| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pepijn P N M Eijsvogel, Laura G J M Borghans, Samantha Prins, Laurence Moss, Sebastiaan J W van Kraaij, Emilie van Brummelen, Erica Klaassen, Renee S Martin, Edgar Bautista, Anthony P Ford, Philip H C Kremer, Geert Jan Groeneveld, Gabriel A Varga. Cognitive Effects of Three β-Adrenoceptor Acting Drugs in Healthy Volunteers and Patients with Parkinson's Disease. Journal of Parkinson's disease. 2024-08-30. PMID:39213090. |
noradrenergic signaling declines in parkinson's disease (pd) following locus coeruleus neurodegeneration. |
2024-08-30 |
2024-09-04 |
human |
| Kenneth Wengler, Paula Trujillo, Clifford M Cassidy, Guillermo Horg. Neuromelanin-sensitive MRI for mechanistic research and biomarker development in psychiatry. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-08-19. PMID:39160355. |
this mri modality is sensitive to the concentration of neuromelanin, which is synthesized from intracellular catecholamines and accumulates in catecholaminergic nuclei including the dopaminergic substantia nigra and the noradrenergic locus coeruleus. |
2024-08-19 |
2024-08-22 |
Not clear |
| Mareike Ludwig, Calida Pereira, Marius Keute, Emrah Düzel, Matthew J Betts, Dorothea Hämmere. Evaluating phasic transcutaneous vagus nerve stimulation (taVNS) with pupil dilation: the importance of stimulation intensity and sensory perception. bioRxiv : the preprint server for biology. 2024-08-12. PMID:39131302. |
the efficacy of transcutaneous auricular vagus nerve stimulation (tavns) as a non-invasive method to modulate physiological markers of noradrenergic activity of the locus coeruleus (lc), such as pupil dilation, is increasingly more discussed. |
2024-08-12 |
2024-08-14 |
Not clear |
| Irina T Sinakevitch, Kelsey E McDermott, Daniel T Gray, Carol A Barne. A combined MRI, histological and immunohistochemical rendering of the rhesus macaque locus coeruleus (LC) enables the differentiation of three distinct LC subcompartments. Journal of chemical neuroanatomy. 2024-07-31. PMID:39084478. |
locus coeruleus (lc) neurons send their noradrenergic axons across multiple brain regions, including neocortex, subcortical regions, and spinal cord. |
2024-07-31 |
2024-08-03 |
human |
| Jingwei Yu, Shuqin Ji, Huixin Tao, Xiaochun Shan, Yu Yan, Xiangzhou Sun, Xiang'an Tu, Lei Li, Chunhua Den. Cell-specific expression of Cre recombinase in rat noradrenergic neurons via CRISPR-Cas9 system. Neuroscience. 2024-07-27. PMID:39067682. |
furthermore, stereotaxic injection of a fluorescence-labeled aav-dio virus illustrated the precise cre-loxp-mediated recombination activity in noradrenergic neurons within the locus coeruleus (lc). |
2024-07-27 |
2024-08-02 |
rat |
| Enes Akyuz, Alina Arulsamy, Feyza Sule Aslan, Bugra Sarisözen, Beyzanur Guney, Abdulhekim Hekimoglu, Beyza Nur Yilmaz, Thaarvena Retinasamy, Mohd Farooq Shaik. An Expanded Narrative Review of Neurotransmitters on Alzheimer's Disease: The Role of Therapeutic Interventions on Neurotransmission. Molecular neurobiology. 2024-07-16. PMID:39012443. |
moreover, the presence of deficiencies in noradrenergic neurons within the locus coeruleus in ad suggests that noradrenergic stimulation could be useful in addressing its pathophysiology. |
2024-07-16 |
2024-07-18 |
Not clear |
| Youngnam Kang, Hiroki Toyoda, Mitsuru Sait. Search for unknown neural link between the masticatory and cognitive brain systems to clarify the involvement of its impairment in the pathogenesis of Alzheimer's disease. Frontiers in cellular neuroscience. vol 18. 2024-07-12. PMID:38994328. |
brain degenerations in sporadic alzheimer's disease (ad) are observed earliest in the locus coeruleus (lc), a population of noradrenergic neurons, in which hyperphosphorylated tau protein expression and β-amyloid (aβ) accumulation begin. |
2024-07-12 |
2024-07-14 |
human |
| Richard J Krauzlis, Divya Subramanian, Gongchen Yu, Leor N Kat. Attention: The blue spot reveals one of its secrets. Neuron. vol 112. issue 13. 2024-07-04. PMID:38964283. |
using optogenetic and electrophysiological tools to selectively interrogate noradrenergic neurons in non-human primates, ghosh and maunsell show how locus coeruleus neurons contribute to a specific aspect of visual attention. |
2024-07-04 |
2024-07-11 |
Not clear |
| Thomas Lodeweyckx, Jan de Hoon, Koen Van Laere, Edgar Bautista, Gaia Rizzo, Courtney Bishop, Eugenii Rabiner, Renee S Martin, Anthony Ford, Gabriel Varga. Effects on cerebral blood flow after single doses of the β British journal of clinical pharmacology. 2024-07-02. PMID:38953404. |
effects on cerebral blood flow after single doses of the β cerebral hypometabolism occurs years prior to a diagnosis of neurodegenerative diseases and coincides with reduced cerebral perfusion and declining noradrenergic transmission from the locus coeruleus. |
2024-07-02 |
2024-07-06 |
Not clear |
| Yang Liu, Ji Chen, Qiang Li, Yan-Xia Guo, Yong-Jin Chen, Ya-Juan Zha. Locus coeruleus activation contributes to masseter muscle overactivity induced by chronic restraint stress in mice. Neuroreport. 2024-06-27. PMID:38935079. |
furthermore, inhibition of noradrenergic neuron activity within the locus coeruleus could alleviate stress-induced anxiety behavior and masseter muscle overactivity. |
2024-06-27 |
2024-06-29 |
mouse |
| Yang Liu, Ji Chen, Qiang Li, Yan-Xia Guo, Yong-Jin Chen, Ya-Juan Zha. Locus coeruleus activation contributes to masseter muscle overactivity induced by chronic restraint stress in mice. Neuroreport. 2024-06-27. PMID:38935079. |
activation of noradrenergic neurons in locus coeruleus induced by stress may be one of the central regulatory mechanisms for stress-induced anxiety-like behaviors and overactivity of masseter muscles. |
2024-06-27 |
2024-06-29 |
mouse |
| Mareike Ludwig, Yeo-Jin Yi, Falk Lüsebrink, Martina F Callaghan, Matthew J Betts, Renat Yakupov, Nikolaus Weiskopf, Raymond J Dolan, Emrah Düzel, Dorothea Hämmere. Functional locus coeruleus imaging to investigate an ageing noradrenergic system. Communications biology. vol 7. issue 1. 2024-06-27. PMID:38937535. |
functional locus coeruleus imaging to investigate an ageing noradrenergic system. |
2024-06-27 |
2024-06-30 |
Not clear |
| Qianqian Lou, Hong-Rui Wei, Danyang Chen, Yuzhuo Zhang, Wan-Ying Dong, Sen Qun, Di Wang, Yanli Luo, Zhi Zhang, Yan Ji. A noradrenergic pathway for the induction of pain by sleep loss. Current biology : CB. vol 34. issue 12. 2024-06-18. PMID:38810638. |
using a combination of advanced neuroscience methods, we found that asd stimulates noradrenergic inputs from locus coeruleus (lc |
2024-06-18 |
2024-06-21 |
mouse |
| Nina Engels-Domínguez, Elouise A Koops, Stephanie Hsieh, Emma E Wiklund, Aaron P Schultz, Joost M Riphagen, Prokopis C Prokopiou, Bernard J Hanseeuw, Dorene M Rentz, Reisa A Sperling, Keith A Johnson, Heidi I L Jacob. Lower in vivo locus coeruleus integrity is associated with lower cortical thickness in older individuals with elevated Alzheimer's pathology: a cohort study. Alzheimer's research & therapy. vol 16. issue 1. 2024-06-18. PMID:38886798. |
autopsy work indicates that the widely-projecting noradrenergic pontine locus coeruleus (lc) is among the earliest regions to accumulate hyperphosphorylated tau, a neuropathological alzheimer's disease (ad) hallmark. |
2024-06-18 |
2024-06-21 |
Not clear |
| Ioannis S Zouridis, Lisa Schmors, Kathrin Maite Fischer, Philipp Berens, Patricia Preston-Ferrer, Andrea Burgaloss. Juxtacellular recordings from identified neurons in the mouse locus coeruleus. The European journal of neuroscience. 2024-06-14. PMID:38872397. |
the locus coeruleus (lc) is the primary source of noradrenergic transmission in the mammalian central nervous system. |
2024-06-14 |
2024-06-16 |
mouse |
| Nmachi Anumba, Michael A Kelberman, Wenju Pan, Alexia Marriott, Xiaodi Zhang, Nan Xu, David Weinshenker, Shella Keilhol. The Effects of Locus Coeruleus Optogenetic Stimulation on Global Spatiotemporal Patterns in Rats. bioRxiv : the preprint server for biology. 2024-06-03. PMID:38826205. |
the noradrenergic locus coeruleus (lc) is a key node in arousal circuits and has extensive projections throughout the brain, giving it neuromodulatory influence over the coordinated activity of structurally separated regions. |
2024-06-03 |
2024-06-05 |
rat |
| Susan T Lubejko, Giulia Livrizzi, Stanley A Buczynski, Janki Patel, Jean C Yung, Tony L Yaksh, Matthew R Banghar. Inputs to the locus coeruleus from the periaqueductal gray and rostroventral medulla shape opioid-mediated descending pain modulation. Science advances. vol 10. issue 17. 2024-04-26. PMID:38669335. |
here, we establish that noradrenergic neurons of the locus coeruleus (lc) are essential for supraspinal opioid antinociception. |
2024-04-26 |
2024-04-29 |
Not clear |
| Alessandro Galgani, Francesco Lombardo, Francesca Frijia, Nicola Martini, Gloria Tognoni, Nicola Pavese, Filippo Sean Giorg. The degeneration of locus coeruleus occurring during Alzheimer's disease clinical progression: a neuroimaging follow-up investigation. Brain structure & function. 2024-04-16. PMID:38625557. |
the noradrenergic nucleus locus coeruleus (lc) is precociously involved in alzheimer's disease (ad) pathology, and its degeneration progresses during the course of the disease. |
2024-04-16 |
2024-04-18 |
Not clear |
| Irene Suárez-Pereira, Carolina López-Martín, Carmen Camarena-Delgado, Meritxell Llorca-Torralba, Francisco González-Saiz, Rocío Ruiz, Martiniano Santiago, Esther Berrocos. Nerve injury triggers time-dependent activation of the locus coeruleus, influencing spontaneous pain-like behavior in rats. Anesthesiology. 2024-04-11. PMID:38602502. |
dynamic changes in neuronal activity and in noradrenergic locus coeruleus (lc) projections have been proposed during the transition from acute to chronic pain. |
2024-04-11 |
2024-04-13 |
rat |
| Jingyun Lee, Zhong-Min Wang, María Laura Messi, Carol Milligan, Cristina M Furdui, Osvaldo Delbon. Sex differences in single neuron function and proteomics profiles examined by patch-clamp and mass spectrometry in the locus coeruleus of the adult mouse. Acta physiologica (Oxford, England). 2024-03-09. PMID:38459766. |
this study aimed to characterize the properties of locus coeruleus (lc) noradrenergic neurons in male and female mice. |
2024-03-09 |
2024-03-11 |
mouse |