| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cintia Klaudia Finszter, Róbert Kemecsei, Gergely Zachar, Ágota Ádám, András Csilla. Gestational VPA exposure reduces the density of juxtapositions between TH+ axons and calretinin or calbindin expressing cells in the ventrobasal forebrain of neonatal mice. Frontiers in neuroanatomy. vol 18. 2024-07-19. PMID:39026519. |
in the present study, the correlative distribution of tyrosine hydroxylase positive (th+) putative axon terminals, presynaptic to the target neurons containing calretinin (cr) or calbindin (cb), was assessed using double fluorescent immunocytochemistry and confocal laser microscopy in two dopamine recipient forebrain regions, nac and olfactory tubercle (ot) of neonatal mice (mothers injected with vpa on ed13.5, pups investigated on pd7). |
2024-07-19 |
2024-07-21 |
mouse |
| Jingjing Yang, Hongjuan Wang, Huan Chen, Hongwei Hou, Qingyuan H. The association of genetic polymorphisms within the dopaminergic system with nicotine dependence: A narrative review. Heliyon. vol 10. issue 12. 2024-07-18. PMID:39021905. |
dopamine levels are greatly influenced by synthesis, storage, release, degradation, and reuptake-related genes, including genes encoding tyrosine hydroxylase, dopamine decarboxylase, dopamine transporter, dopamine receptor, dopamine 3-hydroxylase, catechol- |
2024-07-18 |
2024-07-20 |
Not clear |
| Miguel Ribeiro, Jonas Campos, Tiffany S Pinho, Belém Sampaio-Marques, Sandra Barata-Antunes, Jorge Ribeiro Cibrão, Ricardo Araújo, Sara Duarte-Silva, Elsa Moreira, Rui A Sousa, Pedro M Costa, António J Salgad. Human platelet lysate supports SH-SY5Y neuroblastoma cell proliferation and differentiation into a dopaminergic-like neuronal phenotype under xenogeneic-free culture conditions. Biotechnology journal. vol 19. issue 7. 2024-07-10. PMID:38987218. |
furthermore, following treatment with retinoic acid (ra) and further stimulation with brain-derived neurotrophic factor (bdnf) and nerve growth factor beta (ngf-β), the percentage of sh-sy5y cells stained positive for dopaminergic neuronal differentiation markers (tyrosine hydroxylase [th] and dopamine transporter [dat]) was higher in hpl or fd-hpl than in fbs, and gene expression of dopaminergic markers th, dat, and dr2 was also detected. |
2024-07-10 |
2024-07-13 |
human |
| Wessam H Elesawy, Ayman E El-Sahar, Rabab H Sayed, Ahmed M Ashour, Shuruq E Alsufyani, Hany H Arab, Esraa A Kandi. Repurposing ezetimibe as a neuroprotective agent in a rotenone-induced Parkinson's disease model in rats: Role of AMPK/SIRT-1/PGC-1α signaling and autophagy. International immunopharmacology. vol 138. 2024-07-09. PMID:38981225. |
ezetimibe ameliorated the motor impairments in open field, rotarod and grip strength tests, restored striatal dopamine and tyrosine hydroxylase in the sn, up-regulated p-ampk, sirt1, and pgc1α striatal expression, upsurged the expression of ulk1, beclin1, and lc3ii/i, reduced bax/bcl2 ratio, and alleviated rotenone-induced histopathological changes in striatum and sn. |
2024-07-09 |
2024-07-12 |
rat |
| Ismail Alsalloum, Vitalii S Moskaliuk, Ilya A Rakhov, Daria V Bazovkina, Alexander V Kuliko. The C886T Mutation in the Biochemistry. Biokhimiia. vol 89. issue 6. 2024-07-09. PMID:38981698. |
the c886t mutation in the tyrosine hydroxylase (th) catalyzes hydroxylation of l-tyrosine to l-3,4-dihydroxyphenylalanine, the initial and rate-limiting step in the synthesis of dopamine, noradrenaline, and adrenaline. |
2024-07-09 |
2024-07-12 |
human |
| Vitaly Ryu, Anisa Azatovna Gumerova, Ronit Witztum, Funda Korkmaz, Liam Cullen, Hasni Kannangara, Ofer Moldavski, Orly Barak, Daria Lizneva, Ki A Goosens, Sarah Stanley, Se-Min Kim, Tony Yuen, Mone Zaid. An atlas of brain-bone sympathetic neural circuits in mice. eLife. vol 13. 2024-07-04. PMID:38963696. |
histological studies show abundant sns innervation of the periosteum and bone marrow-these nerves consist of noradrenergic fibers that immunostain for tyrosine hydroxylase, dopamine beta hydroxylase, or neuropeptide y. |
2024-07-04 |
2024-07-10 |
mouse |
| Ella A Kasanga, Isabel Soto, Ashley Centner, Robert McManus, Marla K Shifflet, Walter Navarrete, Yoonhee Han, Jerome Lisk, Travis Ehrhardt, Ken Wheeler, Isha Mhatre-Winters, Jason R Richardson, Christopher Bishop, Vicki A Nejtek, Michael F Salvator. Moderate intensity aerobic exercise alleviates motor deficits in 6-OHDA lesioned rats and reduces serum levels of biomarkers of Parkinson's disease severity without recovery of striatal dopamine or tyrosine hydroxylase. Experimental neurology. 2024-06-29. PMID:38944332. |
moderate intensity aerobic exercise alleviates motor deficits in 6-ohda lesioned rats and reduces serum levels of biomarkers of parkinson's disease severity without recovery of striatal dopamine or tyrosine hydroxylase. |
2024-06-29 |
2024-07-02 |
human |
| Ella A Kasanga, Isabel Soto, Ashley Centner, Robert McManus, Marla K Shifflet, Walter Navarrete, Yoonhee Han, Jerome Lisk, Travis Ehrhardt, Ken Wheeler, Isha Mhatre-Winters, Jason R Richardson, Christopher Bishop, Vicki A Nejtek, Michael F Salvator. Moderate intensity aerobic exercise alleviates motor deficits in 6-OHDA lesioned rats and reduces serum levels of biomarkers of Parkinson's disease severity without recovery of striatal dopamine or tyrosine hydroxylase. Experimental neurology. 2024-06-29. PMID:38944332. |
however, evidence for ae-related recovery of striatal dopamine (da) signaling or tyrosine hydroxylase (th) loss has been inconsistent in rodent studies. |
2024-06-29 |
2024-07-02 |
human |
| Jiahui Liu, Yu Fan, Jinyu Chen, Meili Zhao, Changchun Jian. FOXA1 Suppresses Endoplasmic Reticulum Stress, Oxidative Stress, and Neuronal Apoptosis in Parkinson's Disease by Activating PON2 Transcription. Neurotoxicity research. vol 42. issue 4. 2024-06-27. PMID:38935306. |
through the evaluation of tyrosine hydroxylase, dopamine transporter, reactive oxygen species (ros), and c/ebp homologous protein (chop) levels and neuronal loss in mice, as well as the examination of chop, glucose-regulated protein 94 (grp94), grp78, caspase-12, sarco/endoplasmic reticulum calcium atpase 2, malondialdehyde, and superoxide dismutase levels in sh-sy5y cells, we observed that pon2 overexpression mitigated er stress, os, and neuronal apoptosis both in vivo and in vitro. |
2024-06-27 |
2024-06-29 |
mouse |
| Ana Rosa Montaño-Rodriguez, Tabea Schorling, Jaan-Olle Andresso. Striatal GDNF Neurons Chemoattract RET-Positive Dopamine Axons at Seven Times Farther Distance Than Medium Spiny Neurons. Cells. vol 13. issue 12. 2024-06-26. PMID:38920687. |
furthermore, we provide evidence that tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis, is enriched towards gdnf neurons in the dopamine axons. |
2024-06-26 |
2024-06-29 |
Not clear |
| Rania M Salama, Samar F Darwish, Rana Yehia, Nermin Eissa, Noura F Elmongy, Mona M Abd-Elgalil, Mona F Schaalan, Sara A El Wakee. Apilarnil exerts neuroprotective effects and alleviates motor dysfunction by rebalancing M1/M2 microglia polarization, regulating miR-155 and miR-124 expression in a rotenone-induced Parkinson's disease rat model. International immunopharmacology. vol 137. 2024-06-23. PMID:38909495. |
the high dose of api (800 mg/kg) showed enhanced motor function, higher expression of tyrosine hydroxylase and dopamine levels, less dopamine turnover and α-synuclein expression, and a better histopathological picture when compared to the rot group and the lower two doses. |
2024-06-23 |
2024-06-26 |
rat |
| Yue Niu, Yifan Pan, Yaqi Wang, Yongqi Fu, Zhangwu Zhao, Le Kan. Lead specifically declines tyrosine hydroxylase activity to induce the onset of Parkinson's disease through disrupting dopamine biosynthesis in fly models. Environmental pollution (Barking, Essex : 1987). 2024-06-19. PMID:38897282. |
lead specifically declines tyrosine hydroxylase activity to induce the onset of parkinson's disease through disrupting dopamine biosynthesis in fly models. |
2024-06-19 |
2024-06-22 |
drosophila_melanogaster |
| Yue Niu, Yifan Pan, Yaqi Wang, Yongqi Fu, Zhangwu Zhao, Le Kan. Lead specifically declines tyrosine hydroxylase activity to induce the onset of Parkinson's disease through disrupting dopamine biosynthesis in fly models. Environmental pollution (Barking, Essex : 1987). 2024-06-19. PMID:38897282. |
analyses of gene expression and enzyme activity confirmed that pb exposure reduced tyrosine hydroxylase (th) activity and led to failure of dopamine synthesis. |
2024-06-19 |
2024-06-22 |
drosophila_melanogaster |
| Anna Kaplinsky, Reut Halperin, Gadi Shlomai, Amit Tiros. Role of epigenetic regulation on catecholamine synthesis in pheochromocytoma and paraganglioma. Cancer. 2024-06-14. PMID:38872410. |
catecholamines are synthesized by several enzymes: phenylalanine hydroxylase (encoded by pah), tyrosine hydroxylase (th), aromatic l-amino acid decarboxylase (ddc), dopamine β-hydroxylase (dbh), and phenylethanolamine n-methyltransferase (pnmt). |
2024-06-14 |
2024-06-16 |
Not clear |
| Trent Newman, Teruhito Ishihara, Geoff Shaw, Marilyn B Renfre. The structure of the TH/INS locus and the parental allele expressed are not conserved between mammals. Heredity. 2024-06-04. PMID:38834866. |
the tyrosine hydroxylase gene th encodes an enzyme involved in dopamine synthesis. |
2024-06-04 |
2024-06-07 |
mouse |
| Dong Hwan Ho, Hyejung Kim, Daleum Nam, Mi Kyoung Seo, Sung Woo Park, Ilhong So. Expression of G2019S LRRK2 in Rat Primary Astrocytes Mediates Neurotoxicity and Alters the Dopamine Synthesis Pathway in N27 Cells via Astrocytic Proinflammatory Cytokines and Neurotrophic Factors. Current issues in molecular biology. vol 46. issue 5. 2024-05-26. PMID:38785531. |
consequently, the regulation of the dopamine synthesis pathway was affected in n27 cells, thereby leading to altered levels of tyrosine hydroxylase, dopamine transporter, nurr1, and dopamine release. |
2024-05-26 |
2024-05-27 |
human |
| Adithya Gopinath, Adolfo Ramirez-Zamora, Stephen Franks, Tabish Riaz, Aidan Smith, Glen Dizon, Lauryn Hornstein, Jordan Follett, Camille Swartz, Jonathan Bravo, E Lee Kugelmann, Matthew Farrer, Michael S Okun, Habibeh Khoshboue. Immunophenotyping Tracks Motor Progression in Parkinson's Disease Associated with a TH Mutation. Journal of Parkinson's disease. 2024-05-24. PMID:38788089. |
our previous research indicated that pd patients with increased dopamine transporter (dat) and tyrosine hydroxylase (th) in peripheral blood mononuclear cells (pbmcs) might show disease progression and respond to levodopa treatment. |
2024-05-24 |
2024-05-27 |
Not clear |
| Waicong Dai, Mengsi Zhan, Yue Gao, Huxiao Sun, Yu Zou, Régis Laurent, Serge Mignani, Jean-Pierre Majoral, Mingwu Shen, Xiangyang Sh. Brain delivery of fibronectin through bioactive phosphorous dendrimers for Parkinson's disease treatment via cooperative modulation of microglia. Bioactive materials. vol 38. 2024-05-03. PMID:38699237. |
with the abundant dendrimer surface hydroxyl terminal groups, the developed ncs are able to cross blood-brain barrier (bbb) to exert targeted therapy of a pd mouse model through the ak123-mediated anti-inflammation for m2 polarization of microglia and fn-mediated antioxidant and anti-inflammatory effects, thus reducing the aggregation of α-synuclein and restoring the contents of dopamine and tyrosine hydroxylase to normal levels |
2024-05-03 |
2024-05-05 |
mouse |
| Lili Ma, Na Mi, Zhi Wang, Rui Bao, Jing Fang, Yajing Ren, Xiuzhi Xu, Hongjia Zhang, Ying Tan. Knockdown of IRF8 alleviates neuroinflammation through regulating microglial activation in Parkinson's disease. Journal of chemical neuroanatomy. 2024-04-26. PMID:38670441. |
irf8 was found to be prominently expressed in the substantia nigra pars compacta (snpc) region of pd mice and lps-stimulated bv2 cells, while the expression of tyrosine hydroxylase (th) and dopamine (da) content in the snpc region of pd mice was notably reduced. |
2024-04-26 |
2024-04-29 |
mouse |
| Jia-Yi Yao, Lu Li, Ji-Xuan Xu, Yan-Hong Liu, Jing Shi, Xiao-Qi Yu, Qing-Quan Kong, Kun L. Real-Time Monitoring of Tyrosine Hydroxylase Activity with a Ratiometric Fluorescent Probe. Analytical chemistry. 2024-04-23. PMID:38652135. |
tyrosine hydroxylase (th) is a key enzyme for producing dopamine, the levels of which can serve as an indicator for assessing the severity and progression of pd. |
2024-04-23 |
2024-04-26 |
Not clear |