| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Akane Hayashi, Naoya Matsunaga, Hiroyuki Okazaki, Keisuke Kakimoto, Yoshinori Kimura, Hiroki Azuma, Eriko Ikeda, Takeshi Shiba, Mayumi Yamato, Ken-Ichi Yamada, Satoru Koyanagi, Shigehiro Ohd. A disruption mechanism of the molecular clock in a MPTP mouse model of Parkinson's disease. Neuromolecular medicine. vol 15. issue 2. 2014-01-03. PMID:23292542. |
parkinson's disease (pd) is a common neurodegenerative disorder that is characterized by the degeneration of dopaminergic neurons in the substantia nigra and dopamine depletion in the striatum. |
2014-01-03 |
2023-08-12 |
mouse |
| Hideaki Matsui, Roberto Gavinio, Takeshi Asano, Norihito Uemura, Hidefumi Ito, Yoshihito Taniguchi, Yoshito Kobayashi, Takakuni Maki, Jie Shen, Shunichi Takeda, Kengo Uemura, Hodaka Yamakado, Ryosuke Takahash. PINK1 and Parkin complementarily protect dopaminergic neurons in vertebrates. Human molecular genetics. vol 22. issue 12. 2013-12-31. PMID:23449626. |
we found that despite the lack of a conspicuous phenotype in single mutants for pink1 or parkin, medaka that are deficient in both genes developed phenotypes similar to that of human pd: late-onset locomotor dysfunction, a decrease in dopamine levels and a selective degeneration of dopaminergic neurons. |
2013-12-31 |
2023-08-12 |
human |
| Oliver D Howes, Matthew Williams, Kemal Ibrahim, Garret Leung, Alice Egerton, Philip K McGuire, Federico Turkheime. Midbrain dopamine function in schizophrenia and depression: a post-mortem and positron emission tomographic imaging study. Brain : a journal of neurology. vol 136. issue Pt 11. 2013-12-31. PMID:24097339. |
however, it is not known if the dopaminergic dysfunction is limited to the striatal terminals of dopamine neurons, or is also evident in the dopamine neuron cell bodies, which mostly originate in the substantia nigra. |
2013-12-31 |
2023-08-12 |
human |
| Luke R Gabriel, Sijia Wu, Patrick Kearney, Karl D Bellvé, Clive Standley, Kevin E Fogarty, Haley E Melikia. Dopamine transporter endocytic trafficking in striatal dopaminergic neurons: differential dependence on dynamin and the actin cytoskeleton. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 45. 2013-12-30. PMID:24198373. |
dopamine transporter endocytic trafficking in striatal dopaminergic neurons: differential dependence on dynamin and the actin cytoskeleton. |
2013-12-30 |
2023-08-12 |
mouse |
| Luke R Gabriel, Sijia Wu, Patrick Kearney, Karl D Bellvé, Clive Standley, Kevin E Fogarty, Haley E Melikia. Dopamine transporter endocytic trafficking in striatal dopaminergic neurons: differential dependence on dynamin and the actin cytoskeleton. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 45. 2013-12-30. PMID:24198373. |
the presynaptic dopamine (da) transporter (dat) recaptures released da, thereby limiting synaptic da availability and maintaining dopaminergic tone. |
2013-12-30 |
2023-08-12 |
mouse |
| Fany Messanvi, Ellie Eggens-Meijer, Benno Roozendaal, Johannes J van der Wan. A discrete dopaminergic projection from the incertohypothalamic A13 cell group to the dorsolateral periaqueductal gray in rat. Frontiers in neuroanatomy. vol 7. 2013-12-24. PMID:24367297. |
although the dlpag is known to receive a specific innervation of dopaminergic fibers and abundantly expresses dopamine receptors, the origin of this dopaminergic input is largely unknown. |
2013-12-24 |
2023-08-12 |
rat |
| Fany Messanvi, Ellie Eggens-Meijer, Benno Roozendaal, Johannes J van der Wan. A discrete dopaminergic projection from the incertohypothalamic A13 cell group to the dorsolateral periaqueductal gray in rat. Frontiers in neuroanatomy. vol 7. 2013-12-24. PMID:24367297. |
therefore, although direct behavioral evidence is lacking, our finding that the a13 cell group is also the main source of dopaminergic input to the dlpag suggests that dopamine might contribute to the regulation of dlpag-mediated defensive behaviors. |
2013-12-24 |
2023-08-12 |
rat |
| Judith P Golden, Joseph A Demaro, Amanda Knoten, Masato Hoshi, Elizabeth Pehek, Eugene M Johnson, Robert W Gereau, Sanjay Jai. Dopamine-dependent compensation maintains motor behavior in mice with developmental ablation of dopaminergic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 43. 2013-12-23. PMID:24155314. |
the loss of dopaminergic neurons in the substantia nigra pars compacta (snc) and consequent depletion of striatal dopamine are known to underlie the motor deficits observed in parkinson's disease (pd). |
2013-12-23 |
2023-08-12 |
mouse |
| Judith P Golden, Joseph A Demaro, Amanda Knoten, Masato Hoshi, Elizabeth Pehek, Eugene M Johnson, Robert W Gereau, Sanjay Jai. Dopamine-dependent compensation maintains motor behavior in mice with developmental ablation of dopaminergic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 43. 2013-12-23. PMID:24155314. |
adaptive changes in dopaminergic terminals and in postsynaptic striatal neurons can compensate for significant losses of striatal dopamine, resulting in preservation of motor behavior. |
2013-12-23 |
2023-08-12 |
mouse |
| Judith P Golden, Joseph A Demaro, Amanda Knoten, Masato Hoshi, Elizabeth Pehek, Eugene M Johnson, Robert W Gereau, Sanjay Jai. Dopamine-dependent compensation maintains motor behavior in mice with developmental ablation of dopaminergic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 43. 2013-12-23. PMID:24155314. |
we find that loss of 90% of snc dopaminergic neurons and consequent depletion of >95% of striatal dopamine does not result in changes in motor behavior in young-adult or aged mice as evaluated by an extensive array of motor behavior tests. |
2013-12-23 |
2023-08-12 |
mouse |
| Judith P Golden, Joseph A Demaro, Amanda Knoten, Masato Hoshi, Elizabeth Pehek, Eugene M Johnson, Robert W Gereau, Sanjay Jai. Dopamine-dependent compensation maintains motor behavior in mice with developmental ablation of dopaminergic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 43. 2013-12-23. PMID:24155314. |
our results indicate that congenital loss of dopaminergic neurons induces remarkable adaptions in the nigrostriatal system where limited amounts of dopamine in the dorsal striatum can maintain normal motor function. |
2013-12-23 |
2023-08-12 |
mouse |
| Roberto Coccurello, Alberto Oliverio, Andrea Mel. Impairing effect of amphetamine and concomitant ionotropic glutamate receptors blockade in the ventral striatum on spatial learning in mice. Psychopharmacology. vol 227. issue 4. 2013-12-18. PMID:23380916. |
the multiple cortical glutamatergic and mesolimbic dopaminergic (daergic) afferences on the same neurons in the ventral striatum provide the neuroanatomical substrate for glutamate and dopamine functional interaction. |
2013-12-18 |
2023-08-12 |
mouse |
| Mathew H Gendle, Erica L Young, Alexandra C Roman. Effects of oral 5-hydroxytryptophan on a standardized planning task: insight into possible dopamine/serotonin interactions in the forebrain. Human psychopharmacology. vol 28. issue 3. 2013-12-18. PMID:23609610. |
several studies have suggested that exogenous administration of the serotonin precursor 5-hydroxytryptophan (5-htp) can result in the ectopic production of serotonin in dopaminergic neurons and a concomitant reduction in dopamine release. |
2013-12-18 |
2023-08-12 |
Not clear |
| Kentaro Hanami, Kazuhisa Nakano, Yoshiya Tanak. [Dopamine receptor signaling regulates human osteoclastogenesis]. Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology. vol 36. issue 1. 2013-12-17. PMID:23445730. |
dopamine released by dcs bounded to d1-like dopamine receptors on t cells and induced activation of camp and differentiation to th17 cells via il-6 production we here overview the interplay among the immune system, bone metabolism and neurologic system shedding light upon dopaminergic signals upon osteoclastogenesis. |
2013-12-17 |
2023-08-12 |
human |
| Fabienne Sprenger, Werner Poew. Management of motor and non-motor symptoms in Parkinson's disease. CNS drugs. vol 27. issue 4. 2013-12-17. PMID:23515972. |
levodopa still remains the gold standard for the treatment of motor symptoms of pd but dopamine agonists (das), catechol-o-methyltransferase (comt) inhibitors and monoamine oxidase b (mao-b) inhibitors have also been developed to provide more continuous oral delivery of dopaminergic stimulation in order to improve motor outcomes and decrease the risk of levodopa-induced motor complications. |
2013-12-17 |
2023-08-12 |
Not clear |
| Susumu Hara, Shigeki Arawaka, Hiroyasu Sato, Youhei Machiya, Can Cui, Asuka Sasaki, Shingo Koyama, Takeo Kat. Serine 129 phosphorylation of membrane-associated α-synuclein modulates dopamine transporter function in a G protein-coupled receptor kinase-dependent manner. Molecular biology of the cell. vol 24. issue 11. 2013-12-17. PMID:23576548. |
here we investigate the effects of ser-129 phosphorylation on dopamine (da) uptake in dopaminergic sh-sy5y cells expressing α-syn. |
2013-12-17 |
2023-08-12 |
Not clear |
| Chiara Bianca Maria Platania, Gian Marco Leggio, Filippo Drago, Salvatore Salomone, Claudio Bucol. Regulation of intraocular pressure in mice: structural analysis of dopaminergic and serotonergic systems in response to cabergoline. Biochemical pharmacology. vol 86. issue 9. 2013-12-17. PMID:23962442. |
to investigate the contribution of dopaminergic and serotonergic systems in iop regulation, we used cabergoline, a mixed dopamine and serotonin agonist, in c57bl/6j wt and dopamine d₃ receptor knock-out (d₃r⁻/⁻) mice with normal eye pressure or steroid-induced ocular hypertension. |
2013-12-17 |
2023-08-12 |
mouse |
| Bhavik Anil Patel, Collin C Luk, Pei Ling Leow, Arthur J Lee, Wali Zaidi, Naweed I Sye. A planar microelectrode array for simultaneous detection of electrically evoked dopamine release from distinct locations of a single isolated neuron. The Analyst. vol 138. issue 10. 2013-12-16. PMID:23462822. |
the mea was accessed using freshly isolated dopaminergic somas from the pond snail, lymnaea stagnalis, where electrically evoked dopamine release was clearly observed. |
2013-12-16 |
2023-08-12 |
Not clear |
| Daniel De Backer, Sabino Scollett. Clinical management of the cardiovascular failure in sepsis. Current vascular pharmacology. vol 11. issue 2. 2013-12-16. PMID:23506500. |
furthermore, dopamine stimulates dopaminergic receptors, resulting in doubtful effects on splanchnic and renal perfusion, but also in endocrine alterations. |
2013-12-16 |
2023-08-12 |
Not clear |
| Flavia di Michele, Sabina Luchetti, Giorgio Bernardi, Elena Romeo, Patrizia Longon. Neurosteroid and neurotransmitter alterations in Parkinson's disease. Frontiers in neuroendocrinology. vol 34. issue 2. 2013-12-16. PMID:23563222. |
parkinson's disease (pd) is associated with a massive loss of dopaminergic cells in the substantia nigra leading to dopamine hypofunction and alteration of the basal ganglia circuitry. |
2013-12-16 |
2023-08-12 |
human |