| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C B Ware, M C Horowitz, B R Renshaw, J S Hunt, D Liggitt, S A Koblar, B C Gliniak, H J McKenna, T Papayannopoulou, B Thom. Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death. Development (Cambridge, England). vol 121. issue 5. 1995-07-27. PMID:7789261. |
astrocyte numbers are reduced in the spinal cord and brain stem. |
1995-07-27 |
2023-08-12 |
Not clear |
| M Farooque, T Badonic, Y Olsson, A Holt. Astrocytic reaction after graded spinal cord compression in rats: immunohistochemical studies on glial fibrillary acidic protein and vimentin. Journal of neurotrauma. vol 12. issue 1. 1995-07-17. PMID:7540218. |
this investigation shows that within 24 h after compression of the spinal cord a widespread astrocyte reaction occurs. |
1995-07-17 |
2023-08-12 |
rat |
| M Farooque, T Badonic, Y Olsson, A Holt. Astrocytic reaction after graded spinal cord compression in rats: immunohistochemical studies on glial fibrillary acidic protein and vimentin. Journal of neurotrauma. vol 12. issue 1. 1995-07-17. PMID:7540218. |
even a mild compression that does not produce any signs of motor dysfunction can induce widespread astrocyte alterations in the spinal cord. |
1995-07-17 |
2023-08-12 |
rat |
| C A Pappas, N Ullrich, H Sontheime. Reduction of glial proliferation by K+ channel blockers is mediated by changes in pHi. Neuroreport. vol 6. issue 1. 1995-05-09. PMID:7703413. |
astrocyte proliferation was studied in primary cultures of rat spinal cord by [3h]thymidine uptake and was significantly reduced by culturing cells for 24 h in the presence of agents known to block astrocytic k+ channels: cs+, ba2+, 4-ap and tetraethylammonium (tea). |
1995-05-09 |
2023-08-12 |
rat |
| M F O'Brien, L G Lenke, J Lou, K H Bridwell, M E Joyc. Astrocyte response and transforming growth factor-beta localization in acute spinal cord injury. Spine. vol 19. issue 20. 1995-03-09. PMID:7846578. |
astrocyte response and transforming growth factor-beta localization in acute spinal cord injury. |
1995-03-09 |
2023-08-12 |
rat |
| D Hantaz-Ambroise, B Blondet, M Murawsky, F Riege. Abnormal astrocyte differentiation and defective cellular interactions in wobbler mouse spinal cord. Journal of neurocytology. vol 23. issue 3. 1994-07-19. PMID:8006678. |
abnormal astrocyte differentiation and defective cellular interactions in wobbler mouse spinal cord. |
1994-07-19 |
2023-08-12 |
mouse |
| D Hantaz-Ambroise, B Blondet, M Murawsky, F Riege. Abnormal astrocyte differentiation and defective cellular interactions in wobbler mouse spinal cord. Journal of neurocytology. vol 23. issue 3. 1994-07-19. PMID:8006678. |
the wobbler astrocyte processes are oriented perpendicular to the surface of the spinal cord, which contrasts with the normal parallel, concentric orientation. |
1994-07-19 |
2023-08-12 |
mouse |
| S R Whittemore, J T Neary, N Kleitman, H R Sanon, A Benigno, R P Donahue, M D Norenber. Isolation and characterization of conditionally immortalized astrocyte cell lines derived from adult human spinal cord. Glia. vol 10. issue 3. 1994-06-30. PMID:8194863. |
isolation and characterization of conditionally immortalized astrocyte cell lines derived from adult human spinal cord. |
1994-06-30 |
2023-08-12 |
human |
| H Sontheimer, E Fernandez-Marques, N Ullrich, C A Pappas, S G Waxma. Astrocyte Na+ channels are required for maintenance of Na+/K(+)-ATPase activity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 5 Pt 1. 1994-06-14. PMID:8182422. |
in order to study the function of na+ channels in glial cells, we carried out ion flux measurements, patch-clamp recordings, and ratiometric imaging of [na+]i during blockade of na+ channels on rat spinal cord astrocytes cultured for 7-10 d. acute blockade of astrocyte na+ channels by ttx had multiple effects: (1) ttx reduced, in a dose-dependent manner, na+/k(+)-atpase activity measured as unidirectional influx of 86rb+; (2) ttx depolarized astrocyte membrane potential at a rate of approximately 1 mv/min; (3) ttx (100 microm) reduced [na+]i; and (4) prolonged exposure to micromolar ttx induced astrocyte death. |
1994-06-14 |
2023-08-12 |
rat |
| K Rosewater, H Sontheime. Fibrous and protoplasmic astrocytes express GABAA receptors that differ in benzodiazepine pharmacology. Brain research. vol 636. issue 1. 1994-05-18. PMID:8156413. |
in contrast to these effects that were similar in both astrocytes types and similar to spinal cord neurons, the response to the convulsant methyl-4-ethyl-6,7-dimethoxy-beta-carboline-3-carboxylate (dmcm), which is an inverse benzodiazepine agonist differs between astrocyte subtypes. |
1994-05-18 |
2023-08-12 |
Not clear |
| J Fok-Seang, R H Mille. Distribution and differentiation of A2B5+ glial precursors in the developing rat spinal cord. Journal of neuroscience research. vol 37. issue 2. 1994-05-11. PMID:8151730. |
in the rat spinal cord, during early embryonic development the capacity for oligodendrogenesis appears to be restricted to ventral regions of the spinal cord, while cultures of postnatal rat spinal cord contain a distinct population of a2b5+ astrocyte precursors. |
1994-05-11 |
2023-08-12 |
rat |
| J Fok-Seang, R H Mille. Distribution and differentiation of A2B5+ glial precursors in the developing rat spinal cord. Journal of neuroscience research. vol 37. issue 2. 1994-05-11. PMID:8151730. |
in the presence of high serum, spinal cord a2b5+ cells fail to develop in isolated e14 dorsal spinal cord cultures, while in ventral cultures they subsequently differentiate into a2b5+ astrocytes suggesting that a2b5+ astrocyte precursors are also initially ventrally located. |
1994-05-11 |
2023-08-12 |
rat |
| J Fok-Seang, R H Mille. Distribution and differentiation of A2B5+ glial precursors in the developing rat spinal cord. Journal of neuroscience research. vol 37. issue 2. 1994-05-11. PMID:8151730. |
these observations suggest that local influences may regulate the timing of spinal cord a2b5+ astrocyte development, but not spinal cord oligodendrocyte development. |
1994-05-11 |
2023-08-12 |
rat |
| J Ekblom, S M Aquilonius, S S Jossa. Differential increases in catecholamine metabolizing enzymes in amyotrophic lateral sclerosis. Experimental neurology. vol 123. issue 2. 1993-11-22. PMID:8405291. |
these results suggest that the two enzyme proteins are regulated by more complex mechanisms in the spinal cord in amyotrophic lateral sclerosis than simple general increases caused by elevated astroglial cell numbers. |
1993-11-22 |
2023-08-12 |
human |
| R Kaiser, C H Lückin. GFAP-specific oligoclonal bands in the CSF of a patient with acute myelitis. Acta neurologica Scandinavica. vol 88. issue 2. 1993-11-17. PMID:8213065. |
immune reactions to this astrocyte protein are considered as arising secondary to spinal cord tissue lesion. |
1993-11-17 |
2023-08-12 |
Not clear |
| J A Black, H Sontheimer, S G Waxma. Spinal cord astrocytes in vitro: phenotypic diversity and sodium channel immunoreactivity. Glia. vol 7. issue 4. 1993-08-03. PMID:8391514. |
except for types 1b and 1e, a2b5 staining was present on all astrocyte morphologies at some time in culture, and was generally attenuated with longer times in vitro; in contrast to cultures derived from neonatal rat optic nerve, a2b5 staining does not distinguish unequivocally between the various classes of morphologically different astrocytes derived from spinal cord. |
1993-08-03 |
2023-08-12 |
rat |
| J A Black, H Sontheimer, S G Waxma. Spinal cord astrocytes in vitro: phenotypic diversity and sodium channel immunoreactivity. Glia. vol 7. issue 4. 1993-08-03. PMID:8391514. |
moreover, while spinal cord astrocytes express sodium channels, these astrocytes exhibit a time-course of channel expression that is different from astrocytes derived from several other cns regions where sodium channel staining is maintained even for extended times in culture, suggesting a regional modulation of astrocyte function. |
1993-08-03 |
2023-08-12 |
rat |
| J Sutin, R Griffit. Beta-adrenergic receptor blockade suppresses glial scar formation. Experimental neurology. vol 120. issue 2. 1993-06-17. PMID:8387932. |
these observations, together with the demonstration of beta-adrenergic receptors in astrocytes isolated from adult rat brain, led us to test the hypothesis that beta-antagonists prevent astrocyte hypertrophy in the injured spinal cord. |
1993-06-17 |
2023-08-12 |
rat |
| C L Thio, S G Waxman, H Sontheime. Ion channels in spinal cord astrocytes in vitro. III. Modulation of channel expression by coculture with neurons and neuron-conditioned medium. Journal of neurophysiology. vol 69. issue 3. 1993-05-03. PMID:7681866. |
coculture of spinal cord astrocytes with dorsal root ganglion (drg) neurons substantially reduces the expression of voltage-activated na+ channels in both spinal cord astrocyte types. |
1993-05-03 |
2023-08-12 |
rat |
| C L Thio, S G Waxman, H Sontheime. Ion channels in spinal cord astrocytes in vitro. III. Modulation of channel expression by coculture with neurons and neuron-conditioned medium. Journal of neurophysiology. vol 69. issue 3. 1993-05-03. PMID:7681866. |
culturing spinal cord astrocytes in neuron-conditioned media reduces na+ channel expression in both spinal cord astrocyte types to levels intermediate between coculture and control, suggesting that, at least in part, neuronal effects on na+ channel expression are mediated by a soluble factor secreted into the media by neurons. |
1993-05-03 |
2023-08-12 |
rat |