| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Toide, N Unemi, T Segaw. Effects of a fluorinated pyrimidinedione anti-cancer drug, 5-fluoro-1-(tetrahydro-2-furanyl)-2,4-pyrimidinedione (FT), and related compounds on nigro-striatal dopaminergic neurons in the central nervous system. Archives internationales de pharmacodynamie et de therapie. vol 274. issue 1. 1985-08-22. PMID:3925907. |
these results suggest that the side effects of ft on the cns, especially its action on dopaminergic neurons, may result from blockade of pre- and post-synaptic dopamine receptors, and may be mediated by its main metabolite 5-fu in the brain. |
1985-08-22 |
2023-08-11 |
rat |
| J S Ramsdell, C L Bethea, R B Jaffe, C B Wilson, R I Weine. Characterization of dopamine and alpha-adrenergic receptors in human prolactin-secreting adenomas with [3H]-dihydroergocryptine. Neuroendocrinology. vol 40. issue 6. 1985-08-21. PMID:2861582. |
dopamine receptors have been repeatedly characterized on prolactin-secreting adenomas using labelled antagonists as ligands; however, no data are available on characterization of the receptor with a dopaminergic agonist. |
1985-08-21 |
2023-08-11 |
human |
| J Arnt, A V Christensen, J Hytte. Pharmacology in vivo of the phenylindan derivative, Lu 19-005, a new potent inhibitor of dopamine, noradrenaline and 5-hydroxytryptamine uptake in rat brain. Naunyn-Schmiedeberg's archives of pharmacology. vol 329. issue 2. 1985-08-13. PMID:2409454. |
behavioural effects on dopaminergic transmission of a phenylindane derivative, lu 19-005 [(+/-)-trans-3-(3,4-dichlorophenyl)-n-methyl-l-indanamine, hci], with potent inhibitory effect on dopamine (da), noradrenaline (na) and serotonin (5-ht) uptake in rats and the effect on da, na and 5-ht activity in mice have been studied and compared with those of other known da, na and 5-ht uptake inhibitors with different selectivity ratios. |
1985-08-13 |
2023-08-11 |
mouse |
| S Nagahama, Y F Chen, S Opari. Enhanced depressor effect of bromocriptine in the DOCA/NaCl hypertensive rat. The American journal of physiology. vol 249. issue 1 Pt 2. 1985-08-13. PMID:2861750. |
to elucidate the role of the dopaminergic system in the maintenance of hypertension in the deoxycorticosterone acetate (doca)/nacl hypertensive rat, the responses of mean arterial pressure (map), plasma norepinephrine (ne), epinephrine (e), and prolactin (prl) to intravenous (iv) administration of bromocriptine, a dopamine agonist, and hexamethonium bromide, a ganglion blocker, were examined in conscious, unrestrained 4-wk doca/nacl hypertensive rats. |
1985-08-13 |
2023-08-11 |
rat |
| G W Maguire, E L Smit. Cat retinal ganglion cell receptive-field alterations after 6-hydroxydopamine induced dopaminergic amacrine cell lesions. Journal of neurophysiology. vol 53. issue 6. 1985-08-12. PMID:2861256. |
the impairment of the dopaminergic ac was verified by high pressure-liquid chromatography (hplc) with electrochemical detection of endogenous dopamine content and by [3h]dopamine high-affinity uptake; the dopaminergic acs of the treated eyes demonstrated reduced endogenous dopamine content and reduced [3h]dopamine uptake compared with that of their matched controls. |
1985-08-12 |
2023-08-11 |
cat |
| C J Schmidt, J K Ritter, P K Sonsalla, G R Hanson, J W Gib. Role of dopamine in the neurotoxic effects of methamphetamine. The Journal of pharmacology and experimental therapeutics. vol 233. issue 3. 1985-08-09. PMID:2409267. |
these results suggest that dopamine plays an important role in the changes mediated by the administration of methamphetamine in both the dopaminergic and serotonergic systems. |
1985-08-09 |
2023-08-11 |
rat |
| I Divac, W Lichtensteiger, A Gad. Catecholamine microfluorometry of nigral perikarya and tyrosine hydroxylase assay in some telencephalic structures of rats exposed to different behavioral situations. Acta neurobiologiae experimentalis. vol 44. issue 6. 1985-08-09. PMID:6152597. |
these results-in turn (1) demonstrate an unexpectedly strong dopamine concentration in the nigral neurons which innervate the prefrontal target of the neostriatum; (2) support the evidence of a strong dopaminergic innervation of the prefrontal cortex; and (3) indicate that the dopaminergic transmission in the prefrontal system was not affected by presumed activation of the system to a degree detectable by the presently used methods. |
1985-08-09 |
2023-08-12 |
rat |
| C Verney, M Baulac, B Berger, C Alvarez, A Vigny, K B Hell. Morphological evidence for a dopaminergic terminal field in the hippocampal formation of young and adult rat. Neuroscience. vol 14. issue 4. 1985-07-23. PMID:2860616. |
we have visualized the dopaminergic innervation of the hippocampal formation of the rat using two morphological methods: (1) tyrosine hydroxylase immunocytochemistry on noradrenaline-depleted animals and (2) fluorescence histochemistry after the uptake and storage of dopamine on hippocampal slices in vitro. |
1985-07-23 |
2023-08-11 |
rat |
| J S Hong, K Yoshikawa, T Kanamatsu, S L Sabo. Modulation of striatal enkephalinergic neurons by antipsychotic drugs. Federation proceedings. vol 44. issue 9. 1985-07-17. PMID:3838946. |
several lines of evidence, which showed that striatal levels of [met5]enkephalin (me) increase after the nigrostriatal dopaminergic pathway was interrupted by hemitransection or direct administration of 6-hydroxydopamine to the substantia nigra, or after repeated injections of either reserpine or haloperidol, suggest that dopamine (da) plays an important role in regulating the metabolism of me-containing neurons in the striatum. |
1985-07-17 |
2023-08-11 |
rat |
| C Missale, L Castelletti, S Govoni, P F Spano, M Trabucchi, I Hanbaue. Dopamine uptake is differentially regulated in rat striatum and nucleus accumbens. Journal of neurochemistry. vol 45. issue 1. 1985-07-17. PMID:3998732. |
in rat striatum dopamine uptake is related to a receptor that is specifically labelled by [3h]cocaine in the presence of na+ and is located on dopaminergic terminals. |
1985-07-17 |
2023-08-11 |
rat |
| E M Stricker, M J Zigmon. Brain catecholamines and the central control of food intake. International journal of obesity. vol 8 Suppl 1. 1985-07-08. PMID:6398807. |
studies in which dopaminergic activity was monitored in striatum indicate that dopamine release is markedly, though briefly, elevated in response to a variety of intense environmental stimuli, including cold and tail shock. |
1985-07-08 |
2023-08-12 |
Not clear |
| I Divac, J Mogensen, A Björklun. The prefrontal 'cortex' in the pigeon. Biochemical evidence. Brain research. vol 332. issue 2. 1985-06-25. PMID:3995275. |
a significant variation was found of the dopamine-noradrenaline ratio (da:na), a measure which makes it possible to distinguish dopamine found in dopaminergic fibers from dopamine which is precursor of noradrenaline. |
1985-06-25 |
2023-08-11 |
pigeon |
| A L Gundlach, M J Christie, P M Bear. Activation of accumbal and striatal dopamine autoreceptors by some ergoline derivatives. Research communications in chemical pathology and pharmacology. vol 48. issue 1. 1985-06-20. PMID:3992029. |
all ergolines and apomorphine reduced the increase in dopamine synthesis associated with the gamma-butyrolactone-induced blockade of impulse flow in central dopaminergic neurones. |
1985-06-20 |
2023-08-11 |
Not clear |
| J S Hutchinson, J S Mo. Neuropeptide abnormalities suggest a dopaminergic basis for high blood pressure in the spontaneously hypertensive rat. Clinical and experimental hypertension. Part A, Theory and practice. vol 6. issue 10-11. 1985-06-20. PMID:6099777. |
as the secretion of these peptides is under dopaminergic control and the abnormalities consistently suggest under-activity of the dopaminergic control system in the brain, injections of dopamine (0.4 mg/kg) were given i.c.v. |
1985-06-20 |
2023-08-12 |
rat |
| L J Gooren, W Harmsen-Louman, H van Kesse. Follow-up of prolactin levels in long-term oestrogen-treated male-to-female transsexuals with regard to prolactinoma induction. Clinical endocrinology. vol 22. issue 2. 1985-06-19. PMID:3157511. |
however, administration of monoiodotyrosine, an inhibitor of central dopamine synthesis, to these two groups, induced a significantly smaller release of prl (expressed as percentage change) in subjects with prl greater than 1000 mu/l than in those with prl less than 500 mu/1 possibly indicating a loss of control of central dopaminergic regulation. |
1985-06-19 |
2023-08-11 |
human |
| D Grigoriadis, P Seema. Complete conversion of brain D2 dopamine receptors from the high- to the low-affinity state for dopamine agonists, using sodium ions and guanine nucleotide. Journal of neurochemistry. vol 44. issue 6. 1985-06-18. PMID:3157782. |
in the presence of 50 microm s-sulpiride (to occlude the dopaminergic sites), therefore, we first determined that the residual binding of [3h]spiperone (approximately 20%) was inhibited by serotonergic agonists much more effectively than dopamine or noradrenaline, thus identifying the serotonergic component of [3h]spiperone binding. |
1985-06-18 |
2023-08-11 |
rat |
| F G Gonon, M J Bud. Regulation of dopamine release by impulse flow and by autoreceptors as studied by in vivo voltammetry in the rat striatum. Neuroscience. vol 14. issue 3. 1985-06-14. PMID:2986044. |
interruption of the dopaminergic impulse flow either by an electrolytic lesion or by a low dose of apomorphine (0.05 mg/kg) caused an immediate decrease of the dopamine current. |
1985-06-14 |
2023-08-11 |
rat |
| F G Gonon, M J Bud. Regulation of dopamine release by impulse flow and by autoreceptors as studied by in vivo voltammetry in the rat striatum. Neuroscience. vol 14. issue 3. 1985-06-14. PMID:2986044. |
administration of dopaminergic antagonists such as haloperidol (0.05 and 0.5 mg/kg) or metoclopramide (2 mg/kg) significantly increased the dopamine current up to 317, 340 and 215% of the respective control values. |
1985-06-14 |
2023-08-11 |
rat |
| F G Gonon, M J Bud. Regulation of dopamine release by impulse flow and by autoreceptors as studied by in vivo voltammetry in the rat striatum. Neuroscience. vol 14. issue 3. 1985-06-14. PMID:2986044. |
the study by in vivo voltammetry of the variations in the striatal extracellular dopamine concentrations shows that the release of dopamine is under the influence of both the frequency of impulse flow and of dopaminergic striatal autoreceptors. |
1985-06-14 |
2023-08-11 |
rat |
| B S Huang, R L Malvin, R J Greki. Central effects of angiotensin II and dopamine in sodium-depleted sheep. The American journal of physiology. vol 248. issue 5 Pt 2. 1985-06-14. PMID:3887949. |
the similarity of the responses to sq and dopamine suggests that a dopaminergic pathway may be involved in these responses. |
1985-06-14 |
2023-08-11 |
Not clear |