| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| O Kuchel, J L Cuche, N T Buu, G P Guthrie, T Unger, W Nowaczynski, R Boucher, J Genes. Catecholamine excretion in "idiopathic" edema: decreased dopamine excretion, a pathogenic factor? The Journal of clinical endocrinology and metabolism. vol 44. issue 4. 1977-05-27. PMID:849977. |
these results suggest that a decrease in urinary dopamine, a catecholamine recently recognized to have natriuretic action, possibly reflects a suppression of the renal dopaminergic system and may contribute to the excessive sodium retention in idiopathic edema either directly or indirectly through the renin-aldosterone system. |
1977-05-27 |
2023-08-11 |
human |
| M F Giorguieff, M L Le Floc'h, J Glowinski, M J Besso. Involvement of cholinergic presynaptic receptors of nicotinic and muscarinic types in the control of the spontaneous release of dopamine from striatal dopaminergic terminals in the rat. The Journal of pharmacology and experimental therapeutics. vol 200. issue 3. 1977-05-27. PMID:850127. |
involvement of cholinergic presynaptic receptors of nicotinic and muscarinic types in the control of the spontaneous release of dopamine from striatal dopaminergic terminals in the rat. |
1977-05-27 |
2023-08-11 |
rat |
| J Gerlac. Relationship between tardive dyskinesia, L-Dopa-induced hyperkinesia and parkinsonism. Psychopharmacology. vol 51. issue 3. 1977-05-20. PMID:403541. |
it is concluded that the irreversible neurotoxic effect of neuroleptic drugs may be associated with age-related changes in the oral somatotopic region of the basal ganglia (to be given consideration in any future search for the pathogenetic process underlying irreversible tardive dyskinesia), and that the pathophysiology of involuntary hyperkinesia in neuroleptic-treated psychiatric patients and in l-dopatreated parkinson patients may consist of a primary dopamine deficiency (pharmacological or structural), and a secondary relative hyperactivity in the dopaminergic system ("dopaminergic hypersensitivity") possibly corresponding to hypoactivity in the cholinergic system. |
1977-05-20 |
2023-08-11 |
Not clear |
| J Dankova, R Boucher, L J Poirie. Effects of 1694 and other dopaminergic agents on circling behavior. European journal of pharmacology. vol 42. issue 2. 1977-05-20. PMID:557412. |
although this experimental model is useful to determine the degree of dopaminergic activity of various chemical agents it does not duplicate the motor disorders encountered in parkinsonism which are associated with a decreased concentration of dopamine. |
1977-05-20 |
2023-08-11 |
rat |
| H Y Meltzer, V S Fang, M Simonovich, S M Pau. Effect of metabolites of chlorpromazine on plasma prolactin levels in male rats. European journal of pharmacology. vol 41. issue 4. 1977-05-20. PMID:844484. |
since prolactin secretion is under vigorous dopaminergic inhibition, neuroleptic drugs can, because of their capacity to block dopamine receptors, produce large increases in plasma prolactin levels in man and laboratory animals. |
1977-05-20 |
2023-08-11 |
rat |
| M J Bastie, N Vaysse, B Brenac, J P Pascal, A Ribe. Effects of catecholamines and their inhibitors on the isolated canine pancreas. II. Dopamine. Gastroenterology. vol 72. issue 4 Pt 1. 1977-04-28. PMID:838228. |
dopaminergic agonists (dopamine, 2, 10, 50, and 250 mug; apomorphine, 1 mg; noradrenaline, 2, 20, and 200 mug), and inhibitors (haloperidol, 5 mg; pentamethonium, 500 mg; phenoxybenzamine, 15 mg, and atropine sulfate, 10 mg), were tested on isolated perfused canine pancreas; under basal conditions and under stimulation by a background of secretin (0.1, 0.5, and 10.0 clinical unit per hr), or of caerulein (1200 ng per hr). |
1977-04-28 |
2023-08-11 |
Not clear |
| T Mitsuma, Y Hirooka, N Nihe. [The effect of various amines on TRH contents in rat brain (author's transl)]. Nihon Naibunpi Gakkai zasshi. vol 52. issue 8. 1977-04-25. PMID:138603. |
the above data suggested the trh contents in rat brain were increased with increase of dopamine level in rat brain and decreased with increase of serotonine level or decrease of noradrenaline level in rat brain and inhibitory effect of t4 or t3 on trh release might be mediated through dopaminergic and serotonergic mechanism. |
1977-04-25 |
2023-08-11 |
rat |
| J Costentin, H Marçais, P Protais, M Baudry, M P Martres, J C Schwart. [Facilitation of a stereotyped motor behavior (climbing behavior) by previous stimulation of dopaminergic receptors: hyposensitivity of autoreceptors?]. Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles. vol 284. issue 2. 1977-04-25. PMID:402241. |
the hypothesis is put forward that "behavioural facilitation" results from the hyposensitivity of a class of dopamine receptors, possibly autoreceptors, mediating an impaired activity of dopaminergic neurons and, consequently, inhibitory behavioural effects. |
1977-04-25 |
2023-08-11 |
mouse |
| F Camanni, F Massara, L Belforte, A Rosatello, G M Molinatt. Effect of dopamine on plasma growth hormone and prolactin levels in normal and acromegalic subjects. The Journal of clinical endocrinology and metabolism. vol 44. issue 3. 1977-04-25. PMID:838847. |
in contrast with other dopaminergic drugs (l-dopa, apomorphine or bromocriptine) a 280 mug/min dose of dopamine infused for 120 min failed to induce an increase in plasma gh in 9 normal subjects. |
1977-04-25 |
2023-08-11 |
human |
| F Camanni, F Massara, L Belforte, A Rosatello, G M Molinatt. Effect of dopamine on plasma growth hormone and prolactin levels in normal and acromegalic subjects. The Journal of clinical endocrinology and metabolism. vol 44. issue 3. 1977-04-25. PMID:838847. |
since dopamine does not readily cross the blood-brain barrier, these results suggest that the stimulating effect of dopaminergic drugs on gh secretion in the normal subject is exerted via the cns, whereas in acromegaly there is a direct action on structures lying outside the blood-brain barrier, probably in the hypophysis. |
1977-04-25 |
2023-08-11 |
human |
| J Bockaert, J P Tassin, A M Thierry, J Glowinski, J Premon. Characteristics of dopamine and beta-adrenergic sensitive adenylate cyclases in the frontal cerebral cortex of the rat. Comparative effects of neuroleptics on frontal cortex and striatal dopamine sensitive adenylate cyclases. Brain research. vol 122. issue 1. 1977-04-15. PMID:837225. |
thus, haloperidol was less effective than fluphenazine in blocking the striatal dopaminergic receptors, and equally potent than fluphenazine in inhibiting the frontal cerebral cortex dopamine sensitive adenylate cyclase. |
1977-04-15 |
2023-08-11 |
rat |
| R Schwarcz, J T Coyl. Kainic acid: neurotoxic effects after intraocular injection. Investigative ophthalmology & visual science. vol 16. issue 2. 1977-03-31. PMID:832974. |
the dopaminergic neurons, as assessed by activity of tyrosine hydroxylase and concentration of endogenous dopamine, are reduced only 50% by the kainic acid treatment. |
1977-03-31 |
2023-08-11 |
Not clear |
| R P Ebstein, J Biederman, R Rimon, J Zohar, R H Belmake. Cyclic GMP in the CSF of patients with schizophrenia before and after neuroleptic treatment. Psychopharmacology. vol 51. issue 1. 1977-03-21. PMID:13448. |
measurement of csf cyclic gmp may allow evaluation of possible implications of the dopaminergic hyperactivity in schizophrenia proposed by the dopamine hypothesis. |
1977-03-21 |
2023-08-11 |
Not clear |
| J Biederman, R Rimon, R Ebstein, R H Belmaker, J T Davidso. Cyclic AMP in the CSF of patients with schizophrenia. The British journal of psychiatry : the journal of mental science. vol 130. 1977-03-21. PMID:188506. |
the dopamine hypothesis of schizophrenia proposes that schizophrenia is associated with increased brain dopaminergic function. |
1977-03-21 |
2023-08-11 |
Not clear |
| J Rotrosen, B M Angrist, S Gershon, E J Sachar, F S Halper. Dopamine receptor alteration in schizophrenia: neuroendocrine evidence. Psychopharmacology. vol 51. issue 1. 1977-03-21. PMID:827770. |
growth hormone (hgh) responses to centrally acting dopamine agonists were used as indices of cns dopaminergic function in order to test hypotheses implicating dopaminergic alteration in the etiopathology of schizophrenia. |
1977-03-21 |
2023-08-11 |
Not clear |
| B H Hirst, J D Reed, A Gomez-Pan, L A Labi. Bromocriptine potentiation of gastric acid secretion in cats. Clinical endocrinology. vol 5. issue 6. 1977-03-15. PMID:1036979. |
the mechanism of action of this compound on the stomach does not appear to be mediated through stimulation of dopaminergic receptors as no potentiation was observed with dopamine infusions. |
1977-03-15 |
2023-08-11 |
Not clear |
| Y Kimura, N Kisaki, S Sakurada, T Tadan. On the brain monoaminergic systems relating to ejaculation. I. Brain dopamine and ejaculation. Andrologia. vol 8. issue 4. 1977-02-26. PMID:1008262. |
the results obtained in this study indicate that ejaculation is activated by the dopaminergic system in the brain, and that dopamine in the anterior hypothalamus is closely related to the occurrence of ejaculation. |
1977-02-26 |
2023-08-11 |
rat |
| M H Van Woert, R Jutkowitz, D Rosenbaum, M B Bower. Gilles de la Tourette's syndrome: biochemical approaches. Research publications - Association for Research in Nervous and Mental Disease. vol 55. 1977-02-24. PMID:1070064. |
this supports the hypothesis that tourette symptoms are related to an increased firing of dopaminergic neurons in the central nervous system; haloperidol relieves these symptoms by blocking dopamine receptors. |
1977-02-24 |
2023-08-11 |
Not clear |
| L L Butcher, L Bilezikjia. Acetylcholinesterase-containing neurons in the neostriatum and substantia nigra revealed after punctate intracerebral injection of di-isopropylfluorophosphate. European journal of pharmacology. vol 34. issue 1. 1977-02-24. PMID:1234757. |
although the significance of dopaminergic--cholinergic interactions in the neostriatum could not be elucidated on the basis of these histochemical data, the thesis was advanced that dopamine neurons in the pars compacta of the substantia nigra also contained ache, possibly to inactivate acetylcholine released from cholinergic fibers afferent to this neural structure. |
1977-02-24 |
2023-08-11 |
rat |
| L C Murrin, R H Rot. Dopaminergic neurons: reversal of effects elicited by gamma-butyrolactone by stimulation of the nigro-neostriatal pathway. Naunyn-Schmiedeberg's archives of pharmacology. vol 295. issue 1. 1977-02-16. PMID:12482. |
these results are also consistent with the hypothesis that gbl activates tyrosine hydroxylase and increases endogenous dopamine levels primarily by blocking impulse flow in central dopaminergic neurons. |
1977-02-16 |
2023-08-11 |
Not clear |