| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Enes Akyuz, Alina Arulsamy, Feyza Sule Aslan, Bugra Sarisözen, Beyzanur Guney, Abdulhekim Hekimoglu, Beyza Nur Yilmaz, Thaarvena Retinasamy, Mohd Farooq Shaik. An Expanded Narrative Review of Neurotransmitters on Alzheimer's Disease: The Role of Therapeutic Interventions on Neurotransmission. Molecular neurobiology. 2024-07-16. PMID:39012443. |
moreover, the presence of deficiencies in noradrenergic neurons within the locus coeruleus in ad suggests that noradrenergic stimulation could be useful in addressing its pathophysiology. |
2024-07-16 |
2024-07-18 |
Not clear |
| Youngnam Kang, Hiroki Toyoda, Mitsuru Sait. Search for unknown neural link between the masticatory and cognitive brain systems to clarify the involvement of its impairment in the pathogenesis of Alzheimer's disease. Frontiers in cellular neuroscience. vol 18. 2024-07-12. PMID:38994328. |
brain degenerations in sporadic alzheimer's disease (ad) are observed earliest in the locus coeruleus (lc), a population of noradrenergic neurons, in which hyperphosphorylated tau protein expression and β-amyloid (aβ) accumulation begin. |
2024-07-12 |
2024-07-14 |
human |
| Richard J Krauzlis, Divya Subramanian, Gongchen Yu, Leor N Kat. Attention: The blue spot reveals one of its secrets. Neuron. vol 112. issue 13. 2024-07-04. PMID:38964283. |
using optogenetic and electrophysiological tools to selectively interrogate noradrenergic neurons in non-human primates, ghosh and maunsell show how locus coeruleus neurons contribute to a specific aspect of visual attention. |
2024-07-04 |
2024-07-11 |
Not clear |
| Thomas Lodeweyckx, Jan de Hoon, Koen Van Laere, Edgar Bautista, Gaia Rizzo, Courtney Bishop, Eugenii Rabiner, Renee S Martin, Anthony Ford, Gabriel Varga. Effects on cerebral blood flow after single doses of the β British journal of clinical pharmacology. 2024-07-02. PMID:38953404. |
effects on cerebral blood flow after single doses of the β cerebral hypometabolism occurs years prior to a diagnosis of neurodegenerative diseases and coincides with reduced cerebral perfusion and declining noradrenergic transmission from the locus coeruleus. |
2024-07-02 |
2024-07-06 |
Not clear |
| Yang Liu, Ji Chen, Qiang Li, Yan-Xia Guo, Yong-Jin Chen, Ya-Juan Zha. Locus coeruleus activation contributes to masseter muscle overactivity induced by chronic restraint stress in mice. Neuroreport. 2024-06-27. PMID:38935079. |
furthermore, inhibition of noradrenergic neuron activity within the locus coeruleus could alleviate stress-induced anxiety behavior and masseter muscle overactivity. |
2024-06-27 |
2024-06-29 |
mouse |
| Yang Liu, Ji Chen, Qiang Li, Yan-Xia Guo, Yong-Jin Chen, Ya-Juan Zha. Locus coeruleus activation contributes to masseter muscle overactivity induced by chronic restraint stress in mice. Neuroreport. 2024-06-27. PMID:38935079. |
activation of noradrenergic neurons in locus coeruleus induced by stress may be one of the central regulatory mechanisms for stress-induced anxiety-like behaviors and overactivity of masseter muscles. |
2024-06-27 |
2024-06-29 |
mouse |
| Mareike Ludwig, Yeo-Jin Yi, Falk Lüsebrink, Martina F Callaghan, Matthew J Betts, Renat Yakupov, Nikolaus Weiskopf, Raymond J Dolan, Emrah Düzel, Dorothea Hämmere. Functional locus coeruleus imaging to investigate an ageing noradrenergic system. Communications biology. vol 7. issue 1. 2024-06-27. PMID:38937535. |
functional locus coeruleus imaging to investigate an ageing noradrenergic system. |
2024-06-27 |
2024-06-30 |
Not clear |
| Qianqian Lou, Hong-Rui Wei, Danyang Chen, Yuzhuo Zhang, Wan-Ying Dong, Sen Qun, Di Wang, Yanli Luo, Zhi Zhang, Yan Ji. A noradrenergic pathway for the induction of pain by sleep loss. Current biology : CB. vol 34. issue 12. 2024-06-18. PMID:38810638. |
using a combination of advanced neuroscience methods, we found that asd stimulates noradrenergic inputs from locus coeruleus (lc |
2024-06-18 |
2024-06-21 |
mouse |
| Nina Engels-Domínguez, Elouise A Koops, Stephanie Hsieh, Emma E Wiklund, Aaron P Schultz, Joost M Riphagen, Prokopis C Prokopiou, Bernard J Hanseeuw, Dorene M Rentz, Reisa A Sperling, Keith A Johnson, Heidi I L Jacob. Lower in vivo locus coeruleus integrity is associated with lower cortical thickness in older individuals with elevated Alzheimer's pathology: a cohort study. Alzheimer's research & therapy. vol 16. issue 1. 2024-06-18. PMID:38886798. |
autopsy work indicates that the widely-projecting noradrenergic pontine locus coeruleus (lc) is among the earliest regions to accumulate hyperphosphorylated tau, a neuropathological alzheimer's disease (ad) hallmark. |
2024-06-18 |
2024-06-21 |
Not clear |
| Ioannis S Zouridis, Lisa Schmors, Kathrin Maite Fischer, Philipp Berens, Patricia Preston-Ferrer, Andrea Burgaloss. Juxtacellular recordings from identified neurons in the mouse locus coeruleus. The European journal of neuroscience. 2024-06-14. PMID:38872397. |
the locus coeruleus (lc) is the primary source of noradrenergic transmission in the mammalian central nervous system. |
2024-06-14 |
2024-06-16 |
mouse |
| Nmachi Anumba, Michael A Kelberman, Wenju Pan, Alexia Marriott, Xiaodi Zhang, Nan Xu, David Weinshenker, Shella Keilhol. The Effects of Locus Coeruleus Optogenetic Stimulation on Global Spatiotemporal Patterns in Rats. bioRxiv : the preprint server for biology. 2024-06-03. PMID:38826205. |
the noradrenergic locus coeruleus (lc) is a key node in arousal circuits and has extensive projections throughout the brain, giving it neuromodulatory influence over the coordinated activity of structurally separated regions. |
2024-06-03 |
2024-06-05 |
rat |
| Susan T Lubejko, Giulia Livrizzi, Stanley A Buczynski, Janki Patel, Jean C Yung, Tony L Yaksh, Matthew R Banghar. Inputs to the locus coeruleus from the periaqueductal gray and rostroventral medulla shape opioid-mediated descending pain modulation. Science advances. vol 10. issue 17. 2024-04-26. PMID:38669335. |
here, we establish that noradrenergic neurons of the locus coeruleus (lc) are essential for supraspinal opioid antinociception. |
2024-04-26 |
2024-04-29 |
Not clear |
| Alessandro Galgani, Francesco Lombardo, Francesca Frijia, Nicola Martini, Gloria Tognoni, Nicola Pavese, Filippo Sean Giorg. The degeneration of locus coeruleus occurring during Alzheimer's disease clinical progression: a neuroimaging follow-up investigation. Brain structure & function. 2024-04-16. PMID:38625557. |
the noradrenergic nucleus locus coeruleus (lc) is precociously involved in alzheimer's disease (ad) pathology, and its degeneration progresses during the course of the disease. |
2024-04-16 |
2024-04-18 |
Not clear |
| Irene Suárez-Pereira, Carolina López-Martín, Carmen Camarena-Delgado, Meritxell Llorca-Torralba, Francisco González-Saiz, Rocío Ruiz, Martiniano Santiago, Esther Berrocos. Nerve injury triggers time-dependent activation of the locus coeruleus, influencing spontaneous pain-like behavior in rats. Anesthesiology. 2024-04-11. PMID:38602502. |
dynamic changes in neuronal activity and in noradrenergic locus coeruleus (lc) projections have been proposed during the transition from acute to chronic pain. |
2024-04-11 |
2024-04-13 |
rat |
| Jingyun Lee, Zhong-Min Wang, María Laura Messi, Carol Milligan, Cristina M Furdui, Osvaldo Delbon. Sex differences in single neuron function and proteomics profiles examined by patch-clamp and mass spectrometry in the locus coeruleus of the adult mouse. Acta physiologica (Oxford, England). 2024-03-09. PMID:38459766. |
this study aimed to characterize the properties of locus coeruleus (lc) noradrenergic neurons in male and female mice. |
2024-03-09 |
2024-03-11 |
mouse |
| Kandatege Wimalasena, Oluwatosin Adetuyi, Maya Eldan. Metabolic energy decline coupled dysregulation of catecholamine metabolism in physiologically highly active neurons: implications for selective neuronal death in Parkinson's disease. Frontiers in aging neuroscience. vol 16. 2024-03-07. PMID:38450382. |
two main pathophysiological features of pd are the accumulation of inclusion bodies in the affected neurons and the predominant loss of neuromelanin-containing da neurons in substantia nigra pars compacta (snpc) and noradrenergic (ne) neurons in locus coeruleus (lc). |
2024-03-07 |
2024-03-09 |
Not clear |
| Yayun Yan, Mengchao Zhang, Wenhua Ren, Xiaoqi Zheng, Ying Chan. Neuromelanin-sensitive magnetic resonance imaging: Possibilities and promises as an imaging biomarker for Parkinson's disease. The European journal of neuroscience. 2024-03-05. PMID:38441250. |
parkinson's disease (pd) is an age-related progressive neurodegenerative disorder characterized by both motor and non-motor symptoms resulting from the death of dopaminergic neurons in the substantia nigra pars compacta (snpc) and noradrenergic neurons in the locus coeruleus (lc). |
2024-03-05 |
2024-03-07 |
Not clear |
| Alex I Wiesman, Victoria Madge, Edward A Fon, Alain Dagher, D Louis Collins, Sylvain Baille. Associations between neuromelanin depletion and cortical rhythmic activity in Parkinson's disease. medRxiv : the preprint server for health sciences. 2024-02-26. PMID:38405952. |
parkinson's disease (pd) is marked by the death of neuromelanin-rich dopaminergic and noradrenergic cells in the substantia nigra (sn) and the locus coeruleus (lc), respectively, resulting in motor and cognitive impairments. |
2024-02-26 |
2024-02-28 |
Not clear |
| Charles Rodenkirch, Qi Wan. Optimization of Temporal Coding of Tactile Information in Rat Thalamus by Locus Coeruleus Activation. Biology. vol 13. issue 2. 2024-02-23. PMID:38392298. |
the brainstem noradrenergic nucleus, the locus coeruleus (lc), exerts heavy influences on sensory processing, perception, and cognition through its diffuse projections throughout the brain. |
2024-02-23 |
2024-02-25 |
rat |
| Marcelo Mendonça-Dos-Santos, Thaís Cristina Teixeira Gonçalves, Luiz Luciano Falconi-Sobrinho, Tayllon Dos Anjos-Garcia, Ivair Matias, Rithiele Cristina de Oliveira, Maria de Fátima Dos Santos Sampaio, Fabrízio Dos Santos Cardoso, Wagner Ferreira Dos Santos, Helio Rubens Machado, Norberto Cysne Coimbr. GABAergic and glutamatergic inputs to the medulla oblongata and locus coeruleus noradrenergic pathways are critical for seizures and postictal antinociception neuromodulation. Scientific reports. vol 14. issue 1. 2024-02-20. PMID:38374419. |
we investigated the participation of the nucleus of the tractus solitarius (nts) in tonic‒clonic seizures and postictal antinociception control mediated by nmda receptors, the role of nts gabaergic interneurons and noradrenergic pathways from the locus coeruleus (lc) in these phenomena. |
2024-02-20 |
2024-02-22 |
rat |