| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jessika M Hutchinson, Lori G Isaacso. Elimination of microglia in mouse spinal cord alters the retrograde CNS plasticity observed following peripheral axon injury. Brain research. vol 1721. 2020-10-01. PMID:31295468. |
microglia elimination did not impact baseline neurotransmitter expression in the iml neurons, and the typical neuronal plasticity observed following cst transection was unaffected. |
2020-10-01 |
2023-08-13 |
mouse |
| Pei-Wen Liu, Ming-Xia Yue, Rui Zhou, Juan Niu, Du-Juan Huang, Tao Xu, Pei Luo, Xiao-Hong Liu, Jun-Wei Zen. P2Y Journal of pain research. vol 10. 2020-09-30. PMID:28794655. |
p2y p2 receptors have been implicated in the release of neurotransmitter and pro-inflammatory cytokines due to their response to neuroexcitatory substances in the microglia. |
2020-09-30 |
2023-08-13 |
Not clear |
| Bingying Du, Hailong Li, Huiwen Zheng, Cunxiu Fan, Meng Liang, Yongjie Lian, Zelan Wei, Yanbo Zhang, Xiaoying B. Minocycline Ameliorates Depressive-Like Behavior and Demyelination Induced by Transient Global Cerebral Ischemia by Inhibiting Microglial Activation. Frontiers in pharmacology. vol 10. 2020-09-29. PMID:31695615. |
evidence has indicated that increased levels of inflammatory cytokines released from activated microglia induce depression-like behaviors by affecting neurotransmitter pathways, but the mechanisms remain elusive. |
2020-09-29 |
2023-08-13 |
Not clear |
| Sung Ja Rhie, Eun-Yee Jung, Insop Shi. The role of neuroinflammation on pathogenesis of affective disorders. Journal of exercise rehabilitation. vol 16. issue 1. 2020-09-28. PMID:32161729. |
neuronflammation involves a combination of psychological, neuroendocrine, and nervous systems resulting in changes of neurotransmitter metabolism, dysregulation of the hypothalamuspituitary-adrenal axis, pathologic microglial cell activation, impaired neuroplasticity, and structural and functional brain changes affecting cognition and emotional behavior. |
2020-09-28 |
2023-08-13 |
Not clear |
| Cinzia Volonté, Susanna Amadio, Paola Fabbrizio, Savina Apollon. Functional microglia neurotransmitters in amyotrophic lateral sclerosis. Seminars in cell & developmental biology. vol 94. 2020-06-03. PMID:31009755. |
we will discuss that als microglia can express a variety of classical neurotransmitter receptors comprising those for extracellular atp, glutamate and histamine. |
2020-06-03 |
2023-08-13 |
Not clear |
| Daniel Younger, Madhuvika Murugan, Kakulavarapu V Rama Rao, Long-Jun Wu, Namas Chandr. Microglia Receptors in Animal Models of Traumatic Brain Injury. Molecular neurobiology. vol 56. issue 7. 2020-01-14. PMID:30554385. |
the review explores the repertoire of secondary injury mechanisms such as aberrant neurotransmitter release, oxidative stress, blood-brain barrier disruption, and production of pro-inflammatory cytokines that follow microglia activation. |
2020-01-14 |
2023-08-13 |
Not clear |
| Sabine Jung-Klawitter, Thomas Oplade. Induced pluripotent stem cells (iPSCs) as model to study inherited defects of neurotransmission in inborn errors of metabolism. Journal of inherited metabolic disease. vol 41. issue 6. 2019-11-04. PMID:29980968. |
to study rare diseases affecting neurotransmitter biosynthesis and neurotransmission, stem cell models carrying patient-specific mutations have become highly important as most of the cell types present in the human brain and the central nervous system (cns), including motoneurons, neurons, oligodendrocytes, astrocytes, and microglia, can be differentiated from ipscs following distinct developmental programs. |
2019-11-04 |
2023-08-13 |
human |
| Marco Cascella, Maria R Muzio, Sabrina Bimonte, Arturo Cuomo, Jan G Jakobsso. Postoperative delirium and postoperative cognitive dysfunction: updates in pathophysiology, potential translational approaches to clinical practice and further research perspectives. Minerva anestesiologica. vol 84. issue 2. 2019-10-24. PMID:28984099. |
this paper aimed to provide an update in the pathophysiology of these conditions with special attention to the roles of the neuroinflammation, the microglia activation, the surgical stress response, the impairment of neurotransmitter systems, and the direct neurotoxic effect of general anesthetic drugs. |
2019-10-24 |
2023-08-13 |
Not clear |
| Renato Socodato, Camila C Portugal, Artur Rodrigues, Joana Henriques, Carla Rodrigues, Cláudia Figueira, João B Relva. Redox tuning of Ca Free radical biology & medicine. vol 118. 2019-05-14. PMID:29501565. |
upon activation, microglia release high amounts of the neurotransmitter glutamate, contributing for neuronal excitotoxicity during brain insults. |
2019-05-14 |
2023-08-13 |
human |
| Tobias Bobinger, Petra Burkardt, Hagen B Huttner, Anatol Manaenk. Programmed Cell Death after Intracerebral Hemorrhage. Current neuropharmacology. vol 16. issue 9. 2018-11-26. PMID:28571544. |
the post-ich brain injury can be distinguished in 1) primary, which are caused by disruption and mechanical deformation of brain tissue due to hematoma growth and 2) secondary, which are induced by microglia activation, mitochondrial dysfunction, neurotransmitter and inflammatory mediator release. |
2018-11-26 |
2023-08-13 |
Not clear |
| Wenjuan Ru, Shao-Jun Tan. HIV-associated synaptic degeneration. Molecular brain. vol 10. issue 1. 2018-05-07. PMID:28851400. |
infected cells, including macrophages, microglia and astrocytes, may release viral proteins and other neurotoxins to stimulate neurons and cause excessive calcium influx, overproduction of free radicals and disruption of neurotransmitter hemostasis. |
2018-05-07 |
2023-08-13 |
human |
| Anna R Carta, Giovanna Mulas, Mariza Bortolanza, Terence Duarte, Elisabetta Pillai, Gilberto Fisone, Rita Raisman Vozari, Elaine Del-Be. l-DOPA-induced dyskinesia and neuroinflammation: do microglia and astrocytes play a role? The European journal of neuroscience. vol 45. issue 1. 2018-02-01. PMID:27859864. |
both microglia and astrocytes express a multitude of neurotransmitter receptors and via the release of several soluble molecules modulate synaptic function in neuronal networks. |
2018-02-01 |
2023-08-13 |
Not clear |
| Swetha Vijayaraghavan, Azadeh Karami, Shahin Aeinehband, Homira Behbahani, Alf Grandien, Bo Nilsson, Kristina N Ekdahl, Rickard P F Lindblom, Fredrik Piehl, Taher Darreh-Shor. Regulated Extracellular Choline Acetyltransferase Activity- The Plausible Missing Link of the Distant Action of Acetylcholine in the Cholinergic Anti-Inflammatory Pathway. PloS one. vol 8. issue 6. 2017-10-09. PMID:23840379. |
acetylcholine (ach), the classical neurotransmitter, also affects a variety of nonexcitable cells, such as endothelia, microglia, astrocytes and lymphocytes in both the nervous system and secondary lymphoid organs. |
2017-10-09 |
2023-08-12 |
human |
| Komal Kapoor, Amol M Bhandare, Polina E Nedoboy, Suja Mohammed, Melissa M J Farnham, Paul M Pilowsk. Dynamic changes in the relationship of microglia to cardiovascular neurons in response to increases and decreases in blood pressure. Neuroscience. vol 329. 2017-07-26. PMID:27155147. |
microglia are present throughout the central nervous system (cns) and express receptors for every known neurotransmitter. |
2017-07-26 |
2023-08-13 |
rat |
| Philippe Leff-Gelman, Ismael Mancilla-Herrera, Mónica Flores-Ramos, Carlos Cruz-Fuentes, Juan Pablo Reyes-Grajeda, María Del Pilar García-Cuétara, Marielle Danitza Bugnot-Pérez, David Ellioth Pulido-Ascenci. The Immune System and the Role of Inflammation in Perinatal Depression. Neuroscience bulletin. vol 32. issue 4. 2017-02-24. PMID:27432060. |
microglia and toll-like receptor 4 play a crucial role in triggering wide and varied stress-induced responses mediated through activation of the inflammasome; this leads to the secretion of inflammatory cytokines, increased serotonin metabolism, and reduction of neurotransmitter availability along with hypothalamic-pituitary-adrenal axis hyperactivity. |
2017-02-24 |
2023-08-13 |
Not clear |
| Ana Santos-Carvalho, António Francisco Ambrósio, Cláudia Cavada. Neuropeptide Y system in the retina: From localization to function. Progress in retinal and eye research. vol 47. 2016-01-26. PMID:25797468. |
in the present review, we highlight the putative roles of npy receptor activation in the retina, discussing, in particular, their involvement in retinal development, neurotransmitter release modulation, neuroprotection, microglia and muller cells function, retinal pigmented epithelium changes, retinal endothelial physiology and proliferation of retinal progenitor cells. |
2016-01-26 |
2023-08-13 |
Not clear |
| Anna K Clark, Doris Gruber-Schoffnegger, Ruth Drdla-Schutting, Katharina J Gerhold, Marzia Malcangio, Jürgen Sandkühle. Selective activation of microglia facilitates synaptic strength. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 11. 2015-06-15. PMID:25788673. |
specifically, the activation of the cx3cr1 receptor by fractalkine induces the release of interleukin-1β from microglia, which modulates nmda signaling in postsynaptic neurons, leading to the release of an eicosanoid messenger, which ultimately enhances presynaptic neurotransmitter release. |
2015-06-15 |
2023-08-13 |
rat |
| Ricardo J Rodrigues, Angelo R Tomé, Rodrigo A Cunh. ATP as a multi-target danger signal in the brain. Frontiers in neuroscience. vol 9. 2015-05-14. PMID:25972780. |
atp is released in an activity-dependent manner from different cell types in the brain, fulfilling different roles as a neurotransmitter, neuromodulator, in astrocyte-to-neuron communication, propagating astrocytic responses and formatting microglia responses. |
2015-05-14 |
2023-08-13 |
Not clear |
| C C Watkins, A Sawa, M G Pompe. Glia and immune cell signaling in bipolar disorder: insights from neuropharmacology and molecular imaging to clinical application. Translational psychiatry. vol 4. 2015-03-06. PMID:24448212. |
we review the pharmacological, translational and brain imaging studies that support a role for microglia in regulating neurotransmitter synthesis and immune cell activation. |
2015-03-06 |
2023-08-12 |
Not clear |
| Norbert Mülle. Immunology of major depression. Neuroimmunomodulation. vol 21. issue 2-3. 2014-10-17. PMID:24557045. |
the direct and indirect effects of cytokines on neurotransmitter storage and release - mediated by microglia cells and astrocytes - are discussed. |
2014-10-17 |
2023-08-12 |
Not clear |