023-08-12 |
rat |
| Alice Guyon, Jean-Louis Naho. Multiple actions of the chemokine stromal cell-derived factor-1alpha on neuronal activity. Journal of molecular endocrinology. vol 38. issue 3. 2007-09-18. PMID:17339399. |
in various neuronal populations (ca1 neurons of the hippocampus, granular and purkinje cells of the cerebellum, melanin-concentrating hormone neurons of the lateral hypothalamus, vasopressinergic neurons of the supraoptic and the paraventricular nucleus of the hypothalamus, and dopaminergic neurons of the substantia nigra), sdf-1alpha can modulate the activity of neurons by multiple regulatory pathways including and often combining: (i) modulation of voltage-dependent channels (sodium, potassium, and calcium), (ii) activation of the g-protein-activated inward rectifier potassium current, and (iii) increase in neurotransmitter release (gamma-amino butyric acid (gaba), glutamate, and dopamine), often through ca-dependent mechanisms. |
2007-09-18 |
2023-08-12 |
Not clear |
| Duong P Huynh, Dung T Nguyen, Johannes B Pulst-Korenberg, Alexis Brice, Stefan-M Puls. Parkin is an E3 ubiquitin-ligase for normal and mutant ataxin-2 and prevents ataxin-2-induced cell death. Experimental neurology. vol 203. issue 2. 2007-03-20. PMID:17097639. |
expansion of the polyq repeat in ataxin-2 results in degeneration of purkinje neurons and other neuronal groups including the substantia nigra in patients with spinocerebellar ataxia type 2 (sca2). |
2007-03-20 |
2023-08-12 |
Not clear |
| Dong Liang Ma, Shwn Chin Chia, Yong Cheng Tang, May Ling Joyce Chang, Alphonse Probst, Jean-Marc Burgunder, Feng Ru Tan. Spastin in the human and mouse central nervous system with special reference to its expression in the hippocampus of mouse pilocarpine model of status epilepticus and temporal lobe epilepsy. Neurochemistry international. vol 49. issue 7. 2007-01-05. PMID:16828199. |
in the present in situ hybridization and immunocytochemical studies in the mouse central nervous system (cns), a strong expression of spastin mrna and protein was found in purkinje cells and dentate nucleus in the cerebellum, in hippocampal principal cells and hilar neurons, in amygdala, substantia nigra, striatum, in the motor nuclei of the cranial nerves and in different layers of the cerebral cortex except piriform and entorhinal cortices where only neurons in layer ii were strongly stained. |
2007-01-05 |
2023-08-12 |
mouse |
| E Bahn, S Siegert, T Pfander, M L Kramer, W J Schulz-Schaeffer, J W Hewett, X O Breakefield, J C Hedreen, K M Rostás. TorsinB expression in the developing human brain. Brain research. vol 1116. issue 1. 2006-12-12. PMID:16938275. |
expression of torsinb protein was detectable beginning at four to 8 weeks of age in the cerebellum (purkinje cells), substantia nigra (dopaminergic neurons), hippocampus and basal ganglia and was predominantly restricted to neuronal cells. |
2006-12-12 |
2023-08-12 |
human |
| Jana Boy, Trygve B Leergaard, Thorsten Schmidt, Francis Odeh, Ulrike Bichelmeier, Silke Nuber, Carsten Holzmann, Andreas Wree, Stanley B Prusiner, Hermann Bujard, Olaf Riess, Jan G Bjaali. Expression mapping of tetracycline-responsive prion protein promoter: digital atlasing for generating cell-specific disease models. NeuroImage. vol 33. issue 2. 2006-11-21. PMID:16931059. |
among the ensuing results were expression of this promoter in putative glial cells in the cerebellum (and not in purkinje cells), in putative glial cells in the substantia nigra, in pallidal glial cells or interneurons, and in distinct cell layers and regions of the hippocampus. |
2006-11-21 |
2023-08-12 |
mouse |
| Anna M Lee, Sharon Miksys, Roberta Palmour, Rachel F Tyndal. CYP2B6 is expressed in African Green monkey brain and is induced by chronic nicotine treatment. Neuropharmacology. vol 50. issue 4. 2006-07-10. PMID:16309716. |
basal expression of brain cyp2b6 was strong in specific cells such as the frontal cortical pyramidal cells, the cerebellar purkinje cells and the neurons in the substantia nigra. |
2006-07-10 |
2023-08-12 |
human |
| Danqing Xiao, Gregory M Miller, Amy Jassen, Susan V Westmoreland, Douglas Pauley, Bertha K Madra. Ephrin/Eph receptor expression in brain of adult nonhuman primates: implications for neuroadaptation. Brain research. vol 1067. issue 1. 2006-05-02. PMID:16360648. |
immunocytochemical localization of epha4 protein revealed discrete expression in caudate/putamen, globus pallidus, substantia nigra, cerebellar purkinje cells, pyramidal cells of frontal cortices (layers ii, iii and v) and the subgranular zone of the hippocampus. |
2006-05-02 |
2023-08-12 |
monkey |
| S Siegert, E Bahn, M L Kramer, W J Schulz-Schaeffer, J W Hewett, X O Breakefield, J C Hedreen, K M Rostas. TorsinA expression is detectable in human infants as young as 4 weeks old. Brain research. Developmental brain research. vol 157. issue 1. 2005-08-12. PMID:15939081. |
expression of torsina protein was detectable beginning at 4 to 8 weeks of age postnatally in the cerebellum (purkinje cells), substantia nigra (dopaminergic neurons), hippocampus and basal ganglia. |
2005-08-12 |
2023-08-12 |
human |