| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Mecha, A Feliú, P M Iñigo, L Mestre, F J Carrillo-Salinas, C Guaz. Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: a role for A2A receptors. Neurobiology of disease. vol 59. 2014-05-05. PMID:23851307. |
cannabidiol (cbd), a non-psychotropic cannabinoid constituent of cannabis sativa, has potent anti-inflammatory and immunosuppressive properties. |
2014-05-05 |
2023-08-12 |
Not clear |
| Amir I A Ahmed, Geke A H van den Elsen, Marjolein A van der Marck, Marcel G M Olde Rikker. Medicinal use of cannabis and cannabinoids in older adults: where is the evidence? Journal of the American Geriatrics Society. vol 62. issue 2. 2014-04-15. PMID:24521388. |
medicinal use of cannabis and cannabinoids in older adults: where is the evidence? |
2014-04-15 |
2023-08-12 |
Not clear |
| Steven G Kinsey, Erica C Col. Acute Δ(9)-tetrahydrocannabinol blocks gastric hemorrhages induced by the nonsteroidal anti-inflammatory drug diclofenac sodium in mice. European journal of pharmacology. vol 715. issue 1-3. 2014-04-14. PMID:23769745. |
although inhibitors of endocannabinoid catabolic enzymes protect against gastropathy in fasted nsaid-treated mice, the gastroprotective effects of Δ(9)-tetrahydrocannabinol (thc), the primary psychoactive component of marijuana, have yet to be investigated. |
2014-04-14 |
2023-08-12 |
mouse |
| Robert Kronstrand, Markus Roman, Mikael Andersson, Arne Eklun. Toxicological findings of synthetic cannabinoids in recreational users. Journal of analytical toxicology. vol 37. issue 8. 2014-04-14. PMID:23970540. |
the toxicity of the synthetic cannabinoids seems to be worse than that of natural cannabis, probably owing to the higher potency and perhaps also to the presence of several different cannabinoids in the smoked incense and the difficulties of proper dosing. |
2014-04-14 |
2023-08-12 |
Not clear |
| Dan Okura, Takafumi Horishita, Susumu Ueno, Nobuyuki Yanagihara, Yuka Sudo, Yasuhito Uezono, Takeyoshi Sat. The endocannabinoid anandamide inhibits voltage-gated sodium channels Nav1.2, Nav1.6, Nav1.7, and Nav1.8 in Xenopus oocytes. Anesthesia and analgesia. vol 118. issue 3. 2014-04-14. PMID:24557103. |
anandamide is an endocannabinoid that regulates multiple physiological functions by pharmacological actions, in a manner similar to marijuana. |
2014-04-14 |
2023-08-12 |
xenopus_laevis |
| Muhammad T Akhtar, Shaukat Ali, Hassan Rashidi, Frank van der Kooy, Robert Verpoorte, Michael K Richardso. Developmental effects of cannabinoids on zebrafish larvae. Zebrafish. vol 10. issue 3. 2014-04-08. PMID:23789728. |
cannabinoids are natural or synthetic compounds related chemically to (-)-(6ar,10ar)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6h-benzo[c]chromen-1-ol (Δ(9)-thc), the principle psychotropic constituent of the hemp plant, cannabis sativa l. here we examine the effects of the cannabinoids Δ(9)-thc, (r)-(+)-[2,3-dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo [1,2,3-de]-1,4-benzoxazin-6-yl]-1-napthalenylmethanone and 2-[(1r,2r,5r)-5-hydroxy-2-(3-hydroxypropyl) cyclohexyl]-5-(2-methyloctan-2-yl)phenol, and the cannabinoid antagonist (am 251). |
2014-04-08 |
2023-08-12 |
zebrafish |
| Erika Cottone, Valentina Pomatto, Fulvio Cerri, Ezio Campantico, Ken Mackie, Massimiliano Delpero, Alda Guastalla, Claudio Dati, Patrizia Bovolin, Maria Fosca Franzon. Cannabinoid receptors are widely expressed in goldfish: molecular cloning of a CB2-like receptor and evaluation of CB1 and CB2 mRNA expression profiles in different organs. Fish physiology and biochemistry. vol 39. issue 5. 2014-04-07. PMID:23504102. |
cannabinoids, the bioactive constituents of cannabis sativa, and endocannabinoids, among which the most important are anandamide and 2-arachidonoylglycerol, control various biological processes by binding to specific g protein-coupled receptors, namely cb1 and cb2 cannabinoid receptors. |
2014-04-07 |
2023-08-12 |
zebrafish |
| Ziva D Cooper, Sandra D Comer, Margaret Hane. Comparison of the analgesic effects of dronabinol and smoked marijuana in daily marijuana smokers. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 10. 2014-03-24. PMID:23609132. |
recent studies have demonstrated the therapeutic potential of cannabinoids to treat pain, yet none have compared the analgesic effectiveness of smoked marijuana to orally administered Δ(9)-tetrahydrocannabinol (thc; dronabinol). |
2014-03-24 |
2023-08-12 |
human |
| Sean M Emery, Moureq R Alotaibi, Qing Tao, Dana E Selley, Aron H Lichtman, David A Gewirt. Combined antiproliferative effects of the aminoalkylindole WIN55,212-2 and radiation in breast cancer cells. The Journal of pharmacology and experimental therapeutics. vol 348. issue 2. 2014-03-03. PMID:24259678. |
two other aminoalkylindoles, pravadoline and jwh-015 [(2-methyl-1-propyl-1h-indol-3-yl)-1-naphthalenyl-methanone], also enhanced the antiproliferative effects of radiation, but other synthetic cannabinoids (i.e., nabilone, cp55,940 [(+)-rel-5-(1,1-dimethylheptyl)-2-[(1r,2r,5r)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-phenol], and methanandamide) or phytocannabinoids [i.e., Δ⁹-tetrahydrocannabinol (thc) and cannabidiol] did not. |
2014-03-03 |
2023-08-12 |
human |
| Walter Fratta, Liana Fattor. Molecular mechanisms of cannabinoid addiction. Current opinion in neurobiology. vol 23. issue 4. 2014-02-27. PMID:23490548. |
recently, considerable progress has been made in understanding the cellular and molecular consequences of prolonged cannabis use, among which is the identification of specific set of transcriptional regulations that develop differently after chronic cannabinoids and in the abstinent brain. |
2014-02-27 |
2023-08-12 |
Not clear |
| Raquel Levin, Fernanda F Peres, Valéria Almeida, Mariana B Calzavara, Antonio W Zuardi, Jaime E C Hallak, José Alexandre S Crippa, Vanessa C Abíli. Effects of cannabinoid drugs on the deficit of prepulse inhibition of startle in an animal model of schizophrenia: the SHR strain. Frontiers in pharmacology. vol 5. 2014-02-25. PMID:24567721. |
the following drugs were used: (1) win55212,2 (cannabinoid agonist), (2) rimonabant (cb1 antagonist), (3) am404 (anandamide uptake inhibitor), and (4) cannabidiol (cbd; indirect cb1/cb2 receptor antagonist, among other effects). |
2014-02-25 |
2023-08-12 |
rat |
| Wendy Swift, Alex Wong, Kong M Li, Jonathon C Arnold, Iain S McGrego. Analysis of cannabis seizures in NSW, Australia: cannabis potency and cannabinoid profile. PloS one. vol 8. issue 7. 2014-02-20. PMID:23894589. |
analysis of cannabis seizures in nsw, australia: cannabis potency and cannabinoid profile. |
2014-02-20 |
2023-08-12 |
Not clear |
| Wendy Swift, Alex Wong, Kong M Li, Jonathon C Arnold, Iain S McGrego. Analysis of cannabis seizures in NSW, Australia: cannabis potency and cannabinoid profile. PloS one. vol 8. issue 7. 2014-02-20. PMID:23894589. |
recent analysis of the cannabinoid content of cannabis plants suggests a shift towards use of high potency plant material with high levels of Δ(9)-tetrahydrocannabinol (thc) and low levels of other phytocannabinoids, particularly cannabidiol (cbd). |
2014-02-20 |
2023-08-12 |
Not clear |
| Wendy Swift, Alex Wong, Kong M Li, Jonathon C Arnold, Iain S McGrego. Analysis of cannabis seizures in NSW, Australia: cannabis potency and cannabinoid profile. PloS one. vol 8. issue 7. 2014-02-20. PMID:23894589. |
in the present study we examined the cannabinoid content of 206 cannabis samples that had been confiscated by police from recreational users holding 15 g of cannabis or less, under the new south wales "cannabis cautioning" scheme. |
2014-02-20 |
2023-08-12 |
Not clear |
| Slava Rom, Yuri Persidsk. Cannabinoid receptor 2: potential role in immunomodulation and neuroinflammation. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 8. issue 3. 2014-02-11. PMID:23471521. |
while the addictive properties of marijuana, an extract from the cannabis plant, are well recognized, there is growing appreciation of the therapeutic potential of cannabinoids in multiple pathologic conditions involving chronic inflammation (inflammatory bowel disease, arthritis, autoimmune disorders, multiple sclerosis, hiv-1 infection, stroke, alzheimer's disease to name a few), mainly mediated by cb(2) activation. |
2014-02-11 |
2023-08-12 |
Not clear |
| Pál Pache. Towards the use of non-psychoactive cannabinoids for prostate cancer. British journal of pharmacology. vol 168. issue 1. 2014-02-10. PMID:22849856. |
in this issue of the british journal of pharmacology, de petrocellis and colleagues present comprehensive evidence that plant-derived cannabinoids, especially cannabidiol, are potent inhibitors of prostate carcinoma viability in vitro. |
2014-02-10 |
2023-08-12 |
Not clear |
| Jade M Franklin, Matt Mathew, Gonzalo A Carrasc. Cannabinoid-induced upregulation of serotonin 2A receptors in the hypothalamic paraventricular nucleus and anxiety-like behaviors in rats. Neuroscience letters. vol 548. 2014-02-07. PMID:23721787. |
recent behavioral reports suggest that repeated exposure to cannabis and synthetic cannabinoid agonists is linked with mental disorders associated with dysfunction of serotonin 2a (5-ht2a) receptor neurotransmission such as anxiety and depression. |
2014-02-07 |
2023-08-12 |
rat |
| Kirsten R Müller-Vah. Treatment of Tourette syndrome with cannabinoids. Behavioural neurology. vol 27. issue 1. 2014-02-03. PMID:23187140. |
to day, the cannabinoid delta-9-tetrahydrocannabinol (thc) and the cannabis extract nabiximols are approved for the treatment of nausea, anorexia and spasticity, respectively. |
2014-02-03 |
2023-08-12 |
Not clear |
| . Notes from the field: severe illness associated with reported use of synthetic marijuana - Colorado, August-September 2013. MMWR. Morbidity and mortality weekly report. vol 62. issue 49. 2014-01-30. PMID:24336136. |
synthetic marijuana is dried plant material sprayed with various synthetic cannabinoids and smoked as an alternative to smoking marijuana. |
2014-01-30 |
2023-08-12 |
Not clear |
| Dayong Lee, Erin L Karschner, Garry Milman, Allan J Barnes, Robert S Goodwin, Marilyn A Huesti. Can oral fluid cannabinoid testing monitor medication compliance and/or cannabis smoking during oral THC and oromucosal Sativex administration? Drug and alcohol dependence. vol 130. issue 1-3. 2014-01-27. PMID:23146820. |
can oral fluid cannabinoid testing monitor medication compliance and/or cannabis smoking during oral thc and oromucosal sativex administration? |
2014-01-27 |
2023-08-12 |
Not clear |