| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shibo Zhu, Hongpeng Ma, Mengfan Hou, Hailiang Li, Guangzhi Nin. Schwann Cell-Derived Exosomes Induced Axon Growth after Spinal Cord Injury by Decreasing PTP-σ Activation on CSPGs via the Rho/ROCK Pathway. Neurochemical research. vol 49. issue 8. 2024-07-09. PMID:38819695. |
this process leads to the upregulation of chondroitin sulfate proteoglycans (cspgs) by reactive glia, which impedes repair and regeneration in the spinal cord. |
2024-07-09 |
2024-07-12 |
mouse |
| Yi Huang, Rong Hu, Lei Wu, Kelin He, Ruijie M. Immunoregulation of Glia after spinal cord injury: a bibliometric analysis. Frontiers in immunology. vol 15. 2024-06-28. PMID:38938572. |
immunoregulation of glia after spinal cord injury: a bibliometric analysis. |
2024-06-28 |
2024-06-30 |
Not clear |
| Yali Chen, Yiyong Wei, Jin Liu, Tao Zhu, Cheng Zhou, Donghang Zhan. Spatial transcriptomics combined with single-nucleus RNA sequencing reveals glial cell heterogeneity in the human spinal cord. Neural regeneration research. 2024-06-27. PMID:38934400. |
spatial transcriptomics combined with single-nucleus rna sequencing reveals glial cell heterogeneity in the human spinal cord. |
2024-06-27 |
2024-06-29 |
mouse |
| Yali Chen, Yiyong Wei, Jin Liu, Tao Zhu, Cheng Zhou, Donghang Zhan. Spatial transcriptomics combined with single-nucleus RNA sequencing reveals glial cell heterogeneity in the human spinal cord. Neural regeneration research. 2024-06-27. PMID:38934400. |
despite the greater understanding of glial cell types and functional heterogeneity achieved through single-cell and single-nucleus rna sequencing in animal models, few studies have investigated the transcriptomic profiles of glial cells in the human spinal cord. |
2024-06-27 |
2024-06-29 |
mouse |
| Yali Chen, Yiyong Wei, Jin Liu, Tao Zhu, Cheng Zhou, Donghang Zhan. Spatial transcriptomics combined with single-nucleus RNA sequencing reveals glial cell heterogeneity in the human spinal cord. Neural regeneration research. 2024-06-27. PMID:38934400. |
in the mouse spinal cord, astrocytes, microglia, and oligodendrocytes were divided into five, four, and five distinct transcriptomic subclusters, respectively.the comparative results revealed substantial heterogeneity in all glial cell types between humans and mice. |
2024-06-27 |
2024-06-29 |
mouse |
| Jessica L Funnell, Jasper Fougere, Diana Zahn, Silvio Dutz, Ryan J Gilber. Delivery of TGFβ3 from Magnetically Responsive Coaxial Fibers Reduces Spinal Cord Astrocyte Reactivity In Vitro. Advanced biology. 2024-06-27. PMID:38935534. |
a spinal cord injury (sci) compresses the spinal cord, killing neurons and glia at the injury site and resulting in prolonged inflammation and scarring that prevents regeneration. |
2024-06-27 |
2024-06-30 |
Not clear |
| Jessica L Funnell, Jasper Fougere, Diana Zahn, Silvio Dutz, Ryan J Gilber. Delivery of TGFβ3 from Magnetically Responsive Coaxial Fibers Reduces Spinal Cord Astrocyte Reactivity In Vitro. Advanced biology. 2024-06-27. PMID:38935534. |
astrocytes, the main glia in the spinal cord, become reactive following sci and contribute to adverse outcomes. |
2024-06-27 |
2024-06-30 |
Not clear |
| Giada Amodeo, Giulia Magni, Giulia Galimberti, Benedetta Riboldi, Silvia Franchi, Paola Sacerdote, Stefania Cerut. Neuroinflammation in osteoarthritis: From pain to mood disorders. Biochemical pharmacology. 2024-03-31. PMID:38556026. |
in the present commentary article, we aim to summarize up-to-date results achieved in this experimental model of oa, focusing on glia activation and cytokine production in the sciatic nerve, dorsal root ganglia (drgs), spinal cord and brain areas. |
2024-03-31 |
2024-04-03 |
Not clear |
| Eva E Stefanova, Julian V T Dychiao, Mavis C Chinn, Matin Borhani, Angela L Scot. P2X7 regulates ependymo-radial glial cell proliferation in adult Danio rerio following spinal cord injury. Biology open. 2024-03-25. PMID:38526172. |
p2x7 regulates ependymo-radial glial cell proliferation in adult danio rerio following spinal cord injury. |
2024-03-25 |
2024-03-27 |
zebrafish |
| Eva E Stefanova, Julian V T Dychiao, Mavis C Chinn, Matin Borhani, Angela L Scot. P2X7 regulates ependymo-radial glial cell proliferation in adult Danio rerio following spinal cord injury. Biology open. 2024-03-25. PMID:38526172. |
spinal cord ependymo-radial glia (erg) undergo injury-induced proliferation and neuronal differentiation to replace damaged cells and restore motor function. |
2024-03-25 |
2024-03-27 |
zebrafish |
| Piotr Rogujski, Barbara Lukomska, Miroslaw Janowski, Luiza Stanasze. Glial-restricted progenitor cells: a cure for diseased brain? Biological research. vol 57. issue 1. 2024-03-13. PMID:38475854. |
traditionally, glia was disregarded as just the structural support across the brain and spinal cord, in striking contrast to neurons, always considered critical players in cns functioning. |
2024-03-13 |
2024-03-15 |
Not clear |
| Wenjiao Tai, Xiaolong Du, Chen Chen, Xiao-Ming Xu, Chun-Li Zhang, Wei W. NG2 glia reprogramming induces robust axonal regeneration after spinal cord injury. iScience. vol 27. issue 2. 2024-02-06. PMID:38318363. |
ng2 glia reprogramming induces robust axonal regeneration after spinal cord injury. |
2024-02-06 |
2024-02-09 |
Not clear |
| Obulapathi Ummadisetty, Akhilesh, Anagha Gadepalli, Deepak Chouhan, Utkarsh Patil, Surya Pratap Singh, Sanjay Singh, Vinod Tiwar. Dermorphin [D-Arg2, Lys4] (1-4) Amide Alleviates Frostbite-Induced Pain by Regulating TRP Channel-Mediated Microglial Activation and Neuroinflammation. Molecular neurobiology. 2024-01-26. PMID:38277118. |
further, molecular biology investigations unveiled heightened oxido-nitrosative stress, coupled with a notable upregulation in the expression of trp channels (trpa1, trpv1, and trpm8), glial cell activation, and neuroinflammation (tnf-α, il-1β) in the sciatic nerve, dorsal root ganglion (drg), and spinal cord of frostbite-injured rats. |
2024-01-26 |
2024-01-28 |
rat |
| Mousumi Ghosh, Damien D Pears. Schwann Cell-Derived Exosomal Vesicles: A Promising Therapy for the Injured Spinal Cord. International journal of molecular sciences. vol 24. issue 24. 2023-12-23. PMID:38139147. |
scs, the myelinating glia of the peripheral nervous system, have a long history of demonstrated benefit in repair of the injured spinal cord and peripheral nerves when transplanted, including their recent advancement to clinical investigations for feasibility and safety in humans. |
2023-12-23 |
2023-12-25 |
human |
| Clayton J Becker, Valentina Cigliola, Pierre Gillotay, Ashley Rich, Alessandro De Simone, Yanchao Han, Stefano Di Talia, Kenneth D Pos. In toto imaging of glial JNK signaling during larval zebrafish spinal cord regeneration. Development (Cambridge, England). 2023-11-24. PMID:37997694. |
using a chemical screen, we identify jnk signaling as a necessary regulator of glial cell cycling and tissue bridging during spinal cord regeneration in larval zebrafish. |
2023-11-24 |
2023-11-29 |
zebrafish |
| Clayton J Becker, Valentina Cigliola, Pierre Gillotay, Ashley Rich, Alessandro De Simone, Yanchao Han, Stefano Di Talia, Kenneth D Pos. In toto imaging of glial JNK signaling during larval zebrafish spinal cord regeneration. Development (Cambridge, England). 2023-11-24. PMID:37997694. |
thus, dynamic and regional regulation of jnk signaling help to direct glial cell behaviors during innate spinal cord regeneration. |
2023-11-24 |
2023-11-29 |
zebrafish |
| Yang Liu, Yin Zhao, Xinyuan Liao, Shengyuan Zhou, Xiang Guo, Lili Yang, Bitao L. PD-1 deficiency aggravates spinal cord injury by regulating the reprogramming of NG2 glia and activating the NgR/RhoA/ROCK signaling pathway. Cellular signalling. 2023-11-16. PMID:37972801. |
pd-1 deficiency aggravates spinal cord injury by regulating the reprogramming of ng2 glia and activating the ngr/rhoa/rock signaling pathway. |
2023-11-16 |
2023-11-20 |
mouse |
| Laura Fontena. Glial plasticity at nervous system transition zones. Biology open. vol 12. issue 10. 2023-10-03. PMID:37787575. |
this review highlights recent work on glial cell migration in and out of the spinal cord, at motor exit point (mep) and dorsal root entry zone (drez) transition zones, in the physiological and diseased nervous systems. |
2023-10-03 |
2023-10-07 |
Not clear |
| Yajie Hu, Fengxian Cui, Shenglan Wang, Chen Liu, Shengxiong Zhang, Ruiqi Wang, Jie Song, Yunhui Zhan. MicroRNA expression profile of human umbilical vein endothelial cells in response to coxsackievirus A10 infection reveals a potential role of miR-143-3p in maintaining the integrity of the blood-brain barrier. Frontiers in cellular and infection microbiology. vol 13. 2023-08-14. PMID:37577373. |
after that, gene target prediction and functional annotation revealed that the targets of these dysregulated mirnas were mostly enriched in cell proliferation, signal transduction, camp signalling pathway, cellular response to interleukin-6, ventral spinal cord interneuron differentiation, negative regulation of glial cell differentiation, neuron migration, positive regulation of neuron projection development, etc., which were primarily involved in the processes of basic physiology, host immunity, and neurological impairments and further reflected vital regulatory roles of mirna in viral pathogenicity. |
2023-08-14 |
2023-08-16 |
human |
| Zhihao Zhang, Zhiwen Song, Liang Luo, Zhijie Zhu, Xiaoshuang Zuo, Cheng Ju, Xuankang Wang, Yangguang Ma, Tingyu Wu, Zhou Yao, Jie Zhou, Beiyu Chen, Tan Ding, Zhe Wang, Xueyu H. Photobiomodulation inhibits the expression of chondroitin sulfate proteoglycans after spinal cord injury via the Sox9 pathway. Neural regeneration research. vol 19. issue 1. 2023-07-25. PMID:37488865. |
both glial cells and glia scar greatly affect the development of spinal cord injury and have become hot spots in research on spinal cord injury treatment. |
2023-07-25 |
2023-08-14 |
mouse |