| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tiina Leino, Timo Viitamaa, Antti Haapalinna, Jyrki Lehtimäki, Raimo Virtane. Pharmacological profile of intrathecal fadolmidine, a alpha2-adrenoceptor agonist, in rodent models. Naunyn-Schmiedeberg's archives of pharmacology. vol 380. issue 6. 2010-03-30. PMID:19826791. |
the difference in the systemic effect profile between fadolmidine and clonidine or dexmedetomidine is most probably explained by differences in their ability to spread from the site of administration at the lumbar level into the periphery and/or the brain and further the concentrations of the compounds in the side of action. |
2010-03-30 |
2023-08-12 |
rat |
| Héctor M Torres, Serafín C Lópe. Awake laminotomy and discectomy using Dexmedetomidine as anesthetic. Puerto Rico health sciences journal. vol 28. issue 4. 2010-01-26. PMID:19999245. |
awake laminotomy and discectomy could be performed as an ambulatory procedure, since the use of dexmedetomidine as the main anesthetic represents a safe and convenient alternative to general anesthesia in this patient with lumbar disc herniation. |
2010-01-26 |
2023-08-12 |
Not clear |
| Duncan W Blake, David A Scott, James A Angus, Christine E Wrigh. Synergy between intrathecal omega-conotoxin CVID and dexmedetomidine to attenuate mechanical hypersensitivity in the rat. European journal of pharmacology. vol 506. issue 3. 2005-03-22. PMID:15627431. |
omega-conotoxin cvid, an n-type ca2+ channel antagonist, and the alpha2-adrenoceptor agonist, dexmedetomidine, were tested alone and in combination following unilateral ligation of l (lumbar) 5/6 spinal nerves in rats. |
2005-03-22 |
2023-08-12 |
rat |
| Noriko Shimode, Tetsuo Fukuoka, Masaaki Tanimoto, Chikara Tashiro, Atsushi Tokunaga, Koichi Noguch. The effects of dexmedetomidine and halothane on Fos expression in the spinal dorsal horn using a rat postoperative pain model. Neuroscience letters. vol 343. issue 1. 2003-07-01. PMID:12749994. |
we investigated the effect of an intrathecal injection of a selective alpha2 adrenergic receptor agonist, dexmedetomidine (dex), and halothane anesthesia on fos expression in the lumbar spinal dorsal horn after skin incision of the plantar surface of the hind paw, a postoperative pain model using rats. |
2003-07-01 |
2023-08-12 |
rat |
| P Talke, C Tong, H W Lee, J Caldwell, J C Eisenach, C A Richardso. Effect of dexmedetomidine on lumbar cerebrospinal fluid pressure in humans. Anesthesia and analgesia. vol 85. issue 2. 1997-09-03. PMID:9249114. |
effect of dexmedetomidine on lumbar cerebrospinal fluid pressure in humans. |
1997-09-03 |
2023-08-12 |
Not clear |
| P Talke, C Tong, H W Lee, J Caldwell, J C Eisenach, C A Richardso. Effect of dexmedetomidine on lumbar cerebrospinal fluid pressure in humans. Anesthesia and analgesia. vol 85. issue 2. 1997-09-03. PMID:9249114. |
we therefore studied the effect of dexmedetomidine on lumbar cerebrospinal fluid (csf) pressure in patients after transphenoidal pituitary tumor surgery. |
1997-09-03 |
2023-08-12 |
Not clear |
| P Talke, C Tong, H W Lee, J Caldwell, J C Eisenach, C A Richardso. Effect of dexmedetomidine on lumbar cerebrospinal fluid pressure in humans. Anesthesia and analgesia. vol 85. issue 2. 1997-09-03. PMID:9249114. |
we conclude that dexmedetomidine does not have an effect on lumbar csf pressure in patients with normal intracranial pressure who have undergone transphenoidal pituitary hypophysectomy. |
1997-09-03 |
2023-08-12 |
Not clear |
| T L Yaksh, J W Pogrel, Y W Lee, S R Chapla. Reversal of nerve ligation-induced allodynia by spinal alpha-2 adrenoceptor agonists. The Journal of pharmacology and experimental therapeutics. vol 272. issue 1. 1995-02-08. PMID:7815335. |
lumbar intrathecal injection of alpha-2, but not alpha-1 or an opiate agonist, resulted in a dose-dependent reversal of the allodynia, with the ordering of activity (ed50 in micrograms in parentheses) being dexmedetomidine (0.9) > oxymetazoline (14) = guanfacine (17) = 5-bromo-6-(2-imidazolin-2-ylamino)quinoxaline (19) = 2-(2,6-diethylphenylamino)-2-imidazoline (21) = clonidine (22) > morphine (> 30) = methoxamine (> 30 micrograms). |
1995-02-08 |
2023-08-12 |
rat |
| B Fisher, M H Zornow, T L Yaksh, B M Peterso. Antinociceptive properties of intrathecal dexmedetomidine in rats. European journal of pharmacology. vol 192. issue 2. 1991-06-26. PMID:1674472. |
in this study, the intrathecal administration of dexmedetomidine into the rat lumbar subarachnoid space produced dose-dependent, prolonged antinociception as measured by hot plate and tail flick testing. |
1991-06-26 |
2023-08-11 |
rat |