| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paul J Meyer, Charles K Meshul, Tamara J Phillip. Ethanol- and cocaine-induced locomotion are genetically related to increases in accumbal dopamine. Genes, brain, and behavior. vol 8. issue 3. 2009-07-14. PMID:19220481. |
to test this, we measured drug-induced changes in dopamine and glutamate within the nucleus accumbens (nacc), a major target of mesolimbic dopamine neurons, using in vivo microdialysis in selectively bred fast and slow mouse lines, which were bred for extreme sensitivity (fast) and insensitivity (slow) to the locomotor stimulant effects of ethanol. |
2009-07-14 |
2023-08-12 |
mouse |
| Paul J Meyer, Charles K Meshul, Tamara J Phillip. Ethanol- and cocaine-induced locomotion are genetically related to increases in accumbal dopamine. Genes, brain, and behavior. vol 8. issue 3. 2009-07-14. PMID:19220481. |
single injections of ethanol (2 g/kg) or cocaine (40 mg/kg) resulted in larger increases in dopamine within the nacc in fast compared with slow mice. |
2009-07-14 |
2023-08-12 |
mouse |
| Paul J Meyer, Charles K Meshul, Tamara J Phillip. Ethanol- and cocaine-induced locomotion are genetically related to increases in accumbal dopamine. Genes, brain, and behavior. vol 8. issue 3. 2009-07-14. PMID:19220481. |
because increased sensitivity to the stimulating effects of ethanol appears to be associated with greater risk for alcohol abuse, genetically determined differences in the mesolimbic dopamine response to ethanol may represent a critical underlying mechanism for increased genetic risk for alcoholism. |
2009-07-14 |
2023-08-12 |
mouse |
| B Söderpalm, E Löf, M Ericso. Mechanistic studies of ethanol's interaction with the mesolimbic dopamine reward system. Pharmacopsychiatry. vol 42 Suppl 1. 2009-07-01. PMID:19434560. |
mechanistic studies of ethanol's interaction with the mesolimbic dopamine reward system. |
2009-07-01 |
2023-08-12 |
Not clear |
| B Söderpalm, E Löf, M Ericso. Mechanistic studies of ethanol's interaction with the mesolimbic dopamine reward system. Pharmacopsychiatry. vol 42 Suppl 1. 2009-07-01. PMID:19434560. |
our data indicate that a neuronal circuitry involving glycine receptors in the nucleus accumbens, and, secondarily, nicotinic acetylcholine receptors in the ventral tegmental area is involved in the mesolimbic dopamine activating and reinforcing effects of ethanol. |
2009-07-01 |
2023-08-12 |
Not clear |
| B Söderpalm, E Löf, M Ericso. Mechanistic studies of ethanol's interaction with the mesolimbic dopamine reward system. Pharmacopsychiatry. vol 42 Suppl 1. 2009-07-01. PMID:19434560. |
the proposed neurocircuitry, has implications for understanding ethanol conditioned dopamine activation, chronic effects of ethanol on the mesolimbic dopamine system and the overall role/importance of dopamine and the nucleus accumbens for the reinforcing effects of ethanol. |
2009-07-01 |
2023-08-12 |
Not clear |
| Angela C Scibelli, Tamara J Phillip. Combined scopolamine and ethanol treatment results in a locomotor stimulant response suggestive of synergism that is not blocked by dopamine receptor antagonists. Alcoholism, clinical and experimental research. vol 33. issue 3. 2009-06-19. PMID:19120057. |
we also investigated whether the dopamine d1-like receptor antagonist, sch-23390 or the dopamine d2-like receptor antagonist, haloperidol, could block the extreme stimulant response found following co-administration of scopolamine and ethanol. |
2009-06-19 |
2023-08-12 |
Not clear |
| Cunlan Guo, Zhelin Liu, Fugang Xu, Lanlan Sun, Yujing Sun, Tao Yang, Zhuang L. Surface-relevant regulable DNA toroids induced by dopamine. The journal of physical chemistry. B. vol 113. issue 17. 2009-06-19. PMID:19344139. |
though the electrostatic interaction of dna and dopamine was weak in aqueous solution, dopamine condensed circular pbr322 dna into toroids on the mica surface cooperatively with ethanol. |
2009-06-19 |
2023-08-12 |
Not clear |
| Christina M Gremel, Christopher L Cunningha. Involvement of amygdala dopamine and nucleus accumbens NMDA receptors in ethanol-seeking behavior in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 6. 2009-06-17. PMID:18830237. |
in the present experiments, we used site-specific microinfusions of dopamine and nmda receptor antagonists to examine the roles of accumbens and amygdala in the expression of ethanol conditioned place preference (cpp) in mice. |
2009-06-17 |
2023-08-12 |
mouse |
| Ryan Ting-A-Kee, Colleen Dockstader, Andrew Heinmiller, Taryn Grieder, Derek van der Koo. GABA(A) receptors mediate the opposing roles of dopamine and the tegmental pedunculopontine nucleus in the motivational effects of ethanol. The European journal of neuroscience. vol 29. issue 6. 2009-06-09. PMID:19302158. |
gaba(a) receptors mediate the opposing roles of dopamine and the tegmental pedunculopontine nucleus in the motivational effects of ethanol. |
2009-06-09 |
2023-08-12 |
mouse |
| Jonathan W Theile, Hitoshi Morikawa, Rueben A Gonzales, Richard A Morriset. Role of 5-hydroxytryptamine2C receptors in Ca2+-dependent ethanol potentiation of GABA release onto ventral tegmental area dopamine neurons. The Journal of pharmacology and experimental therapeutics. vol 329. issue 2. 2009-05-22. PMID:19225162. |
role of 5-hydroxytryptamine2c receptors in ca2+-dependent ethanol potentiation of gaba release onto ventral tegmental area dopamine neurons. |
2009-05-22 |
2023-08-12 |
Not clear |
| Matthew J Wanat, Dennis R Sparta, F Woodward Hopf, M Scott Bowers, Miriam Melis, Antonello Bonc. Strain specific synaptic modifications on ventral tegmental area dopamine neurons after ethanol exposure. Biological psychiatry. vol 65. issue 8. 2009-05-19. PMID:19118821. |
strain specific synaptic modifications on ventral tegmental area dopamine neurons after ethanol exposure. |
2009-05-19 |
2023-08-12 |
mouse |
| Matthew J Wanat, Dennis R Sparta, F Woodward Hopf, M Scott Bowers, Miriam Melis, Antonello Bonc. Strain specific synaptic modifications on ventral tegmental area dopamine neurons after ethanol exposure. Biological psychiatry. vol 65. issue 8. 2009-05-19. PMID:19118821. |
whereas the ventral tegmental area (vta) importantly regulates dopamine levels and ethanol intake, it is unknown whether ethanol experience differentially alters synaptic properties of vta dopamine neurons in ethanol-preferring and non-preferring mice. |
2009-05-19 |
2023-08-12 |
mouse |
| Chunyu Deng, Ke-Yong Li, Chunyi Zhou, Jiang-Hong Y. Ethanol enhances glutamate transmission by retrograde dopamine signaling in a postsynaptic neuron/synaptic bouton preparation from the ventral tegmental area. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 5. 2009-05-07. PMID:18784647. |
ethanol enhances glutamate transmission by retrograde dopamine signaling in a postsynaptic neuron/synaptic bouton preparation from the ventral tegmental area. |
2009-05-07 |
2023-08-12 |
rat |
| Chunyu Deng, Ke-Yong Li, Chunyi Zhou, Jiang-Hong Y. Ethanol enhances glutamate transmission by retrograde dopamine signaling in a postsynaptic neuron/synaptic bouton preparation from the ventral tegmental area. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 5. 2009-05-07. PMID:18784647. |
we hypothesized that ethanol facilitation might result from an increase in somatodendritically released dopamine, which acts retrogradely on dopamine d(1) receptors on glutamate-releasing axons and consequently leads to an increase in glutamate release onto dopaminergic neurons. |
2009-05-07 |
2023-08-12 |
rat |
| Chunyu Deng, Ke-Yong Li, Chunyi Zhou, Jiang-Hong Y. Ethanol enhances glutamate transmission by retrograde dopamine signaling in a postsynaptic neuron/synaptic bouton preparation from the ventral tegmental area. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 5. 2009-05-07. PMID:18784647. |
ethanol facilitation was mimicked by the d(1) agonist skf 38393 and by the dopamine uptake blocker gbr 12935 but was blocked by the d(1) antagonist skf 83566, and by depleting dopamine stores with reserpine, as well as by chelating postsynaptic calcium with bapta. |
2009-05-07 |
2023-08-12 |
rat |
| Chunyu Deng, Ke-Yong Li, Chunyi Zhou, Jiang-Hong Y. Ethanol enhances glutamate transmission by retrograde dopamine signaling in a postsynaptic neuron/synaptic bouton preparation from the ventral tegmental area. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 5. 2009-05-07. PMID:18784647. |
furthermore, ethanol stimulation of a single dopaminergic neuron is capable of eliciting the release of somatodendritic dopamine, which is sufficient to influence glutamatergic transmission at individual synapses. |
2009-05-07 |
2023-08-12 |
rat |
| Michael J Beckstead, Tamara J Phillip. Mice selectively bred for high- or low-alcohol-induced locomotion exhibit differences in dopamine neuron function. The Journal of pharmacology and experimental therapeutics. vol 329. issue 1. 2009-04-28. PMID:19122113. |
midbrain dopamine neurons are thought to be important mediators of both ethanol reward and locomotor stimulation. |
2009-04-28 |
2023-08-12 |
mouse |
| Michael J Beckstead, Tamara J Phillip. Mice selectively bred for high- or low-alcohol-induced locomotion exhibit differences in dopamine neuron function. The Journal of pharmacology and experimental therapeutics. vol 329. issue 1. 2009-04-28. PMID:19122113. |
patch-clamp recordings were used to examine the electrical properties of dopamine neurons in a genetic model of heightened (fast) and reduced (slow) sensitivity to the locomotor-activating effects of ethanol. |
2009-04-28 |
2023-08-12 |
mouse |
| Michael J Beckstead, Tamara J Phillip. Mice selectively bred for high- or low-alcohol-induced locomotion exhibit differences in dopamine neuron function. The Journal of pharmacology and experimental therapeutics. vol 329. issue 1. 2009-04-28. PMID:19122113. |
acute administration of ethanol accelerated the firing of dopamine neurons to a greater extent in recordings from fast than slow mice. |
2009-04-28 |
2023-08-12 |
mouse |