| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michaela R Breach, Courtney N Dye, Aarohi Joshi, Steven Platko, Rachel A Gilfarb, Annemarie R Krug, Dominic V Franceschelli, Anabel Galan, Claire M Dodson, Kathryn M Len. Maternal allergic inflammation in rats impacts the offspring perinatal neuroimmune milieu and the development of social play, locomotor behavior, and cognitive flexibility. Brain, behavior, and immunity. vol 95. 2021-06-23. PMID:33798637. |
allergic inflammation upregulated microglia in the fetal brain, increased mast cell number in the hippocampus on the day of birth, and conferred region-, time- and sex- specific changes in microglia measures. |
2021-06-23 |
2023-08-13 |
rat |
| Virginia L De Sousa, Suzana B Araújo, Leticia M Antonio, Mariana Silva-Queiroz, Lilian C Colodeti, Carolina Soares, Fernanda Barros-Aragão, Hannah P Mota-Araujo, Vinícius S Alves, Robson Coutinho-Silva, Luiz Eduardo B Savio, Sergio T Ferreira, Robson Da Costa, Julia R Clarke, Claudia P Figueired. Innate immune memory mediates increased susceptibility to Alzheimer's disease-like pathology in sepsis surviving mice. Brain, behavior, and immunity. vol 95. 2021-06-23. PMID:33838250. |
hippocampal microglia from sepsis-surviving mice shift to an amoeboid/phagocytic morphological profile when exposed to low amounts of aβo, and this event was accompanied by the upregulation of several pro-inflammatory proteins (il-1β, il-6, inf-γ and p2x7 receptor) in the mouse hippocampus, suggesting that a trained innate immune memory occurs in the brain after sepsis. |
2021-06-23 |
2023-08-13 |
mouse |
| Ban-Yu Saitoh, Eizo Tanaka, Norio Yamamoto, Daan van Kruining, Kyoko Iinuma, Yuko Nakamuta, Hiroo Yamaguchi, Ryo Yamasaki, Koichiro Matsumoto, Jun-Ichi Kir. Early postnatal allergic airway inflammation induces dystrophic microglia leading to excitatory postsynaptic surplus and autism-like behavior. Brain, behavior, and immunity. vol 95. 2021-06-23. PMID:33862170. |
in the hippocampus, iba-1-positive areas, the size of iba-1-positive microglial cell bodies, and the ramification index of microglia by sholl analysis were significantly smaller in the ova group than in the control group on p30 and p70, although iba-1-positive microglia numbers did not differ significantly between the two groups. |
2021-06-23 |
2023-08-13 |
mouse |
| Ban-Yu Saitoh, Eizo Tanaka, Norio Yamamoto, Daan van Kruining, Kyoko Iinuma, Yuko Nakamuta, Hiroo Yamaguchi, Ryo Yamasaki, Koichiro Matsumoto, Jun-Ichi Kir. Early postnatal allergic airway inflammation induces dystrophic microglia leading to excitatory postsynaptic surplus and autism-like behavior. Brain, behavior, and immunity. vol 95. 2021-06-23. PMID:33862170. |
compared with the control group, serum basal corticosterone levels were significantly elevated and hippocampal glucocorticoid receptor (gr) amounts and nuclear gr translocation in microglia, but not in neurons or astrocytes, were significantly decreased in the ova group on p70 but not on p30. |
2021-06-23 |
2023-08-13 |
mouse |
| Ting Ye, Dan Wang, Zixuan Cai, Lijuan Tong, Zhuo Chen, Jiashu Lu, Xu Lu, Chao Huang, Xiaomei Yua. Antidepressive properties of macrophage-colony stimulating factor in a mouse model of depression induced by chronic unpredictable stress. Neuropharmacology. vol 172. 2021-06-21. PMID:32407925. |
the antidepressant effect of m-csf appeared to be mediated by the activation of the hippocampal microglia, as pre-inhibition of microglia by minocycline (40 mg/kg) or plx3397 (290 mg/kg) pretreatment prevented the antidepressant effect of m-csf in cus mice. |
2021-06-21 |
2023-08-13 |
mouse |
| Ting Ye, Dan Wang, Zixuan Cai, Lijuan Tong, Zhuo Chen, Jiashu Lu, Xu Lu, Chao Huang, Xiaomei Yua. Antidepressive properties of macrophage-colony stimulating factor in a mouse model of depression induced by chronic unpredictable stress. Neuropharmacology. vol 172. 2021-06-21. PMID:32407925. |
these results demonstrate that m-csf produces rapid and sustained antidepressant effects via the activation of the microglia in the hippocampus in a dose- and time-dependent manner. |
2021-06-21 |
2023-08-13 |
mouse |
| Shanshan Zhang, Ying Zong, Zhonggan Ren, Juntao Hu, Xinyuan Wu, Honglei Xiao, Song Qin, Guomin Zhou, Yuanyuan Ma, Yaodong Zhang, Jin Yu, Kaidi Wang, Guocai Lu, Qiong Li. Regulation of indoleamine 2, 3-dioxygenase in hippocampal microglia by NLRP3 inflammasome in lipopolysaccharide-induced depressive-like behaviors. The European journal of neuroscience. vol 52. issue 11. 2021-06-21. PMID:33098156. |
regulation of indoleamine 2, 3-dioxygenase in hippocampal microglia by nlrp3 inflammasome in lipopolysaccharide-induced depressive-like behaviors. |
2021-06-21 |
2023-08-13 |
mouse |
| Shanshan Zhang, Ying Zong, Zhonggan Ren, Juntao Hu, Xinyuan Wu, Honglei Xiao, Song Qin, Guomin Zhou, Yuanyuan Ma, Yaodong Zhang, Jin Yu, Kaidi Wang, Guocai Lu, Qiong Li. Regulation of indoleamine 2, 3-dioxygenase in hippocampal microglia by NLRP3 inflammasome in lipopolysaccharide-induced depressive-like behaviors. The European journal of neuroscience. vol 52. issue 11. 2021-06-21. PMID:33098156. |
in the brain, nlrp3 (nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin-domain-containing 3) inflammasome is mainly expressed in microglia located in the hippocampus and other mood-regulated regions, which are particularly susceptible to stress. |
2021-06-21 |
2023-08-13 |
mouse |
| Hongjie Chen, Jun Zho. Effects of Sodium Selenite on Oxidative Damage in the Liver, Kidney and Brain in a Selenite Cataract Rat Model. Biological trace element research. vol 197. issue 2. 2021-06-18. PMID:31832924. |
this damage was evidenced by mild gliocyte proliferation, significant disorder of neuronal arrangement with acidophilic changes in the hippocampus, and significant occurrence of focal microglia or lymphocytic infiltration in the corpus striatum after selenite injection for cataract simulation. |
2021-06-18 |
2023-08-13 |
human |
| Sinead Rooney, Anupam Sah, Michael S Unger, Maria Kharitonova, Simone B Sartori, Christoph Schwarzer, Ludwig Aigner, Helmut Kettenmann, Susanne A Wolf, Nicolas Singewal. Neuroinflammatory alterations in trait anxiety: modulatory effects of minocycline. Translational psychiatry. vol 10. issue 1. 2021-06-18. PMID:32732969. |
in particular, the dentate gyrus (dg) of the hippocampus of habs exhibited enhanced density and average cell area of iba1+, and density of phagocytic (cd68+/iba1+) microglia compared to normal anxiety (nab) controls. |
2021-06-18 |
2023-08-13 |
mouse |
| Gao Xiaoying, Mian Guo, Liu Jie, Zhu Yanmei, Cui Ying, Shu Shengjie, Gou Haiyan, Sun Feixiang, Qi Sihua, Sun Jiahan. CircHivep2 contributes to microglia activation and inflammation via miR-181a-5p/SOCS2 signalling in mice with kainic acid-induced epileptic seizures. Journal of cellular and molecular medicine. vol 24. issue 22. 2021-06-18. PMID:33002329. |
the expression of circhivep2 was significantly down-regulated in hippocampus tissues of mice with ka-induced epileptic seizures and bv-2 microglia cells upon ka treatment. |
2021-06-18 |
2023-08-13 |
mouse |
| Chad Smith, Kyle J Trageser, Henry Wu, Francis J Herman, Umar Haris Iqbal, Maria Sebastian-Valverde, Tal Frolinger, Emma Zeng, Giulio Maria Pasinett. Anxiolytic effects of NLRP3 inflammasome inhibition in a model of chronic sleep deprivation. Translational psychiatry. vol 11. issue 1. 2021-06-18. PMID:33446652. |
the results show a flavanol-rich dietary preparation (fdp) exhibits anxiolytic properties by attenuating markers of neuroimmune activation, which included il-1β upregulation, nlrp3 signaling, and microglia activation in the cortex and hippocampus of sleep-deprived mice. |
2021-06-18 |
2023-08-13 |
mouse |
| Yiwei Liu, Xia Chen, Qihai Gong, Jingshan Shi, Fei L. Osthole Improves Cognitive Function of Vascular Dementia Rats: Reducing Aβ Deposition via Inhibition NLRP3 Inflammasome. Biological & pharmaceutical bulletin. vol 43. issue 9. 2021-06-16. PMID:32879205. |
the study results showed that ost obviously enhanced the spatial learning, memory and working abilities induced by modified bilateral common carotid artery occlusion (bccao) in rats, improved the pathological damage of hippocampal neurons induced by bccao in rats, inhibited the activation of microglia induced by bccao in rats. |
2021-06-16 |
2023-08-13 |
rat |
| Andrei Turkin, Oksana Tuchina, Friederike Klempi. Microglia Function on Precursor Cells in the Adult Hippocampus and Their Responsiveness to Serotonin Signaling. Frontiers in cell and developmental biology. vol 9. 2021-06-12. PMID:34109176. |
microglia function on precursor cells in the adult hippocampus and their responsiveness to serotonin signaling. |
2021-06-12 |
2023-08-13 |
Not clear |
| Andrei Turkin, Oksana Tuchina, Friederike Klempi. Microglia Function on Precursor Cells in the Adult Hippocampus and Their Responsiveness to Serotonin Signaling. Frontiers in cell and developmental biology. vol 9. 2021-06-12. PMID:34109176. |
in this chapter, we illustrate how microglia contribute to neuroplasticity of the hippocampus and interact with local factors, e.g., bdnf, and external stimuli that promote neurogenesis. |
2021-06-12 |
2023-08-13 |
Not clear |
| Jie Chen, Haochen Wang, Chengliang Luo, Cheng Gao, Yalai Zhang, Guang Chen, Wei Chen, Xiping Chen, Luyang Ta. Chd8 Rescued TBI-Induced Neurological Deficits by Suppressing Apoptosis and Autophagy Via Wnt Signaling Pathway. Cellular and molecular neurobiology. vol 40. issue 7. 2021-06-11. PMID:32034634. |
in vivo, we found that chd8 co-localized in neurons, astrocytes, and microglia, but predominantly presented in neurons in the prefrontal cortex, hippocampus, and cortex. |
2021-06-11 |
2023-08-13 |
Not clear |
| Max Rudolph, Christian W Schmeer, Madlen Günther, Florus Woitke, Carolin Kathner-Schaffert, Lina Karapetow, Julia Lindner, Thomas Lehmann, Gustav Jirikowski, Otto W Witte, Christoph Redecker, Silke Keine. Microglia-mediated phagocytosis of apoptotic nuclei is impaired in the adult murine hippocampus after stroke. Glia. vol 69. issue 8. 2021-06-09. PMID:33942391. |
here, we evaluated the effect of a prefrontal stroke lesion on the phagocytic activity of microglia in the dentate gyrus (dg) of the hippocampus. |
2021-06-09 |
2023-08-13 |
mouse |
| Alok Kumar, J Kalita, Rohit A Sinha, Gajendra Singh, Anjum B, Mukti Shukla, Swasti Tiwari, T N Dhole, U K Misr. Impaired Autophagy Flux is Associated with Proinflammatory Microglia Activation Following Japanese Encephalitis Virus Infection. Neurochemical research. vol 45. issue 9. 2021-06-08. PMID:32613347. |
microglia in cortex were activated and showed higher expression of proinflammatory mrna of il1β, tnf-α, ifnγ and il6, with increased dna damage (h2ax) and neuronal cell death pathways in hippocampus and neurobehavioral dysfunction. |
2021-06-08 |
2023-08-13 |
mouse |
| Yangyang Lin, Jian Jin, Rongke Lv, Yuan Luo, Weiping Dai, Wenchang Li, Yamei Tang, Yuling Wang, Xiaojing Ye, Wei-Jye Li. Repetitive transcranial magnetic stimulation increases the brain's drainage efficiency in a mouse model of Alzheimer's disease. Acta neuropathologica communications. vol 9. issue 1. 2021-06-07. PMID:34078467. |
significant reduction of aβ deposits, suppression of microglia and astrocyte activation, and prevention of decline of neuronal activity as indicated by the elevated c-fos expression, were observed in the prefrontal cortex and hippocampus of the rtms-treated 5xfad mice. |
2021-06-07 |
2023-08-13 |
mouse |
| Zixuan Cai, Ting Ye, Xing Xu, Minhui Gao, Yaru Zhang, Dan Wang, Yiming Gu, Haojie Zhu, Lijuan Tong, Jiashu Lu, Zhuo Chen, Chao Huan. Antidepressive properties of microglial stimulation in a mouse model of depression induced by chronic unpredictable stress. Progress in neuro-psychopharmacology & biological psychiatry. vol 101. 2021-06-04. PMID:32201112. |
the decrease of microglia in the hippocampus is a novel mechanism for depression onset. |
2021-06-04 |
2023-08-13 |
mouse |