| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marvin R Diaz, Daniel T Christian, Nancy J Anderson, Brian A McCoo. Chronic ethanol and withdrawal differentially modulate lateral/basolateral amygdala paracapsular and local GABAergic synapses. The Journal of pharmacology and experimental therapeutics. vol 337. issue 1. 2011-05-19. PMID:21209156. |
in the present study, we found that withdrawal from chronic ethanol robustly decreased presynaptic function at feed-forward gaba synapses but did not alter neurotransmitter release from local interneurons. |
2011-05-19 |
2023-08-12 |
Not clear |
| Pravinkumar Bhutada, Yogita Mundhada, Kuldeep Bansod, Rahul Hiware, Sumit Rathod, Pankaj Dixit, Dharmendra Mundhad. Berberine protects C57BL/6J mice against ethanol withdrawal-induced hyperexcitability. Phytotherapy research : PTR. vol 25. issue 2. 2011-04-21. PMID:20734325. |
plethora of recent reports has indicated its ability to modulate several neurotransmitter systems, especially those implicated in ethanol dependence. |
2011-04-21 |
2023-08-12 |
mouse |
| Loren J Martin, Agnieszka A Zurek, Robert P Bonin, Gabriel H T Oh, John H Kim, Howard T J Mount, Beverley A Orse. The sedative but not the memory-blocking properties of ethanol are modulated by α5-subunit-containing γ-aminobutyric acid type A receptors. Behavioural brain research. vol 217. issue 2. 2011-04-18. PMID:21070817. |
the precise mechanisms underlying the memory-blocking properties of ethanol are unknown, in part because ethanol targets a wide array of neurotransmitter receptors and transporters. |
2011-04-18 |
2023-08-12 |
mouse |
| Hitoshi Morikawa, Richard A Morriset. Ethanol action on dopaminergic neurons in the ventral tegmental area: interaction with intrinsic ion channels and neurotransmitter inputs. International review of neurobiology. vol 91. 2010-12-21. PMID:20813245. |
ethanol action on dopaminergic neurons in the ventral tegmental area: interaction with intrinsic ion channels and neurotransmitter inputs. |
2010-12-21 |
2023-08-12 |
Not clear |
| T J Searl, E M Silinsk. The mechanism for prejunctional enhancement of neuromuscular transmission by ethanol in the mouse. The Journal of pharmacology and experimental therapeutics. vol 335. issue 2. 2010-11-23. PMID:20709936. |
however, the mechanisms by which ethanol affects evoked neurotransmitter release have not been studied at the mouse neuromuscular junction, a synapse at which binomial analysis of neurotransmitter release and measurements of prejunctional ionic currents can be made. |
2010-11-23 |
2023-08-12 |
mouse |
| T J Searl, E M Silinsk. The mechanism for prejunctional enhancement of neuromuscular transmission by ethanol in the mouse. The Journal of pharmacology and experimental therapeutics. vol 335. issue 2. 2010-11-23. PMID:20709936. |
ethanol (400 mm) increased neurotransmitter release independently of both the camp and phorbol ester/munc13 signaling pathways. |
2010-11-23 |
2023-08-12 |
mouse |
| T J Searl, E M Silinsk. The mechanism for prejunctional enhancement of neuromuscular transmission by ethanol in the mouse. The Journal of pharmacology and experimental therapeutics. vol 335. issue 2. 2010-11-23. PMID:20709936. |
binomial analysis of neurotransmitter release revealed that ethanol increases the average probability of secretion without an effect on the immediately available store of the neurotransmitter. |
2010-11-23 |
2023-08-12 |
mouse |
| T J Searl, E M Silinsk. The mechanism for prejunctional enhancement of neuromuscular transmission by ethanol in the mouse. The Journal of pharmacology and experimental therapeutics. vol 335. issue 2. 2010-11-23. PMID:20709936. |
these results suggest that the potentiating effects of ethanol on neurotransmitter release at the skeletal neuromuscular junction are mediated by an inhibition of the delayed rectifier potassium current, thus increasing both calcium entry into the nerve ending and the probability of neurotransmitter release. |
2010-11-23 |
2023-08-12 |
mouse |
| T J Searl, E M Silinsk. The mechanism for prejunctional enhancement of neuromuscular transmission by ethanol in the mouse. The Journal of pharmacology and experimental therapeutics. vol 335. issue 2. 2010-11-23. PMID:20709936. |
identifying the mechanism through which ethanol enhances neurotransmitter release at the neuromuscular junction may be useful in determining the processes underlying the enhancement of neurotransmitter release at other synapses. |
2010-11-23 |
2023-08-12 |
mouse |
| József Nagy, Sándor Kolok, András Boros, Péter Dezs. Role of altered structure and function of NMDA receptors in development of alcohol dependence. Current neuropharmacology. vol 3. issue 4. 2010-06-09. PMID:18369402. |
accumulating evidence suggests that the glutamatergic neurotransmitter system, especially the n-methyl-d-aspartate (nmda) type of glutamate receptors is a particularly important site of ethanol's action, since ethanol is a potent inhibitor of the nmda receptors (nmdars) and prolonged ethanol exposition leads to a compensatory "upregulation" of nmdar mediated functions supposedly contributing to the occurrence of ethanol tolerance, dependence as well as the acute and delayed signs of ethanol withdrawal.recently, expression of different types of nmdar subunits was found altered after long-term ethanol exposure. |
2010-06-09 |
2023-08-12 |
Not clear |
| Deborah A Finn, Ethan H Beckley, Katherine R Kaufman, Matthew M For. Manipulation of GABAergic steroids: Sex differences in the effects on alcohol drinking- and withdrawal-related behaviors. Hormones and behavior. vol 57. issue 1. 2010-04-26. PMID:19615369. |
additionally, alcohol (ethanol) influences the function of many neurotransmitter systems, with the interaction at gamma-aminobutyric acid(a) (gaba(a)) receptors being integral for ethanol's reinforcing and several withdrawal-related effects. |
2010-04-26 |
2023-08-12 |
Not clear |
| Zhimin Li, Alevtina Zharikova, Cheryl H Vaughan, Jaime Bastian, Shannon Zandy, Leonardo Esperon, Elyssia Axman, Neil E Rowland, Joanna Peri. Intermittent high-dose ethanol exposures increase motivation for operant ethanol self-administration: possible neurochemical mechanism. Brain research. vol 1310. 2010-03-30. PMID:19944084. |
thus, it appears that intermittent high-dose ethanol exposure not only increases motivation for ethanol responding but may also change neurotransmitter release that mediates anticipation of reinforcement, which may play a key role in the development of alcoholism. |
2010-03-30 |
2023-08-12 |
rat |
| B McElroy, A Zakaria, J D Glass, R A Prosse. Ethanol modulates mammalian circadian clock phase resetting through extrasynaptic GABA receptor activation. Neuroscience. vol 164. issue 2. 2010-02-12. PMID:19695310. |
ethanol modulates the actions of multiple neurotransmitter systems, including gaba. |
2010-02-12 |
2023-08-12 |
mouse |
| B McElroy, A Zakaria, J D Glass, R A Prosse. Ethanol modulates mammalian circadian clock phase resetting through extrasynaptic GABA receptor activation. Neuroscience. vol 164. issue 2. 2010-02-12. PMID:19695310. |
in contrast, although gaba is a prominent neurotransmitter in the circadian clock of the suprachiasmatic nucleus (scn), we see ethanol modulation of clock phase resetting at low concentrations (<50 mm). |
2010-02-12 |
2023-08-12 |
mouse |
| Viviana Trezza, Petra J J Baarendse, Louk J M J Vanderschure. Prosocial effects of nicotine and ethanol in adolescent rats through partially dissociable neurobehavioral mechanisms. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 12. 2010-01-12. PMID:19657330. |
these results show that the facilitatory effects of nicotine and ethanol on social play are behaviorally specific and mediated through neurotransmitter systems involved in positive emotions and motivation, through partially dissociable mechanisms. |
2010-01-12 |
2023-08-12 |
rat |
| A K Läck, O J Ariwodola, A M Chappell, J L Weiner, B A McCoo. Ethanol inhibition of kainate receptor-mediated excitatory neurotransmission in the rat basolateral nucleus of the amygdala. Neuropharmacology. vol 55. issue 5. 2009-01-15. PMID:18617194. |
given that the amygdala is a major emotional center in the brain and regulates the expression of both learned fear and anxiety, neurotransmitter systems within the basolateral amygdala represent likely mechanisms governing the anxiety-related effects of acute ethanol exposure. |
2009-01-15 |
2023-08-12 |
rat |
| R Adron Harris, James R Trudell, S John Mihi. Ethanol's molecular targets. Science signaling. vol 1. issue 28. 2008-08-07. PMID:18632551. |
although ethanol affects various biochemical processes such as neurotransmitter release, enzyme function, and ion channel kinetics, we are only beginning to understand the specific molecular sites to which ethanol molecules bind to produce these myriad effects. |
2008-08-07 |
2023-08-12 |
Not clear |
| Chun Jin, C Thetford Smothers, John J Woodwar. Enhanced ethanol inhibition of recombinant N-methyl-D-aspartate receptors by magnesium: role of NR3A subunits. Alcoholism, clinical and experimental research. vol 32. issue 6. 2008-07-01. PMID:18445116. |
results from previous studies from this lab and others have shown that ethanol inhibits the function of the n-methyl-d-aspartate (nmda) receptors, a calcium-permeable ion channel activated by the neurotransmitter glutamate. |
2008-07-01 |
2023-08-12 |
Not clear |
| Ligia Esperanza Diaz, Pilar Cano, Vanesa Jimenez-Ortega, Esther Nova, Javier Romeo, Asunción Marcos, Ana Isabel Esquifin. Effects of moderate consumption of distilled and fermented alcohol on some aspects of neuroimmunomodulation. Neuroimmunomodulation. vol 14. issue 3-4. 2008-03-31. PMID:18073515. |
this work was aimed at evaluating the effects of moderate alcohol consumption (beer or ethanol) on plasma hormone concentrations, blood and thymus lymphocyte phenotypes and brain neurotransmitter levels. |
2008-03-31 |
2023-08-12 |
rat |
| Cindy K Funk, Douglas P Dohrma. Chronic ethanol exposure inhibits dopamine release via effects on the presynaptic actin cytoskeleton in PC12 cells. Brain research. vol 1185. 2008-03-28. PMID:17996852. |
these data suggest that chronic ethanol inhibits presynaptic actin breakdown, likely resulting in decreased neurotransmitter release. |
2008-03-28 |
2023-08-12 |
Not clear |