| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M A Raskind, E R Peskind, J B Halter, D C Jimerso. Norepinephrine and MHPG levels in CSF and plasma in Alzheimer's disease. Archives of general psychiatry. vol 41. issue 4. 1984-04-24. PMID:6703854. |
postmortem findings of decreased brain norepinephrine (ne) content and decreased locus ceruleus neuronal density have suggested a possible noradrenergic deficit in alzheimer's disease (ad). |
1984-04-24 |
2023-08-12 |
human |
| K N Westlund, R M Bowker, M G Ziegler, J D Coulte. Origins and terminations of descending noradrenergic projections to the spinal cord of monkey. Brain research. vol 292. issue 1. 1984-04-03. PMID:6365245. |
the results of these studies indicate that 79% of all noradrenergic cells with axons projecting to the spinal cord are located in the nucleus subcoeruleus and nucleus locus coeruleus. |
1984-04-03 |
2023-08-12 |
monkey |
| M G De Simoni, F Gonon, M Buda, J F Pujo. Cholinergic control of catechol metabolism in the rat locus coeruleus as studied by in vivo voltammetry. European journal of pharmacology. vol 95. issue 1-2. 1984-03-29. PMID:6141945. |
differential pulse voltammetry with treated carbon fibre electrodes was used to study the effect of cholinergic drugs on the metabolism of locus coeruleus (lc) noradrenergic cells in vivo. |
1984-03-29 |
2023-08-12 |
rat |
| H E Savaki, D I Graham, J J Grome, J McCulloc. Functional consequences of unilateral lesion of the locus coeruleus: a quantitative [14C]2-deoxyglucose investigation. Brain research. vol 292. issue 2. 1984-03-23. PMID:6692157. |
the functional consequences, as reflected in local rates of glucose utilization, of ablation of the locus coeruleus (the nucleus from which a major portion of the ascending noradrenergic fibres arise) have been examined in conscious rats with the quantitative autoradiographic [14c]2-deoxyglucose technique. |
1984-03-23 |
2023-08-12 |
rat |
| R J Valentino, G Aston-Jone. Activation of locus coeruleus neurons in the rat by a benzazocine derivative (UM 1046) that mimics opiate withdrawal. Neuropharmacology. vol 22. issue 12A. 1984-03-14. PMID:6686652. |
it was of interest to determine whether um 1046 had an effect on noradrenergic neurons of the locus coeruleus (ne-lc) since increased activity of these cells has been reported to occur during antagonist-precipitated opiate withdrawal (aghajanian, 1978) and after the administration of drugs that mimic this syndrome in normal animals. |
1984-03-14 |
2023-08-12 |
rat |
| R J Valentino, G Aston-Jone. Activation of locus coeruleus neurons in the rat by a benzazocine derivative (UM 1046) that mimics opiate withdrawal. Neuropharmacology. vol 22. issue 12A. 1984-03-14. PMID:6686652. |
caused a dose-dependent increase (of up to 200%) in the spontaneous discharge rate of noradrenergic neurons of the locus coeruleus in rats anesthetized with halothane. |
1984-03-14 |
2023-08-12 |
rat |
| R J Valentino, G Aston-Jone. Activation of locus coeruleus neurons in the rat by a benzazocine derivative (UM 1046) that mimics opiate withdrawal. Neuropharmacology. vol 22. issue 12A. 1984-03-14. PMID:6686652. |
this study complements previous findings of increased activity in noradrenergic neurons of the locus coeruleus during withdrawal-like behavior. |
1984-03-14 |
2023-08-12 |
rat |
| B E Levi. Alterations of norepinephrine metabolism in rat locus coeruleus neurons in response to axonal injury. Brain research. vol 289. issue 1-2. 1984-03-12. PMID:6198035. |
adult male sprague-dawley rats were injected in the right cerebral hemisphere with the neurotoxin 6-hydroxydopamine (6-ohda) at a site which interrupted the noradrenergic axons ascending from the locus coeruleus (lc). |
1984-03-12 |
2023-08-12 |
rat |
| K T Britton, T Svensson, J Schwartz, F E Bloom, G F Koo. Dorsal noradrenergic bundle lesions fail to alter opiate withdrawal or suppression of opiate withdrawal by clonidine. Life sciences. vol 34. issue 2. 1984-03-12. PMID:6537983. |
the present study was designed to test the hypothesis that the suppression of opiate withdrawal by clonidine is mediated by forebrain noradrenergic projections of the locus coeruleus. |
1984-03-12 |
2023-08-12 |
rat |
| D M Man. The locus coeruleus and its possible role in ageing and degenerative disease of the human central nervous system. Mechanisms of ageing and development. vol 23. issue 1. 1984-02-24. PMID:6228698. |
the central noradrenergic pathways with the mammalian brain are principally based on that group of nerve cells within the reticular substance of the upper pons known as the locus coeruleus. |
1984-02-24 |
2023-08-12 |
human |
| D M Man. The locus coeruleus and its possible role in ageing and degenerative disease of the human central nervous system. Mechanisms of ageing and development. vol 23. issue 1. 1984-02-24. PMID:6228698. |
the extensive ramifications of these noradrenergic terminals mean that the atrophy and loss of nerve cells from locus coeruleus that occurs in old age, and especially so in degenerative diseases of the central nervous system such as alzheimer's disease and other conditions, will have widespread repercussions for brain function. |
1984-02-24 |
2023-08-12 |
human |
| B Berger, C Alvare. [Pathology of catecholaminergic innervation of the cerebral cortex in Alzheimer's dementia]. Presse medicale (Paris, France : 1983). vol 12. issue 48. 1984-02-24. PMID:6228924. |
these histochemical findings have been confirmed by other teams, who have demonstrated a neuronal loss of 20 to 80% in the locus coeruleus, a nucleus providing the cortical noradrenergic bundle. |
1984-02-24 |
2023-08-12 |
Not clear |
| P Bagnoli, R Barsellotti, M Pellegrini, R Alesc. Norepinephrine levels in developing pigeon brain: effect of monocular deprivation on the Wulst noradrenergic system. Brain research. vol 312. issue 2. 1984-02-24. PMID:6652516. |
the ne content in the wulst could be related to noradrenergic afferents originating in the ipsilateral locus coeruleus and substantia grisea centralis, since an electrolytic lesion of the pontine tegmentum caused a 60% reduction in the ne level in the ipsilateral wulst. |
1984-02-24 |
2023-08-12 |
pigeon |
| M Carli, T W Robbins, J L Evenden, B J Everit. Effects of lesions to ascending noradrenergic neurones on performance of a 5-choice serial reaction task in rats; implications for theories of dorsal noradrenergic bundle function based on selective attention and arousal. Behavioural brain research. vol 9. issue 3. 1984-01-07. PMID:6639741. |
five experiments examined the effects of destruction of the dorsal noradrenergic bundle (dnab), arising in the locus coeruleus, both on brightness and spatial visual discrimination, and selective attention. |
1984-01-07 |
2023-08-12 |
human |
| S T Mason, A Ange. Brain noradrenaline and anaesthesia: further characterization of the beta-receptor. Neuropharmacology. vol 22. issue 9. 1983-12-21. PMID:6314170. |
destruction of the noradrenaline system in the locus coeruleus with 6-hydroxydopamine prevented the effect of a racemic mixture of propranolol in elevating thiopentone-induced sleeping time, thus confirming a noradrenergic mechanism and indicating that the coerulear, rather than the medullary, noradrenaline fibres were involved. |
1983-12-21 |
2023-08-12 |
rat |
| J A Hobson, R W McCarley, J P Nelso. Location and spike-train characteristics of cells in anterodorsal pons having selective decreases in firing rate during desynchronized sleep. Journal of neurophysiology. vol 50. issue 4. 1983-12-20. PMID:6631462. |
the d-off cell population was distributed in a bandlike zone across the brain stem at the pontomesencephalic junction with dense concentration of cells in aminergic nuclei: the serotonergic dorsal raphe and raphe linearis centralis and noradrenergic locus ceruleus and peribrachial regions. |
1983-12-20 |
2023-08-12 |
Not clear |
| B J Everitt, T W Robbins, M Gaskin, P J Fra. The effects of lesions to ascending noradrenergic neurons on discrimination learning and performance in the rat. Neuroscience. vol 10. issue 2. 1983-12-20. PMID:6633868. |
the results are discussed in terms of other acquisition deficits shown by rats with central noradrenaline depletion and their significance for determining the functions of the projections from the locus caeruleus via the dorsal noradrenergic bundle to the neocortex and hippocampus. |
1983-12-20 |
2023-08-12 |
rat |
| H R Olpe, J Laszlo, D J Dooley, J Heid, M W Steinman. Decreased activity of locus coeruleus neurons in the rat after DSP-4 treatment. Neuroscience letters. vol 40. issue 1. 1983-12-20. PMID:6633969. |
the activity of noradrenergic neurons of the rat locus coeruleus was investigated at 10 and 50 days after the administration of dsp-4 (n-(2-chloroethyl)-n-ethyl-2-bromobenzyl-amine), a selective noradrenergic neurotoxin. |
1983-12-20 |
2023-08-12 |
rat |
| L L Iversen, M N Rossor, G P Reynolds, R Hills, M Roth, C Q Mountjoy, S L Foote, J H Morrison, F E Bloo. Loss of pigmented dopamine-beta-hydroxylase positive cells from locus coeruleus in senile dementia of Alzheimer's type. Neuroscience letters. vol 39. issue 1. 1983-12-17. PMID:6633940. |
the loss of noradrenergic neurones from locus coeruleus was accompanied by an average reduction of similar magnitude in noradrenaline concentration in temporal cortex, with no change or an increase in dopamine content. |
1983-12-17 |
2023-08-12 |
human |
| G K Aghajanian, C P Vandermaelen, R Andrad. Intracellular studies on the role of calcium in regulating the activity and reactivity of locus coeruleus neurons in vivo. Brain research. vol 273. issue 2. 1983-11-23. PMID:6311349. |
egta, a specific calcium chelator, was injected intracellularly into presumed noradrenergic neurons of the rat locus coeruleus to evaluate the importance of calcium-dependent processes in regulating the activity and reactivity of these cells in vivo. |
1983-11-23 |
2023-08-12 |
rat |