| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H T Chan. Substance P-dopamine relationship in the rat substantia nigra: a light and electron microscopy study of double immunocytochemically labeled materials. Brain research. vol 448. issue 2. 1988-07-22. PMID:2454145. |
since most of the substance p-containing axon terminals arise from the striatum, this result suggests that striatal substance p neurons can have monosynaptic influence on nigral dopaminergic neurons. |
1988-07-22 |
2023-08-11 |
rat |
| D J Clarke, S B Dunnett, O Isacson, D J Sirinathsinghji, A Björklun. Striatal grafts in rats with unilateral neostriatal lesions--I. Ultrastructural evidence of afferent synaptic inputs from the host nigrostriatal pathway. Neuroscience. vol 24. issue 3. 1988-07-18. PMID:2898109. |
tyrosine hydroxylase immunocytochemistry, in combination with golgi impregnation, has been used to study the dopaminergic afferent input to striatal suspension grafts implanted into the previously ibotenic acid-lesioned striatum in adult recipient rats. |
1988-07-18 |
2023-08-11 |
rat |
| D J Clarke, S B Dunnett, O Isacson, D J Sirinathsinghji, A Björklun. Striatal grafts in rats with unilateral neostriatal lesions--I. Ultrastructural evidence of afferent synaptic inputs from the host nigrostriatal pathway. Neuroscience. vol 24. issue 3. 1988-07-18. PMID:2898109. |
the results indicate that the medium-sized densely spiny neuron type (which is a predominant target for the dopaminergic afferents in the normal striatum) is abundant in the grafted tissue, and that these neurons represent a synaptic target also for the tyrosine hydroxylase-positive innervation of the striatal grafts. |
1988-07-18 |
2023-08-11 |
rat |
| D J Sirinathsinghji, S B Dunnett, O Isacson, D J Clarke, K Kendrick, A Björklun. Striatal grafts in rats with unilateral neostriatal lesions--II. In vivo monitoring of GABA release in globus pallidus and substantia nigra. Neuroscience. vol 24. issue 3. 1988-07-18. PMID:3380300. |
the results support the view that activation of the dopaminergic inputs to the striatum is functionally excitatory on the major striatal output projections to the globus pallidus and substantia nigra pars reticulata. |
1988-07-18 |
2023-08-11 |
rat |
| J Tedroff, S M Aquilonius, P Hartvig, H Lundqvist, A G Gee, J Uhlin, B Långströ. Monoamine re-uptake sites in the human brain evaluated in vivo by means of 11C-nomifensine and positron emission tomography: the effects of age and Parkinson's disease. Acta neurologica Scandinavica. vol 77. issue 3. 1988-06-27. PMID:3259784. |
the highest accumulation of radioactivity was found in areas rich in dopaminergic and noradrenergic innervation, such as the striatum and the thalamus. |
1988-06-27 |
2023-08-11 |
human |
| S Algeri, G Calderini, G Lomuscio, M Rocchetti, G Sacchetti, G Toffano, F Ponzi. Differential response to immobilization stress of striatal dopaminergic and hippocampal noradrenergic systems in aged rats. Neurobiology of aging. vol 9. issue 2. 1988-06-24. PMID:3131691. |
the rate of in vivo synthesis of the two catecholamines was determined in hippocampus (a prevalently noradrenergic area) and in striatum (a prevalently dopaminergic area) by measuring the accumulation of dopa for 60 min after decarboxylase inhibition. |
1988-06-24 |
2023-08-11 |
rat |
| S Nedergaard, J P Bolam, S A Greenfiel. Facilitation of a dendritic calcium conductance by 5-hydroxytryptamine in the substantia nigra. Nature. vol 333. issue 6169. 1988-06-13. PMID:2897080. |
within the substantia nigra, the dendrites of dopaminergic neurons that project to the striatum appear to play an active and nonclassical role in the physiology of the neuron in that they release transmitter and protein, but little is known of the factors controlling release of substances from these dendrites. |
1988-06-13 |
2023-08-11 |
Not clear |
| E Normand, T Popovici, B Onteniente, D Fellmann, D Piatier-Tonneau, C Auffray, B Bloc. Dopaminergic neurons of the substantia nigra modulate preproenkephalin A gene expression in rat striatal neurons. Brain research. vol 439. issue 1-2. 1988-06-08. PMID:3129123. |
the 6-hydroxydopamine lesion which destroyed all dopaminergic neurons in the right substantia nigra, provoked a large increase in the number of ppa mrna copies in enkephalin neurons of the right striatum, and decreased the number of cells expressing the ppa mrna in the left striatum. |
1988-06-08 |
2023-08-11 |
rat |
| R Stron. Regionally selective manifestations of neostriatal aging. Annals of the New York Academy of Sciences. vol 515. 1988-06-07. PMID:2966603. |
presynaptic and postsynaptic markers of the cholinergic and dopaminergic systems have characteristic topographical distributions within the striatum. |
1988-06-07 |
2023-08-11 |
Not clear |
| R Stron. Regionally selective manifestations of neostriatal aging. Annals of the New York Academy of Sciences. vol 515. 1988-06-07. PMID:2966603. |
aside from the dopaminergic afferents, several other afferent systems exhibit a heterogeneous distribution in the striatum. |
1988-06-07 |
2023-08-11 |
Not clear |
| M A Arian. Striatal D1 dopamine receptor distribution following chemical lesion of the nigrostriatal pathway. Brain research. vol 443. issue 1-2. 1988-05-31. PMID:2965958. |
the morphochemical and biochemical distribution of the adenylate cyclase-linked dopamine receptor, or d1 subpopulation, has been examined in the rat striatum following a chemical lesion of the dopaminergic nigrostriatal pathway. |
1988-05-31 |
2023-08-11 |
rat |
| J B Justice, L C Nicolaysen, A C Michae. Modeling the dopaminergic nerve terminal. Journal of neuroscience methods. vol 22. issue 3. 1988-05-31. PMID:3361950. |
computer simulation and simplex optimization are used to examine a model of the dopaminergic nerve terminal of the rat striatum. |
1988-05-31 |
2023-08-11 |
rat |
| C A Bourk. A novel nigrostriatal dopaminergic disorder in sheep affected by Tribulus terrestris staggers. Research in veterinary science. vol 43. issue 3. 1988-05-12. PMID:3444981. |
the findings of asymmetrical atrophy of pelvic limb extensor muscles, asymmetrical paresis of the limbs, a left:right dominance ratio of 50:50, spontaneous rotational behaviour, decreased response to levodopa loading, and decreased levels of da (19 per cent reduction) and dopac (30 per cent reduction) in the striatum of affected sheep, were interpreted as indicative of a primary nigrostriatal dopaminergic disorder. |
1988-05-12 |
2023-08-11 |
Not clear |
| E Melame. Brain grafting may reverse loss of responsiveness to levodopa therapy in Parkinson's disease. Clinical neuropharmacology. vol 11. issue 1. 1988-04-25. PMID:3280129. |
this may be due in part to near-total degeneration of the surviving nigrostriatal dopaminergic neurons during disease progression, with massive decreases in the capacity of the striatum to form and store dopamine from exogenous levodopa. |
1988-04-25 |
2023-08-11 |
Not clear |
| M Mogi, M Harada, K Kojima, K Kiuchi, T Nagats. Effects of systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine to mice on tyrosine hydroxylase, L-3,4-dihydroxyphenylalanine decarboxylase, dopamine beta-hydroxylase, and monoamine oxidase activities in the striatum and hypothalamus. Journal of neurochemistry. vol 50. issue 4. 1988-04-21. PMID:2894407. |
these data indicate that mptp administration to mice results in specific degeneration of the dopaminergic nigrostriatal pathway and that ddc in the mouse striatum may mainly be localized in the dopaminergic neurons with th. |
1988-04-21 |
2023-08-11 |
mouse |
| T Suzuki, K Takahashi, T Yoshii, M Misaw. [Changes in CNS catecholamine levels in tolerance to morphine-induced central excitation in mice]. Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology. vol 7. issue 3. 1988-04-19. PMID:3442131. |
it is suggested that dopaminergic neurons in striatum and cortex were hardly activated by morphine injection in maf-treated mice, which might lead to tolerance to morphine-induced ambulatory activation. |
1988-04-19 |
2023-08-11 |
mouse |
| J W Haycoc. Stimulation-dependent phosphorylation of tyrosine hydroxylase in rat corpus striatum. Brain research bulletin. vol 19. issue 6. 1988-04-15. PMID:2894236. |
thus, depolarization of dopaminergic terminals from the rat corpus striatum increased the phosphorylation of tyrosine hydroxylase, and the increase in phosphorylation appeared to occur at multiple sites. |
1988-04-15 |
2023-08-11 |
rat |
| H Criswell, R A Mueller, G R Brees. Assessment of purine-dopamine interactions in 6-hydroxydopamine-lesioned rats: evidence for pre- and postsynaptic influences by adenosine. The Journal of pharmacology and experimental therapeutics. vol 244. issue 2. 1988-04-12. PMID:3126293. |
even though dopamine levels were decreased by at least 92%, both neonatal- and adult-6-ohda-lesioned rats had normal hypoxanthine-guanine phosphoribosyltransferase function and purine nucleotide levels (adenosine, adp, atp and amp), indicating that hypoxanthine-guanine phosphoribosyltransferase is not localized only to dopaminergic neurons in striatum. |
1988-04-12 |
2023-08-11 |
rat |
| N Panagopoulos, N A Matsokis, T Valcan. Kinetic and pharmacologic characterization of dopamine binding in the mouse cerebellum and the effects of the reeler mutation. Journal of neuroscience research. vol 19. issue 1. 1988-03-25. PMID:3343704. |
from the analysis of (3h) dopamine ((3h)da) and (3h)spiperone ((3h)sp) binding, the study of the effects of several drugs on this binding, and the comparison of these parameters between the cerebellum and striatum, we conclude that a dopaminergic system exists in the cerebellum with properties common to the striatal system but also with some differences. |
1988-03-25 |
2023-08-11 |
mouse |
| J Knol. R-(-)-deprenyl (Selegiline, Movergan) facilitates the activity of the nigrostriatal dopaminergic neuron. Journal of neural transmission. Supplementum. vol 25. 1988-03-18. PMID:2828537. |
2) the (-)deprenyl-induced increase of the dopaminergic tone in the striatum was proved by measurements of the activity of the nigrostriatal dopaminergic neuron. |
1988-03-18 |
2023-08-11 |
rat |