| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qiaowei Xie, Rohan Dasari, Mark D Namba, Lauren A Buck, Christine M Side, Kyewon Park, Joshua G Jackson, Jacqueline M Barke. Astrocytic Regulation of Cocaine Locomotor Sensitization in EcoHIV Infected Mice. Neuropharmacology. 2024-12-04. PMID:39631679. |
we found that chemogenetic activation of nac astrocyte gq signaling attenuated ecohiv-enhanced cocaine sensitization. |
2024-12-04 |
2024-12-07 |
mouse |
| Anze Testen, Jonathan W VanRyzin, Tania J Bellinger, Ronald Kim, Han Wang, Matthew J Gastinger, Emily A Witt, Janay P Franklin, Haley A Vecchiarelli, Katherine Picard, Marie-Ève Tremblay, Kathryn J Reissne. Abstinence from cocaine self-administration promotes microglia pruning of astrocytes which drives cocaine-seeking behavior. bioRxiv : the preprint server for biology. 2024-09-30. PMID:39345569. |
inhibition of complement c3-mediated phagocytosis using the neutrophil inhibitory peptide (nif) rescued astrocyte structure and decreased cocaine seeking behavior following cocaine self-administration and abstinence. |
2024-09-30 |
2024-10-02 |
Not clear |
| Anze Testen, Jonathan W VanRyzin, Tania J Bellinger, Ronald Kim, Han Wang, Matthew J Gastinger, Emily A Witt, Janay P Franklin, Haley A Vecchiarelli, Katherine Picard, Marie-Ève Tremblay, Kathryn J Reissne. Abstinence from cocaine self-administration promotes microglia pruning of astrocytes which drives cocaine-seeking behavior. bioRxiv : the preprint server for biology. 2024-09-30. PMID:39345569. |
however, the mechanisms driving astrocyte responses to cocaine are unknown. |
2024-09-30 |
2024-10-02 |
Not clear |
| Qiaowei Xie, Rohan Dasari, Mark D Namba, Lauren A Buck, Christine M Side, Kyewon Park, Joshua G Jackson, Jacqueline M Barke. Astrocytic Regulation of Cocaine Locomotor Sensitization in EcoHIV Infected Mice. bioRxiv : the preprint server for biology. 2024-09-16. PMID:39282274. |
we found that chemogenetic activation of nac astrocyte gq signaling attenuated ecohiv-enhanced cocaine sensitization. |
2024-09-16 |
2024-09-19 |
mouse |
| Janay P Franklin, Anze Testen, Piotr A Mieczkowski, Austin Hepperla, Gogce Crynen, Jeremy M Simon, Jonathan D Wood, Eden V Harder, Tania J Bellinger, Emily A Witt, N LaShae Powell, Kathryn J Reissne. Investigating cocaine- and abstinence-induced effects on astrocyte gene expression in the nucleus accumbens. bioRxiv : the preprint server for biology. 2024-08-16. PMID:39149305. |
overall, the results of this study provide insight into astrocyte functional adaptations that occur due to cocaine exposure or during cocaine withdrawal, which may pinpoint further mechanisms that contribute to cocaine-seeking behavior. |
2024-08-16 |
2024-08-18 |
rat |
| Janay P Franklin, Anze Testen, Piotr A Mieczkowski, Austin Hepperla, Gogce Crynen, Jeremy M Simon, Jonathan D Wood, Eden V Harder, Tania J Bellinger, Emily A Witt, N LaShae Powell, Kathryn J Reissne. Investigating cocaine- and abstinence-induced effects on astrocyte gene expression in the nucleus accumbens. bioRxiv : the preprint server for biology. 2024-08-16. PMID:39149305. |
the current study aims to elucidate the molecular modifications that lead to observed astrocyte structural changes in rats across cocaine abstinence using astrocyte-specific ribotag and rna-seq, as an unbiased, comprehensive approach to identify genes whose transcription or translation change within nac astrocytes following cocaine self- administration and extended abstinence. |
2024-08-16 |
2024-08-18 |
rat |
| Janay P Franklin, Anze Testen, Piotr A Mieczkowski, Austin Hepperla, Gogce Crynen, Jeremy M Simon, Jonathan D Wood, Eden V Harder, Tania J Bellinger, Emily A Witt, N LaShae Powell, Kathryn J Reissne. Investigating cocaine- and abstinence-induced effects on astrocyte gene expression in the nucleus accumbens. bioRxiv : the preprint server for biology. 2024-08-16. PMID:39149305. |
using this method, our data reveal cellular processes including cholesterol biosynthesis that are altered specifically by cocaine self-administration and abstinence, suggesting that astrocyte involvement in these processes is changed in cocaine-abstinent rats. |
2024-08-16 |
2024-08-18 |
rat |
| Mengfan Xia, Tanner A Anderson, Emily R Prantzalos, Tara R Hawkinson, Harrison A Clarke, Shannon B Keohane, Ramon C Sun, Jill R Turner, Pavel I Ortinsk. Voltage-gated potassium channels control extended access cocaine seeking: a role for nucleus accumbens astrocytes. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023-09-02. PMID:37660129. |
although astrocytes respond to dopamine and cocaine with structural changes, the impact of dopamine and cocaine on astrocyte functional plasticity has not been widely studied. |
2023-09-02 |
2023-09-07 |
Not clear |
| Marina Fandaros, Yanzuo Liu, Yueming Hua, Yingtian Pan, David A Rubenstein, Congwu Du, Wei Yi. Cocaine affects astrocyte activation and iNOS expression. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35553228. |
sholl analysis demonstrated that cocaine and lps both induced significant morphological changes and reduced the number of astrocyte processes. |
2022-05-13 |
2023-08-13 |
mouse |
| Marina Fandaros, Yanzuo Liu, Yueming Hua, Yingtian Pan, David A Rubenstein, Congwu Du, Wei Yi. Cocaine affects astrocyte activation and iNOS expression. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35553228. |
we hypothesize that cocaine can cause astrocyte activation and inflammation, resulting in inos upregulation, which can in turn, affect both neuronal and brain microvascular endothelial functions. |
2022-05-13 |
2023-08-13 |
mouse |
| Marina Fandaros, Yanzuo Liu, Yueming Hua, Yingtian Pan, David A Rubenstein, Congwu Du, Wei Yi. Cocaine affects astrocyte activation and iNOS expression. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35553228. |
cocaine affects astrocyte activation and inos expression. |
2022-05-13 |
2023-08-13 |
mouse |
| Marina Fandaros, Yanzuo Liu, Yueming Hua, Yingtian Pan, David A Rubenstein, Congwu Du, Wei Yi. Cocaine affects astrocyte activation and iNOS expression. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35553228. |
to test this hypothesis, an in vitro astrocyte culture model and an in vivo chronic cocaine mouse model were used. |
2022-05-13 |
2023-08-13 |
mouse |
| Mayur Doke, Fatah Kashanchi, Mansoor A Khan, Thangavel Samikkann. HIV-1 Tat and cocaine coexposure impacts piRNAs to affect astrocyte energy metabolism. Epigenomics. 2022-02-16. PMID:35170353. |
hiv-1 tat and cocaine coexposure impacts pirnas to affect astrocyte energy metabolism. |
2022-02-16 |
2023-08-13 |
Not clear |
| Hong-Ju Yang, Briana J Hempel, Guo-Hua Bi, Yi He, Hai-Ying Zhang, Eliot L Gardner, Zheng-Xiong X. Elevation of extracellular glutamate by blockade of astrocyte glutamate transporters inhibits cocaine reinforcement in rats via a NMDA-GluN2B receptor mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-01-29. PMID:35091501. |
elevation of extracellular glutamate by blockade of astrocyte glutamate transporters inhibits cocaine reinforcement in rats via a nmda-glun2b receptor mechanism. |
2022-01-29 |
2023-08-13 |
rat |
| Mayur Doke, Fatah Kashanchi, Mansoor A Khan, Thangavel Samikkann. HIV-1 Tat and cocaine impact astrocytic energy reservoir influence on miRNA epigenetic regulation. Genomics. vol 113. issue 6. 2021-12-11. PMID:34418497. |
however, mirna-mediated astrocyte energy metabolism has not been delineated in hiv infection and cocaine abuse. |
2021-12-11 |
2023-08-13 |
Not clear |
| Kalaiselvi Sivalingam, Thomas J Cirino, Jay P McLaughlin, Thangavel Samikkann. HIV-Tat and Cocaine Impact Brain Energy Metabolism: Redox Modification and Mitochondrial Biogenesis Influence NRF Transcription-Mediated Neurodegeneration. Molecular neurobiology. vol 58. issue 2. 2021-09-01. PMID:32978730. |
these processes are important components of the astrocyte signaling network regulating brain energy metabolism in hiv-positive cocaine users. |
2021-09-01 |
2023-08-13 |
mouse |
| Kalaiselvi Sivalingam, Thomas J Cirino, Jay P McLaughlin, Thangavel Samikkann. HIV-Tat and Cocaine Impact Brain Energy Metabolism: Redox Modification and Mitochondrial Biogenesis Influence NRF Transcription-Mediated Neurodegeneration. Molecular neurobiology. vol 58. issue 2. 2021-09-01. PMID:32978730. |
the mechanisms by which hiv infection and cocaine consumption affect astrocyte energy metabolism, and how this leads to neurodegenerative dysfunction, remain poorly understood. |
2021-09-01 |
2023-08-13 |
mouse |
| Christopher D Walker, W Christopher Risher, Mary-Louise Rishe. Regulation of Synaptic Development by Astrocyte Signaling Factors and Their Emerging Roles in Substance Abuse. Cells. vol 9. issue 2. 2020-10-26. PMID:31991879. |
we also explore how these astrocyte signaling factors are impacted by and contribute to substance abuse, particularly alcohol and cocaine use. |
2020-10-26 |
2023-08-13 |
Not clear |
| Anze Testen, Marian T Sepulveda-Orengo, Christiann H Gaines, Kathryn J Reissne. Region-Specific Reductions in Morphometric Properties and Synaptic Colocalization of Astrocytes Following Cocaine Self-Administration and Extinction. Frontiers in cellular neuroscience. vol 12. 2020-09-30. PMID:30147645. |
these results provide insights into the influence of cocaine use on astrocytes within the brain reward circuitry, and inform both regional heterogeneity as well as temporal dynamics of astrocyte responsiveness to cocaine self-administration. |
2020-09-30 |
2023-08-13 |
rat |
| Anze Testen, Marian T Sepulveda-Orengo, Christiann H Gaines, Kathryn J Reissne. Region-Specific Reductions in Morphometric Properties and Synaptic Colocalization of Astrocytes Following Cocaine Self-Administration and Extinction. Frontiers in cellular neuroscience. vol 12. 2020-09-30. PMID:30147645. |
in the current study, we have extended our assessment of the effects of cocaine self-administration on morphometric properties and synaptic colocalization of astrocyte peripheral processes in the prelimbic region of the medial prefrontal cortex (pl) and basolateral nucleus of the amygdala (bla), both known to also contribute significantly to motivated behaviors. |
2020-09-30 |
2023-08-13 |
rat |