| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Junyoung Oh, Woo-Hyun Cho, Ellane Barcelon, Kwang Hwan Kim, Jinpyo Hong, Sung Joong Le. SARS-CoV-2 spike protein induces cognitive deficit and anxiety-like behavior in mouse via non-cell autonomous hippocampal neuronal death. Scientific reports. vol 12. issue 1. 2022-04-01. PMID:35361832. |
in conclusion, our data suggest a novel pathogenic mechanism for the covid-19-associated neurological symptoms that involves glia activation and non-cell autonomous hippocampal neuronal death by the brain-infiltrating s1 protein. |
2022-04-01 |
2023-08-13 |
mouse |
| Noelia Rodríguez-Iglesias, Agnes Nadjar, Amanda Sierra, Jorge Valer. Susceptibility of Female Mice to the Dietary Omega-3/Omega-6 Fatty-Acid Ratio: Effects on Adult Hippocampal Neurogenesis and Glia. International journal of molecular sciences. vol 23. issue 6. 2022-03-25. PMID:35328825. |
susceptibility of female mice to the dietary omega-3/omega-6 fatty-acid ratio: effects on adult hippocampal neurogenesis and glia. |
2022-03-25 |
2023-08-13 |
mouse |
| Niya Wang, Yahong Tan, Qixin Zhou, Rongrong Mao, Yuexiong Yan. The impairment of the hippocampal neuro-vascular unit precedes changes in spatial cognition in naturally aged rats. Neuroscience letters. 2022-03-21. PMID:35307332. |
we found that the impairments of microvessels, glia, neurons, and spatial memory were age-dependent in the rat hippocampus. |
2022-03-21 |
2023-08-13 |
rat |
| Christopher Hoyle, Jack P Green, Stuart M Allan, David Brough, Eloise Lemarchan. Itaconate and fumarate derivatives inhibit priming and activation of the canonical NLRP3 inflammasome in macrophages. Immunology. 2022-02-09. PMID:35137954. |
using murine bone marrow-derived macrophages, mixed glia and organotypic hippocampal slice cultures (ohscs), we demonstrate that dmi, 4oi and dmf pre-treatment inhibit pro-inflammatory cytokine production in response to lipopolysaccharide (lps), as well as inhibiting subsequent nlrp3 inflammasome activation induced by nigericin. |
2022-02-09 |
2023-08-13 |
human |
| Dongze Li, Na Xu, Yanyan Hou, Wenjing Ren, Na Zhang, Xi Wang, Yeying Sun, Wenxue Lu, Guiwu Qu, Yan Yu, Changjun Lv, Fang Ha. Abnormal lipid droplets accumulation induced cognitive deficits in obstructive sleep apnea syndrome mice via JNK/SREBP/ACC pathway but not through PDP1/PDC pathway. Molecular medicine (Cambridge, Mass.). vol 28. issue 1. 2022-01-15. PMID:35030992. |
here, our study found that about 3 months cih treatment induced lipid droplets (lds) accumulation in hippocampal nerve and glia cells of c57bl/6 mice, and caused severe neuro damage including neuron lesions, neuroblast (nb) apoptosis and abnormal glial activation. |
2022-01-15 |
2023-08-13 |
mouse |
| Xiaoyan Zheng, Wenjia Lin, Yimin Jiang, Kejia Lu, Wenjing Wei, Qingwei Huo, Shaoyang Cui, Xifei Yang, Min Li, Nenggui Xu, Chunzhi Tang, Ju-Xian Son. Electroacupuncture ameliorates beta-amyloid pathology and cognitive impairment in Alzheimer disease via a novel mechanism involving activation of TFEB (transcription factor EB). Autophagy. vol 17. issue 11. 2021-12-11. PMID:33622188. |
tnea reduced app (amyloid beta (a4) precursor protein), c-terminal fragments (ctfs) of app and aβ load, and inhibited glial cell activation in the prefrontal cortex and hippocampus of 5xfad. |
2021-12-11 |
2023-08-13 |
human |
| Célia Lentini, Marie d'Orange, Nicolás Marichal, Marie-Madeleine Trottmann, Rory Vignoles, Louis Foucault, Charlotte Verrier, Céline Massera, Olivier Raineteau, Karl-Klaus Conzelmann, Sylvie Rival-Gervier, Antoine Depaulis, Benedikt Berninger, Christophe Heinric. Reprogramming reactive glia into interneurons reduces chronic seizure activity in a mouse model of mesial temporal lobe epilepsy. Cell stem cell. vol 28. issue 12. 2021-12-06. PMID:34592167. |
using a mtle mouse model, we show that retrovirus-driven expression of ascl1 and dlx2 in reactive hippocampal glia in situ, or in cortical astroglia grafted in the epileptic hippocampus, causes efficient reprogramming into ins exhibiting hallmarks of interneurons. |
2021-12-06 |
2023-08-13 |
mouse |
| Murat Sırrı Akosman, Ruhi Türkmen, Hasan Hüseyin Demire. Investigation of the protective effect of resveratrol in an MK-801-induced mouse model of schizophrenia. Environmental science and pollution research international. vol 28. issue 46. 2021-12-02. PMID:34322799. |
according to the results obtained, this study showed for the first time that resveratrol prevented glial cell infiltration induced in the brain by mk-801 and shrinkage of nerve cell nuclei in the hippocampus and corpus callosum. |
2021-12-02 |
2023-08-13 |
mouse |
| Alish B Palmos, Rodrigo R R Duarte, Demelza M Smeeth, Erin C Hedges, Douglas F Nixon, Sandrine Thuret, Timothy R Powel. Lithium treatment and human hippocampal neurogenesis. Translational psychiatry. vol 11. issue 1. 2021-11-17. PMID:34718328. |
we observed that high-dose lithium treatment in human hippocampal progenitors increased the generation of neuroblasts (p ≤ 0.01), neurons (p ≤ 0.01), and glia (p ≤ 0.001), alongside the expression of genes, which regulate the volume of the molecular layer of the dentate gyrus. |
2021-11-17 |
2023-08-13 |
human |
| Elodie M Richard, Somayeh Bakhtiari, Ashley P L Marsh, Rauan Kaiyrzhanov, Matias Wagner, Sheetal Shetty, Alex Pagnozzi, Sandra M Nordlie, Brandon S Guida, Patricia Cornejo, Helen Magee, James Liu, Bethany Y Norton, Richard I Webster, Lisa Worgan, Hakon Hakonarson, Jiankang Li, Yiran Guo, Mahim Jain, Alyssa Blesson, Lance H Rodan, Mary-Alice Abbott, Anne Comi, Julie S Cohen, Bader Alhaddad, Thomas Meitinger, Dominic Lenz, Andreas Ziegler, Urania Kotzaeridou, Theresa Brunet, Anna Chassevent, Constance Smith-Hicks, Joseph Ekstein, Tzvi Weiden, Andreas Hahn, Nazira Zharkinbekova, Peter Turnpenny, Arianna Tucci, Melissa Yelton, Rita Horvath, Serdal Gungor, Semra Hiz, Yavuz Oktay, Hanns Lochmuller, Marcella Zollino, Manuela Morleo, Giuseppe Marangi, Vincenzo Nigro, Annalaura Torella, Michele Pinelli, Simona Amenta, Ralf A Husain, Benita Grossmann, Marion Rapp, Claudia Steen, Iris Marquardt, Mona Grimmel, Ute Grasshoff, G Christoph Korenke, Marta Owczarek-Lipska, John Neidhardt, Francesca Clementina Radio, Cecilia Mancini, Dianela Judith Claps Sepulveda, Kirsty McWalter, Amber Begtrup, Amy Crunk, Maria J Guillen Sacoto, Richard Person, Rhonda E Schnur, Maria Margherita Mancardi, Florian Kreuder, Pasquale Striano, Federico Zara, Wendy K Chung, Warren A Marks, Clare L van Eyk, Dani L Webber, Mark A Corbett, Kelly Harper, Jesia G Berry, Alastair H MacLennan, Jozef Gecz, Marco Tartaglia, Vincenzo Salpietro, John Christodoulou, Jan Kaslin, Sergio Padilla-Lopez, Kaya Bilguvar, Alexander Munchau, Zubair M Ahmed, Robert B Hufnagel, Michael C Fahey, Reza Maroofian, Henry Houlden, Heinrich Sticht, Shrikant M Mane, Aboulfazl Rad, Barbara Vona, Sheng Chih Jin, Tobias B Haack, Christine Makowski, Yoel Hirsch, Saima Riazuddin, Michael C Krue. Bi-allelic variants in SPATA5L1 lead to intellectual disability, spastic-dystonic cerebral palsy, epilepsy, and hearing loss. American journal of human genetics. vol 108. issue 10. 2021-11-15. PMID:34626583. |
immunofluorescent imaging in rat hippocampal neurons revealed localization of spata5l1 in neuronal and glial cell nuclei and more prominent expression in neurons. |
2021-11-15 |
2023-08-13 |
human |
| Ryota Araki, Hayato Tachioka, Ayami Kita, Hironori Fujiwara, Kazufumi Toume, Kinzo Matsumoto, Takeshi Yab. Kihito prevents corticosterone-induced brain dysfunctions in mice. Journal of traditional and complementary medicine. vol 11. issue 6. 2021-11-13. PMID:34765515. |
hippocampal cell survival, the number of hippocampal new-born immature neurons, hippocampal and accumbal dendritic spine density and mrna levels for neurotrophic factors such as glial cell line-derived neurotrophic factor (gdnf) were decreased in cort-treated mice without kit treatment. |
2021-11-13 |
2023-08-13 |
mouse |
| Elise C Cope, Anna D Zych, Nicole J Katchur, Renée C Waters, Blake J Laham, Emma J Diethorn, Christin Y Park, William R Meara, Elizabeth Goul. Atypical perineuronal nets in the CA2 region interfere with social memory in a mouse model of social dysfunction. Molecular psychiatry. 2021-11-09. PMID:34183768. |
we sought to identify potential mechanisms of social memory dysfunction in the hippocampus by investigating features of neurons, glia, and the extracellular matrix (ecm) of btbr mice, an inbred mouse strain with deficient social memory. |
2021-11-09 |
2023-08-13 |
mouse |
| Allison M Bond, Guo-Li Ming, Hongjun Son. Ontogeny of adult neural stem cells in the mammalian brain. Current topics in developmental biology. vol 142. 2021-11-05. PMID:33706926. |
neural stem cells (nscs) persist into adulthood in the subgranular zone (sgz) of the dentate gyrus in the hippocampus and in the ventricular-subventricular zone (v-svz) of the lateral ventricles, where they generate new neurons and glia cells that contribute to neural plasticity. |
2021-11-05 |
2023-08-13 |
Not clear |
| Luke Parkitny, Mirjana Maletic-Savati. Glial PAMPering and DAMPening of Adult Hippocampal Neurogenesis. Brain sciences. vol 11. issue 10. 2021-10-26. PMID:34679362. |
the hippocampal neurogenic niche hosts neural progenitors, glia, and vasculature, which all respond to intrinsic and environmental cues, helping determine their current state and ultimate fate. |
2021-10-26 |
2023-08-13 |
Not clear |
| Nathan A DeCarolis, Phillip D Rivera, Francisca Ahn, Wellington Z Amaral, Junie A LeBlanc, Shveta Malhotra, Hung-Ying Shih, David Petrik, Neal Melvin, Benjamin P C Chen, Amelia J Eisc. Life sciences in space research. vol 2. 2021-10-21. PMID:25170435. |
given that neurogenesis in the hippocampus has been linked to learning and memory, we investigated the response and recovery of neurogenesis and neural stem cells in the adult mouse hippocampal dentate gyrus after hze particle exposure using two nestin transgenic reporter mouse lines to label and track radial glia stem cells (nestin-gfp and nestin-creer |
2021-10-21 |
2023-08-13 |
mouse |
| Xiao Zhang, Yao Liu, Xiaoqi Hong, Xia Li, Charles K Meshul, Cynthia Moore, Yabing Yang, Yanfei Han, Wei-Guang Li, Xin Qi, Huifang Lou, Shumin Duan, Tian-Le Xu, Xiaoping Ton. NG2 glia-derived GABA release tunes inhibitory synapses and contributes to stress-induced anxiety. Nature communications. vol 12. issue 1. 2021-10-21. PMID:34593806. |
here, we report that ng2 glia form synaptic complexes with hippocampal interneurons and that selective photostimulation of ng2 glia (expressing channelrhodopsin-2) functionally drives gaba release and enhances inhibitory synaptic transmission onto proximal interneurons in a microcircuit. |
2021-10-21 |
2023-08-13 |
Not clear |
| Lushuang Xie, Yi Liu, Ning Zhang, Chenyu Li, Aaron F Sandhu, George Williams, Yan Shen, Hongying Li, Qiaofeng Wu, Shuguang Y. Electroacupuncture Improves M2 Microglia Polarization and Glia Anti-inflammation of Hippocampus in Alzheimer's Disease. Frontiers in neuroscience. vol 15. 2021-10-15. PMID:34646113. |
electroacupuncture improves m2 microglia polarization and glia anti-inflammation of hippocampus in alzheimer's disease. |
2021-10-15 |
2023-08-13 |
Not clear |
| Ying-Shao Lin, Ching-Kuan Liu, Hsiang-Chun Lee, Mei-Chuan Chou, Liang-Yin Ke, Chu-Huang Chen, Shiou-Lan Che. Electronegative very-low-density lipoprotein induces brain inflammation and cognitive dysfunction in mice. Scientific reports. vol 11. issue 1. 2021-10-14. PMID:33727609. |
however, in mice injected with metvldl, plasma and brain tnf-α and aβ-42 levels and glial cell activation in the mpfc and whole hippocampus were higher than those in control mice. |
2021-10-14 |
2023-08-13 |
mouse |
| Orly Lazarov, Richard D Minshall, Marcelo G Bonin. Harnessing neurogenesis in the adult brain-A role in type 2 diabetes mellitus and Alzheimer's disease. International review of neurobiology. vol 155. 2021-10-11. PMID:32854856. |
hippocampal neurogenesis is the generation of new neurons and glia in the adult brain throughout life. |
2021-10-11 |
2023-08-13 |
mouse |
| William Stevenson, Yoshiki Hase, Elle Wilson, Annabel Hollins, Mai Hase, Abdel Ennaceur, Lucy Craggs, Masafumi Ihara, Karen Horsburgh, Raj N Kalari. Long-term effects of experimental carotid stenosis on hippocampal infarct pathology, neurons and glia and amelioration by environmental enrichment. Brain research bulletin. vol 163. 2021-09-29. PMID:32707262. |
long-term effects of experimental carotid stenosis on hippocampal infarct pathology, neurons and glia and amelioration by environmental enrichment. |
2021-09-29 |
2023-08-13 |
mouse |