| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Torvik, S Torp, B F Kase, J Ek, O Skjeldal, O Stokk. Infantile Refsum's disease: a generalized peroxisomal disorder. Case report with postmortem examination. Journal of the neurological sciences. vol 85. issue 1. 1988-08-11. PMID:2455020. |
the brain showed no malformations except for a severe hypoplasia of the cerebellar granule layer and ectopic location of the purkinje cells in the molecular layer. |
1988-08-11 |
2023-08-11 |
Not clear |
| K Kawamura, T Nanami, Y Kikuchi, A Kitakam. Grafted granule and Purkinje cells can migrate into the mature cerebellum of normal adult rats. Experimental brain research. vol 70. issue 3. 1988-08-08. PMID:3384049. |
in about 80% of our successful experiments, grafted purkinje and/or granule cells migrated into the host molecular layer. |
1988-08-08 |
2023-08-11 |
rat |
| K Kawamura, T Nanami, Y Kikuchi, A Kitakam. Grafted granule and Purkinje cells can migrate into the mature cerebellum of normal adult rats. Experimental brain research. vol 70. issue 3. 1988-08-08. PMID:3384049. |
some grafted purkinje cells were also located ectopically in the host molecular layer. |
1988-08-08 |
2023-08-11 |
rat |
| K Kawamura, T Nanami, Y Kikuchi, A Kitakam. Grafted granule and Purkinje cells can migrate into the mature cerebellum of normal adult rats. Experimental brain research. vol 70. issue 3. 1988-08-08. PMID:3384049. |
where the grafted purkinje cells were located on top of the host molecular layer, their primary dendrites faced vertically downwards into the host molecular layer. |
1988-08-08 |
2023-08-11 |
rat |
| R Gardette, R M Alvarado-Mallart, F Crepel, C Sotel. Electrophysiological demonstration of a synaptic integration of transplanted Purkinje cells into the cerebellum of the adult Purkinje cell degeneration mutant mouse. Neuroscience. vol 24. issue 3. 1988-07-18. PMID:3380299. |
after implantation of solid pieces of cerebellar primordia from 12-day-old c57bl embryos into the cerebellar parenchyma of 3- to 4-month-old "purkinje cell degeneration" mutant mice, purkinje cells from the donor leave the implant and differentiate while migrating into the host molecular layer. |
1988-07-18 |
2023-08-11 |
mouse |
| R Gardette, R M Alvarado-Mallart, F Crepel, C Sotel. Electrophysiological demonstration of a synaptic integration of transplanted Purkinje cells into the cerebellum of the adult Purkinje cell degeneration mutant mouse. Neuroscience. vol 24. issue 3. 1988-07-18. PMID:3380299. |
electrophysiological studies were performed using in vitro cerebellar slice preparations from "purkinje cell degeneration" mutants 1-2 months after grafting, when grafted purkinje cells have reached their final location in the host molecular layer and have completed their morphological differentiation. |
1988-07-18 |
2023-08-11 |
mouse |
| R Gardette, R M Alvarado-Mallart, F Crepel, C Sotel. Electrophysiological demonstration of a synaptic integration of transplanted Purkinje cells into the cerebellum of the adult Purkinje cell degeneration mutant mouse. Neuroscience. vol 24. issue 3. 1988-07-18. PMID:3380299. |
the ectopic location of their perikarya, the presence of dendritic trees spanning most of the molecular layer (without entering the granular layer), and the occasional presence of axons emerging from the ectopic neurons and forming loose bundles at the white matter axis of the folia, corroborate the grafted nature of the purkinje cells studied. |
1988-07-18 |
2023-08-11 |
mouse |
| J Hámori, J Takác. Morphological study of cerebellar transplant cocultivated with cerebral cortical graft in the anterior eye chamber. II. Purkinje cells and molecular layer. Anatomy and embryology. vol 177. issue 6. 1988-07-08. PMID:3377196. |
purkinje cells and molecular layer. |
1988-07-08 |
2023-08-11 |
Not clear |
| D Kumar, W R Timperle. The clinical, pathological and genetic aspects of sporadic late onset cerebellar ataxia: observations on a series of ten patients. Acta neurologica Scandinavica. vol 77. issue 3. 1988-06-27. PMID:3376743. |
histopathological examination in one patient, clinically diagnosed as multiple sclerosis, revealed complete loss of purkinje cells from the cerebellar folia with gliosis in the molecular layer and loss of small granular neurones. |
1988-06-27 |
2023-08-11 |
Not clear |
| G Poeggel, H Luppa, W Ludwig, P Bornelei. Production of an antiserum against cyclic nucleotide phosphodiesterase and its use for the immunocytochemical demonstration of this enzyme in rat cerebellum. Histochemistry. vol 88. issue 3-6. 1988-06-22. PMID:2835339. |
most of the antigenic sites were present in the neuropil of the molecular layer and around purkinje cells. |
1988-06-22 |
2023-08-11 |
rat |
| A Rotter, C Gorenstein, A Frosthol. The localization of GABAA receptors in mice with mutations affecting the structure and connectivity of the cerebellum. Brain research. vol 439. issue 1-2. 1988-06-08. PMID:2833984. |
in the 54-57-day-old purkinje cell degeneration mutant, where essentially all purkinje cells have disappeared by day 45, a 29% decrease in grain density over the granule cell layer was observed, while labeling was still present in the molecular layer. |
1988-06-08 |
2023-08-11 |
mouse |
| M Sakura. Synaptic modification of parallel fibre-Purkinje cell transmission in in vitro guinea-pig cerebellar slices. The Journal of physiology. vol 394. 1988-05-12. PMID:2832595. |
intracellular recordings were made from purkinje cells, mainly from dendrites in the middle third of the molecular layer, but also, in a few cases, from somata. |
1988-05-12 |
2023-08-11 |
Not clear |
| J L Smith, J C Finley, V A Lenno. Autoantibodies in paraneoplastic cerebellar degeneration bind to cytoplasmic antigens of Purkinje cells in humans, rats and mice and are of multiple immunoglobulin classes. Journal of neuroimmunology. vol 18. issue 1. 1988-04-18. PMID:3346369. |
antibodies of each isotype gave a similar staining pattern, highlighting the cytoplasm of purkinje cells in a coarse granular pattern, and the peripheral cytoplasm of discrete molecular layer cells. |
1988-04-18 |
2023-08-11 |
mouse |
| S W Schoen, M B Graeber, M Reddington, G W Kreutzber. Light and electron microscopical immunocytochemistry of 5'-nucleotidase in rat cerebellum. Histochemistry. vol 87. issue 2. 1987-10-22. PMID:3040642. |
bergmann glial cell processes crossing the molecular layer, astrocytic end-feet around blood vessels and glial cell extensions surrounding single purkinje cells. |
1987-10-22 |
2023-08-11 |
rat |
| N G Conrad. Cerebellar foliation in rats. 5. Structural relations between Purkinje cells and heterotopic external granular layer in normal and protein deprived foetal rats. Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology. vol 95. issue 5. 1987-10-16. PMID:3630708. |
these heterotopic purkinje cells had an apical process mostly pointing towards the egl nests and there was a primitive molecular layer lying between the heterotopic purkinje cells and the egl cells. |
1987-10-16 |
2023-08-11 |
rat |
| T Hanamori, N Ishik. Response properties of cerebellar neurons to stimulation of the frog glossopharyngeal nerve and tongue. Brain research bulletin. vol 18. issue 4. 1987-09-03. PMID:3496939. |
in the present study, negative cerebellar field potentials in the molecular layer and single unit responses of purkinje cells induced by electrical stimulation of the bullfrog glossopharyngeal (ixth) nerve or tongue surface were investigated. |
1987-09-03 |
2023-08-11 |
Not clear |
| C Gravel, R Hawke. Neuronal maturation in the normal and hypothyroid rat cerebellar cortex studied with monoclonal antibody MIT-23. The Journal of comparative neurology. vol 258. issue 3. 1987-07-10. PMID:3294926. |
furthermore, secondary branching of ectopic dendrites is confined exclusively to the developing molecular layer, as in normal purkinje cells, thus suggesting that neither the mature nor immature granule cell environment is sufficient to sustain normal dendritic development. |
1987-07-10 |
2023-08-11 |
rat |
| C Sotelo, R M Alvarado-Mallar. Embryonic and adult neurons interact to allow Purkinje cell replacement in mutant cerebellum. Nature. vol 327. issue 6121. 1987-06-30. PMID:3587363. |
grafted purkinje cells leave the graft to migrate along stereotyped pathways to their final position in the deficient molecular layer, where they receive synaptic contacts from adult host neurons. |
1987-06-30 |
2023-08-11 |
mouse |
| C Sotelo, R M Alvarado-Mallar. Reconstruction of the defective cerebellar circuitry in adult Purkinje cell degeneration mutant mice by Purkinje cell replacement through transplantation of solid embryonic implants. Neuroscience. vol 20. issue 1. 1987-05-11. PMID:3561760. |
in all three situations, a large number of grafted purkinje cells succeeded in moving out of the implants and in invading the host molecular layer. |
1987-05-11 |
2023-08-11 |
mouse |
| C Sotelo, R M Alvarado-Mallar. Reconstruction of the defective cerebellar circuitry in adult Purkinje cell degeneration mutant mice by Purkinje cell replacement through transplantation of solid embryonic implants. Neuroscience. vol 20. issue 1. 1987-05-11. PMID:3561760. |
ultrastructural examination of the synaptic investment of purkinje cells which have reached the host molecular layer revealed that they acquire normal synaptic inputs although complex pericellular baskets and pinceau formation do not develop. |
1987-05-11 |
2023-08-11 |
mouse |