| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J C Newman, R J Holde. The 'cerebral diabetes' paradigm for unipolar depression. Medical hypotheses. vol 41. issue 5. 1994-05-03. PMID:8145651. |
genetic studies have attempted to link (bipolar) affective disorder to the short arm of chromosome 11 (where the loci for insulin, insulin growth factor (igf), tyrosine hydroxylase (th) and h-ras-oncogene are located) but these have failed. |
1994-05-03 |
2023-08-12 |
Not clear |
| G Teitelman, S Alpert, J M Polak, A Martinez, D Hanaha. Precursor cells of mouse endocrine pancreas coexpress insulin, glucagon and the neuronal proteins tyrosine hydroxylase and neuropeptide Y, but not pancreatic polypeptide. Development (Cambridge, England). vol 118. issue 4. 1994-02-03. PMID:7903631. |
precursor cells of mouse endocrine pancreas coexpress insulin, glucagon and the neuronal proteins tyrosine hydroxylase and neuropeptide y, but not pancreatic polypeptide. |
1994-02-03 |
2023-08-12 |
mouse |
| A De bruyn, K Mendelbaum, L A Sandkuijl, V Delvenne, D Hirsch, L Staner, J Mendlewicz, C Van Broeckhove. Nonlinkage of bipolar illness to tyrosine hydroxylase, tyrosinase, and D2 and D4 dopamine receptor genes on chromosome 11. The American journal of psychiatry. vol 151. issue 1. 1994-01-27. PMID:7903509. |
the authors examined linkage in the families of 14 probands with bipolar illness, with the candidate genes tyrosine hydroxylase (th), d4 dopamine receptor (drd4) at 11p15, tyrosinase (tyr) at 11q14-q21, and d2 dopamine receptor (drd2) at 11q22-q23, as well as with the c-harvey-ras oncogene (hras) and insulin gene (ins), both located at 11p15, a region that previously showed linkage to bipolar illness. |
1994-01-27 |
2023-08-12 |
Not clear |
| Z G Xue, X J Xue, M Fauquet, J Smith, N Le Douari. Expression of the gene encoding tyrosine hydroxylase in a subpopulation of quail dorsal root ganglion cells cultured in the presence of insulin or chick embryo extract. Brain research. Developmental brain research. vol 69. issue 1. 1992-12-14. PMID:1358478. |
expression of the gene encoding tyrosine hydroxylase in a subpopulation of quail dorsal root ganglion cells cultured in the presence of insulin or chick embryo extract. |
1992-12-14 |
2023-08-11 |
chicken |
| Y K Jung, C J Kunczt, R K Pearson, J E Dixon, L D Fricke. Structural characterization of the rat carboxypeptidase-E gene. Molecular endocrinology (Baltimore, Md.). vol 5. issue 9. 1992-02-25. PMID:1770952. |
however, comparison of the cpe sequence with 5' flanking regions of other neuroendocrine genes has revealed a short region (12-18 nucleotides) that is highly conserved among cpe, neuropeptide-y, oxytocin, insulin, and tyrosine hydroxylase genes. |
1992-02-25 |
2023-08-11 |
rat |
| M F Blouquit, M Valens, A Bagayoko, D Gripoi. Adrenal tyrosine hydroxylase activation in the developing rat: influence of the thyroid status. Journal of developmental physiology. vol 14. issue 6. 1991-09-06. PMID:1983197. |
the study of time-course of tyrosine hydroxylase activation showed that the maximum value was observed 2 h after insulin administration. |
1991-09-06 |
2023-08-11 |
rat |
| P Mitchell, B Waters, N Morrison, J Shine, J Donald, J Eisma. Close linkage of bipolar disorder to chromosome 11 markers is excluded in two large Australian pedigrees. Journal of affective disorders. vol 21. issue 1. 1991-06-07. PMID:1673974. |
linkage of bipolar disorder and recurrent depression to the chromosome 11p15 markers c-harvey ras, insulin and tyrosine hydroxylase was tested using a series of genetic models with varying penetrance levels. |
1991-06-07 |
2023-08-11 |
Not clear |
| H Tanaka, A Ishikawa, E I Ginns, T Miyatake, S Tsuj. Linkage analysis of juvenile parkinsonism to tyrosine hydroxylase gene locus on chromosome 11. Neurology. vol 41. issue 5. 1991-06-07. PMID:1674118. |
we performed linkage analyses of juvenile parkinsonism with autosomal recessive inheritance (ar-jp) to chromosome 11p15.5 locus including tyrosine hydroxylase (th), harvey-ras-1 (hras), and insulin (ins) genes by analyzing genomic dna from 28 members of seven japanese ar-jp families containing 10 affected individuals. |
1991-06-07 |
2023-08-11 |
Not clear |
| S Amoroso, G Di Renzo, M Taglialatela, L M Canzoniero, E J Cragoe, L Annunziat. Cytoplasmic alkalinization induced by insulin through an activation of Na(+)-H+ antiporter inhibits tyrosine hydroxylase activity in striatal synaptosomes. Biochemical pharmacology. vol 41. issue 9. 1991-05-17. PMID:1673339. |
cytoplasmic alkalinization induced by insulin through an activation of na(+)-h+ antiporter inhibits tyrosine hydroxylase activity in striatal synaptosomes. |
1991-05-17 |
2023-08-11 |
rat |
| S Amoroso, G Di Renzo, M Taglialatela, L M Canzoniero, E J Cragoe, L Annunziat. Cytoplasmic alkalinization induced by insulin through an activation of Na(+)-H+ antiporter inhibits tyrosine hydroxylase activity in striatal synaptosomes. Biochemical pharmacology. vol 41. issue 9. 1991-05-17. PMID:1673339. |
insulin dose-dependently inhibited tyrosine hydroxylase (th) activity and increased intrasynaposomal ph (phi) in rat striatal nerve endings. |
1991-05-17 |
2023-08-11 |
rat |
| D Owerbach, S Gunn, K H Gabba. Multigenic basis for type I diabetes. Association of HRAS1 polymorphism with HLA-DR3, DQw2/DR4, DQw8. Diabetes. vol 39. issue 12. 1991-01-08. PMID:1978827. |
the markers for these loci are tyrosine hydroxylase, insulin, and c-ha-ras-1 proto-oncogene (hras1). |
1991-01-08 |
2023-08-11 |
human |
| G T Coker, D Studelska, S Harmon, W Burke, K L O'Malle. Analysis of tyrosine hydroxylase and insulin transcripts in human neuroendocrine tissues. Brain research. Molecular brain research. vol 8. issue 2. 1990-10-19. PMID:1976199. |
analysis of tyrosine hydroxylase and insulin transcripts in human neuroendocrine tissues. |
1990-10-19 |
2023-08-11 |
human |
| M A Permutt, S C Elbei. Insulin gene in diabetes. Analysis through RFLP. Diabetes care. vol 13. issue 3. 1990-04-12. PMID:1968374. |
the combined rflps for the insulin, igf-ii, and tyrosine hydroxylase genes make this a highly informative locus for genetic studies of the insulin gene in diabetes. |
1990-04-12 |
2023-08-11 |
Not clear |
| M A Permutt, S C Elbei. Insulin gene in diabetes. Analysis through RFLP. Diabetes care. vol 13. issue 3. 1990-04-12. PMID:1968374. |
cloning of this gene has permitted molecular-genetic studies including the definition of multiple-dna-sequence polymorphisms detected with restriction endonucleases, or restriction-fragment-length polymorphisms (rflps), and the mapping of the insulin gene to the short arm of chromosome 11 adjacent to the insulinlike growth factor ii (igf-ii) and tyrosine hydroxylase genes. |
1990-04-12 |
2023-08-11 |
Not clear |
| M Sten-Linder, M Granqvist, I Stern, G I Bell, H Luthma. DraI and PstI RFLPs in the tyrosine hydroxylase (TH) and insulin gene (INS) region of chromosome 11. Nucleic acids research. vol 17. issue 14. 1989-09-08. PMID:2569725. |
drai and psti rflps in the tyrosine hydroxylase (th) and insulin gene (ins) region of chromosome 11. |
1989-09-08 |
2023-08-11 |
Not clear |
| T Hashimoto, H Kawano, S Daikoku, K Shima, H Taniguchi, S Bab. Transient coappearance of glucagon and insulin in the progenitor cells of the rat pancreatic islets. Anatomy and embryology. vol 178. issue 6. 1989-03-23. PMID:2464956. |
ontogenetic appearances of glucagon, insulin and tyrosine hydroxylase (th) were immunohistochemically investigated on developing pancreatic islets of rats. |
1989-03-23 |
2023-08-11 |
rat |
| F Xue, J R Kidd, A J Pakstis, C M Castiglione, J Mallet, K K Kid. Tyrosine hydroxylase maps to the short arm of chromosome 11 proximal to the insulin and HRAS1 loci. Genomics. vol 2. issue 4. 1989-03-22. PMID:2906039. |
tyrosine hydroxylase maps to the short arm of chromosome 11 proximal to the insulin and hras1 loci. |
1989-03-22 |
2023-08-11 |
Not clear |
| K L O'Malley, P Rotwei. Human tyrosine hydroxylase and insulin genes are contiguous on chromosome 11. Nucleic acids research. vol 16. issue 10. 1988-07-15. PMID:2898127. |
the gene for the catecholamine biosynthetic enzyme, tyrosine hydroxylase (th), has been previously mapped to human chromosome 11 p15.5 in the vicinity of the loci for insulin (ins) and for the oncogene harvey ras 1 (hras). |
1988-07-15 |
2023-08-11 |
human |
| K L O'Malley, P Rotwei. Human tyrosine hydroxylase and insulin genes are contiguous on chromosome 11. Nucleic acids research. vol 16. issue 10. 1988-07-15. PMID:2898127. |
human tyrosine hydroxylase and insulin genes are contiguous on chromosome 11. |
1988-07-15 |
2023-08-11 |
human |
| S Hodgkinson, R Sherrington, H Gurling, R Marchbanks, S Reeders, J Mallet, M McInnis, H Petursson, J Brynjolfsso. Molecular genetic evidence for heterogeneity in manic depression. Nature. vol 325. issue 6107. 1987-04-08. PMID:2881210. |
genetic linkage studies were carried out using clones encoding tyrosine hydroxylase the variable portion of the harvey-ras-1 (hras1) locus and the variable region of the insulin gene (ins). |
1987-04-08 |
2023-08-11 |
Not clear |