| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Glaucia Monteiro de Castro, Natalia A Deja, Dan Ma, Chao Zhao, Robin J M Frankli. Astrocyte Activation via Stat3 Signaling Determines the Balance of Oligodendrocyte versus Schwann Cell Remyelination. The American journal of pathology. vol 185. issue 9. 2016-05-10. PMID:26193667. |
here, we used a conditional astrocytic phosphorylated signal transducer and activator of transcription 3 knockout mouse model to investigate the effect of abrogating astrocyte activation on remyelination after lysolecithin-induced demyelination of spinal cord white matter. |
2016-05-10 |
2023-08-13 |
mouse |
| Mark A Anderson, Joshua E Burda, Yilong Ren, Yan Ao, Timothy M O'Shea, Riki Kawaguchi, Giovanni Coppola, Baljit S Khakh, Timothy J Deming, Michael V Sofronie. Astrocyte scar formation aids central nervous system axon regeneration. Nature. vol 532. issue 7598. 2016-04-27. PMID:27027288. |
here, using three genetically targeted loss-of-function manipulations in adult mice, we show that preventing astrocyte scar formation, attenuating scar-forming astrocytes, or ablating chronic astrocytic scars all failed to result in spontaneous regrowth of transected corticospinal, sensory or serotonergic axons through severe spinal cord injury (sci) lesions. |
2016-04-27 |
2023-08-13 |
mouse |
| Ze-Min Ling, Ying Tang, Ying-Qin Li, Hao-Xuan Luo, Lin-Lin Liu, Qing-Qiang Tu, Li-Hua Zho. Evaluation of Avulsion-Induced Neuropathology in Rat Spinal Cords with 18F-FDG Micro-PET/CT. PloS one. vol 10. issue 5. 2016-04-21. PMID:26010770. |
bpra-induced astrocyte reactions and overexpression of neuronal nitric oxide synthase in the motoneurons correlated with higher 18f-fdg uptake in the ipsilateral cervical spinal cord during the first 2 w post-injury. |
2016-04-21 |
2023-08-13 |
rat |
| E E O'Brien, B A Smeester, K S Michlitsch, J-H Lee, A J Beit. Colocalization of aromatase in spinal cord astrocytes: differences in expression and relationship to mechanical and thermal hyperalgesia in murine models of a painful and a non-painful bone tumor. Neuroscience. vol 301. 2016-04-18. PMID:26071956. |
while spinal cord astrocytes play a key role in the generation of cancer pain, there have been no studies that have examined the relationship of tumor-induced astrocyte activation and aromatase expression during the development of cancer pain. |
2016-04-18 |
2023-08-13 |
mouse |
| Yilin Mao, Kathryn Mathews, Catherine A Gorri. Temporal Response of Endogenous Neural Progenitor Cells Following Injury to the Adult Rat Spinal Cord. Frontiers in cellular neuroscience. vol 10. 2016-03-25. PMID:27013972. |
this study used a mild contusion injury in rat spinal cord and immunohistochemistry to determine the temporal response of ependymal npcs following injury and their correlation to astrocyte activation at the lesion edge. |
2016-03-25 |
2023-08-13 |
rat |
| Florencia Labombarda, Ignacio Jure, Susana Gonzalez, Analia Lima, Paulina Roig, Rachida Guennoun, Michael Schumacher, Alejandro F De Nicol. A functional progesterone receptor is required for immunomodulation, reduction of reactive gliosis and survival of oligodendrocyte precursors in the injured spinal cord. The Journal of steroid biochemistry and molecular biology. vol 154. 2016-01-19. PMID:26369614. |
our results support a role of pr in: (a) the anti-inflammatory effects of progesterone; (b) the modulation of astrocyte and microglial responses and (c) the prevention of opc apoptosis, a mechanism that would enhance the commitment of progenitors to the remyelination pathway in the injured spinal cord. |
2016-01-19 |
2023-08-13 |
mouse |
| Ke Li, Elham Javed, Daniel Scura, Tamara J Hala, Suneil Seetharam, Aditi Falnikar, Jean-Philippe Richard, Ashley Chorath, Nicholas J Maragakis, Megan C Wright, Angelo C Lepor. Human iPS cell-derived astrocyte transplants preserve respiratory function after spinal cord injury. Experimental neurology. vol 271. 2015-12-22. PMID:26216662. |
human ips cell-derived astrocyte transplants preserve respiratory function after spinal cord injury. |
2015-12-22 |
2023-08-13 |
mouse |
| Jaime L Watson, Tamara J Hala, Rajarshi Putatunda, Daniel Sannie, Angelo C Lepor. Persistent at-level thermal hyperalgesia and tactile allodynia accompany chronic neuronal and astrocyte activation in superficial dorsal horn following mouse cervical contusion spinal cord injury. PloS one. vol 9. issue 9. 2015-12-21. PMID:25268642. |
persistent at-level thermal hyperalgesia and tactile allodynia accompany chronic neuronal and astrocyte activation in superficial dorsal horn following mouse cervical contusion spinal cord injury. |
2015-12-21 |
2023-08-13 |
mouse |
| Jaime L Watson, Tamara J Hala, Rajarshi Putatunda, Daniel Sannie, Angelo C Lepor. Persistent at-level thermal hyperalgesia and tactile allodynia accompany chronic neuronal and astrocyte activation in superficial dorsal horn following mouse cervical contusion spinal cord injury. PloS one. vol 9. issue 9. 2015-12-21. PMID:25268642. |
following injury, an increase in the number of neurons expressing Δfosb (a marker of chronic neuronal activation), persistent astrocyte activation and proliferation (as measured by gfap and ki67 expression), and a decrease in the expression of the astrocyte glutamate transporter glt1 are observed in the ipsilateral superficial dorsal horn of cervical spinal cord. |
2015-12-21 |
2023-08-13 |
mouse |
| Saïd M'Dahoma, Sylvie Bourgoin, Valérie Kayser, Sandrine Barthélémy, Caroline Chevarin, Farah Chali, Didier Orsal, Michel Hamo. Spinal cord transection-induced allodynia in rats--behavioral, physiopathological and pharmacological characterization. PloS one. vol 9. issue 7. 2015-11-17. PMID:25019623. |
this led us to thoroughly investigate (i) mechanical and thermal sensory alterations, (ii) responses to acute treatments with drugs having patent or potential anti-allodynic properties and (iii) the spinal/ganglion expression of transcripts encoding markers of neuronal injury, microglia and astrocyte activation in rats that underwent complete spinal cord transection (sct). |
2015-11-17 |
2023-08-13 |
rat |
| Ke Li, Elham Javed, Tamara J Hala, Daniel Sannie, Kathleen A Regan, Nicholas J Maragakis, Megan C Wright, David J Poulsen, Angelo C Lepor. Transplantation of glial progenitors that overexpress glutamate transporter GLT1 preserves diaphragm function following cervical SCI. Molecular therapy : the journal of the American Society of Gene Therapy. vol 23. issue 3. 2015-11-16. PMID:25492561. |
given our observations of glt1 dysfunction post-sci, we evaluated intraspinal transplantation of glial-restricted precursors (grps)--a class of lineage-restricted astrocyte progenitors--into ventral horn following cervical hemicontusion as a novel strategy for reconstituting glt1 function, preventing excitotoxicity and protecting pmns in the acutely injured spinal cord. |
2015-11-16 |
2023-08-13 |
Not clear |
| Matteo Zanardelli, Laura Micheli, Lorenzo Cinci, Paola Failli, Carla Ghelardini, Lorenzo Di Cesare Mannell. Oxaliplatin neurotoxicity involves peroxisome alterations. PPARγ agonism as preventive pharmacological approach. PloS one. vol 9. issue 7. 2015-11-05. PMID:25036594. |
in the spinal cord, catalase protection was showed by the lower rosiglitazone dosage without effect on the astrocyte density increase induced by oxaliplatin. |
2015-11-05 |
2023-08-13 |
human |
| David J Baker, Daniel J Blackburn, Marcus Keatinge, Dilraj Sokhi, Paulius Viskaitis, Paul R Heath, Laura Ferraiuolo, Janine Kirby, Pamela J Sha. Lysosomal and phagocytic activity is increased in astrocytes during disease progression in the SOD1 (G93A) mouse model of amyotrophic lateral sclerosis. Frontiers in cellular neuroscience. vol 9. 2015-11-03. PMID:26528138. |
here, we have performed microarray analysis of symptomatic and late-stage disease astrocytes isolated by laser capture microdissection (lcm) from the lumbar spinal cord of the sod1(g93a) mouse to complete the picture of astrocyte behavior throughout the disease course. |
2015-11-03 |
2023-08-13 |
mouse |
| David J Baker, Daniel J Blackburn, Marcus Keatinge, Dilraj Sokhi, Paulius Viskaitis, Paul R Heath, Laura Ferraiuolo, Janine Kirby, Pamela J Sha. Lysosomal and phagocytic activity is increased in astrocytes during disease progression in the SOD1 (G93A) mouse model of amyotrophic lateral sclerosis. Frontiers in cellular neuroscience. vol 9. 2015-11-03. PMID:26528138. |
functional analysis of hexosaminidase b enzyme activity in the spinal cord and of astrocyte phagocytic ability has demonstrated a significant increase in lysosomal enzyme activity and phagocytic activity in sod1(g93a) vs. littermate controls, validating the findings of the microarray study. |
2015-11-03 |
2023-08-13 |
mouse |
| Víctor Caraballo-Miralles, Andrea Cardona-Rossinyol, Ana Garcera, Laura Torres-Benito, Rosa M Soler, Lucía Tabares, Jerònia Lladó, Gabriel Olmo. Notch signaling pathway is activated in motoneurons of spinal muscular atrophy. International journal of molecular sciences. vol 14. issue 6. 2015-10-19. PMID:23759991. |
in the smnΔ7 mouse model of sma we also found increased astrocyte processes positive for jagged1 and delta1 in intimate contact with lumbar spinal cord motoneurons. |
2015-10-19 |
2023-08-12 |
mouse |
| F Guida, R Lattanzi, S Boccella, D Maftei, R Romano, V Marconi, G Balboni, S Salvadori, M A Scafuro, V de Novellis, L Negri, S Maione, L Luong. PC1, a non-peptide PKR1-preferring antagonist, reduces pain behavior and spinal neuronal sensitization in neuropathic mice. Pharmacological research. vol 91. 2015-10-09. PMID:25434589. |
to do this, we assessed the activity of spinal cord nociceptive neurons as well as astrocyte and microglia phenotypes after repeated administration of pc1 in vivo. |
2015-10-09 |
2023-08-13 |
mouse |
| Da Liu, Ying Huang, Bin Li, Changqing Jia, Feng Liang, Qin F. Carvedilol promotes neurological function, reduces bone loss and attenuates cell damage after acute spinal cord injury in rats. Clinical and experimental pharmacology & physiology. vol 42. issue 2. 2015-09-22. PMID:25424914. |
in addition, carvedilol reduced sci-induced neural damage, increased neuron number and reduced astrocyte activation in the spinal cord. |
2015-09-22 |
2023-08-13 |
rat |
| Le Wang, Liu Yuzhou, Zhou Yingjie, Lao Jie, Zhao Xi. A new rat model of neuropathic pain: complete brachial plexus avulsion. Neuroscience letters. vol 589. 2015-08-27. PMID:25596440. |
we observed the activation of astrocyte and microglial in cervical spinal cord after bpa. |
2015-08-27 |
2023-08-13 |
human |
| Rana R Khankan, Ina B Wanner, Patricia E Phelp. Olfactory ensheathing cell-neurite alignment enhances neurite outgrowth in scar-like cultures. Experimental neurology. vol 269. 2015-08-11. PMID:25863021. |
our results show that oecs can independently enhance neurite elongation and that direct oec-neurite cell contact can provide a permissive substrate that overcomes the inhibitory nature of the reactive astrocyte scar border and the fibroblast-rich spinal cord lesion core. |
2015-08-11 |
2023-08-13 |
Not clear |
| Yiyi Zhou, Yi Lu, Xin Fang, Jie Zhang, Jiao Li, Shujuan Li, Xia Deng, Yaqing Yu, Renshi X. An astrocyte regenerative response from vimentin-containing cells in the spinal cord of amyotrophic lateral sclerosis's disease-like transgenic (G93A SOD1) mice. Neuro-degenerative diseases. vol 15. issue 1. 2015-07-30. PMID:25591625. |
an astrocyte regenerative response from vimentin-containing cells in the spinal cord of amyotrophic lateral sclerosis's disease-like transgenic (g93a sod1) mice. |
2015-07-30 |
2023-08-13 |
mouse |