| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael J Beckstead, Tamara J Phillip. Mice selectively bred for high- or low-alcohol-induced locomotion exhibit differences in dopamine neuron function. The Journal of pharmacology and experimental therapeutics. vol 329. issue 1. 2009-04-28. PMID:19122113. |
the results suggest that dopamine neuron i(h) channels, firing rate, and gabaergic input may play a role in sensitivity to the locomotor activation observed at early time points after ethanol administration and could underlie differences in sensitivity to alcohol relevant to risk for alcohol abuse. |
2009-04-28 |
2023-08-12 |
mouse |
| Mia Ericson, Elin Löf, Rosita Stomberg, Bo Söderpal. The smoking cessation medication varenicline attenuates alcohol and nicotine interactions in the rat mesolimbic dopamine system. The Journal of pharmacology and experimental therapeutics. vol 329. issue 1. 2009-04-28. PMID:19126781. |
using the in vivo microdialysis method, we investigated the effects of systemic injections of varenicline on the extracellular accumbal dopamine levels in response to a systemic challenge of ethanol, nicotine, or the combination of nicotine and ethanol in the experimental rat. |
2009-04-28 |
2023-08-12 |
rat |
| Mia Ericson, Elin Löf, Rosita Stomberg, Bo Söderpal. The smoking cessation medication varenicline attenuates alcohol and nicotine interactions in the rat mesolimbic dopamine system. The Journal of pharmacology and experimental therapeutics. vol 329. issue 1. 2009-04-28. PMID:19126781. |
acute systemic coadministration of varenicline and ethanol counteracted each others' respective enhancing effect on dopamine levels in the nucleus accumbens. |
2009-04-28 |
2023-08-12 |
rat |
| Mia Ericson, Elin Löf, Rosita Stomberg, Bo Söderpal. The smoking cessation medication varenicline attenuates alcohol and nicotine interactions in the rat mesolimbic dopamine system. The Journal of pharmacology and experimental therapeutics. vol 329. issue 1. 2009-04-28. PMID:19126781. |
however, after 5 days of varenicline pretreatment, acute combined varenicline and ethanol administration raised dopamine levels to the same extent as either drug alone. |
2009-04-28 |
2023-08-12 |
rat |
| Mia Ericson, Elin Löf, Rosita Stomberg, Bo Söderpal. The smoking cessation medication varenicline attenuates alcohol and nicotine interactions in the rat mesolimbic dopamine system. The Journal of pharmacology and experimental therapeutics. vol 329. issue 1. 2009-04-28. PMID:19126781. |
furthermore, after varenicline pretreatment an acute injection of varenicline antagonized the dopamine stimulatory effect of acute nicotine as well as that of systemic coadministration of ethanol and nicotine. |
2009-04-28 |
2023-08-12 |
rat |
| Mia Ericson, Elin Löf, Rosita Stomberg, Bo Söderpal. The smoking cessation medication varenicline attenuates alcohol and nicotine interactions in the rat mesolimbic dopamine system. The Journal of pharmacology and experimental therapeutics. vol 329. issue 1. 2009-04-28. PMID:19126781. |
in contrast, a pronounced additive dopamine increase was observed when nicotine and ethanol were coadministered in vehicle-pretreated rats. |
2009-04-28 |
2023-08-12 |
rat |
| Maria Pascual, Jordi Boix, Vicente Felipo, Consuelo Guerr. Repeated alcohol administration during adolescence causes changes in the mesolimbic dopaminergic and glutamatergic systems and promotes alcohol intake in the adult rat. Journal of neurochemistry. vol 108. issue 4. 2009-04-20. PMID:19077056. |
in vivo microdialysis demonstrates that ethanol elicits a similar prolonged dopamine response in the nucleus accumbens of both adolescent and adult animals pre-treated with multiple doses of ethanol, although the basal dopamine levels were higher in ethanol-treated adolescents than in adult-treated animals. |
2009-04-20 |
2023-08-12 |
rat |
| K J Gill, A E Boyl. Genetic influences on drug-induced psychomotor activation in mice. Genes, brain, and behavior. vol 7. issue 8. 2009-02-27. PMID:19076633. |
the objectives of the present study were (1) to identify quantitative trait loci (qtls) associated with the initial sensitivity to the effects of morphine in the a/j, c57bl/6j and axb/bxa recombinant inbred strains of mice; (2) to identify potential commonalities in the chromosomal regions associated with morphine, cocaine and ethanol sensitivity using multiple-trait genetic analysis and (3) to determine whether there were interstrain differences in dopamine uptake and transporter binding. |
2009-02-27 |
2023-08-12 |
mouse |
| Anne E Heikkinen, Tommi P Möykkynen, Esa R Korp. Long-lasting modulation of glutamatergic transmission in VTA dopamine neurons after a single dose of benzodiazepine agonists. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 2. 2009-02-23. PMID:18563060. |
here we report that single in vivo doses of benzodiazepine-site agonists, similar to morphine and ethanol, induce a modulation in the glutamatergic transmission of vta dopamine neurons. |
2009-02-23 |
2023-08-12 |
mouse |
| Cheng Xiao, Xuesi Max Shao, M Foster Olive, William C Griffin, Ke-Yong Li, Kresimir Krnjević, Chunyi Zhou, Jiang-Hong Y. Ethanol facilitates glutamatergic transmission to dopamine neurons in the ventral tegmental area. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 2. 2009-02-23. PMID:18596684. |
ethanol facilitates glutamatergic transmission to dopamine neurons in the ventral tegmental area. |
2009-02-23 |
2023-08-12 |
rat |
| Cheng Xiao, Xuesi Max Shao, M Foster Olive, William C Griffin, Ke-Yong Li, Kresimir Krnjević, Chunyi Zhou, Jiang-Hong Y. Ethanol facilitates glutamatergic transmission to dopamine neurons in the ventral tegmental area. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 2. 2009-02-23. PMID:18596684. |
in several brain areas, ethanol depresses glutamatergic excitatory transmission, but how it affects excitatory synapses on dopamine neurons of the ventral tegmental area (vta), a crucial site for the development of drug addiction, is not known. |
2009-02-23 |
2023-08-12 |
rat |
| Cheng Xiao, Xuesi Max Shao, M Foster Olive, William C Griffin, Ke-Yong Li, Kresimir Krnjević, Chunyi Zhou, Jiang-Hong Y. Ethanol facilitates glutamatergic transmission to dopamine neurons in the ventral tegmental area. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 2. 2009-02-23. PMID:18596684. |
we report here that in midbrain slices from rats, clinically relevant concentrations of ethanol (10-80 mm) increase the amplitude of evoked epscs and reduce their paired-pulse ratio in dopamine neurons in the vta. |
2009-02-23 |
2023-08-12 |
rat |
| Cheng Xiao, Xuesi Max Shao, M Foster Olive, William C Griffin, Ke-Yong Li, Kresimir Krnjević, Chunyi Zhou, Jiang-Hong Y. Ethanol facilitates glutamatergic transmission to dopamine neurons in the ventral tegmental area. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 2. 2009-02-23. PMID:18596684. |
the effects of ethanol are mimicked by skf 38393, a dopamine d(1) receptor agonist, and by gbr 12935, a dopamine reuptake inhibitor, and they are blocked by skf 83566, a d(1) antagonist, or by reserpine, which depletes dopamine stores. |
2009-02-23 |
2023-08-12 |
rat |
| Cheng Xiao, Xuesi Max Shao, M Foster Olive, William C Griffin, Ke-Yong Li, Kresimir Krnjević, Chunyi Zhou, Jiang-Hong Y. Ethanol facilitates glutamatergic transmission to dopamine neurons in the ventral tegmental area. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 2. 2009-02-23. PMID:18596684. |
we therefore conclude that, acting via presynaptic d(1) receptors, ethanol at low concentrations increases glutamate release in the vta, thus raising somatodendritic dopamine release, which further activates the presynaptic d(1) receptors. |
2009-02-23 |
2023-08-12 |
rat |
| Céline Riegert, Franziska Wedekind, Sami Ben Hamida, Susanne Rutz, Anna Katharina Rothmaier, Byron C Jones, Jean-Christophe Cassel, Rolf Jackisc. Effects of ethanol and 3,4-methylenedioxymethamphetamine (MDMA) alone or in combination on spontaneous and evoked overflow of dopamine, serotonin and acetylcholine in striatal slices of the rat brain. The international journal of neuropsychopharmacology. vol 11. issue 6. 2008-12-18. PMID:18248690. |
effects of ethanol and 3,4-methylenedioxymethamphetamine (mdma) alone or in combination on spontaneous and evoked overflow of dopamine, serotonin and acetylcholine in striatal slices of the rat brain. |
2008-12-18 |
2023-08-12 |
rat |
| K G Akash, T R Anju, K T Peeyush, C S Paulos. Enhanced dopamine D2 receptor function in hypothalamus and corpus striatum: their role in liver, plasma and in vitro hepatocyte ALDH regulation in ethanol treated rats. Journal of biomedical science. vol 15. issue 5. 2008-12-03. PMID:18536982. |
enhanced dopamine d2 receptor function in hypothalamus and corpus striatum: their role in liver, plasma and in vitro hepatocyte aldh regulation in ethanol treated rats. |
2008-12-03 |
2023-08-12 |
rat |
| K G Akash, T R Anju, K T Peeyush, C S Paulos. Enhanced dopamine D2 receptor function in hypothalamus and corpus striatum: their role in liver, plasma and in vitro hepatocyte ALDH regulation in ethanol treated rats. Journal of biomedical science. vol 15. issue 5. 2008-12-03. PMID:18536982. |
dopamine d(2) receptors are involved in ethanol self- administration behavior and also suggested to mediate the onset and offset of ethanol drinking. |
2008-12-03 |
2023-08-12 |
rat |
| K G Akash, T R Anju, K T Peeyush, C S Paulos. Enhanced dopamine D2 receptor function in hypothalamus and corpus striatum: their role in liver, plasma and in vitro hepatocyte ALDH regulation in ethanol treated rats. Journal of biomedical science. vol 15. issue 5. 2008-12-03. PMID:18536982. |
in the present study, we investigated dopamine (da) content and dopamine d(2) (da d(2)) receptors in the hypothalamus and corpus striatum of ethanol treated rats and aldehyde dehydrogenase (aldh) activity in the liver and plasma of ethanol treated rats and in vitro hepatocyte cultures. |
2008-12-03 |
2023-08-12 |
rat |
| K G Akash, T R Anju, K T Peeyush, C S Paulos. Enhanced dopamine D2 receptor function in hypothalamus and corpus striatum: their role in liver, plasma and in vitro hepatocyte ALDH regulation in ethanol treated rats. Journal of biomedical science. vol 15. issue 5. 2008-12-03. PMID:18536982. |
sulpiride, an antagonist of da d(2), reversed the effect of dopamine on 10% ethanol induced aldh activity in hepatocytes. |
2008-12-03 |
2023-08-12 |
rat |
| K G Akash, T R Anju, K T Peeyush, C S Paulos. Enhanced dopamine D2 receptor function in hypothalamus and corpus striatum: their role in liver, plasma and in vitro hepatocyte ALDH regulation in ethanol treated rats. Journal of biomedical science. vol 15. issue 5. 2008-12-03. PMID:18536982. |
our results showed a decreased dopamine concentration with enhanced da d(2) receptors in the hypothalamus and corpus striatum of ethanol treated rats. |
2008-12-03 |
2023-08-12 |
rat |