| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| V Vazquez, C Gury, X Laqueill. [Methadone: from pharmacokinetic profile to clinical pharmacology]. L'Encephale. vol 32. issue 4 Pt 1. 2006-12-28. PMID:17099560. |
metabolism inhibitors such as selective serotonin reuptake inhibitors (fluvoxamine, fluoxetine, paroxetine, sertraline) or antifungals of the azol groups could enhance plasma concentration and may sometimes lead to respiratory depression or death. |
2006-12-28 |
2023-08-12 |
human |
| Elisabeth Friess, Tania Kuempfel, Sieglinde Modell, Juliane Winkelmann, Florian Holsboer, Marcus Ising, Claudia Trenkwalde. Paroxetine treatment improves motor symptoms in patients with multiple system atrophy. Parkinsonism & related disorders. vol 12. issue 7. 2006-12-15. PMID:16769235. |
in view of the putative role of serotonergic neurotransmission in basal ganglia circuitry we investigated the effects of paroxetine (pxt) as a selective serotonin reuptake inhibitor (ssri) on the motor performance in n=19 patients clinically diagnosed as msa using a double-blind placebo-controlled randomized study design. |
2006-12-15 |
2023-08-12 |
Not clear |
| Graziano Pinna, Erminio Costa, Alessandro Guidott. Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake. Psychopharmacology. vol 186. issue 3. 2006-12-04. PMID:16432684. |
thus, the neurosteroid-induced positive allosteric modulation of gaba action at gabaa receptors is facilitated by fluoxetine or its congeners (i.e., paroxetine, fluvoxamine, sertraline), which may not block 5-ht reuptake at the doses currently prescribed in the clinic. |
2006-12-04 |
2023-08-12 |
mouse |
| H Kosaka, N Omata, M Omori, T Shimoyama, T Murata, K Kashikura, T Takahashi, J Murayama, Y Yonekura, Y Wad. Abnormal pontine activation in pathological laughing as shown by functional magnetic resonance imaging. Journal of neurology, neurosurgery, and psychiatry. vol 77. issue 12. 2006-12-04. PMID:17110751. |
here, we report that the patient consistently showed exaggerated pontine activation during the performance of three tasks before treatment, whereas abnormal pontine activation was no longer found after successful treatment with the selective serotonin reuptake inhibitor, paroxetine. |
2006-12-04 |
2023-08-12 |
Not clear |
| T Sugai, Y Suzuki, K Sawamura, N Fukui, Y Inoue, T Somey. The effect of 5-hydroxytryptamine 3A and 3B receptor genes on nausea induced by paroxetine. The pharmacogenomics journal. vol 6. issue 5. 2006-11-21. PMID:16534507. |
the effect of 5-hydroxytryptamine 3a and 3b receptor genes on nausea induced by paroxetine. |
2006-11-21 |
2023-08-12 |
Not clear |
| T Sugai, Y Suzuki, K Sawamura, N Fukui, Y Inoue, T Somey. The effect of 5-hydroxytryptamine 3A and 3B receptor genes on nausea induced by paroxetine. The pharmacogenomics journal. vol 6. issue 5. 2006-11-21. PMID:16534507. |
we investigated the effect of 5-hydroxytryptamine 3a and 3b receptor (htr3a and htr3b) gene polymorphisms on nausea induced by paroxetine in japanese psychiatric patients. |
2006-11-21 |
2023-08-12 |
Not clear |
| Jean-Philippe Guilloux, Denis J P David, Bruno P Guiard, Franck Chenu, Christelle Repérant, Miklos Toth, Michel Bourin, Alain M Gardie. Blockade of 5-HT1A receptors by (+/-)-pindolol potentiates cortical 5-HT outflow, but not antidepressant-like activity of paroxetine: microdialysis and behavioral approaches in 5-HT1A receptor knockout mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 10. 2006-11-01. PMID:16452992. |
blockade of 5-ht1a receptors by (+/-)-pindolol potentiates cortical 5-ht outflow, but not antidepressant-like activity of paroxetine: microdialysis and behavioral approaches in 5-ht1a receptor knockout mice. |
2006-11-01 |
2023-08-12 |
mouse |
| Jean-Philippe Guilloux, Denis J P David, Bruno P Guiard, Franck Chenu, Christelle Repérant, Miklos Toth, Michel Bourin, Alain M Gardie. Blockade of 5-HT1A receptors by (+/-)-pindolol potentiates cortical 5-HT outflow, but not antidepressant-like activity of paroxetine: microdialysis and behavioral approaches in 5-HT1A receptor knockout mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 10. 2006-11-01. PMID:16452992. |
selective serotonin reuptake inhibitors like paroxetine (prx) often requires 4-6 weeks to achieve clinical benefits in depressed patients. |
2006-11-01 |
2023-08-12 |
mouse |
| Koichiro Satoh, Shizuko Takano, Takashi Onogi, Koji Ohtsuki, Toshio Kobayash. Serotonin syndrome caused by minimum doses of SSRIS in a patient with spinal cord injury. Fukushima journal of medical science. vol 52. issue 1. 2006-10-19. PMID:16995352. |
we report a case of serotonin syndrome caused by long-term therapy with fluvoxamine prior to treatment with paroxetine. |
2006-10-19 |
2023-08-12 |
Not clear |
| Koichiro Satoh, Shizuko Takano, Takashi Onogi, Koji Ohtsuki, Toshio Kobayash. Serotonin syndrome caused by minimum doses of SSRIS in a patient with spinal cord injury. Fukushima journal of medical science. vol 52. issue 1. 2006-10-19. PMID:16995352. |
an 18-year-old man with spinal cord injury (sci) at thoracic level 2-3 presented with onset of serotonin syndrome after taking fluvoxamine (50 mg per day) for 8 weeks prior to treatment with paroxetine (10 mg per day) for 6 days. |
2006-10-19 |
2023-08-12 |
Not clear |
| Ellen R A de Bruijn, Bernard G C Sabbe, Wouter Hulstijn, Gé S F Ruigt, Robbert J Verke. Effects of antipsychotic and antidepressant drugs on action monitoring in healthy volunteers. Brain research. vol 1105. issue 1. 2006-09-29. PMID:16499887. |
in the current study, we investigated action monitoring after administration of the classic antipsychotic haloperidol (2.5 mg), the atypical antipsychotic olanzapine (10 mg), and the antidepressant paroxetine (20 mg), a selective serotonin reuptake inhibitor. |
2006-09-29 |
2023-08-12 |
human |
| Ellen R A de Bruijn, Bernard G C Sabbe, Wouter Hulstijn, Gé S F Ruigt, Robbert J Verke. Effects of antipsychotic and antidepressant drugs on action monitoring in healthy volunteers. Brain research. vol 1105. issue 1. 2006-09-29. PMID:16499887. |
finally, the absence of any effects after paroxetine suggests that serotonin transmission does not play a direct role in regulating mechanisms related to action monitoring. |
2006-09-29 |
2023-08-12 |
human |
| Masaki Kato, Tsuyoshi Fukuda, Masataka Wakeno, Kazuhiro Fukuda, Gaku Okugawa, Yuka Ikenaga, Megumi Yamashita, Yoshiteru Takekita, Kenji Nobuhara, Junichi Azuma, Toshihiko Kinoshit. Effects of the serotonin type 2A, 3A and 3B receptor and the serotonin transporter genes on paroxetine and fluvoxamine efficacy and adverse drug reactions in depressed Japanese patients. Neuropsychobiology. vol 53. issue 4. 2006-09-29. PMID:16874005. |
effects of the serotonin type 2a, 3a and 3b receptor and the serotonin transporter genes on paroxetine and fluvoxamine efficacy and adverse drug reactions in depressed japanese patients. |
2006-09-29 |
2023-08-12 |
Not clear |
| Masaki Kato, Tsuyoshi Fukuda, Masataka Wakeno, Kazuhiro Fukuda, Gaku Okugawa, Yuka Ikenaga, Megumi Yamashita, Yoshiteru Takekita, Kenji Nobuhara, Junichi Azuma, Toshihiko Kinoshit. Effects of the serotonin type 2A, 3A and 3B receptor and the serotonin transporter genes on paroxetine and fluvoxamine efficacy and adverse drug reactions in depressed Japanese patients. Neuropsychobiology. vol 53. issue 4. 2006-09-29. PMID:16874005. |
in this study, we tested the influence of the serotonin type 2a, 3a and 3b receptor genes (htr2a, htr3a, htr3b) in addition to a polymorphism in the promoter region of the serotonin transporter (sertpr), and investigated the different characteristics of clinical responses to paroxetine and fluvoxamine. |
2006-09-29 |
2023-08-12 |
Not clear |
| Nicole Kotzailias, Toni Andonovski, Alexander Dukic, Victor L Serebruany, Bernd Jilm. Antiplatelet activity during coadministration of the selective serotonin reuptake inhibitor paroxetine and aspirin in male smokers: a randomized, placebo-controlled, double-blind trial. Journal of clinical pharmacology. vol 46. issue 4. 2006-09-21. PMID:16554456. |
antiplatelet activity during coadministration of the selective serotonin reuptake inhibitor paroxetine and aspirin in male smokers: a randomized, placebo-controlled, double-blind trial. |
2006-09-21 |
2023-08-12 |
Not clear |
| Katie A Jennings, Merewyn K Loder, W John Sheward, Qi Pei, Robert M J Deacon, Matthew A Benson, Henry J Olverman, Nicholas D Hastie, Anthony J Harmar, Sanbing Shen, Trevor Shar. Increased expression of the 5-HT transporter confers a low-anxiety phenotype linked to decreased 5-HT transmission. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 35. 2006-09-21. PMID:16943551. |
the transgenic mice had reduced regional brain whole-tissue levels of 5-ht and, in microdialysis experiments, decreased brain extracellular 5-ht, which reversed on administration of the 5-htt inhibitor paroxetine. |
2006-09-21 |
2023-08-12 |
mouse |
| Katie A Jennings, Merewyn K Loder, W John Sheward, Qi Pei, Robert M J Deacon, Matthew A Benson, Henry J Olverman, Nicholas D Hastie, Anthony J Harmar, Sanbing Shen, Trevor Shar. Increased expression of the 5-HT transporter confers a low-anxiety phenotype linked to decreased 5-HT transmission. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 35. 2006-09-21. PMID:16943551. |
furthermore, in the plus maze test, the low-anxiety phenotype of the transgenic mice was reversed by acute administration of paroxetine, suggesting a direct link between the behavior, 5-htt overexpression, and low extracellular 5-ht. |
2006-09-21 |
2023-08-12 |
mouse |
| Howard Steiger, Lise Gauvin, Ridha Joober, Mimi Israel, N M K Ng Ying Kin, Kenneth R Bruce, Jodie Richardson, Simon N Young, Julie Haki. Intrafamilial correspondences on platelet [3H-]paroxetine-binding indices in bulimic probands and their unaffected first-degree relatives. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 8. 2006-08-31. PMID:16407896. |
we applied density (bmax) of platelet [3h-]paroxetine binding as a proxy for central 5-ht reuptake activity in two groups of women (33 with bn-spectrum disorders and 19 with no apparent eating or psychiatric disorders), most of these individuals' mothers (31 and 18, respectively), and a small sampling of their sisters (seven and eight, respectively). |
2006-08-31 |
2023-08-12 |
Not clear |
| Muneki Tanaka, Toshihiro Nakahara, Tetsuro Muranaga, Shinya Kojima, Daisuke Yasuhara, Hiroaki Ueno, Masamitsu Nakazato, Akio Inu. Ghrelin concentrations and cardiac vagal tone are decreased after pharmacologic and cognitive-behavioral treatment in patients with bulimia nervosa. Hormones and behavior. vol 50. issue 2. 2006-08-29. PMID:16643914. |
we investigated ghrelin and leptin levels, cardiac vagal tone and sympathovagal balance, frequency of sets of binge-eating and vomiting episodes per week and the profile of mood states (poms) depression scale in bn before and after a 16-week administration of the serotonin selective reuptake inhibitor (ssri) paroxetine combined with cognitive-behavioral therapy. |
2006-08-29 |
2023-08-12 |
human |
| Shaista Hayat, Robert J Williams, Marcus Rattra. Serotonin transporter expression is not sufficient to confer cytotoxicity to 3,4-methylenedioxymethamphetamine (MDMA) in vitro. Journal of psychopharmacology (Oxford, England). vol 20. issue 2. 2006-08-09. PMID:16510483. |
cytotoxicity caused by 48 h exposure to 1 mm mdma at 37 degrees c was not related to the level of sert expression, not blocked by the sert-blocking drugs paroxetine or fluoxetine and not enhanced, in jar cells, by forskolin preincubation that increased 5-ht uptake capacity by 50%. |
2006-08-09 |
2023-08-12 |
human |