| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cynthia L Bethea, Kenny Phu, Arubala P Reddy, Judy L Camero. The effect of short-term stress on serotonin gene expression in high and low resilient macaques. Progress in neuro-psychopharmacology & biological psychiatry. vol 44. 2013-12-18. PMID:23357537. |
tryptophan hydroxylase 2 (tph2), the serotonin reuptake transporter (sert), and the 5ht1a autoreceptor mrnas expression were determined at 4 morphological levels of the dorsal raphe nucleus with in situ hybridization (ish) using digoxigenin-incorporated riboprobes. |
2013-12-18 |
2023-08-12 |
monkey |
| Nina C Donner, Christian D Montoya, Jodi L Lukkes, Christopher A Lowr. Chronic non-invasive corticosterone administration abolishes the diurnal pattern of tph2 expression. Psychoneuroendocrinology. vol 37. issue 5. 2012-07-27. PMID:21924839. |
remarkably, all doses of corticosterone treatment abolished the diurnal variation of tph2 mrna expression in the brainstem dorsal raphe nucleus (dr) by elevating the gene's expression during the animals' inactive (light) phase. |
2012-07-27 |
2023-08-12 |
rat |
| Margaret Czesak, Brice Le François, Anne M Millar, Mariam Deria, Mireille Daigle, Jane E Visvader, Hymie Anisman, Paul R Alber. Increased serotonin-1A (5-HT1A) autoreceptor expression and reduced raphe serotonin levels in deformed epidermal autoregulatory factor-1 (Deaf-1) gene knock-out mice. The Journal of biological chemistry. vol 287. issue 9. 2012-04-25. PMID:22232550. |
in the dorsal raphe, deaf-1 knock-out mice displayed increased 5-ht1a mrna, protein, and 5-ht1a-positive cell counts but reduced 5-ht levels, whereas other serotonergic markers, such as tryptophan hydroxylase (tph)- or 5-ht-positive cells and tph2 rna levels, were unchanged. |
2012-04-25 |
2023-08-12 |
mouse |
| Cynthia L Bethea, Fernanda B Lima, Maria L Centeno, Karin V Weissheimer, Olga Senashova, Arubala P Reddy, Judy L Camero. Effects of citalopram on serotonin and CRF systems in the midbrain of primates with differences in stress sensitivity. Journal of chemical neuroanatomy. vol 41. issue 4. 2012-02-22. PMID:21683135. |
examination of the serotonin system revealed that ss monkeys had significantly lower fev (fifth ewing variant, rodent pet1), tph2 (tryptophan hydroxylase 2), 5ht1a autoreceptor and sert (serotonin reuptake transporter) expression in the dorsal raphe than sr monkeys. |
2012-02-22 |
2023-08-12 |
monkey |
| Helene Bach, Victoria Arango, Yung-Yu Huang, Sharlene Leong, J John Mann, Mark D Underwoo. Neuronal tryptophan hydroxylase expression in BALB/cJ and C57Bl/6J mice. Journal of neurochemistry. vol 118. issue 6. 2011-11-01. PMID:21740442. |
tph2 mrna and tph2 protein in brainstem dorsal raphe nuclei was assayed by in situ hybridization and immunocytochemistry respectively. |
2011-11-01 |
2023-08-12 |
mouse |
| Helene Bach, Victoria Arango, Yung-Yu Huang, Sharlene Leong, J John Mann, Mark D Underwoo. Neuronal tryptophan hydroxylase expression in BALB/cJ and C57Bl/6J mice. Journal of neurochemistry. vol 118. issue 6. 2011-11-01. PMID:21740442. |
the largest difference in tph2 transcript expression was in rostral dorsal raphe nuclei (t = 2.731, p = 0.008). |
2011-11-01 |
2023-08-12 |
mouse |
| R Hiroi, R A McDevitt, P A Morcos, M S Clark, J F Neumaie. Overexpression or knockdown of rat tryptophan hyroxylase-2 has opposing effects on anxiety behavior in an estrogen-dependent manner. Neuroscience. vol 176. 2011-06-01. PMID:21182901. |
previous studies showed that chronic estrogen treatment increases tryptophan hydroxylase-2 (tph2) mrna in the caudal dorsal raphe nucleus (drn), and this increase was associated with decreased anxiety. |
2011-06-01 |
2023-08-12 |
rat |
| K L Gardner, M W Hale, S Oldfield, S L Lightman, P M Plotsky, C A Lowr. Adverse experience during early life and adulthood interact to elevate tph2 mRNA expression in serotonergic neurons within the dorsal raphe nucleus. Neuroscience. vol 163. issue 4. 2010-02-12. PMID:19647049. |
adverse experience during early life and adulthood interact to elevate tph2 mrna expression in serotonergic neurons within the dorsal raphe nucleus. |
2010-02-12 |
2023-08-12 |
rat |
| K L Gardner, M W Hale, S Oldfield, S L Lightman, P M Plotsky, C A Lowr. Adverse experience during early life and adulthood interact to elevate tph2 mRNA expression in serotonergic neurons within the dorsal raphe nucleus. Neuroscience. vol 163. issue 4. 2010-02-12. PMID:19647049. |
to evaluate the effects of ele, adverse experiences during adulthood, and potential interactions between these factors on neuronal tryptophan hydroxylase 2 (tph2) mrna expression, we investigated in rats the effects of maternal separation (ms)(separation from the dam for 180 min/day from postnatal day 2-14; ms180, a model of vulnerability to a depression-like syndrome), neonatal handling (separation from the dam for 15 min/day from postnatal day 2-14; ms15, a model of decreased stress sensitivity), or normal animal facility rearing (afr) control conditions, with or without subsequent exposure to adult social defeat, on tph2 mrna expression in the dorsal raphe nucleus (dr). |
2010-02-12 |
2023-08-12 |
rat |
| F B Lima, M L Centeno, M E Costa, A P Reddy, J L Cameron, C L Bethe. Stress sensitive female macaques have decreased fifth Ewing variant (Fev) and serotonin-related gene expression that is not reversed by citalopram. Neuroscience. vol 164. issue 2. 2010-02-12. PMID:19671441. |
fev (fifth ewing variant) ets transcription factor, tryptophan hydroxylase 2 (tph2), the serotonin reuptake transporter (sert), and the 5ht1a autoreceptor were determined at 7-8 levels of the dorsal raphe nucleus with in situ hybridization (ish) using radiolabeled- and digoxygenin-incorporated riboprobes. |
2010-02-12 |
2023-08-12 |
monkey |
| F B Lima, M L Centeno, M E Costa, A P Reddy, J L Cameron, C L Bethe. Stress sensitive female macaques have decreased fifth Ewing variant (Fev) and serotonin-related gene expression that is not reversed by citalopram. Neuroscience. vol 164. issue 2. 2010-02-12. PMID:19671441. |
ss monkeys also had significantly lower levels of tph2, sert and 5ht1a mrnas in the dorsal raphe nucleus than hsr monkeys. |
2010-02-12 |
2023-08-12 |
monkey |
| N Donner, R J Hand. Estrogen receptor beta regulates the expression of tryptophan-hydroxylase 2 mRNA within serotonergic neurons of the rat dorsal raphe nuclei. Neuroscience. vol 163. issue 2. 2009-12-14. PMID:19559077. |
therefore, we tested the hypothesis that er beta may contribute to the regulation of gene expression in 5-ht neurons of the dorsal raphe nuclei (drn) by examining the effects of systemic and local application of the selective er beta agonist diarylpropionitrile (dpn) on tph2 mrna expression. |
2009-12-14 |
2023-08-12 |
rat |
| Christopher A Lowry, Matthew W Hale, Andrew K Evans, Jasper Heerkens, Daniel R Staub, Paul J Gasser, Anantha Shekha. Serotonergic systems, anxiety, and affective disorder: focus on the dorsomedial part of the dorsal raphe nucleus. Annals of the New York Academy of Sciences. vol 1148. 2009-01-23. PMID:19120094. |
here we review our current understanding of how genetic and environmental factors may influence tph2 mrna expression and serotonergic neurotransmission, focusing in particular on the dorsomedial part of the dorsal raphe nucleus. |
2009-01-23 |
2023-08-12 |
Not clear |
| W L Bonkale, M C Austi. 3,4-Methylenedioxymethamphetamine induces differential regulation of tryptophan hydroxylase 2 protein and mRNA levels in the rat dorsal raphe nucleus. Neuroscience. vol 155. issue 1. 2008-11-05. PMID:18515011. |
the present study was designed to assess the effect of mdma on the rate-limiting enzyme in 5-ht biosynthesis, tryptophan hydroxylase (tph), by measuring tph2 protein and mrna levels in rat dorsal raphe (dr) nucleus. |
2008-11-05 |
2023-08-12 |
rat |
| Nashat Abumaria, Adema Ribic, Christoph Anacker, Eberhard Fuchs, Gabriele Flügg. Stress upregulates TPH1 but not TPH2 mRNA in the rat dorsal raphe nucleus: identification of two TPH2 mRNA splice variants. Cellular and molecular neurobiology. vol 28. issue 3. 2008-08-11. PMID:18197473. |
stress upregulates tph1 but not tph2 mrna in the rat dorsal raphe nucleus: identification of two tph2 mrna splice variants. |
2008-08-11 |
2023-08-12 |
rat |
| H Bach-Mizrachi, M D Underwood, A Tin, S P Ellis, J J Mann, V Arang. Elevated expression of tryptophan hydroxylase-2 mRNA at the neuronal level in the dorsal and median raphe nuclei of depressed suicides. Molecular psychiatry. vol 13. issue 5. 2008-07-03. PMID:18180753. |
paradoxically, in the dorsal raphe nucleus (drn) there are more serotonin neurons and more neuronal tryptophan hydroxylase-2 (tph2) expression postmortem in depressed suicides. |
2008-07-03 |
2023-08-12 |
Not clear |
| G T Shishkina, T S Kalinina, N N Dygal. Up-regulation of tryptophan hydroxylase-2 mRNA in the rat brain by chronic fluoxetine treatment correlates with its antidepressant effect. Neuroscience. vol 150. issue 2. 2008-04-03. PMID:17950541. |
using real-time reverse transcription-polymerase chain reaction (rt-pcr) and semi-quantitative rt-pcr techniques, we have examined the effects of fluoxetine administration with drinking water (7.5 mg/kg/day) for 2, 4 and 8 weeks on tph2 mrna expression in the midbrain part of the dorsal raphe nucleus (drn) and in the brainstem containing the rest of the raphe complex. |
2008-04-03 |
2023-08-12 |
rat |
| Helene Bach-Mizrachi, Mark D Underwood, Suham A Kassir, Mihran J Bakalian, Etienne Sibille, Hadassah Tamir, J John Mann, Victoria Arang. Neuronal tryptophan hydroxylase mRNA expression in the human dorsal and median raphe nuclei: major depression and suicide. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 4. 2006-05-25. PMID:16192985. |
previously, we reported elevated levels of tph protein in the dorsal raphe nucleus (drn) of depressed suicides and now examine expression of neuronal tph2 mrna in a cohort of matched controls and depressed suicides (n = 11 pairs). |
2006-05-25 |
2023-08-12 |
human |
| Zeina S Malek, Hugues Dardente, Paul Pevet, Sylvie Raiso. Tissue-specific expression of tryptophan hydroxylase mRNAs in the rat midbrain: anatomical evidence and daily profiles. The European journal of neuroscience. vol 22. issue 4. 2005-10-18. PMID:16115212. |
our results demonstrate that: (i) tph2 gene is exclusively expressed in the raphe nuclei, whereas tph1 gene is expressed in the pineal gland; (ii) under light-dark cycle (ld), tph2 mrna levels present daily variation within both median and dorsal raphe nuclei; (iii) under constant darkness tph2 mrna levels in both nuclei exhibit the same variation reported under ld cycle. |
2005-10-18 |
2023-08-12 |
rat |
| Janet A Clark, Lee-Yuh Pai, Rosemarie Beth Flick, Susan P Rohre. Differential hormonal regulation of tryptophan hydroxylase-2 mRNA in the murine dorsal raphe nucleus. Biological psychiatry. vol 57. issue 8. 2005-05-16. PMID:15820718. |
hormonal effects on tph2 mrna expression in the rodent dorsal raphe nucleus (drn) are unknown. |
2005-05-16 |
2023-08-12 |
Not clear |