| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Peyronnet, J C Roux, A Geloën, L Q Tang, J M Pequignot, H Lagercrantz, Y Dalma. Prenatal hypoxia impairs the postnatal development of neural and functional chemoafferent pathway in rat. The Journal of physiology. vol 524 Pt 2. 2000-06-23. PMID:10766931. |
prenatal hypoxia decreased the dopamine content in the carotid bodies at all ages, and decreased the utilisation rate of noradrenaline in the caudal part of the a2 (a2c), a1 and a5 noradrenergic brainstem cell groups at 3 weeks after birth. |
2000-06-23 |
2023-08-12 |
rat |
| E Van Winkl. The toxic mind: the biology of mental illness and violence. Medical hypotheses. vol 54. issue 1. 2000-06-23. PMID:10790741. |
when toxic metabolites, which may include excess dopamine, epinephrine, serotonin, gamma-aminobutyric acid, peptides, amino acids, and various metabolic waste products, are bound to noradrenergic receptor sites, these sites become unavailable to norepinephrine. |
2000-06-23 |
2023-08-12 |
Not clear |
| U Ernsberger, E Reissmann, I Mason, H Rohre. The expression of dopamine beta-hydroxylase, tyrosine hydroxylase, and Phox2 transcription factors in sympathetic neurons: evidence for common regulation during noradrenergic induction and diverging regulation later in development. Mechanisms of development. vol 92. issue 2. 2000-06-16. PMID:10727856. |
the expression of dopamine beta-hydroxylase, tyrosine hydroxylase, and phox2 transcription factors in sympathetic neurons: evidence for common regulation during noradrenergic induction and diverging regulation later in development. |
2000-06-16 |
2023-08-12 |
chicken |
| B A Morrow, J D Elsworth, E J Lee, R H Rot. Divergent effects of putative anxiolytics on stress-induced fos expression in the mesoprefrontal system of the rat. Synapse (New York, N.Y.). vol 36. issue 2. 2000-05-12. PMID:10767061. |
previously, we reported that r(+)ha-966, a weak partial agonist for the glycine/nmda receptor, and guanfacine, a noradrenergic alpha2 agonist, have anxiolytic-like actions on the biochemical activation of the mesoprefrontal dopamine neurons and fear-induced behaviors. |
2000-05-12 |
2023-08-12 |
rat |
| D S Melchitzky, D A Lewi. Tyrosine hydroxylase- and dopamine transporter-immunoreactive axons in the primate cerebellum. Evidence for a lobular- and laminar-specific dopamine innervation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 22. issue 5. 2000-05-09. PMID:10731621. |
in contrast, axons immunoreactive for dopamine beta-hydroxylase, a marker of noradrenergic axons, exhibited a different and more widespread pattern of innervation. |
2000-05-09 |
2023-08-12 |
monkey |
| K Yui, K Goto, S Ikemoto, T Ishigur. Stress induced spontaneous recurrence of methamphetamine psychosis: the relation between stressful experiences and sensitivity to stress. Drug and alcohol dependence. vol 58. issue 1-2. 2000-03-14. PMID:10669056. |
stressful experiences, together with map use, may therefore induce sensitization to stress associated with noradrenergic hyperactivity, involving increased dopamine release, and so triggering flashbacks. |
2000-03-14 |
2023-08-12 |
human |
| D J Swanson, M Adachi, E J Lewi. The homeodomain protein Arix promotes protein kinase A-dependent activation of the dopamine beta-hydroxylase promoter through multiple elements and interaction with the coactivator cAMP-response element-binding protein-binding protein. The Journal of biological chemistry. vol 275. issue 4. 2000-02-29. PMID:10644760. |
for the noradrenergic phenotype, these influences combine to activate the expression of the catecholaminergic biosynthetic enzymes tyrosine hydroxylase and dopamine beta-hydroxylase (dbh). |
2000-02-29 |
2023-08-12 |
rat |
| J S Dixon, P Y Jen, J A Goslin. Tyrosine hydroxylase and vesicular acetylcholine transporter are coexpressed in a high proportion of intramural neurons of the human neonatal and child urinary bladder. Neuroscience letters. vol 277. issue 3. 2000-01-24. PMID:10626837. |
previous studies have used the immunocytochemical demonstration of tyrosine hydroxylase (th), either alone or in combination with dopamine beta-hydroxylase, to identify noradrenergic neurons in these ganglia. |
2000-01-24 |
2023-08-12 |
human |
| J I Friedman, D N Adler, K L Davi. The role of norepinephrine in the pathophysiology of cognitive disorders: potential applications to the treatment of cognitive dysfunction in schizophrenia and Alzheimer's disease. Biological psychiatry. vol 46. issue 9. 1999-12-15. PMID:10560029. |
the evidence of noradrenergic dysfunction occurring concomitantly with dopamine dysfunction in schizophrenia and acetylcholine dysfunction in alzheimer's disease supports therapeutic approaches using noradrenergic drugs in combination with neuroleptics and cholinesterase inhibitors, respectively, to enhance the treatment of cognitive impairment. |
1999-12-15 |
2023-08-12 |
human |
| K Yui, K Goto, S Ikemoto, T Ishiguro, Y Kamad. Increased sensitivity to stress and episode recurrence in spontaneous recurrence of methamphetamine psychosis. Psychopharmacology. vol 145. issue 3. 1999-10-18. PMID:10494575. |
thus, a mild fear of other people may have elicited memories of map psychosis, related to frightening stressful experiences through increased sensitivity to stress associated with noradrenergic hyperactivity, involving increased dopamine release. |
1999-10-18 |
2023-08-12 |
human |
| M A Alonso-Vanegas, J P Fawcett, C G Causing, F D Miller, A F Sadiko. Characterization of dopaminergic midbrain neurons in a DBH:BDNF transgenic mouse. The Journal of comparative neurology. vol 413. issue 3. 1999-10-18. PMID:10502251. |
to determine whether bdnf might play a role in the development of dopaminergic neurons in vivo, we used a previously characterized transgenic mouse (dbh:bdnf) that overexpresses bdnf in adrenergic and noradrenergic neurons as a result of fusion of the bdnf gene to the dopamine beta-hydroxylase (dbh) gene promoter. |
1999-10-18 |
2023-08-12 |
mouse |
| K Ishihara, M Sas. Mechanism underlying the therapeutic effects of electroconvulsive therapy (ECT) on depression. Japanese journal of pharmacology. vol 80. issue 3. 1999-09-24. PMID:10461762. |
in contrast, ect decreases the auto-receptor functions in noradrenergic and dopaminergic neurons in the locus coeruleus and substantia nigra, respectively, resulting in an increase in release of noradrenaline and dopamine. |
1999-09-24 |
2023-08-12 |
Not clear |
| Y Kawahara, H Kawahara, B H Westerin. Comparison of effects of hypotension and handling stress on the release of noradrenaline and dopamine in the locus coeruleus and medial prefrontal cortex of the rat. Naunyn-Schmiedeberg's archives of pharmacology. vol 360. issue 1. 1999-09-16. PMID:10463333. |
lesioning of the noradrenergic lc neurons did not the prevent the hypotension-related stimulation of dopamine release, but shortened the time course of the effect dramatically. |
1999-09-16 |
2023-08-12 |
rat |
| Y Kawahara, H Kawahara, B H Westerin. Comparison of effects of hypotension and handling stress on the release of noradrenaline and dopamine in the locus coeruleus and medial prefrontal cortex of the rat. Naunyn-Schmiedeberg's archives of pharmacology. vol 360. issue 1. 1999-09-16. PMID:10463333. |
lesioning of the noradrenergic neurons had no effect on the stimulatory effect of handling on the release of dopamine in the mpfc. |
1999-09-16 |
2023-08-12 |
rat |
| U Henning, K Krieger, A Klimk. Specific binding of 3H-spiperone to peripheral blood cells: relevance for the interpretation of binding studies in psychiatric disorders. Progress in neuro-psychopharmacology & biological psychiatry. vol 23. issue 2. 1999-08-17. PMID:10368866. |
the pharmacological profile of the high-affinity 3h-spiperone binding site is clearly different from the dopamine d2 and d4, serotonin 5-ht2 histamine h1 and noradrenergic alpha1 and alpha2 receptor, respectively. |
1999-08-17 |
2023-08-12 |
Not clear |
| K Yui, T Ishiguro, K Goto, S Ikemoto, Y Kamat. Spontaneous recurrence of methampetamine psychosis: increased sensitivity to stress associated with noradrenergic hyperactivity and dopaminergic change. European archives of psychiatry and clinical neuroscience. vol 249. issue 2. 1999-07-27. PMID:10369157. |
noradrenergic hyperactivity and some degree of increased dopamine release may be involved in this process. |
1999-07-27 |
2023-08-12 |
human |
| K Yui, T Ishiguro, K Goto, S Ikemoto, Y Kamat. Spontaneous recurrence of methampetamine psychosis: increased sensitivity to stress associated with noradrenergic hyperactivity and dopaminergic change. European archives of psychiatry and clinical neuroscience. vol 249. issue 2. 1999-07-27. PMID:10369157. |
sensitization to stress associated with noradrenergic hyperactivity, involving increased dopamine release may be central to spontaneous recurrences of map psychosis. |
1999-07-27 |
2023-08-12 |
human |
| H Y Meltze. Suicide and schizophrenia: clozapine and the InterSePT study. International Clozaril/Leponex Suicide Prevention Trial. The Journal of clinical psychiatry. vol 60 Suppl 12. 1999-06-24. PMID:10372612. |
clozapine's modulation of serotonergic, noradrenergic, cholinergic, and dopamine function may be the biological basis for the reduction in suicide. |
1999-06-24 |
2023-08-12 |
Not clear |
| D E Comings, R Gade-Andavolu, N Gonzalez, H Blake, S Wu, J P MacMurra. Additive effect of three noradrenergic genes (ADRA2a, ADRA2C, DBH) on attention-deficit hyperactivity disorder and learning disabilities in Tourette syndrome subjects. Clinical genetics. vol 55. issue 3. 1999-06-18. PMID:10334470. |
we examined the hypothesis that adhd + ld was associated with ne dysfunction at a molecular genetic level by testing for associations and additive effects between polymorphisms at three noradrenergic genes the adrenergic alpha2a receptor (adra2a), adrenergic alpha2c receptor (adra2c), and dopamine beta-hydroxylase (dbh) genes. |
1999-06-18 |
2023-08-12 |
human |
| W Zhang, V Klimek, J T Farley, M Y Zhu, G A Ordwa. alpha2C adrenoceptors inhibit adenylyl cyclase in mouse striatum: potential activation by dopamine. The Journal of pharmacology and experimental therapeutics. vol 289. issue 3. 1999-06-15. PMID:10336518. |
given the sparse innervation of the striatum by noradrenergic neurons, the possibility that dopamine can activate the mouse alpha2c adrenoceptor at physiologically relevant concentrations was investigated using normal rat kidney (nrk) cells transfected with the mouse alpha2a or alpha2c adrenoceptor cdna (nrk-alpha2a or nrk-alpha2c cells). |
1999-06-15 |
2023-08-12 |
mouse |