| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Louise M Collins, Giorgia Dal Bo, Mariangela Calcagno, Jimena Monzón-Sandoval, Aideen M Sullivan, Humberto Gutierrez, Michele Morari, Gerard W O'Keeff. Nociceptin/Orphanin FQ Inhibits the Survival and Axon Growth of Midbrain Dopaminergic Neurons Through a p38-MAPK Dependent Mechanism. Molecular neurobiology. vol 53. issue 10. 2017-12-25. PMID:26687234. |
here, we show that n/ofq has a detrimental effect on the survival of dopaminergic neurons and the growth of their axons in primary cultures of the e14 rat ventral mesencephalon. |
2017-12-25 |
2023-08-13 |
rat |
| Louise M Collins, Giorgia Dal Bo, Mariangela Calcagno, Jimena Monzón-Sandoval, Aideen M Sullivan, Humberto Gutierrez, Michele Morari, Gerard W O'Keeff. Nociceptin/Orphanin FQ Inhibits the Survival and Axon Growth of Midbrain Dopaminergic Neurons Through a p38-MAPK Dependent Mechanism. Molecular neurobiology. vol 53. issue 10. 2017-12-25. PMID:26687234. |
these results demonstrate for the first time that n/ofq is detrimental to the survival and growth of dopaminergic neurons and that its expression is altered in the midbrain of patients with parkinson's disease. |
2017-12-25 |
2023-08-13 |
rat |
| Shane V Hegarty, Aideen M Sullivan, Gerard W O'Keeff. Endocytosis contributes to BMP2-induced Smad signalling and neuronal growth. Neuroscience letters. vol 643. 2017-12-19. PMID:28188849. |
bone morphogenetic protein 2 (bmp2) is a neurotrophic factor which induces the growth of midbrain dopaminergic (da) neurons in vitro and in vivo, and its neurotrophic effects have been shown to be dependent on activation of bmp receptors (bmprs) and smad 1/5/8 signalling. |
2017-12-19 |
2023-08-13 |
human |
| Shane V Hegarty, Aideen M Sullivan, Gerard W O'Keeff. Endocytosis contributes to BMP2-induced Smad signalling and neuronal growth. Neuroscience letters. vol 643. 2017-12-19. PMID:28188849. |
this study demonstrates that bmp2-induced smad signalling and neurite growth is regulated by dynamin-dependent endocytosis in a model of human midbrain dopaminergic neurons. |
2017-12-19 |
2023-08-13 |
human |
| Pablo Ripollés, Josep Marco-Pallarés, Helena Alicart, Claus Tempelmann, Antoni Rodríguez-Fornells, Toemme Noessel. Intrinsic monitoring of learning success facilitates memory encoding via the activation of the SN/VTA-Hippocampal loop. eLife. vol 5. 2017-12-11. PMID:27644419. |
here, participants who completed a task in which no external reward/feedback was provided, exhibited enhanced fmri-signals within the dopaminergic midbrain, hippocampus, and ventral striatum (the sn/vta-hippocampal loop) when successfully grasping the meaning of new-words. |
2017-12-11 |
2023-08-13 |
human |
| Pablo Ripollés, Josep Marco-Pallarés, Helena Alicart, Claus Tempelmann, Antoni Rodríguez-Fornells, Toemme Noessel. Intrinsic monitoring of learning success facilitates memory encoding via the activation of the SN/VTA-Hippocampal loop. eLife. vol 5. 2017-12-11. PMID:27644419. |
these results suggest that intrinsic-potentially reward-related-signals, triggered by self-monitoring of correct performance, can promote the storage of new information into long-term memory through the activation of the sn/vta-hippocampal loop, possibly via dopaminergic modulation of the midbrain. |
2017-12-11 |
2023-08-13 |
human |
| Changsun Yu, Bok-Seok Kim, Eunhee Ki. FAF1 mediates regulated necrosis through PARP1 activation upon oxidative stress leading to dopaminergic neurodegeneration. Cell death and differentiation. vol 23. issue 11. 2017-12-11. PMID:27662363. |
indeed, the overexpression of faf1 using a recombinant adeno-associated virus system in the mouse ventral midbrain promoted parp1 activation and dopaminergic neurodegeneration in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) mouse model of parkinson's disease. |
2017-12-11 |
2023-08-13 |
mouse |
| Chunhai Chen, Qinglong Ma, Ping Deng, Jianjing Yang, Lingling Yang, Min Lin, Zhengping Yu, Zhou Zho. Critical role of TRPC1 in thyroid hormone-dependent dopaminergic neuron development. Biochimica et biophysica acta. Molecular cell research. vol 1864. issue 10. 2017-12-06. PMID:28779972. |
thyroid hormones play a crucial role in midbrain dopaminergic (da) neuron development. |
2017-12-06 |
2023-08-13 |
Not clear |
| Ninuo Xia, Fang Fang, Pengbo Zhang, Jun Cui, Chhavy Tep-Cullison, Tim Hamerley, Hyun Joo Lee, Theo Palmer, Brian Bothner, Jin Hyung Lee, Renee Reijo Per. A Knockin Reporter Allows Purification and Characterization of mDA Neurons from Heterogeneous Populations. Cell reports. vol 18. issue 10. 2017-11-28. PMID:28273465. |
generation of midbrain dopaminergic (mda) neurons from human pluripotent stem cells provides a platform for inquiry into basic and translational studies of parkinson's disease (pd). |
2017-11-28 |
2023-08-13 |
human |
| Tim Kao, Tanya Labonne, Jonathan C Niclis, Ritu Chaurasia, Zerina Lokmic, Elizabeth Qian, Freya F Bruveris, Sara E Howden, Ali Motazedian, Jacqueline V Schiesser, Magdaline Costa, Koula Sourris, Elizabeth Ng, David Anderson, Antonietta Giudice, Peter Farlie, Michael Cheung, Shireen R Lamande, Anthony J Penington, Clare L Parish, Lachlan H Thomson, Arash Rafii, David A Elliott, Andrew G Elefanty, Edouard G Stanle. GAPTrap: A Simple Expression System for Pluripotent Stem Cells and Their Derivatives. Stem cell reports. vol 7. issue 3. 2017-11-21. PMID:27594589. |
differentiation experiments showed that reporter expression was reliably maintained in hematopoietic cells, cardiac mesoderm, definitive endoderm, and ventral midbrain dopaminergic neurons. |
2017-11-21 |
2023-08-13 |
human |
| Du Fang, Yu Qing, Shijun Yan, Doris Chen, Shirley ShiDu Ya. Development and Dynamic Regulation of Mitochondrial Network in Human Midbrain Dopaminergic Neurons Differentiated from iPSCs. Stem cell reports. vol 7. issue 4. 2017-11-21. PMID:27666790. |
development and dynamic regulation of mitochondrial network in human midbrain dopaminergic neurons differentiated from ipscs. |
2017-11-21 |
2023-08-13 |
human |
| Zhan-Ying Hu, Bo Chen, Jing-Pu Zhang, Yuan-Yuan M. Up-regulation of autophagy-related gene 5 ( The Journal of biological chemistry. vol 292. issue 44. 2017-11-21. PMID:28928221. |
up-regulation of autophagy-related gene 5 ( parkinson's disease (pd) is one of the most epidemic neurodegenerative diseases and is characterized by movement disorders arising from loss of midbrain dopaminergic (da) neurons. |
2017-11-21 |
2023-08-13 |
Not clear |
| Ima Trempler, Anne-Marike Schiffer, Nadiya El-Sourani, Christiane Ahlheim, Gereon R Fink, Ricarda I Schubot. Frontostriatal Contribution to the Interplay of Flexibility and Stability in Serial Prediction. Journal of cognitive neuroscience. vol 29. issue 2. 2017-11-20. PMID:27626228. |
finally, we observed that the dopaminergic midbrain modulates the transition between different cognitive states, thresholded by participants' individual performance history in response to temporal environmental demands. |
2017-11-20 |
2023-08-13 |
human |
| Sarah X Luo, Leah Timbang, Jae-Ick Kim, Yulei Shang, Kadellyn Sandoval, Amy A Tang, Jennifer L Whistler, Jun B Ding, Eric J Huan. TGF-β Signaling in Dopaminergic Neurons Regulates Dendritic Growth, Excitatory-Inhibitory Synaptic Balance, and Reversal Learning. Cell reports. vol 17. issue 12. 2017-11-20. PMID:28009292. |
neural circuits involving midbrain dopaminergic (da) neurons regulate reward and goal-directed behaviors. |
2017-11-20 |
2023-08-13 |
mouse |
| Francesco Rigoli, Benjamin Chew, Peter Dayan, Raymond J Dola. The Dopaminergic Midbrain Mediates an Effect of Average Reward on Pavlovian Vigor. Journal of cognitive neuroscience. vol 28. issue 9. 2017-11-17. PMID:27082045. |
the dopaminergic midbrain mediates an effect of average reward on pavlovian vigor. |
2017-11-17 |
2023-08-13 |
human |
| Francesco Rigoli, Benjamin Chew, Peter Dayan, Raymond J Dola. The Dopaminergic Midbrain Mediates an Effect of Average Reward on Pavlovian Vigor. Journal of cognitive neuroscience. vol 28. issue 9. 2017-11-17. PMID:27082045. |
greater average reward was associated with enhanced activity in dopaminergic midbrain to a degree that correlated with the relationship between average reward and pressing vigor. |
2017-11-17 |
2023-08-13 |
human |
| Francesco Rigoli, Benjamin Chew, Peter Dayan, Raymond J Dola. The Dopaminergic Midbrain Mediates an Effect of Average Reward on Pavlovian Vigor. Journal of cognitive neuroscience. vol 28. issue 9. 2017-11-17. PMID:27082045. |
these findings highlight a crucial role for dopaminergic midbrain in representing aspects of average reward and motivational vigor. |
2017-11-17 |
2023-08-13 |
human |
| Jaron T Colas, Wolfgang M Pauli, Tobias Larsen, J Michael Tyszka, John P O'Dohert. Distinct prediction errors in mesostriatal circuits of the human brain mediate learning about the values of both states and actions: evidence from high-resolution fMRI. PLoS computational biology. vol 13. issue 10. 2017-11-13. PMID:29049406. |
prediction-error signals consistent with formal models of "reinforcement learning" (rl) have repeatedly been found within dopaminergic nuclei of the midbrain and dopaminoceptive areas of the striatum. |
2017-11-13 |
2023-08-13 |
human |
| Jaron T Colas, Wolfgang M Pauli, Tobias Larsen, J Michael Tyszka, John P O'Dohert. Distinct prediction errors in mesostriatal circuits of the human brain mediate learning about the values of both states and actions: evidence from high-resolution fMRI. PLoS computational biology. vol 13. issue 10. 2017-11-13. PMID:29049406. |
to test for the presence of these prediction-error signals in the brain, we scanned human participants with a high-resolution functional magnetic-resonance imaging (fmri) protocol optimized to enable measurement of neural activity in the dopaminergic midbrain as well as the striatal areas to which it projects. |
2017-11-13 |
2023-08-13 |
human |
| Thomas G McWilliams, Laura Howard, Sean Wyatt, Alun M Davie. TNF superfamily member APRIL enhances midbrain dopaminergic axon growth and contributes to the nigrostriatal projection in vivo. Experimental neurology. vol 298. issue Pt A. 2017-11-06. PMID:28911883. |
tnf superfamily member april enhances midbrain dopaminergic axon growth and contributes to the nigrostriatal projection in vivo. |
2017-11-06 |
2023-08-13 |
mouse |