| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David Grommisch, Harald Lund, Evelien Eenjes, Anais Julien, Christian Göritz, Robert A Harris, Rickard Sandberg, Michael Hagemann-Jensen, Maria Genande. Regionalized cell and gene signatures govern esophageal epithelial homeostasis. Developmental cell. 2024-10-19. PMID:39426382. |
finally, we predict and verify how wnt, bmp, insulin growth factor (igf), and neuregulin (nrg) signaling are differentially engaged along the esophageal axis. |
2024-10-19 |
2024-10-22 |
mouse |
| Payal Chauhan, Karan Wadhwa, Govind Singh, Saurabh Gupta, Danish Iqbal, Mosleh Mohammad Abomughaid, Abdulmajeed G Almutary, Prabhu Chandra Mishra, Vinod Kumar Nelson, Niraj Kumar Jh. Exploring complexities of Alzheimer's disease: New insights into molecular and cellular mechanisms of neurodegeneration and targeted therapeutic interventions. Ageing research reviews. 2024-10-17. PMID:39419399. |
signal transduction and biological activities, including cell metabolism, growth, and death are regulated by different signaling pathways including akt/mapk, wnt, leptin, mtor, ubiquitin, sirt1, and insulin. |
2024-10-17 |
2024-10-20 |
Not clear |
| Xin Hua, Dayong Wan. Transgenerational response of germline histone acetyltransferases and deacetylases to nanoplastics at predicted environmental doses in Caenorhabditis elegans. The Science of the total environment. 2024-09-01. PMID:39218082. |
meanwhile, in ps-np exposed nematodes, germline rnai of cbp-1, taf-1, sir-2.1 and hda-3 increased expression of genes encoding insulin, fgf, wnt, and/or notch ligands and expressions of their receptor genes in the offspring. |
2024-09-01 |
2024-09-04 |
caenorhabditis_elegans |
| Wei Gong, Xin Liu, Xiaoqian Lv, Yani Zhang, Yingjie Niu, Kai Jin, Bichun Li, Qisheng Zu. Ubiquitination plays an important role during the formation of chicken primordial germ cells. Journal of animal science. 2024-08-27. PMID:39187982. |
furthermore, go and kegg enrichment analysis showed that ubiquitination regulates key proteins to participate in the progression of key events related to pgc formation and the transduction of key signals such as wnt, mapk and insulin signals, followed by the detailed explanation of the specific regulatory mechanism of ubiquitination through the combined proteome and ubiquitome analysis. |
2024-08-27 |
2024-08-30 |
chicken |
| Soo Jin Kim, Yeseul Park, Yuri Cho, Heeyoun Hwang, Dong Jin Joo, Kyu Ha Huh, Juhan Le. Proteomics Profiling of Bilirubin Nanoparticle Treatment against Myocardial Ischemia-Reperfusion Injury. Journal of proteome research. 2024-08-09. PMID:39121348. |
our proteomic analysis identified significant upregulation in the wnt and insulin signaling pathways and increased golgi markers, indicating their role in mediating bilirubin nanoparticle's protective effects. |
2024-08-09 |
2024-08-12 |
human |
| Nina Sofi Funa, Heidi Katharina Mjoseng, Kristian Honnens de Lichtenberg, Silvia Raineri, Deniz Esen, Anuska la Rosa Egeskov-Madsen, Roberto Quaranta, Mette Christine Jørgensen, Maria Skjøtt Hansen, Jonas van Cuyl Kuylenstierna, Kim Bak Jensen, Yi Miao, K Christopher Garcia, Philip A Seymour, Palle Seru. TGF-β modulates cell fate in human ES cell-derived foregut endoderm by inhibiting Wnt and BMP signaling. Stem cell reports. 2024-06-28. PMID:38942030. |
furthermore, combined tgf-β1 treatment and wnt inhibition during pancreatic specification reproducibly and robustly enhance insulin |
2024-06-28 |
2024-07-01 |
human |
| Chunzhu Song, Kendal Broadi. Corrigendum: Dysregulation of BMP, Wnt, and insulin signaling in fragile X syndrome. Frontiers in cell and developmental biology. vol 12. 2024-06-19. PMID:38895159. |
corrigendum: dysregulation of bmp, wnt, and insulin signaling in fragile x syndrome. |
2024-06-19 |
2024-06-21 |
Not clear |
| Sven Schmidt, Felicia A M Klampfleuthner, Tobias Renkawitz, Solvig Diederich. Cause and chondroprotective effects of prostaglandin E2 secretion during mesenchymal stromal cell chondrogenesis. European journal of cell biology. vol 103. issue 2. 2024-04-12. PMID:38608422. |
pge2 release, which rose in the first three weeks of msc chondrogenesis, was jointly stimulated by endogenous bmp, wnt, and hedgehog activity that supported the exogenous stimulation by tgf-β1 and insulin to overcome the pge2 inhibition by dexamethasone. |
2024-04-12 |
2024-04-15 |
Not clear |
| Ruchi Yadav, Bhumika Pate. Insights on effects of Wnt pathway modulation on insulin signaling and glucose homeostasis for the treatment of type 2 diabetes mellitus: Wnt activation or Wnt inhibition? International journal of biological macromolecules. 2024-01-25. PMID:38272413. |
insights on effects of wnt pathway modulation on insulin signaling and glucose homeostasis for the treatment of type 2 diabetes mellitus: wnt activation or wnt inhibition? |
2024-01-25 |
2024-01-28 |
Not clear |
| Yinglin Lu, Jing Zhou, Fan Li, Heng Cao, Xingyu Zhang, Debing Yu, Zongliang He, Hongjie Ji, Kunpeng Lv, Guansuo Wu, Minli Y. The Integration of Genome-Wide DNA Methylation and Transcriptomics Identifies the Potential Genes That Regulate the Development of Skeletal Muscles in Ducks. International journal of molecular sciences. vol 24. issue 20. 2023-10-30. PMID:37895154. |
the kyoto encyclopedia of genes and genomes (keggs) analysis showed significant enrichment in mapk signaling, wnt signaling, apelin signaling, insulin signaling, and foxo signaling. |
2023-10-30 |
2023-11-08 |
Not clear |
| Tingyi He, Wenrui Guo, Guang Yang, Hong Su, Aolei Dou, Lu Chen, Teng Ma, Jie Su, Moning Liu, Budeng Su, Wangmei Qi, Haijun Li, Wei Mao, Xiumei Wang, Xihe Li, Yanyan Yang, Yongli Song, Guifang Ca. A Single-Cell Atlas of an Early Mongolian Sheep Embryo. Veterinary sciences. vol 10. issue 9. 2023-09-27. PMID:37756065. |
function enrichment analysis showed that several pathways were significantly enriched in the tgf-beta signaling pathway, the hippo signaling pathway, the platelet activation pathway, the riboflavin metabolism pathway, the wnt signaling pathway, regulation of the actin cytoskeleton, and the insulin signaling pathway in the notochord cluster. |
2023-09-27 |
2023-10-07 |
mouse |
| Hannah Reich, Cathy Savage-Dun. Signaling Circuits and the Apical Extracellular Matrix In Aging: Connections Identified in the Nematode American journal of physiology. Cell physiology. 2023-09-18. PMID:37721005. |
signaling circuits and the apical extracellular matrix in aging: connections identified in the nematode numerous conserved signaling pathways play critical roles in aging, including insulin, tgf-β, wnt, and autophagy pathways. |
2023-09-18 |
2023-10-07 |
Not clear |
| Sok Kuan Wong, Nur Vaizura Mohamad, Putri Ayu Jayusman, Nurul 'Izzah Ibrahi. A Review on the Crosstalk between Insulin and Wnt/β-Catenin Signalling for Bone Health. International journal of molecular sciences. vol 24. issue 15. 2023-08-12. PMID:37569816. |
however, crosstalk between the signalling molecules in insulin and wingless (wnt)/beta-(β-)catenin transduction cascades orchestrating bone homeostasis remains not well understood. |
2023-08-12 |
2023-08-16 |
Not clear |
| Fangfang Mo, Bohan Lv, Dandan Zhao, Ziye Xi, Yining Qian, Dongyu Ge, Nan Yang, Dongwei Zhang, Guangjian Jiang, Sihua Ga. Small RNA Sequencing Analysis of STZ-Injured Pancreas Reveals Novel MicroRNA and Transfer RNA-Derived RNA with Biomarker Potential for Diabetes Mellitus. International journal of molecular sciences. vol 24. issue 12. 2023-06-28. PMID:37373469. |
in addition, the results of kegg analysis showed that the target genes were significantly enriched in the wnt signaling pathway, insulin pathway, mapk signaling pathway and hippo signaling pathway. |
2023-06-28 |
2023-08-14 |
rat |
| Vrunda Sagathia, Chirag Patel, Jayesh Beladiya, Sandip Patel, Devang Sheth, Gaurang Sha. Tankyrase: a promising therapeutic target with pleiotropic action. Naunyn-Schmiedeberg's archives of pharmacology. 2023-06-20. PMID:37338576. |
their functions include cell cycle homeostasis (primarily in mitosis), telomere maintenance, wnt signaling pathway regulation, and insulin signaling (particularly glut4 translocation). |
2023-06-20 |
2023-08-14 |
Not clear |
| Carlos A Ibáñez, Gabriela Lira-León, Luis A Reyes-Castro, Guadalupe L Rodríguez-González, Consuelo Lomas-Soria, Alejandra Hernández-Rojas, Eyerahí Bravo-Flores, Juan Mario Solis-Paredes, Guadalupe Estrada-Gutierrez, Elena Zambran. Programming Mechanism of Adipose Tissue Expansion in the Rat Offspring of Obese Mothers Occurs in a Sex-Specific Manner. Nutrients. vol 15. issue 10. 2023-05-27. PMID:37242132. |
wnt, pi3k-akt, and insulin signaling pathways in f1mo males and |
2023-05-27 |
2023-08-14 |
rat |
| Sourbh Suren Garg, Kriti Kushwaha, Rupal Dubey, Jeena Gupt. Association between obesity, inflammation and insulin resistance: insights into signaling pathways and therapeutic interventions. Diabetes research and clinical practice. 2023-05-07. PMID:37150407. |
researchers have identified several pathways that link the impairment of insulin resistance through obesity-induced inflammation like activation of nuclear factor kappa b (nf-κb), suppressor of cytokine signaling (socs) proteins, cjun-n-terminal kinase (jnk), wingless-related integration site (wnt), and toll-like receptor (tlr) signaling pathways. |
2023-05-07 |
2023-08-14 |
Not clear |
| Dun Li, Hongxi Yang, Mingqian Lyu, Lihui Zhou, Yuan Zhang, Chunsheng Kang, Ju Wang, Yaogang Wan. Association between Behavioural Risks and Alzheimer's Disease: Elucidated with an Integrated Analysis of Gene Expression Patterns and Molecular Mechanisms. Neuroscience and biobehavioral reviews. 2023-05-05. PMID:37146892. |
our results demonstrated that multiple behavioural risk exposures could independently or collectively influence diverse hierarchical levels of gene expression patterns through multiple biological mechanisms such as wnt, mitogen-activated protein kinase (mapk), amp-activated protein kinase (ampk), nuclear factor (nf)-κb, phosphatidylinositol 3-kinase (pi3k)-akt, and insulin (ins) signalling pathways-mediated pathological processes, thereby prodromally or intermediately impacting ad. |
2023-05-05 |
2023-08-14 |
Not clear |
| Xue-Yan Huang, Lu-Lu Xue, Ting-Bao Chen, Li-Ren Huangfu, Ting-Hua Wang, Liu-Lin Xiong, Chang-Yin Y. Miracle fruit seed as a potential supplement for the treatment of learning and memory disorders in Alzheimer's disease. Frontiers in pharmacology. vol 13. 2023-01-30. PMID:36712676. |
mfss may play a therapeutic role in ad by affecting the insulin signaling pathway and the wnt pathway. |
2023-01-30 |
2023-08-14 |
mouse |
| Hui Ma, Shixiong Bian, Yunlei Li, Aixin Ni, Ran Zhang, Pingzhuang Ge, Pengmin Han, Yuanmei Wang, Jinmeng Zhao, Yunhe Zong, Jingwei Yuan, Yanyan Sun, Jilan Che. Analyses of circRNAs profiles of the lactating and nonlactating crops in pigeon (Columba livia). Poultry science. vol 102. issue 3. 2023-01-21. PMID:36680859. |
the kyoto encyclopedia of genes and genomes (kegg) pathway enrichment analysis revealed that the host genes of decs were enriched in gnrh, mapk, insulin, wnt, and ampk signaling pathways. |
2023-01-21 |
2023-08-14 |
pigeon |