| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniel Dautan, Albert S Souza, Icnelia Huerta-Ocampo, Miguel Valencia, Maxime Assous, Ilana B Witten, Karl Deisseroth, James M Tepper, J Paul Bolam, Todor V Gerdjikov, Juan Mena-Segovi. Segregated cholinergic transmission modulates dopamine neurons integrated in distinct functional circuits. Nature neuroscience. vol 19. issue 8. 2017-08-18. PMID:27348215. |
dopamine neurons in the ventral tegmental area (vta) receive cholinergic innervation from brainstem structures that are associated with either movement or reward. |
2017-08-18 |
2023-08-13 |
Not clear |
| Daniel Dautan, Albert S Souza, Icnelia Huerta-Ocampo, Miguel Valencia, Maxime Assous, Ilana B Witten, Karl Deisseroth, James M Tepper, J Paul Bolam, Todor V Gerdjikov, Juan Mena-Segovi. Segregated cholinergic transmission modulates dopamine neurons integrated in distinct functional circuits. Nature neuroscience. vol 19. issue 8. 2017-08-18. PMID:27348215. |
we used optogenetics and in vivo juxtacellular recording and labeling to examine the influence of brainstem cholinergic innervation of distinct neuronal subpopulations in the vta. |
2017-08-18 |
2023-08-13 |
Not clear |
| John McDaid, Chandrika Abburi, Shannon L Wolfman, Keith Gallagher, Daniel S McGehe. Ethanol-Induced Motor Impairment Mediated by Inhibition of α7 Nicotinic Receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 29. 2017-07-11. PMID:27445152. |
the α7 nachr subtype is highly expressed in the laterodorsal tegmental nucleus (ldtg), a brainstem cholinergic center that contributes to motor performance through its projections to thalamic motor relay centers, including the mediodorsal thalamus. |
2017-07-11 |
2023-08-13 |
rat |
| Jonathan D Kenny, Jessica J Chemali, Joseph F Cotten, Christa J Van Dort, Seong-Eun Kim, Demba Ba, Norman E Taylor, Emery N Brown, Ken Sol. Physostigmine and Methylphenidate Induce Distinct Arousal States During Isoflurane General Anesthesia in Rats. Anesthesia and analgesia. vol 123. issue 5. 2017-06-29. PMID:26991753. |
cholinergic neurons in the brainstem and basal forebrain are also known to promote arousal. |
2017-06-29 |
2023-08-13 |
rat |
| Helena Janickova, Kaie Rosborough, Mohammed Al-Onaizi, Ornela Kljakic, Monica S Guzman, Robert Gros, Marco A M Prado, Vania F Prad. Deletion of the vesicular acetylcholine transporter from pedunculopontine/laterodorsal tegmental neurons modifies gait. Journal of neurochemistry. vol 140. issue 5. 2017-06-23. PMID:27889925. |
postural instability and gait disturbances, common disabilities in the elderly and frequently present in parkinson's disease (pd), have been suggested to be related to dysfunctional cholinergic signaling in the brainstem. |
2017-06-23 |
2023-08-13 |
mouse |
| Santiago Perez-Lloret, María Cecilia Peralta, Francisco J Barrante. Pharmacotherapies for Parkinson's disease symptoms related to cholinergic degeneration. Expert opinion on pharmacotherapy. vol 17. issue 18. 2017-02-13. PMID:27785919. |
stimulation of the pedunculo-pontine tegmental nuclei (which provide cholinergic innervation to the brain stem and subcortical nuclei) has also been used with some success for the treatment of gait dysfunction. |
2017-02-13 |
2023-08-13 |
Not clear |
| Lara Eid, André Parent, Martin Paren. Asynaptic feature and heterogeneous distribution of the cholinergic innervation of the globus pallidus in primates. Brain structure & function. vol 221. issue 2. 2016-12-14. PMID:25523104. |
the internal (gpi) and external (gpe) segments of the primate globus pallidus receive a significant cholinergic (ach) innervation from the brainstem pedunculopontine tegmental nucleus. |
2016-12-14 |
2023-08-13 |
squirrel_monkey |
| Maxime Veleanu, Tina E Axen, Morten P Kristensen, Kristi A Kohlmeie. Comparison of bNOS and chat immunohistochemistry in the laterodorsal tegmentum (LDT) and the pedunculopontine tegmentum (PPT) of the mouse from brain slices prepared for electrophysiology. Journal of neuroscience methods. vol 263. 2016-12-14. PMID:26820905. |
in such studies, antibody labeling against neuronal nitric oxide synthase (bnos) has been used to identify cholinergic neurons of the laterodorsal tegmental nucleus (ldt) and the pedunculopontine tegmental nuclei (ppt), two brainstem nuclei importantly involved in arousal. |
2016-12-14 |
2023-08-13 |
mouse |
| Kun-Ming Ni, Xiao-Jun Hou, Ci-Hang Yang, Ping Dong, Yue Li, Ying Zhang, Ping Jiang, Darwin K Berg, Shumin Duan, Xiao-Ming L. Selectively driving cholinergic fibers optically in the thalamic reticular nucleus promotes sleep. eLife. vol 5. 2016-10-26. PMID:26880556. |
cholinergic projections from the basal forebrain and brainstem are thought to play important roles in rapid eye movement (rem) sleep and arousal. |
2016-10-26 |
2023-08-13 |
mouse |
| Stefan Reuss, Christina Closhen, Randolf Riemann, Mirko Jaumann, Marlies Knipper, Lukas Rüttiger, Stephan Wolper. Absence of Early Neuronal Death in the Olivocochlear System Following Acoustic Overstimulation. Anatomical record (Hoboken, N.J. : 2007). vol 299. issue 1. 2016-10-11. PMID:26452751. |
the incubation of a second set of sections with antibodies against choline-acetyltransferase (the enzyme responsible for acetylcholine synthesis) showed the cholinergic neurons of the brainstem, however, without suggesting differences between groups. |
2016-10-11 |
2023-08-13 |
rat |
| Patrick P Gao, Jevin W Zhang, Shu-Juan Fan, Dan H Sanes, Ed X W. Auditory midbrain processing is differentially modulated by auditory and visual cortices: An auditory fMRI study. NeuroImage. vol 123. 2016-08-11. PMID:26306991. |
in the central auditory system, the auditory cortex contains direct and indirect pathways (via brainstem cholinergic cells) to nuclei of the auditory midbrain, called the inferior colliculus (ic). |
2016-08-11 |
2023-08-13 |
rat |
| Elizabeth A Stubblefield, John A Thompson, Gidon Felse. Optogenetic cholinergic modulation of the mouse superior colliculus in vivo. Journal of neurophysiology. vol 114. issue 2. 2016-04-25. PMID:26019317. |
many species exhibit a robust brain stem cholinergic projection to the intermediate and deep layers of the sc arising mainly from the pedunculopontine tegmental nucleus (pptg), which may serve to modulate sc function. |
2016-04-25 |
2023-08-13 |
mouse |
| Elizabeth A Stubblefield, John A Thompson, Gidon Felse. Optogenetic cholinergic modulation of the mouse superior colliculus in vivo. Journal of neurophysiology. vol 114. issue 2. 2016-04-25. PMID:26019317. |
here we used anatomical and optogenetic techniques to identify and selectively activate brain stem cholinergic terminals entering the intermediate and deep layers of the awake mouse sc and recorded sc neuronal responses. |
2016-04-25 |
2023-08-13 |
mouse |
| Moran Furman, Qiong Zhan, Cian McCafferty, Benjamin A Lerner, Joshua E Motelow, Jin Meng, Chanthia Ma, Gordon F Buchanan, Ilana B Witten, Karl Deisseroth, Jessica A Cardin, Hal Blumenfel. Optogenetic stimulation of cholinergic brainstem neurons during focal limbic seizures: Effects on cortical physiology. Epilepsia. vol 56. issue 12. 2016-04-08. PMID:26530287. |
optogenetic stimulation of cholinergic brainstem neurons during focal limbic seizures: effects on cortical physiology. |
2016-04-08 |
2023-08-13 |
rat |
| Moran Furman, Qiong Zhan, Cian McCafferty, Benjamin A Lerner, Joshua E Motelow, Jin Meng, Chanthia Ma, Gordon F Buchanan, Ilana B Witten, Karl Deisseroth, Jessica A Cardin, Hal Blumenfel. Optogenetic stimulation of cholinergic brainstem neurons during focal limbic seizures: Effects on cortical physiology. Epilepsia. vol 56. issue 12. 2016-04-08. PMID:26530287. |
here we used an optogenetic approach to selectively stimulate cholinergic brainstem neurons in the pedunculopontine tegmental nucleus during focal limbic seizures induced in a lightly anesthetized rat model. |
2016-04-08 |
2023-08-13 |
rat |
| Anna Maria Lavezzi, Achille Cappiello, Teresa Pusiol, Melissa Felicita Corna, Veronica Termopoli, Luigi Matturr. Pesticide exposure during pregnancy, like nicotine, affects the brainstem α7 nicotinic acetylcholine receptor expression, increasing the risk of sudden unexplained perinatal death. Journal of the neurological sciences. vol 348. issue 1-2. 2016-04-04. PMID:25433450. |
this study indicates the impact of nicotine and pesticides (organochlorine and organophosphate insecticides used in agriculture) on neuronal α7-nicotinic acetylcholine receptor expression in brainstem regions receiving cholinergic projections in human perinatal life. |
2016-04-04 |
2023-08-13 |
human |
| Luiz O S Leiria, Fernanda M Arantes-Costa, Marina C Calixto, Eduardo C Alexandre, Rodrigo F Moura, Franco Folli, Carla M Prado, Marco Antonio Prado, Vania F Prado, Licio A Velloso, José Donato, Edson Antunes, Milton A Martins, Mario J A Saa. Increased airway reactivity and hyperinsulinemia in obese mice are linked by ERK signaling in brain stem cholinergic neurons. Cell reports. vol 11. issue 6. 2016-02-16. PMID:25937275. |
increased airway reactivity and hyperinsulinemia in obese mice are linked by erk signaling in brain stem cholinergic neurons. |
2016-02-16 |
2023-08-13 |
mouse |
| Daniel Dautan, Husniye Hacioğlu Bay, J Paul Bolam, Todor V Gerdjikov, Juan Mena-Segovi. Extrinsic Sources of Cholinergic Innervation of the Striatal Complex: A Whole-Brain Mapping Analysis. Frontiers in neuroanatomy. vol 10. 2016-02-02. PMID:26834571. |
systematic mapping of the projections of all cholinergic structures in the brain (ch1 to ch8) by means of conditional tracing of cholinergic axons, revealed that the only extrinsic source of cholinergic innervation arises in the brainstem pedunculopontine and laterodorsal tegmental nuclei. |
2016-02-02 |
2023-08-13 |
Not clear |
| Aaron Kucinski, Martin Sarte. Modeling Parkinson's disease falls associated with brainstem cholinergic systems decline. Behavioral neuroscience. vol 129. issue 2. 2015-12-04. PMID:25798629. |
modeling parkinson's disease falls associated with brainstem cholinergic systems decline. |
2015-12-04 |
2023-08-13 |
rat |
| Aaron Kucinski, Martin Sarte. Modeling Parkinson's disease falls associated with brainstem cholinergic systems decline. Behavioral neuroscience. vol 129. issue 2. 2015-12-04. PMID:25798629. |
because evidence suggests that degeneration of brainstem cholinergic neurons arising from the pedunculopontine nucleus (ppn) also contributes to impaired gait and falls, here we assessed the effects of selective cholinergic ppn lesions in combination with striatal da loss or bf cholinergic cells loss as well as losses in all 3 regions. |
2015-12-04 |
2023-08-13 |
rat |