| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hajra Khurshid, Israa A Qureshi, Nasrin Jahan, Terry R Went, Waleed Sultan, Alisha Sapkota, Michael Alfons. A Systematic Review of Fibromyalgia and Recent Advancements in Treatment: Is Medicinal Cannabis a New Hope? Cureus. vol 13. issue 8. 2021-09-29. PMID:34567876. |
the two main compounds of cannabis with analgesic and anti-inflammatory properties are cannabidiol (cbd) and delta-9-tetrahydrocannabinol (thc), and their ratio determines the effect on various symptoms of fms. we included studies regarding the use of cannabinoids in the treatment of fibromyalgia, investigating the use of nabilone, dronabinol (a synthetic analog of thc), bedrocan (22.4 mg thc, <1 mg cbd), bediol (13.4 mg thc, 17.8 mg cbd), and bedrolite (18.4 mg cbd, <1 mg thc). |
2021-09-29 |
2023-08-13 |
human |
| Grace Blest-Hopley, Aisling O'Neill, Robin Wilson, Vincent Giampietro, David Lythgoe, Alice Egerton, Sagnik Bhattacharyy. Adolescent-onset heavy cannabis use associated with significantly reduced glial but not neuronal markers and glutamate levels in the hippocampus. Addiction biology. vol 25. issue 6. 2021-09-28. PMID:31478302. |
we investigated the effect of persistent cannabis use on the brain levels of n-acetyl aspartate (naa) and myoinositol, the metabolite markers of neurons and glia, the site of the main central cannabinoid cb1 receptor, and the levels of glutamate, the neurotransmitter directly affected by cb1 modulation. |
2021-09-28 |
2023-08-13 |
human |
| Grace Blest-Hopley, Aisling O'Neill, Robin Wilson, Vincent Giampietro, David Lythgoe, Alice Egerton, Sagnik Bhattacharyy. Adolescent-onset heavy cannabis use associated with significantly reduced glial but not neuronal markers and glutamate levels in the hippocampus. Addiction biology. vol 25. issue 6. 2021-09-28. PMID:31478302. |
we investigated cannabis users (cus) who started using during adolescence, the period of greatest vulnerability to cannabis effects and focused on the hippocampus, where type 1 cannabinoid receptors (cbr1) are expressed in high density and have been linked to altered glutamatergic neurotransmission. |
2021-09-28 |
2023-08-13 |
human |
| Julia Sweigert, Kathleen Pagulayan, Gabriella Greco, Matthew Blake, Mary Larimer, Natalia M Kleinhan. A multimodal investigation of cerebellar integrity associated with high-risk cannabis use. Addiction biology. vol 25. issue 6. 2021-09-28. PMID:31814242. |
recent evidence increasingly points to the role of the cerebellum in various nonmotor networks, and the cerebellum's expression of cannabinoid receptors may pose particular vulnerabilities to the consequences of cannabis use. |
2021-09-28 |
2023-08-13 |
Not clear |
| b' Pietro Brunetti, Alfredo Fabrizio Lo Faro, Filippo Pirani, Paolo Berretta, Roberta Pacifici, Simona Pichini, Francesco Paolo Busard\\xc3\\xb. Pharmacology and legal status of cannabidiol. Annali dell\'Istituto superiore di sanita. vol 56. issue 3. 2021-09-27. PMID:32959794.' |
cannabidiol (cbd) is the second most abundant cannabinoid present in cannabis sativa l. it is not associated with psychotropic activity and is capable to mitigate the psychotomimetic effects produced by tetrahydrocannabinol (thc). |
2021-09-27 |
2023-08-13 |
Not clear |
| Itziar Bonilla-Del Río, Nagore Puente, Amaia Mimenza, Almudena Ramos, Maitane Serrano, Leire Lekunberri, Inmaculada Gerrikagoitia, Brian R Christie, Patrick C Nahirney, Pedro Grande. Acute Δ9-tetrahydrocannabinol prompts rapid changes in cannabinoid CB The Journal of comparative neurology. vol 529. issue 9. 2021-09-23. PMID:33368252. |
acute Δ9-tetrahydrocannabinol prompts rapid changes in cannabinoid cb the use and abuse of cannabis can be associated with significant pathophysiology, however, it remains unclear whether (1) acute administration of Δ-9-tetrahydrocannabinol (thc) during early adulthood alters the cannabinoid type 1 (cb |
2021-09-23 |
2023-08-13 |
Not clear |
| Shane Darke, Samuel Banister, Michael Farrell, Johan Duflou, Julia Lappi. 'Synthetic cannabis': A dangerous misnomer. The International journal on drug policy. vol 98. 2021-09-23. PMID:34343944. |
rather, the substances referred to as 'synthetic cannabis' in public discourse should instead be referred to consistently as synthetic cannabinoid receptor agonists (scras), a drug class distinct from plant-derived cannabinoids. |
2021-09-23 |
2023-08-13 |
Not clear |
| Giorgia Galiazzo, Margherita De Silva, Fiorella Giancola, Riccardo Rinnovati, Angelo Peli, Roberto Chiocchett. Cellular distribution of cannabinoid-related receptors TRPV1, PPAR-gamma, GPR55 and GPR3 in the equine cervical dorsal root ganglia. Equine veterinary journal. 2021-09-23. PMID:34418142. |
of the cannabinoids contained in cannabis sativa, cannabidiol (cbd) does not produce psychotropic effects and seems to represent a molecule having great therapeutic potential. |
2021-09-23 |
2023-08-13 |
Not clear |
| Giorgia Galiazzo, Margherita De Silva, Fiorella Giancola, Riccardo Rinnovati, Angelo Peli, Roberto Chiocchett. Cellular distribution of cannabinoid-related receptors TRPV1, PPAR-gamma, GPR55 and GPR3 in the equine cervical dorsal root ganglia. Equine veterinary journal. 2021-09-23. PMID:34418142. |
cannabidiol acts on a great number of cannabinoid and cannabinoid-related g-protein-coupled receptors and ionotropic receptors which have, to date, been understudied in veterinary medicine particularly in equine medicine. |
2021-09-23 |
2023-08-13 |
Not clear |
| Jenny L Wiley, Shanequa I Taylor, Julie A Marusic. Δ Drug and alcohol dependence. vol 225. 2021-09-22. PMID:34186444. |
Δ cannabis users typically smoke or vape cannabis or ingest it in edibles, whereas cannabinoids are typically administered via injection in rodent research. |
2021-09-22 |
2023-08-13 |
Not clear |
| Tomasz Charytoniuk, Klaudia Sztolsztener, Ewa Harasim-Symbor, Klaudia Berk, Adrian Chabowski, Karolina Konstantynowicz-Nowick. Cannabidiol - A phytocannabinoid that widely affects sphingolipid metabolism under conditions of brain insulin resistance. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 142. 2021-09-22. PMID:34435590. |
we believe that our research will concern a new possible therapeutic approach with cannabis -plant derived compounds and within a few years, cannabinoids would be considered as prominent substances for targeting both metabolic and neurodegenerative pathologies. |
2021-09-22 |
2023-08-13 |
rat |
| Nicholas Pintori, Maria Paola Castelli, Cristina Miliano, Nicola Simola, Paola Fadda, Liana Fattore, Maria Scherma, Maria Grazia Ennas, Rafaela Mostallino, Giovanna Flore, Marta De Felice, Claudia Sagheddu, Marco Pistis, Gaetano Di Chiara, Maria Antonietta De Luc. Repeated exposure to JWH-018 induces adaptive changes in the mesolimbic and mesocortical dopaminergic pathways, glial cells alterations, and behavioural correlates. British journal of pharmacology. vol 178. issue 17. 2021-09-21. PMID:33837969. |
spice/k2 herbal mixtures, containing synthetic cannabinoids such as jwh-018, have been marketed as marijuana surrogates since 2004. |
2021-09-21 |
2023-08-13 |
Not clear |
| Mahmood AminiLari, Li Wang, Samuel Neumark, Taranah Adli, Rachel J Couban, Aidan Giangregorio, Colleen E Carney, Jason W Buss. Medical Cannabis and Cannabinoids for Impaired Sleep: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Sleep. 2021-09-21. PMID:34546363. |
medical cannabis and cannabinoids for impaired sleep: a systematic review and meta-analysis of randomized clinical trials. |
2021-09-21 |
2023-08-13 |
Not clear |
| Thies Gülck, J K Booth, Â Carvalho, B Khakimov, C Crocoll, M S Motawia, B L Møller, J Bohlmann, N J Gallag. Synthetic Biology of Cannabinoids and Cannabinoid Glucosides in Journal of natural products. vol 83. issue 10. 2021-09-20. PMID:33000946. |
the production of pharmaceutically relevant cannabinoids relies on extraction and purification from cannabis ( |
2021-09-20 |
2023-08-13 |
Not clear |
| Cynthia Coulter, Jarrad R Wagne. Cannabinoids in Oral Fluid: Limiting Potential Sources of Cannabidiol Conversion to Δ9- and Δ8-Tetrahydrocannabinol. Journal of analytical toxicology. vol 45. issue 8. 2021-09-20. PMID:34137890. |
cannabinoids in oral fluid: limiting potential sources of cannabidiol conversion to Δ9- and Δ8-tetrahydrocannabinol. |
2021-09-20 |
2023-08-13 |
Not clear |
| Melissa A Hoffman, Jacqueline A Hubbard, Philip M Sobolesky, Breland E Smith, Raymond T Suhandynata, Sandra Sanford, Emily G Sones, Shannon Ellis, Anya Umlauf, Marilyn A Huestis, David J Grelotti, Igor Grant, Thomas D Marcotte, Robert L Fitzgeral. Blood and Oral Fluid Cannabinoid Profiles of Frequent and Occasional Cannabis Smokers. Journal of analytical toxicology. vol 45. issue 8. 2021-09-20. PMID:34173005. |
blood and oral fluid cannabinoid profiles of frequent and occasional cannabis smokers. |
2021-09-20 |
2023-08-13 |
human |
| Melissa A Hoffman, Jacqueline A Hubbard, Philip M Sobolesky, Breland E Smith, Raymond T Suhandynata, Sandra Sanford, Emily G Sones, Shannon Ellis, Anya Umlauf, Marilyn A Huestis, David J Grelotti, Igor Grant, Thomas D Marcotte, Robert L Fitzgeral. Blood and Oral Fluid Cannabinoid Profiles of Frequent and Occasional Cannabis Smokers. Journal of analytical toxicology. vol 45. issue 8. 2021-09-20. PMID:34173005. |
understanding cannabinoid profiles of frequent and occasional users and the subsequent impact on detectability with current drug per se driving limits is important to support forensic interpretations and the development of scientifically supported driving under the influence of cannabis laws. |
2021-09-20 |
2023-08-13 |
human |
| Marina Gabaglio, Erica Zamberletti, Cristina Manenti, Daniela Parolaro, Tiziana Rubin. Long-Term Consequences of Adolescent Exposure to THC-Rich/CBD-Poor and CBD-Rich/THC-Poor Combinations: A Comparison with Pure THC Treatment in Female Rats. International journal of molecular sciences. vol 22. issue 16. 2021-09-20. PMID:34445602. |
however, these studies investigated the effects of pure thc, without taking into account other cannabinoids present in the cannabis plant. |
2021-09-20 |
2023-08-13 |
rat |
| Ramesh Adhikari, Deepika Manduva, Srikrishna V Malayala, Romil Singh, Nitesh K Jain, Keerti Deepika, Thoyaja Korital. A Rare Case of Vaping-Induced Spontaneous Pneumomediastinum. Cureus. vol 13. issue 8. 2021-09-18. PMID:34532191. |
vaping is the process of inhaling an aerosol produced by heating a liquid or wax containing substances such as nicotine, cannabinoids (e.g., tetrahydrocannabinol, cannabidiol), flavoring, and additives (e.g., glycerol, propylene glycol). |
2021-09-18 |
2023-08-13 |
Not clear |
| Andrzej L Dawidowicz, Małgorzata Olszowy-Tomczyk, Rafał Type. Synergistic and antagonistic antioxidant effects in the binary cannabinoids mixtures. Fitoterapia. vol 153. 2021-09-17. PMID:34273440. |
from the group of nearly 120 cannabinoids identified in the hemp sativa and marijuana, cbg, cbd, thc and their acidic forms cbga, cbda and thca are the most frequently studied. |
2021-09-17 |
2023-08-13 |
Not clear |