| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M H Makman, H S Ahn, L J Thal, N S Sharpless, B Dvorkin, S G Horowitz, M Rosenfel. Evidence for selective loss of brain dopamine- and histamine-stimulated adenylate cyclase activities in rabbits with aging. Brain research. vol 192. issue 1. 1980-08-15. PMID:7378778. |
there was no measurable decrease in the old animals in either dopamine or norepinephrine concentration in striatum, anterior limbic cortex or retina, or in choline acetylase activity or [3h]quinuclidinylbenzilate binding in striatum, anterior limbic cortex or frontal cortex. |
1980-08-15 |
2023-08-12 |
Not clear |
| C Lindamood, B K Colasant. Effects of delta 9-tetrahydrocannabinol and cannabidiol on sodium-dependent high affinity choline uptake in the rat hippocampus. The Journal of pharmacology and experimental therapeutics. vol 213. issue 2. 1980-06-27. PMID:6245205. |
doses of delta 9-tetrahydrocannabinol (delta 9-thc) and cannabidiol (cbd) affording the same degree of protection against seizures induced by maximal electroshock were compared for their effects on sodium-dependent high affinity choline uptake into six rat brain regions: cortex, striatum, medulla-pons, hypothalamus, midbrain and hippocampus. |
1980-06-27 |
2023-08-12 |
rat |
| J W Spokes, J O Doll. Complete purification of beta-bungarotoxin. Characterization of its action and that of tityustoxin on synaptosomal accumulation and release of acetylcholine. Biochimica et biophysica acta. vol 596. issue 1. 1980-04-17. PMID:7353009. |
in the presence of deoxycholate, it showed phospholipase activity which was activated by ca2+ but not sr2+.beta-bungarotoxin and tityustoxin, a polypeptide that prolongs the opening of sodium channels, inhibited choline accumulation by synaptosomes purified from rat cortex. |
1980-04-17 |
2023-08-12 |
rat |
| K Krnjević, W Reinhard. Choline excites cortical neurons. Science (New York, N.Y.). vol 206. issue 4424. 1980-02-15. PMID:515735. |
in cats under halothane or methoxyflurane, iontophoretic applications of choline are only eight times weaker than applications of acetylcholine in evoking firing of neurons in the sensorimotor region of the cerebral cortex. |
1980-02-15 |
2023-08-11 |
Not clear |
| P D Hrdina, K Elso. High-affinity choline uptake in regions of rat brain and the effect of antidepressants. Canadian journal of physiology and pharmacology. vol 57. issue 6. 1979-12-27. PMID:487267. |
the effect of tricyclic antidepressants, chlorpromazine, and some monoamine oxidase inhibitors on the accumulation of [14c]choline by crude synaptosomal (p2) fraction from different regions of rat brain (cortex, striatum, and hippocampus) was investigated. |
1979-12-27 |
2023-08-11 |
rat |
| M Quik, P C Emson, J Fahrenkrug, L L Iverse. Effect of kainic acid injections and other brain lesions on vasoactive intestinal peptide (VIP)-stimulated formation of cAMP in rat brain. Naunyn-Schmiedeberg's archives of pharmacology. vol 306. issue 3. 1979-10-24. PMID:38409. |
kainic acid injection into several other brain regions, including hippocampus, cortex and hypothalamus also failed to affect the vip-elicited increase in camp in slices, despite reductions in choline acetyl-transferase, glutamate decarboxylase, cyclic nucleotide phosphodiesterase and basal levels of camp. |
1979-10-24 |
2023-08-11 |
rat |
| M H Makman, H S Ahn, L J Thal, B Dvorkin, S G Horowitz, N S Sharpless, M Rosenfel. Biogenic amine-stimulated adenylate cyclase and spiroperidol-binding sites in rabbit brain: evidence for selective loss of receptors with aging. Advances in experimental medicine and biology. vol 113. 1979-09-27. PMID:753089. |
these changes in striatum and cortex were evident in the absence of decreases in either dopamine content or choline acetylase activity, an activity presumed to be present in neurons containing dopamine receptors. |
1979-09-27 |
2023-08-11 |
rabbit |
| M H Makman, H S Ahn, L J Thal, N S Sharpless, B Dvorkin, S G Horowitz, M Rosenfel. Aging and monoamine receptors in brain. Federation proceedings. vol 38. issue 5. 1979-06-29. PMID:218850. |
these changes in striatum and cortex occurred in the absence of decreases in either dopamine concentration or choline acetylase activity. |
1979-06-29 |
2023-08-11 |
rabbit |
| R S Jope, D J Jende. Choline and phospholipid metabolism and the synthesis of acetylcholine in rat brain. Journal of neuroscience research. vol 4. issue 1. 1979-05-23. PMID:423317. |
in the cortex and the striatum, choline and combined choline plasmalogen and lysophosphatidylcholine fraction generally had the highest specific activities. |
1979-05-23 |
2023-08-11 |
rat |
| T M Shih, I Hani. Effects of chronic lead exposure on levels of acetylcholine and choline and on acetylcholine turnover rate in rat brain areas in vivo. Psychopharmacology. vol 58. issue 3. 1978-10-18. PMID:98796. |
similarly, no changes in choline (ch) concentrations were found in cortex, hippocampus, or striatum. |
1978-10-18 |
2023-08-11 |
rat |
| T Durkin, G Ayad, A Ebel, P Mande. Regional acetylcholine turnover rates in the brains of three inbred strains of mice: correlation with some interstrain behavioural differences. Brain research. vol 136. issue 3. 1978-01-27. PMID:922496. |
in vivo ach turnover rates have been measured in three regions (hippocampus, caudate nucleus and frontal-parietal cortex) of the brains of each strain by following the rate of formation of labelled ach, in these regions, after a pulse intravenous injection of a tracer dose of 3h labelled choline. |
1978-01-27 |
2023-08-11 |
mouse |
| J Hol. Effect of choline on tetraethylammonium transport in mouse kidney cortex slices. Biochemical pharmacology. vol 26. issue 20. 1977-11-30. PMID:911348. |
effect of choline on tetraethylammonium transport in mouse kidney cortex slices. |
1977-11-30 |
2023-08-11 |
mouse |
| A M Benjamin, J H Quaste. Effects of acetylcholine on potassium-induced changes of water and sodium uptakes in cerebral cortex slices from the rat. Canadian journal of physiology and pharmacology. vol 55. issue 3. 1977-09-29. PMID:884589. |
the increases in uptakes of water and of sodium ions that occur in rat brain cortex slices when they are incubated in a physiological saline-glucose medium in presence of a high concentration of potassium ions (105 muequiv./ml) are abolished by acetylcholine in presence of eserine but not by choline. |
1977-09-29 |
2023-08-11 |
rat |
| P M Hughes, A D Macknigh. Effects of replacing medium sodium by choline, caesium, or rubidium, on water and ion contents of renal cortical slices. The Journal of physiology. vol 267. issue 1. 1977-08-12. PMID:874826. |
slices of rabbit and guinea-pig renal cortex incubated in oxygenated choline ringer decreased in volume initially and did not swell over 3 hr at 25 degrees c. there was a steady loss of potassium. |
1977-08-12 |
2023-08-11 |
rat |
| P M Hughes, A D Macknigh. Effects of replacing medium sodium by choline, caesium, or rubidium, on water and ion contents of renal cortical slices. The Journal of physiology. vol 267. issue 1. 1977-08-12. PMID:874826. |
slices of rat renal cortex similarly incubated in choline ringer swelled over 3 hr at 25 degrees c whether or not metabolism was inhibited; ouabain (15 mm) affected neither tissue potassium loss nor tissue water content.4. |
1977-08-12 |
2023-08-11 |
rat |
| I A Gerasimova, M A Flero. [Effect of amizil on phospholipid metabolism in different parts of the brain]. Voprosy meditsinskoi khimii. vol 22. issue 1. 1977-06-30. PMID:193289. |
in cortex of big hemispheres the specific activity of inosine monophosphate and phosphatidyl choline were increased by 77% and 97%, respectively; the specific activity of phosphatidic acid was decreased by 63%. |
1977-06-30 |
2023-08-11 |
Not clear |
| P Hadházy, J C Szer. The effect of cholinergic drugs on [3H]acetylcholine release from slices of rat hippocampus, striatum and cortex. Brain research. vol 123. issue 2. 1977-05-25. PMID:843927. |
slices from rat hippocampus, striatum or cortex were incubated with l mum [3h] choline and following 75 min superfusion with krebs solution the efflux of radioactivity was measured. |
1977-05-25 |
2023-08-11 |
rat |
| N G Ordóñez, F G Toback, H N Aithal, B J Sparg. Zonal changes in renal structure and phospholipid metabolism during reversal of potassium depletion nephropathy. Laboratory investigation; a journal of technical methods and pathology. vol 36. issue 1. 1977-02-24. PMID:830994. |
alterations in membrane metabolism during autophagocytosis and organelle regression were assessed by measuring the in vivo breakdown of [14c]phosphatidylcholine, phospholipase a activity, and the rate of [14c]choline incorporation into phospholipid in papilla, inner red medulla, and inner cortex. |
1977-02-24 |
2023-08-11 |
rat |
| G C Palmer, A A Manian, C R Sanbor. Effects of neuroleptic agents on cyclic GMP in rat cerebral cortex. European journal of pharmacology. vol 38. issue 1. 1976-11-01. PMID:182505. |
cyclic guanosine 3' ,5'-monophosphate(cyclic gmp) levels were increased in incubated tissue slices from rat cerebral cortex in response to added cholinomimetic agents (carbachol and choline chloride) and neuroleptic compounds (chlorpromazine, 8-hydroxychlorpromazine, 7-hydroxychlorpromazine methiodide, haloperidol, thioridazine, chlorpromazine sulfoxide and promethazine). |
1976-11-01 |
2023-08-11 |
rat |
| D Górny, J Billewicz-Stankiewicz, M Zajaczkowska, A Kutarsk. Effect of noradrenaline on the content, synthesis and catabolism of acetylcholine in the brain. Acta physiologica Polonica. vol 27. issue 1. 1976-08-02. PMID:946930. |
ach synthesis and content in the cerebral cortex and brain stem as well as the activity of choline acetylase (acch) and acetylcholinesterase (ache) in brain homogenates were determined after na administration both in vivo and in in vitro. |
1976-08-02 |
2023-08-11 |
Not clear |