| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Irma E Cisneros, Mert Erdenizmenli, Kathryn A Cunningham, Slobodan Paessler, Kelly T Dinele. Cocaine evokes a profile of oxidative stress and impacts innate antiviral response pathways in astrocytes. Neuropharmacology. vol 135. 2019-02-20. PMID:29578037. |
both ppf/pio protected against cocaine-mediated generation of reactive oxygen species (ros), increased dsdna, antiviral signaling pathways and increased type i interferon, indicating that cocaine induces astrocyte type i interferon signaling in the absence of virus and oxidative stress is a major driver of cocaine-mediated astrocyte antiviral immunity. |
2019-02-20 |
2023-08-13 |
Not clear |
| Bianca Cotto, Kalimuthusamy Natarajaseenivasan, Kimberly Ferrero, Leroy Wesley, Matthew Sayre, Dianne Langfor. Cocaine and HIV-1 Tat disrupt cholesterol homeostasis in astrocytes: Implications for HIV-associated neurocognitive disorders in cocaine user patients. Glia. vol 66. issue 4. 2018-08-30. PMID:29330881. |
hiv infection of the cns in combination with cocaine use is associated with astrocyte and neuronal energy deficit and damage. |
2018-08-30 |
2023-08-13 |
Not clear |
| Chun-Ting Lee, Kristen L Boeshore, Chun Wu, Kevin G Becker, Stacie L Errico, Deborah C Mash, William J Free. Cocaine promotes primary human astrocyte proliferation via JNK-dependent up-regulation of cyclin A2. Restorative neurology and neuroscience. vol 34. issue 6. 2018-01-09. PMID:27834787. |
cocaine promotes primary human astrocyte proliferation via jnk-dependent up-regulation of cyclin a2. |
2018-01-09 |
2023-08-13 |
human |
| Lu Cao, Mary P Walker, Naveen K Vaidya, Mingui Fu, Santosh Kumar, Anil Kuma. Cocaine-Mediated Autophagy in Astrocytes Involves Sigma 1 Receptor, PI3K, mTOR, Atg5/7, Beclin-1 and Induces Type II Programed Cell Death. Molecular neurobiology. vol 53. issue 7. 2018-01-08. PMID:26243186. |
we employed astrocyte, the most abundant cell in the cns, to define the effects of cocaine on autophagy. |
2018-01-08 |
2023-08-13 |
human |
| Robert M Rapoport, SeongHun Yoon, Mario Zuccarell. Cocaine Constrictor Mechanisms of the Cerebral Vasculature. Journal of cardiovascular pharmacology. vol 67. issue 5. 2017-09-11. PMID:26771152. |
despite these apparent limitations, we surmise that the vasoconstriction relevant to cocaine-induced ischemia is elicited by inhibition of dilator and activation of constrictor pathways because of cocaine action on the neurovascular unit (neuron, astrocyte, and vessel) and on vessels outside the unit. |
2017-09-11 |
2023-08-13 |
human |
| Yu Cai, Lu Yang, Shannon Callen, Shilpa Buc. Multiple Faceted Roles of Cocaine in Potentiation of HAND. Current HIV research. vol 14. issue 5. 2017-08-10. PMID:27009095. |
cocaine also enhances viral replication in cns astrocytes and promotes astrogliosis via astrocyte activation and proliferation. |
2017-08-10 |
2023-08-13 |
human |
| Michael D Scofield, Hao Li, Benjamin M Siemsen, Kati L Healey, Phuong K Tran, Nicholas Woronoff, Heather A Boger, Peter W Kalivas, Kathryn J Reissne. Cocaine Self-Administration and Extinction Leads to Reduced Glial Fibrillary Acidic Protein Expression and Morphometric Features of Astrocytes in the Nucleus Accumbens Core. Biological psychiatry. vol 80. issue 3. 2017-08-07. PMID:26946381. |
we investigated the effects of extinction from daily cocaine self-administration on astrocyte characteristics including glial fibrillary acidic protein (gfap) expression, surface area, volume, and colocalization with a synaptic marker. |
2017-08-07 |
2023-08-13 |
Not clear |
| Lu Yang, Honghong Yao, Xufeng Chen, Yu Cai, Shannon Callen, Shilpa Buc. Role of Sigma Receptor in Cocaine-Mediated Induction of Glial Fibrillary Acidic Protein: Implications for HAND. Molecular neurobiology. vol 53. issue 2. 2016-12-13. PMID:25631712. |
we next sought to explore whether cocaine exposure could result in increased expression of glial fibrillary acidic protein (gfap), a filament protein critical for astrocyte activation. |
2016-12-13 |
2023-08-13 |
mouse |
| Lu Yang, Honghong Yao, Xufeng Chen, Yu Cai, Shannon Callen, Shilpa Buc. Role of Sigma Receptor in Cocaine-Mediated Induction of Glial Fibrillary Acidic Protein: Implications for HAND. Molecular neurobiology. vol 53. issue 2. 2016-12-13. PMID:25631712. |
cocaine abuse has been shown to accelerate the progression of human immunodeficiency virus (hiv)-1-associated neurological disorders (hands) partially through increasing neuroinflammatory response mediated by activated astrocytes; however, the detailed molecular mechanism of cocaine-mediated astrocyte activation is unclear. |
2016-12-13 |
2023-08-13 |
mouse |
| Ramesh B Badisa, Carl B Goodma. Effects of chronic cocaine in rat C6 astroglial cells. International journal of molecular medicine. vol 30. issue 3. 2012-11-06. PMID:22735768. |
it was observed that cocaine caused a significant dose-dependent decrease in astroglial cell viability with an lc(50) of 4.717 mm. |
2012-11-06 |
2023-08-12 |
rat |
| Yanjing Yang, Honghong Yao, Yaman Lu, Chao Wang, Shilpa Buc. Cocaine potentiates astrocyte toxicity mediated by human immunodeficiency virus (HIV-1) protein gp120. PloS one. vol 5. issue 10. 2011-03-07. PMID:20976166. |
cocaine potentiates astrocyte toxicity mediated by human immunodeficiency virus (hiv-1) protein gp120. |
2011-03-07 |
2023-08-12 |
human |
| Oren Ben-Ami, Noa Kinor, Alexander Perelman, Gal Yadi. Dopamine-1 receptor agonist, but not cocaine, modulates sigma(1) gene expression in SVG cells. Journal of molecular neuroscience : MN. vol 29. issue 2. 2007-04-02. PMID:16954606. |
herein we describe the effects of cocaine and the selective dopamine-1 receptor (d(1)r) agonist, (+)-skf38393, on gene expression of the sigma(1)r in a human fetal astrocyte cell line (svg cells). |
2007-04-02 |
2023-08-12 |
human |
| L Hertz, Y Chen, M E Gibbs, P Zang, L Pen. Astrocytic adrenoceptors: a major drug target in neurological and psychiatric disorders? Current drug targets. CNS and neurological disorders. vol 3. issue 3. 2004-08-20. PMID:15180484. |
noradrenergic function in astrocytes is severely disturbed by chronic exposure to cocaine, which also changes astrocyte morphology. |
2004-08-20 |
2023-08-12 |
Not clear |
| Eugene D Festa, Christine Cecala, Vanya Quinones-Jenab, Shirzad Jena. Cocaine modulates mu-opioid receptor mRNA but not c-fos mRNA levels in primary cortical astrocytes. Brain research bulletin. vol 58. issue 3. 2002-11-06. PMID:12128154. |
our data suggest that cocaine differentially modulates c-fos and opioid signaling in astrocyte cell culture. |
2002-11-06 |
2023-08-12 |
rat |
| Eugene D Festa, Christine Cecala, Vanya Quinones-Jenab, Shirzad Jena. Cocaine modulates mu-opioid receptor mRNA but not c-fos mRNA levels in primary cortical astrocytes. Brain research bulletin. vol 58. issue 3. 2002-11-06. PMID:12128154. |
in this study we investigated the effects of cocaine on c-fos and mu-opioid receptor mrna levels in primary cortical astrocyte cultures, using rt-pcr and quantitative solution hybridization assays. |
2002-11-06 |
2023-08-12 |
rat |
| Eugene D Festa, Christine Cecala, Vanya Quinones-Jenab, Shirzad Jena. Cocaine modulates mu-opioid receptor mRNA but not c-fos mRNA levels in primary cortical astrocytes. Brain research bulletin. vol 58. issue 3. 2002-11-06. PMID:12128154. |
astrocyte cultures from 1-day-old fischer rats were untreated or treated with cocaine for 30min, 2h, or 5h. |
2002-11-06 |
2023-08-12 |
rat |
| A L Silva-Araújo, M A Tavare. Expression of glial fibrillary acidic protein in the rat retina after exposure to psychostimulants. Retina (Philadelphia, Pa.). vol 15. issue 3. 1995-11-07. PMID:7569352. |
this study was designed to evaluate the extent of retinal astrocytic response by using the astrocyte localized protein, glial fibrillary acidic protein, after neonatal exposure to cocaine and amphetamine. |
1995-11-07 |
2023-08-12 |
rat |