All Relations between tyrosine hydroxylase and dopamine

Publication Sentence Publish Date Extraction Date Species
Vitaly Ryu, Anisa Gumerova, Ronit Witztum, Funda Korkmaz, Hasni Kannangara, Ofer Moldavski, Orly Barak, Daria Lizneva, Ki A Goosens, Sarah Stanley, Se-Min Kim, Tony Yuen, Mone Zaid. An Atlas of Brain-Bone Sympathetic Neural Circuits. bioRxiv : the preprint server for biology. 2024-02-19. PMID:38370676. histological studies show abundant sns innervation of the periosteum and bone marrow--these nerves consist of noradrenergic fibers that immunostain for tyrosine hydroxylase, dopamine beta hydroxylase, or neuropeptide y. 2024-02-19 2024-02-21 Not clear
Isabel Soto, Robert McManus, Walter Navarrete-Barahona, Ella A Kasanga, Kirby Doshier, Vicki A Nejtek, Michael F Salvator. Aging hastens locomotor decline in PINK1 knockout rats in association with decreased nigral, but not striatal, dopamine and tyrosine hydroxylase expression. bioRxiv : the preprint server for biology. 2024-02-14. PMID:38352365. aging hastens locomotor decline in pink1 knockout rats in association with decreased nigral, but not striatal, dopamine and tyrosine hydroxylase expression. 2024-02-14 2024-02-16 human
Cameron Keomanivong, Josephine Schamp, Ervina Tabakovic, Ramasamy Thangavel, Georgina Aldridge, Andrew A Pieper, Nandakumar S Narayana. Mice Expressing A53T/A30P Mutant Alpha-Synuclein in Dopamine Neurons Do Not Display Behavioral Deficits. eNeuro. vol 11. issue 2. 2024-02-13. PMID:38351057. it has been reported that hemizygous transgenic mice with tyrosine hydroxylase promotor-driven expression of a53t/a30p mutant alpha-synuclein in dopamine neurons provide a useful preclinical model of these conditions by virtue of developing behavioral deficits. 2024-02-13 2024-02-16 mouse
Cameron Keomanivong, Josephine Schamp, Ervina Tabakovic, Ramasamy Thangavel, Georgina Aldridge, Andrew A Pieper, Nandakumar S Narayana. Mice Expressing A53T/A30P Mutant Alpha-Synuclein in Dopamine Neurons Do Not Display Behavioral Deficits. eNeuro. vol 11. issue 2. 2024-02-13. PMID:38351057. despite detecting robust overexpression of a53t/a30p mutant alpha-synuclein in dopamine neurons, we did not observe decreased tyrosine hydroxylase immunofluorescence or behavioral deficits in these mice. 2024-02-13 2024-02-16 mouse
Yoshiaki Soejima, Nahoko Iwata, Koichiro Yamamoto, Atsuhito Suyama, Yasuhiro Nakano, Fumio Otsuk. Mutual Effects of Orexin and Bone Morphogenetic Proteins on Catecholamine Regulation Using Adrenomedullary Cells. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38338864. orexin a treatment reduced the mrna levels of key enzymes for catecholamine synthesis, including tyrosine hydroxylase (th), 3,4-dihydroxyphenylalanie decarboxylase (ddc) and dopamine β-hydroxylase (dbh), in a concentration-dependent manner. 2024-02-10 2024-02-12 rat
Yeqing Xu, Jun Nie, Chenghao Lu, Chao Hu, Yunlu Chen, Ying Ma, Yuru Huang, Liping L. Effects and mechanisms of bisphenols exposure on neurodegenerative diseases risk: A systemic review. The Science of the total environment. 2024-02-07. PMID:38325473. this study provides an overview of the underlying pathogenic molecular mechanisms as a valuable basis for understanding neurodegenerative disease responses to bps, including accumulation of misfolded proteins, reduction of tyrosine hydroxylase and dopamine, abnormal hormone signaling, neuronal death, oxidative stress, calcium homeostasis, and inflammation. 2024-02-07 2024-02-10 human
Raman Kumar Tripathi, Lav Goyal, Shamsher Sing. Potential Therapeutic Approach Using Aromatic l-amino Acid Decarboxylase and Glial-derived Neurotrophic Factor Therapy Targeting Putamen in Parkinson's Disease. Current gene therapy. 2024-02-04. PMID:38310455. enhancing the enzymatic activity of tyrosine hydroxylase (th), glucocorticoid hormone (gch), and aadc in the striatum would be useful for external l-dopa to restore the dopamine (da) level. 2024-02-04 2024-02-06 Not clear
Anna Kolacheva, Ekaterina Pavlova, Alyona Bannikova, Vsevolod Bogdanov, Michael Ugrumo. Initial Molecular Mechanisms of the Pathogenesis of Parkinson's Disease in a Mouse Neurotoxic Model of the Earliest Preclinical Stage of This Disease. International journal of molecular sciences. vol 25. issue 2. 2024-01-27. PMID:38279354. it was shown that the content of tyrosine hydroxylase (th), the first enzyme in dopamine synthesis, does not change within 6 h after the administration of mptp, but decreases after 24 h. in turn, th activity increases after 1 h, decreases after 3 h, remains at the control level after 6 h, and decreases 24 h after the administration of mptp. 2024-01-27 2024-01-29 mouse
Adedamola Bayo-Olugbami, AbdulRazaq Bidemi Nafiu, Abdulbasit Amin, Olalekan Michael Ogundele, Charles C Lee, Bamidele Victor Owoyel. Cholecalciferol (VD3) Attenuates L-DOPA-Induced Dyskinesia in Parkinsonian Mice Via Modulation of Microglia and Oxido-Inflammatory Mechanisms. Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria. vol 37. issue 2. 2024-01-20. PMID:38243560. using western blot, striatum was assessed for expression of dopamine metabolic enzymes: tyrosine hydroxylase (th) and monoamine oxidase-b (mao-b); cd11b, bax, p47phox, and il-1β. 2024-01-20 2024-01-22 mouse
A C Akinmoladun, Ibrahim Saliu, Olaoluwa Abilogun, Omotola Helen Ajibola, Zainab Abiola Amoo, Olubukola Benedicta Ojo, Ebenezer O Farombi, Mary Tolulope Olaley. Comparative influence of kolaviron and coenzyme Q10 on complex I activity, glutamate clearance, 3,4-dihydroxyphenethylamine metabolism, and redox stress in rotenone-induced neurotoxicity. Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria. vol 37. issue 2. 2024-01-20. PMID:38243568. in all brain regions examined, kv and coenzyme q10 pretreatment modulated complex i activity, ameliorated redox imbalance, and enhanced dopamine metabolism via increasing the activity of tyrosine hydroxylase and decreasing monoamine oxidase activity. 2024-01-20 2024-01-22 rat
A C Akinmoladun, Bidemi Sikirat Jiddah Kazeem, Morenikejimi Bello, M Tolulope Olaley. Effect of standardized Eucalyptus globulus leaf extract on brain oxidative stress and aberrant neurochemistry of fructose-streptozotocin-induced diabetic rats. Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria. vol 38. issue 1. 2024-01-19. PMID:38243358. the brains of animals in the untreated diabetic group with increased blood glucose level showed oxidative stress (increased level of mda and myeloperoxidase but decreased level of reduced glutathione and superoxide dismutase) and disturbed neurochemistry (increased level of acetylcholinesterase and monoamine oxidase but decreased level of na+k+atpase, tyrosine hydroxylase and dopamine). 2024-01-19 2024-01-22 rat
Kunwar Jung-Kc, Alba Tristán-Noguero, Altanchimeg Altankhuyag, David Piñol Belenguer, Karina S Prestegård, Irene Fernandez-Carasa, Arianna Colini Baldeshi, Maria Sigatulina Bondarenko, Angeles García-Cazorla, Antonella Consiglio, Aurora Martine. Tetrahydrobiopterin (BH Journal of inherited metabolic disease. 2024-01-10. PMID:38196161. tetrahydrobiopterin (bh proteostatic regulation of tyrosine hydroxylase (th), the rate-limiting enzyme in dopamine biosynthesis, is crucial for maintaining proper brain neurotransmitter homeostasis. 2024-01-10 2024-01-13 Not clear
John Tyler, Madeline Podaras, Brittany Richardson, Nicole Roeder, Nikki Hammond, John Hamilton, Kenneth Blum, Mark Gold, David A Baron, Panayotis K Thano. High intensity interval training exercise increases dopamine D2 levels and modulates brain dopamine signaling. Frontiers in public health. vol 11. 2024-01-09. PMID:38192549. the present study examined the effects of chronic hiit exercise on dopamine signaling as measured by dopamine type 1-like receptor (d1r)-like, dopamine type 2-like receptor (d2r)-like, and tyrosine hydroxylase (th) quantification in the brains of male and female rats as measured by [ 2024-01-09 2024-01-10 rat
Jun Sung Park, Riaz Ahmad, Kyonghwan Choe, Min Hwa Kang, Tae Ju Park, Myeong Ok Ki. Immunization Effects of a Novel α-Synuclein-Based Peptide Epitope Vaccine in Parkinson's Disease-Associated Pathology. Vaccines. vol 11. issue 12. 2023-12-23. PMID:38140224. furthermore, vaccinated groups, especially ova and klh groups, showed decrease in α-syn levels and increased dopamine-related markers, i.e., tyrosine hydroxylase (th), vesicle monoamine transporter 2 (vmat2), and dopamine transporter (dat), and autophagy activities in the striatum and snpc. 2023-12-23 2023-12-25 mouse
Luca Lo Piccolo, Ranchana Yeewa, Sureena Pohsa, Titaree Yamsri, Daniel Calovi, Jutarop Phetcharaburanin, Manida Suksawat, Thanaporn Kulthawatsiri, Vorasuk Shotelersuk, Salinee Jantrapiro. FAME4-associating YEATS2 knockdown impairs dopaminergic synaptic integrity and leads to seizure-like behaviours in Drosophila melanogaster. Progress in neurobiology. 2023-12-21. PMID:38128822. additionally, reducing dyeats2 expression negatively affected tyrosine hydroxylase (th) gene expression, resulting in decreased dopamine biosynthesis. 2023-12-21 2023-12-24 drosophila_melanogaster
Yahong Zhang, Tsung-Huang Tsai, Michael Ezrokhi, Carl Stoelzel, Anthony H Cincott. Tyrosine Hydroxylase Knockdown at the Hypothalamic Supramammillary Nucleus Area Induces Obesity and Glucose Intolerance. Neuroendocrinology. 2023-12-21. PMID:38128505. this study investigated the effect of sumn tyrosine hydroxylase (rate-limiting enzyme in dopamine synthesis) knockdown (thx) on peripheral fuel metabolism. 2023-12-21 2023-12-24 Not clear
Sabine Jung-Klawitter, Petra Richter, Yuheng Yuan, Karin Welzel, Marie Kube, Stella Bähr, Alexander Leibner, Egbert Flory, Thomas Oplade. Tyrosine hydroxylase variants influence protein expression, cellular localization, stability, enzymatic activity and the physical interaction between tyrosine hydroxylase and GTP cyclohydrolase 1. Journal of inherited metabolic disease. 2023-12-12. PMID:38084654. tyrosine hydroxylase (th) is the rate-limiting enzyme in dopamine biosynthesis catalyzing the tetrahydrobiopterin (bh 2023-12-12 2023-12-17 Not clear
Ichiro Kawahata, Kohji Fukunag. Pathogenic Impact of Fatty Acid-Binding Proteins in Parkinson's Disease-Potential Biomarkers and Therapeutic Targets. International journal of molecular sciences. vol 24. issue 23. 2023-12-09. PMID:38069360. in particular, fabp3, abundant in nigrostriatal dopaminergic neurons, is responsible for α-synuclein propagation into neurons and intracellular accumulation, affecting the loss of mesencephalic tyrosine hydroxylase protein, a rate-limiting enzyme of dopamine biosynthesis. 2023-12-09 2023-12-17 Not clear
Sarita Pyatha, Haesoo Kim, Daeun Lee, Kisok Ki. Co-exposure to lead, mercury, and cadmium induces neurobehavioral impairments in mice by interfering with dopaminergic and serotonergic neurotransmission in the striatum. Frontiers in public health. vol 11. 2023-12-01. PMID:38026429. furthermore, compared to the control group, the metal mixture exposure group showed a significantly lower expression level of tyrosine hydroxylase (th) and significantly higher expression levels of dopamine transporter (dat), tryptophan hydroxylase 1 (tph1), and serotonin reuptake transporter (sert). 2023-12-01 2023-12-10 mouse
Noha Nabil Mohammed, Mariane G Tadros, Mina Y Georg. Empagliflozin repurposing in Parkinson's disease; modulation of oxidative stress, neuroinflammation, AMPK/SIRT-1/PGC-1α, and wnt/β-catenin pathways. Inflammopharmacology. 2023-12-01. PMID:38038781. moreover, rotenone induced alpha-synuclein accumulation, reduced tyrosine hydroxylase expression, dopamine, 3,4-dihydroxyphenylacetic acid, and homovanillic acid concentrations. 2023-12-01 2023-12-10 rat