| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anna K Läck, Marvin R Diaz, Ann Chappell, Dustin W DuBois, Brian A McCoo. Chronic ethanol and withdrawal differentially modulate pre- and postsynaptic function at glutamatergic synapses in rat basolateral amygdala. Journal of neurophysiology. vol 98. issue 6. 2008-03-05. PMID:17898152. |
because evidence suggests that glutamate-gated neurotransmitter receptors are sensitive to acute ethanol exposure, we examined the effect of chronic intermittent ethanol (cie) and withdrawal (wd) on glutamatergic synaptic transmission in the bla. |
2008-03-05 |
2023-08-12 |
rat |
| József Nag. Recent patents on pharmacotherapy for alcoholism. Recent patents on CNS drug discovery. vol 1. issue 2. 2008-02-15. PMID:18221202. |
besides altering the release of neurotransmitters like dopamine, ethanol alters the function of a number of neurotransmitter receptors as well as transporters. |
2008-02-15 |
2023-08-12 |
Not clear |
| József Nag. Recent patents on pharmacotherapy for alcoholism. Recent patents on CNS drug discovery. vol 1. issue 2. 2008-02-15. PMID:18221202. |
when ethanol is used for longer period of time, changes in these specific neurotransmitter functions occur possibly underlying the development of alcohol dependence. |
2008-02-15 |
2023-08-12 |
Not clear |
| Brian A McMillen, J Elizabeth Shank, Kirstin B Jordan, Helen L Williams, A S Basil. Effect of DOV 102,677 on the volitional consumption of ethanol by Myers' high ethanol-preferring rat. Alcoholism, clinical and experimental research. vol 31. issue 11. 2008-01-22. PMID:17908267. |
however, the evidence that single (serotonin) or dual (serotonin-norepinephrine) neurotransmitter uptake inhibitors can treat ethanol abuse, either as a comorbidity with depression or as a separate entity, is inconsistent. |
2008-01-22 |
2023-08-12 |
rat |
| M Katherine Kelm, Hugh E Criswell, George R Brees. Calcium release from presynaptic internal stores is required for ethanol to increase spontaneous gamma-aminobutyric acid release onto cerebellum Purkinje neurons. The Journal of pharmacology and experimental therapeutics. vol 323. issue 1. 2007-11-05. PMID:17652632. |
it is generally accepted that ethanol increases levels of intracellular calcium and that changes in intracellular calcium can alter neurotransmitter release. |
2007-11-05 |
2023-08-12 |
Not clear |
| David M Lovinger, Gregg E Homanic. Tonic for what ails us? high-affinity GABAA receptors and alcohol. Alcohol (Fayetteville, N.Y.). vol 41. issue 3. 2007-08-15. PMID:17521844. |
ethanol interactions with gamma-aminobutyric acid (gaba), the major inhibitory neurotransmitter in the brain, play key roles in acute intoxication. |
2007-08-15 |
2023-08-12 |
human |
| Martin Wallner, H Jacob Hanchar, Richard W Olse. Low dose acute alcohol effects on GABA A receptor subtypes. Pharmacology & therapeutics. vol 112. issue 2. 2007-02-27. PMID:16814864. |
gaba(a) receptors (gaba(a)rs) are the main inhibitory neurotransmitter receptors and have long been implicated in mediating at least part of the acute actions of ethanol. |
2007-02-27 |
2023-08-12 |
rat |
| Michael Köhnke, Sandra Schick, Ulrich Lutz, Annette Köhnke, Reinhard Vonthein, Werner Kolb, Anil Batr. The polymorphism GABABR1 T1974C[rs29230] of the GABAB receptor gene is not associated with the diagnosis of alcoholism or alcohol withdrawal seizures. Addiction biology. vol 11. issue 2. 2006-11-30. PMID:16800828. |
as the inhibitory neurotransmitter gamma aminobutyric acid (gaba) modulates ethanol consumption, alcohol withdrawal symptoms and seizure generation by interacting with the gabab receptor, the genes encoding for the gabab receptor can be considered as candidate genes for alcoholism and alcohol withdrawal seizures (aws). |
2006-11-30 |
2023-08-12 |
Not clear |
| Sergio Gustavo Evrard, Maite Duhalde-Vega, Patricia Tagliaferro, Sebastián Mirochnic, Laura Romina Caltana, Alicia Brusc. A low chronic ethanol exposure induces morphological changes in the adolescent rat brain that are not fully recovered even after a long abstinence: an immunohistochemical study. Experimental neurology. vol 200. issue 2. 2006-09-21. PMID:16631170. |
we studied here the relationship between two neurotransmitter systems (the serotoninergic and nitrergic) and the astrocytic and neuronal cytoskeleton immediately and long after drinking cessation of a chronic, but low, ethanol administration. |
2006-09-21 |
2023-08-12 |
rat |
| Ertuğrul Eşe. [Neurobiology of alcohol withdrawal inhibitory and excitatory neurotransmitters]. Turk psikiyatri dergisi = Turkish journal of psychiatry. vol 17. issue 2. 2006-06-27. PMID:16755413. |
long-term exposure to ethanol leads to an imbalance in different excitatory (especially glutamate, a major excitatory amino acid), and inhibitory neurotransmitter (especially gaba, a major inhibitory amino acid) systems. |
2006-06-27 |
2023-08-12 |
Not clear |
| Maité Carre-Pierrat, Karine Grisoni, Kathrin Gieseler, Marie-Christine Mariol, Edwige Martin, Maelle Jospin, Bruno Allard, Laurent Ségala. The SLO-1 BK channel of Caenorhabditis elegans is critical for muscle function and is involved in dystrophin-dependent muscle dystrophy. Journal of molecular biology. vol 358. issue 2. 2006-05-30. PMID:16527307. |
slo-1 has been shown to be involved in neurotransmitter release and ethanol response. |
2006-05-30 |
2023-08-12 |
caenorhabditis_elegans |
| K Mann, K Ackermann, A Diehl, D Ebert, G Mundle, H Nakovics, T Reker, G Richter, L G Schmidt, M Driessen, K Rettig, K Opitz, B Croissan. Galantamine: a cholinergic patch in the treatment of alcoholism: a randomized, placebo-controlled trial. Psychopharmacology. vol 184. issue 1. 2006-04-28. PMID:16328375. |
it is possible that the reinforcing effects of ethanol are partially mediated by nicotinic receptors, which modulate neurotransmitter release. |
2006-04-28 |
2023-08-12 |
rat |
| Kazuhiro Kamada, F Spencer Gaskin, Taiji Yamaguchi, Patsy Carter, Toshikazu Yoshikawa, Mozow Yusof, Ronald J Korthui. Role of calcitonin gene-related peptide in the postischemic anti-inflammatory effects of antecedent ethanol ingestion. American journal of physiology. Heart and circulatory physiology. vol 290. issue 2. 2006-02-28. PMID:16143644. |
the postischemic anti-inflammatory effects of ethanol consumption were abolished by administration of a specific cgrp receptor antagonist [cgrp-(8-37)] or after sensory nerve neurotransmitter depletion using capsaicin administered 4 days before ethanol ingestion, which initially induces rapid release of cgrp from sensory nerves, thereby depleting stored neuropeptide. |
2006-02-28 |
2023-08-12 |
mouse |
| M V Pivovarchi. [Change of dopamine, serotonin and opioid neuromediator systems in the brain of rats adapted to prolonged effect of ethanol]. Ukrains'kyi biokhimichnyi zhurnal (1999 ). vol 76. issue 2. 2005-06-17. PMID:15915718. |
the data obtained suggest that the response of neurotransmitter systems to short-term ethanol administration in different regions of rats brain is not identical. |
2005-06-17 |
2023-08-12 |
rat |
| Mathias Zink, Rainer Spanage. Ethanol induces GAD67 and VGAT in slice cultures of newborn rat cerebral cortex. Neuroreport. vol 16. issue 4. 2005-06-13. PMID:15729141. |
exposure of the developing brain to ethanol disposes to the fetal alcohol syndrome, causing changes in the neurotransmitter systems of glutamate and gamma-amino butyric acid (gaba). |
2005-06-13 |
2023-08-12 |
rat |
| Bankole A Johnso. An overview of the development of medications including novel anticonvulsants for the treatment of alcohol dependence. Expert opinion on pharmacotherapy. vol 5. issue 9. 2005-04-21. PMID:15330732. |
the development of treatments for alcohol dependence has been significantly complicated by the multiple actions of ethanol at the neurotransmitter level, heterogeneity among patients with alcohol dependence, the complexity of defining and measuring the phenomenon of craving, and the challenge of quantifying alcohol intake in patients. |
2005-04-21 |
2023-08-12 |
Not clear |
| Michael F Stromber. The effect of baclofen alone and in combination with naltrexone on ethanol consumption in the rat. Pharmacology, biochemistry, and behavior. vol 78. issue 4. 2005-03-04. PMID:15301930. |
while naltrexone targets opioid receptors, many other neurotransmitter systems are targeted by ethanol and, to a greater or lesser extent, contribute to modulating ethanol's reinforcing effects. |
2005-03-04 |
2023-08-12 |
rat |
| Jozsef Nag. The NR2B subtype of NMDA receptor: a potential target for the treatment of alcohol dependence. Current drug targets. CNS and neurological disorders. vol 3. issue 3. 2004-08-20. PMID:15180478. |
ethanol is a small molecule acting on several neurotransmitter systems in the brain. |
2004-08-20 |
2023-08-12 |
rat |
| Jozsef Nag. The NR2B subtype of NMDA receptor: a potential target for the treatment of alcohol dependence. Current drug targets. CNS and neurological disorders. vol 3. issue 3. 2004-08-20. PMID:15180478. |
the glutamatergic--neurotransmitter system is a particularly important site of ethanol's action. |
2004-08-20 |
2023-08-12 |
rat |
| Patricia H Janak, T Michael Gil. Comparison of the effects of allopregnanolone with direct GABAergic agonists on ethanol self-administration with and without concurrently available sucrose. Alcohol (Fayetteville, N.Y.). vol 30. issue 1. 2004-03-16. PMID:12878269. |
behavioral effects of ethanol are mediated by actions at multiple neurotransmitter receptors and signaling systems; prominent among these is the type a gamma-aminobutyric acid (gaba(a)) receptor. |
2004-03-16 |
2023-08-12 |
human |