| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tyler E Gaston, Daniel Friedma. Pharmacology of cannabinoids in the treatment of epilepsy. Epilepsy & behavior : E&B. vol 70. issue Pt B. 2018-01-16. PMID:28087250. |
this article summarizes the available scientific data of pharmacology from human and animal studies on the major cannabinoids which have been of interest in the treatment of epilepsy, including ∆9-tetrahydrocannabinol (∆9-thc), cannabidiol (cbd), ∆9-tetrahydrocannabivarin (∆9-thcv), cannabidivarin (cbdv), and ∆9-tetrahydrocannabinolic acid (Δ9-thca). |
2018-01-16 |
2023-08-13 |
human |
| Alice Mea. The legal status of cannabis (marijuana) and cannabidiol (CBD) under U.S. law. Epilepsy & behavior : E&B. vol 70. issue Pt B. 2018-01-16. PMID:28169144. |
in the united states, federal and state laws regarding the medical use of cannabis and cannabinoids are in conflict and have led to confusion among patients, caregivers, and healthcare providers. |
2018-01-16 |
2023-08-13 |
Not clear |
| Brooke K O'Connell, David Gloss, Orrin Devinsk. Cannabinoids in treatment-resistant epilepsy: A review. Epilepsy & behavior : E&B. vol 70. issue Pt B. 2018-01-16. PMID:28188044. |
previously, information was limited to case reports, small series, and surveys reporting on the use of cbd and diverse medical marijuana (mmj) preparations containing: tetrahydrocannabinol (thc), cbd, and many other cannabinoids in differing combinations. |
2018-01-16 |
2023-08-13 |
Not clear |
| Evan C Rosenberg, Pabitra H Patra, Benjamin J Whalle. Therapeutic effects of cannabinoids in animal models of seizures, epilepsy, epileptogenesis, and epilepsy-related neuroprotection. Epilepsy & behavior : E&B. vol 70. issue Pt B. 2018-01-16. PMID:28190698. |
the isolation and identification of the discrete plant cannabinoids in marijuana revived interest in analyzing historical therapeutic claims made for cannabis in clinical case studies and anecdotes. |
2018-01-16 |
2023-08-13 |
Not clear |
| Evan C Rosenberg, Pabitra H Patra, Benjamin J Whalle. Therapeutic effects of cannabinoids in animal models of seizures, epilepsy, epileptogenesis, and epilepsy-related neuroprotection. Epilepsy & behavior : E&B. vol 70. issue Pt B. 2018-01-16. PMID:28190698. |
in particular, sources as old as the 11th and 15th centuries claimed efficacy for crude marijuana extracts in the treatment of convulsive disorders, prompting a particularly active area of preclinical research into the therapeutic potential of plant cannabinoids in epilepsy. |
2018-01-16 |
2023-08-13 |
Not clear |
| Suman Chandra, Hemant Lata, Mahmoud A ElSohly, Larry A Walker, David Potte. Cannabis cultivation: Methodological issues for obtaining medical-grade product. Epilepsy & behavior : E&B. vol 70. issue Pt B. 2018-01-16. PMID:28202406. |
such practices have yielded desirable outcomes in cannabis breeding and production: gw pharmaceuticals has a collection of chemotypes dominant in any one of eight cannabinoids, two of which-cannabidiol and cannabidivarin-are supporting epilepsy clinical trial research, whereas in addition to a germplasm bank of high-thc, high-cbd, and intermediate type cannabis varieties, the team at university of mississippi has established an in vitro propagation protocol for cannabis with no detectable variations in morphologic, physiologic, biochemical, and genetic profiles as compared to the mother plants. |
2018-01-16 |
2023-08-13 |
Not clear |
| Valérie Wolff, Emilie Jouanju. Strokes are possible complications of cannabinoids use. Epilepsy & behavior : E&B. vol 70. issue Pt B. 2018-01-16. PMID:28237318. |
considering the worldwide use of cannabinoids (cannabis and synthetic cannabinoids), the recent legalization of their consumption in some countries, and their supposed involvement in cardiovascular events, we evaluated their role in the occurrence of neurovascular complications among the young. |
2018-01-16 |
2023-08-13 |
Not clear |
| Valérie Wolff, Emilie Jouanju. Strokes are possible complications of cannabinoids use. Epilepsy & behavior : E&B. vol 70. issue Pt B. 2018-01-16. PMID:28237318. |
ninety-eight patients were described in the literature as having a cannabinoids-related stroke (85 after cannabis use and 13 after synthetic cannabinoids). |
2018-01-16 |
2023-08-13 |
Not clear |
| Valérie Wolff, Emilie Jouanju. Strokes are possible complications of cannabinoids use. Epilepsy & behavior : E&B. vol 70. issue Pt B. 2018-01-16. PMID:28237318. |
besides this vascular role of cannabinoids in the occurrence of stroke, a cellular effect of cannabis on brain mitochondria was recently suggested in an experimental study. |
2018-01-16 |
2023-08-13 |
Not clear |
| Valérie Wolff, Emilie Jouanju. Strokes are possible complications of cannabinoids use. Epilepsy & behavior : E&B. vol 70. issue Pt B. 2018-01-16. PMID:28237318. |
we suggest to systematically ask all young adults with stroke about their drug consumption including cannabinoids, to screen urine for cannabis or to include a specific diagnostic test to detect synthetic cannabinoids, and to obtain non-invasive intracranial arterial investigations (i.e. |
2018-01-16 |
2023-08-13 |
Not clear |
| Dustin Sulak, Russell Saneto, Bonni Goldstei. The current status of artisanal cannabis for the treatment of epilepsy in the United States. Epilepsy & behavior : E&B. vol 70. issue Pt B. 2018-01-16. PMID:28254350. |
neurologists and cannabinoid specialists are increasingly in a position to monitor and guide the use of herbal cannabis in epilepsy patients. |
2018-01-16 |
2023-08-13 |
Not clear |
| Claire E Blevins, Kelsey E Banes, Robert S Stephens, Denise D Walker, Roger A Roffma. A preliminary evaluation of synthetic cannabinoid use among adolescent cannabis users: Characteristics and treatment outcomes. Addictive behaviors. vol 63. 2018-01-12. PMID:27454353. |
a preliminary evaluation of synthetic cannabinoid use among adolescent cannabis users: characteristics and treatment outcomes. |
2018-01-12 |
2023-08-13 |
human |
| Giovanna Tassoni, Marta Cippitelli, Giovanni Ottaviani, Rino Froldi, Mariano Cingolan. Detection of Cannabinoids by ELISA and GC-MS Methods in a Hair Sample Previously Used to Detect Other Drugs of Abuse. Journal of analytical toxicology. vol 40. issue 6. 2018-01-09. PMID:26487640. |
after derivatization, the gc-ms parameters were the same for both the aliquots for the determination of the cannabinoids (Δ(9)-tetrahydrocannabinol, cannabidiol and cannabinol). |
2018-01-09 |
2023-08-13 |
Not clear |
| José Capece, Federico Pavlovsk. [The treatment of cannabis dependence: Clinical work, psychotherapy and evidence]. Vertex (Buenos Aires, Argentina). vol XXVII. issue 130. 2018-01-09. PMID:28898308. |
the administration of medications such as gabepentin, the aminoacid n-acetyl cysteine (nac) and the cannabinoid cannabidiol (cbd) appear to be very promising. |
2018-01-09 |
2023-08-13 |
Not clear |
| John R Richards, Jeff M Lapoint, Guillermo Burillo-Putz. Cannabinoid hyperemesis syndrome: potential mechanisms for the benefit of capsaicin and hot water hydrotherapy in treatment. Clinical toxicology (Philadelphia, Pa.). vol 56. issue 1. 2018-01-04. PMID:28730896. |
cannabinoid hyperemesis syndrome is a clinical disorder that has become more prevalent with increasing use of cannabis and synthetic cannabinoids, and which is difficult to treat. |
2018-01-04 |
2023-08-13 |
Not clear |
| Cristiane R de Carvalho, Alexandre A Hoeller, Pedro L C Franco, Athos P S Martini, Flávia M S Soares, Katia Lin, Rui D Prediger, Benjamin J Whalley, Roger Wal. The cannabinoid CB2 receptor-specific agonist AM1241 increases pentylenetetrazole-induced seizure severity in Wistar rats. Epilepsy research. vol 127. 2018-01-02. PMID:27608434. |
the potential efficacy of cannabinoid receptor ligands for the treatment of epilepsy remains controversial; cannabis components that act via cannabinoid type 1 (cb1) receptors produce anticonvulsant effects in animal models despite treatment with the cb receptor agonist reliably inducing convulsions in various species. |
2018-01-02 |
2023-08-13 |
rat |
| Kenta Kuramoto, Nan Wang, Yuying Fan, Weiran Zhang, Frank J Schoenen, Kevin J Frankowski, Juan Marugan, Yifa Zhou, Sui Huang, Congcong H. Autophagy activation by novel inducers prevents BECN2-mediated drug tolerance to cannabinoids. Autophagy. vol 12. issue 9. 2017-12-29. PMID:27305347. |
however, repeated cannabinoid administration triggers lysosomal degradation of the receptor and rapid development of drug tolerance, limiting the medical use of marijuana in chronic diseases. |
2017-12-29 |
2023-08-13 |
mouse |
| Maria M Steenkamp, Esther M Blessing, Isaac R Galatzer-Levy, Laura C Hollahan, William T Anderso. Marijuana and other cannabinoids as a treatment for posttraumatic stress disorder: A literature review. Depression and anxiety. vol 34. issue 3. 2017-12-29. PMID:28245077. |
marijuana and other cannabinoids as a treatment for posttraumatic stress disorder: a literature review. |
2017-12-29 |
2023-08-13 |
human |
| Maria M Steenkamp, Esther M Blessing, Isaac R Galatzer-Levy, Laura C Hollahan, William T Anderso. Marijuana and other cannabinoids as a treatment for posttraumatic stress disorder: A literature review. Depression and anxiety. vol 34. issue 3. 2017-12-29. PMID:28245077. |
we review the extant knowledge on the effects of marijuana and other cannabinoids on ptsd. |
2017-12-29 |
2023-08-13 |
human |
| Maria M Steenkamp, Esther M Blessing, Isaac R Galatzer-Levy, Laura C Hollahan, William T Anderso. Marijuana and other cannabinoids as a treatment for posttraumatic stress disorder: A literature review. Depression and anxiety. vol 34. issue 3. 2017-12-29. PMID:28245077. |
treatment outcome studies of whole plant marijuana and related cannabinoids on ptsd are limited and not methodologically rigorous, precluding conclusions about their potential therapeutic effects. |
2017-12-29 |
2023-08-13 |
human |