| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Petra Nette. Benefits and limitations of drug studies in temperament research: biochemical responses as indicators of temperament. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 373. issue 1744. 2019-01-18. PMID:29483349. |
drugs targeting synthesis, release, receptors or reuptake of dopamine, serotonin and noradrenergic transmitter (tm) systems were used for characterizing or discriminating certain temperament or personality traits and their sub-factors. |
2019-01-18 |
2023-08-13 |
Not clear |
| Meng-Yang Zh. Noradrenergic Modulation on Dopaminergic Neurons. Neurotoxicity research. vol 34. issue 4. 2018-11-26. PMID:29572781. |
it is now well accepted that there is a close relationship between noradrenergic and dopaminergic neurons in the brain, especially referring to the modulation of the locus coeruleus-norepinephrine (lc-ne) system on dopamine transmission. |
2018-11-26 |
2023-08-13 |
Not clear |
| Teng-Fei Li, Hai-Yun Wu, Yi-Rui Wang, Xin-Yan Li, Yong-Xiang Wan. Molecular signaling underlying bulleyaconitine A (BAA)-induced microglial expression of prodynorphin. Scientific reports. vol 7. 2018-11-14. PMID:28327597. |
the data showed that (1) baa treatment induced phosphorylation of creb (rather than nf-κb) and prodynorphin expression in cultured primary microglia, and antiallodynia in neuropathy, which were totally inhibited by the creb inhibitor kg-501; (2) baa upregulated phosphorylation of p38 (but not erk or jnk), and the p38 inhibitor sb203580 (but not erk or jnk inhibitor) and p38β gene silencer sirna/p38β (but not sirna/p38α) completely blocked baa-induced p38 phosphorylation and/or prodynorphin expression, and antiallodynia; (3) baa stimulated camp production and pka phosphorylation, and the adenylate cyclase inhibitor dda and pka inhibitor h-89 entirely antagonized baa-induced prodynorphin expression and antiallodynia; (4) the gs-protein inhibitor nf449 completely inhibited baa-increased camp level, prodynorphin expression and antiallodynia, whereas the antagonists of noradrenergic, corticotrophin-releasing factor, a1 adenosine, formyl peptide, d1/d2 dopamine, and glucagon like-peptide-1 receptors failed to block baa-induced antiallodynia. |
2018-11-14 |
2023-08-13 |
Not clear |
| Carolyn W Roman, Victor A Derkach, Richard D Palmite. Genetically and functionally defined NTS to PBN brain circuits mediating anorexia. Nature communications. vol 7. 2018-09-05. PMID:27301688. |
here we identify cholecystokinin (cck) and noradrenergic, dopamine β-hydroxylase (dbh)-expressing nts neurons as two separate populations that directly excite cgrp(pbn) neurons. |
2018-09-05 |
2023-08-13 |
mouse |
| Rita Gálosi, Zoltán Petykó, Veronika Kállai, Attila Tóth, Tamás Ollmann, László Péczely, Anita Kovács, Beáta Berta, László Lénár. Destruction of noradrenergic terminals increases dopamine concentration and reduces dopamine metabolism in the medial prefrontal cortex. Behavioural brain research. vol 344. 2018-09-04. PMID:29454007. |
destruction of noradrenergic terminals increases dopamine concentration and reduces dopamine metabolism in the medial prefrontal cortex. |
2018-09-04 |
2023-08-13 |
Not clear |
| Rita Gálosi, Zoltán Petykó, Veronika Kállai, Attila Tóth, Tamás Ollmann, László Péczely, Anita Kovács, Beáta Berta, László Lénár. Destruction of noradrenergic terminals increases dopamine concentration and reduces dopamine metabolism in the medial prefrontal cortex. Behavioural brain research. vol 344. 2018-09-04. PMID:29454007. |
effects of destroyed noradrenergic (ne) innervation in the medial prefrontal cortex (mpfc) were examined on dopamine (da) content and metabolism. |
2018-09-04 |
2023-08-13 |
Not clear |
| Hideaki Obat. Analgesic Mechanisms of Antidepressants for Neuropathic Pain. International journal of molecular sciences. vol 18. issue 11. 2018-07-03. PMID:29160850. |
serotonin and dopamine may reinforce the noradrenergic effects to inhibit neuropathic pain. |
2018-07-03 |
2023-08-13 |
Not clear |
| Jin W Park, Rohan V Bhimani, Jinwoo Par. Noradrenergic Modulation of Dopamine Transmission Evoked by Electrical Stimulation of the Locus Coeruleus in the Rat Brain. ACS chemical neuroscience. vol 8. issue 9. 2018-06-12. PMID:28594540. |
noradrenergic modulation of dopamine transmission evoked by electrical stimulation of the locus coeruleus in the rat brain. |
2018-06-12 |
2023-08-13 |
rat |
| Claire O'Callaghan, Simon J G Lewi. Cognition in Parkinson's Disease. International review of neurobiology. vol 133. 2018-04-26. PMID:28802933. |
increasingly, changes in neurotransmitter systems beyond dopamine, including the noradrenergic, serotonergic, and cholinergic systems, are being recognized for their contribution to cognitive decline. |
2018-04-26 |
2023-08-13 |
human |
| Kimberly A Kempadoo, Eugene V Mosharov, Se Joon Choi, David Sulzer, Eric R Kande. Dopamine release from the locus coeruleus to the dorsal hippocampus promotes spatial learning and memory. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 51. 2018-04-13. PMID:27930324. |
these results suggest that spatial learning and memory are energized by the release of dopamine in the dorsal hippocampus from noradrenergic neurons of the lc. |
2018-04-13 |
2023-08-13 |
Not clear |
| Roberto Mandrioli, Michele Protti, Laura Mercolin. New-Generation, Non-SSRI Antidepressants: Therapeutic Drug Monitoring and Pharmacological Interactions. Part 1: SNRIs, SMSs, SARIs. Current medicinal chemistry. vol 25. issue 7. 2018-04-03. PMID:28707591. |
after the introduction of selective serotonin reuptake inhibitors (ssris), a plethora of other groups followed, identified by their main mechanisms of activity: serotonin and norepinephrine reuptake inhibitors (snri); serotonin modulators and stimulators (sms); serotonin antagonists and reuptake inhibitors (sari); noradrenergic and selective serotonergic antidepressants (nassa); norepinephrine reuptake inhibitors (neri); serotonin, norepinephrine and dopamine reuptake inhibitors (sndri) or triple reuptake inhibitors (tri); and melatonin and serotonin agonists (masa). |
2018-04-03 |
2023-08-13 |
Not clear |
| Mary F Brunette, Sarah C Akerman, Ree Dawson, Christopher D O'Keefe, Alan I Gree. An open-label pilot study of quetiapine plus mirtazapine for heavy drinkers with alcohol use disorder. Alcohol (Fayetteville, N.Y.). vol 53. 2018-01-03. PMID:27256763. |
animal research suggests that medications that produce a weak dopamine d2 receptor blockade and potentiate noradrenergic activity may decrease alcohol drinking. |
2018-01-03 |
2023-08-13 |
human |
| Megan K Mahoney, John H Barnes, David Wiercigroch, Mary C Olmstea. Pharmacological investigations of a yohimbine-impulsivity interaction in rats. Behavioural pharmacology. vol 27. issue 7. 2018-01-03. PMID:27509312. |
in subsequent experiments, yohimbine (2.5 mg/kg) was injected following pretreatment with the following receptor antagonists: corticotropin-releasing factor receptor 1, antalarmin (0-20 mg/kg); glucocorticoid, mifepristone (0-30 mg/kg); noradrenergic (na) α1, prazosin (0-2 mg/kg); na α2, guanfacine (0-0.5 mg/kg); na β2, propranolol (0.5-2.0 mg/kg); dopamine d1/5, sch 39166 (0-0.0625 mg/kg); μ opioid, naloxone (0-2 mg/kg); or 5-ht2a, m100907 (0.005-0.05 mg/kg). |
2018-01-03 |
2023-08-13 |
rat |
| James T McCracken, James J McGough, Sandra K Loo, Jennifer Levitt, Melissa Del'Homme, Jennifer Cowen, Alexandra Sturm, Fiona Whelan, Gerhard Hellemann, Catherine Sugar, Robert M Bilde. Combined Stimulant and Guanfacine Administration in Attention-Deficit/Hyperactivity Disorder: A Controlled, Comparative Study. Journal of the American Academy of Child and Adolescent Psychiatry. vol 55. issue 8. 2017-12-19. PMID:27453079. |
this study tested the hypothesis that combined effects of a dopamine and noradrenergic agonist, d-methylphenidate extended-release (dmph) with guanfacine (guan), an α2a receptor agonist, would be clinically superior to either monotherapy and would have equal tolerability. |
2017-12-19 |
2023-08-13 |
Not clear |
| A P N de Lima, T M Sandini, T M Reis-Silva, C O Massoc. Long-lasting monoaminergic and behavioral dysfunctions in a mice model of socio-environmental stress during adolescence. Behavioural brain research. vol 317. 2017-12-05. PMID:27641324. |
furthermore, decreased serotonergic activity on hippocampus, hypothalamus and cortex, decreased noradrenergic activity on hippocampus and hypothalamus, and increased the turnover of dopamine in cortex. |
2017-12-05 |
2023-08-13 |
mouse |
| David J Braun, Sergey Kalinin, Douglas L Feinstei. Conditional Depletion of Hippocampal Brain-Derived Neurotrophic Factor Exacerbates Neuropathology in a Mouse Model of Alzheimer's Disease. ASN neuro. vol 9. issue 2. 2017-10-12. PMID:28266222. |
bdnf depletion also reduced noradrenergic innervation in the hippocampus, the frontal cortex, and molecular layer of the cerebellum, assessed by staining for dopamine beta hydroxylase. |
2017-10-12 |
2023-08-13 |
mouse |
| Garima Gupta, Karel Paca. PRECISION MEDICINE: AN UPDATE ON GENOTYPE/BIOCHEMICAL PHENOTYPE RELATIONSHIPS IN PHEOCHROMOCYTOMA/PARAGANGLIOMA PATIENTS. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. vol 23. issue 6. 2017-08-31. PMID:28332883. |
the adrenergic, noradrenergic and dopaminergic phenotypes are defined by predominant elevations in epinephrine and metanephrine, norepinephrine and normetanephrine, and dopamine and 3-methoxytyramine, respectively. |
2017-08-31 |
2023-08-13 |
Not clear |
| Karl T Schmidt, Jason P Schroeder, Stephanie L Foster, Katherine Squires, Brilee M Smith, Elizabeth G Pitts, Michael P Epstein, David Weinshenke. Norepinephrine regulates cocaine-primed reinstatement via α1-adrenergic receptors in the medial prefrontal cortex. Neuropharmacology. vol 119. 2017-08-31. PMID:28392265. |
cocaine-primed reinstatement can also be attenuated by systemic administration of dopamine β-hydroxylase (dbh) inhibitors, which prevent norepinephrine (ne) synthesis, or by α1-adrenergic receptor (α1ar) antagonists, indicating functional modulation by the noradrenergic system. |
2017-08-31 |
2023-08-13 |
rat |
| Adam Z Weitemier, Thomas J McHug. Noradrenergic modulation of evoked dopamine release and pH shift in the mouse dorsal hippocampus and ventral striatum. Brain research. vol 1657. 2017-07-31. PMID:27919729. |
noradrenergic modulation of evoked dopamine release and ph shift in the mouse dorsal hippocampus and ventral striatum. |
2017-07-31 |
2023-08-13 |
mouse |
| Joseph F Cubells, Jason P Schroeder, Elizabeth S Barrie, Daniel F Manvich, Wolfgang Sadee, Tiina Berg, Kristina Mercer, Taylor A Stowe, L Cameron Liles, Katherine E Squires, Andrew Mezher, Patrick Curtin, Dannie L Perdomo, Patricia Szot, David Weinshenke. Human Bacterial Artificial Chromosome (BAC) Transgenesis Fully Rescues Noradrenergic Function in Dopamine β-Hydroxylase Knockout Mice. PloS one. vol 11. issue 5. 2017-07-17. PMID:27148966. |
human bacterial artificial chromosome (bac) transgenesis fully rescues noradrenergic function in dopamine β-hydroxylase knockout mice. |
2017-07-17 |
2023-08-13 |
mouse |