| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jennyfer M Payet, Eliza Burnie, Nick J Sathananthan, Adrian M Russo, Adam J Lawther, Stephen Kent, Christopher A Lowry, Matthew W Hal. Exposure to Acute and Chronic Fluoxetine has Differential Effects on Sociability and Activity of Serotonergic Neurons in the Dorsal Raphe Nucleus of Juvenile Male BALB/c Mice. Neuroscience. vol 386. 2019-03-11. PMID:29940216. |
one cohort of mice then received an injection of the aromatic amino acid decarboxylase inhibitor, nsd-1015, and one hour later brain tissue was collected for quantification of 5-hydroxytryptophan accumulation in the dorsal raphe nucleus (dr) as a measure of tph2 activity. |
2019-03-11 |
2023-08-13 |
mouse |
| Helene Bach, Victoria Arango, Suham A Kassir, Andrew J Dwork, J John Mann, Mark D Underwoo. Cigarette Smoking and Tryptophan Hydroxylase 2 mRNA in the Dorsal Raphe Nucleus in Suicides. Archives of suicide research : official journal of the International Academy for Suicide Research. vol 20. issue 3. 2018-01-24. PMID:26954509. |
tph2 mrna was measured postmortem in the dorsal raphe nucleus (drn) of controls (n = 26, 17 nonsmokers and nine smokers) and suicides (n = 23, 5 nonsmokers and 18 smokers). |
2018-01-24 |
2023-08-13 |
Not clear |
| Kaitlyn M Harding, Joseph S Lonstei. Extensive juvenile "babysitting" facilitates later adult maternal responsiveness, decreases anxiety, and increases dorsal raphe tryptophan hydroxylase-2 expression in female laboratory rats. Developmental psychobiology. vol 58. issue 4. 2017-01-17. PMID:26806471. |
we examined the effect of chronic exposure to pups during post-weaning juvenile life (days 22-36) on adult maternal responsiveness, anxiety-related behaviors, and dorsal raphe tryptophan hydroxylase-2 (tph2) and serotonin transporter (sert) levels in nulliparous rats. |
2017-01-17 |
2023-08-13 |
rat |
| Kaitlyn M Harding, Joseph S Lonstei. Extensive juvenile "babysitting" facilitates later adult maternal responsiveness, decreases anxiety, and increases dorsal raphe tryptophan hydroxylase-2 expression in female laboratory rats. Developmental psychobiology. vol 58. issue 4. 2017-01-17. PMID:26806471. |
adult females with juvenile alloparental experience showed significantly faster sensitized maternal responsiveness, less anxiety, and more dorsal raphe tph2. |
2017-01-17 |
2023-08-13 |
rat |
| R Hiroi, D L Carbone, D G Zuloaga, H A Bimonte-Nelson, R J Hand. Sex-dependent programming effects of prenatal glucocorticoid treatment on the developing serotonin system and stress-related behaviors in adulthood. Neuroscience. vol 320. 2016-12-13. PMID:26844389. |
we examined the effects of dexamethasone (dex; a synthetic gc) during prenatal life on stress-related behaviors in adulthood and on the tryptophan hydroxylase-2 (tph2) gene expression in the adult dorsal raphe nucleus (drn). |
2016-12-13 |
2023-08-13 |
human |
| Nina C Donner, Philip H Siebler, Danté T Johnson, Marcos D Villarreal, Sofia Mani, Allison J Matti, Christopher A Lowr. Serotonergic systems in the balance: CRHR1 and CRHR2 differentially control stress-induced serotonin synthesis. Psychoneuroendocrinology. vol 63. 2016-10-19. PMID:26454419. |
here, we found that adult male rats treated with corticosterone (cort, 100 μg/ml) via the drinking water for 21 days indeed show increased tph2 protein expression in the dorsal and ventral part of the dorsal raphe nucleus (drd, drv) during the light phase, abolishing the enzyme's diurnal rhythm. |
2016-10-19 |
2023-08-13 |
rat |
| Rani K Vasudeva, Alexander R Hobby, Lynn G Kirb. Ethanol consumption in the Sprague-Dawley rat increases sensitivity of the dorsal raphe nucleus to 5,7-dihydroxytryptamine. Behavioural brain research. vol 295. 2016-09-05. PMID:26073764. |
quantification of 5-ht depletion in the dorsal raphe nucleus (drn) using tryptophan hydroxylase-2 (tph2) immunohistochemistry resulted in a 76% decrease in staining with 5,7-dht treatment. |
2016-09-05 |
2023-08-13 |
rat |
| Alberto Montalbano, Jonas Waider, Mario Barbieri, Ozan Baytas, Klaus-Peter Lesch, Renato Corradetti, Boris Mlina. Cellular resilience: 5-HT neurons in Tph2(-/-) mice retain normal firing behavior despite the lack of brain 5-HT. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 11. 2016-08-26. PMID:26409296. |
we report that the active properties of dorsal raphe nucleus (drn) 5-ht neurons in vivo (firing rate magnitude and variability; the presence of spike doublets) and in vitro (firing in response to depolarizing current pulses; action potential shape) as well as the resting membrane potential remained essentially unchanged across tph2 genotypes. |
2016-08-26 |
2023-08-13 |
mouse |
| Boris Mlinar, Alberto Montalbano, Lukasz Piszczek, Cornelius Gross, Renato Corradett. Firing Properties of Genetically Identified Dorsal Raphe Serotonergic Neurons in Brain Slices. Frontiers in cellular neuroscience. vol 10. 2016-08-18. PMID:27536220. |
in order to examine in an unbiased manner whether serotonergic neurons of the dorsal raphe nucleus (drn) are heterogeneous, we used a non-invasive loose-seal cell-attached method to record α1 adrenergic receptor-stimulated spiking of a large sample of neurons in brain slices obtained from transgenic mice lines that express fluorescent marker proteins under the control of serotonergic system-specific tph2 and pet-1 promoters. |
2016-08-18 |
2023-08-13 |
mouse |
| D L A Van den Hove, N K Leibold, E Strackx, M Martinez-Claros, K P Lesch, H W M Steinbusch, K R J Schruers, J Prickaert. Prenatal stress and subsequent exposure to chronic mild stress in rats; interdependent effects on emotional behavior and the serotonergic system. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 24. issue 4. 2016-05-06. PMID:24139910. |
at the neurochemical level, both ps and cms induced various sex-specific alterations in serotonin (5-ht) and tryptophan hydroxylase 2 (tph2) immunoreactivity in the dorsal raphe nucleus, hippocampus and prefrontal cortex with, in line with the behavioral observations, more profound effects in male offspring. |
2016-05-06 |
2023-08-12 |
rat |
| Cynthia L Bethea, Kenny Phu, Yelena Belikova, Sarah C Bethe. Localization and regulation of reproductive steroid receptors in the raphe serotonin system of male macaques. Journal of chemical neuroanatomy. vol 66-67. 2016-05-05. PMID:25908331. |
however, approximately 40% of dorsal raphe serotonin neurons contained erα or erβ⋅ in conclusion, the stimulatory effect of androgens on tph2 and sert mrna expression is mediated indirectly by neighboring neurons contain ar. |
2016-05-05 |
2023-08-13 |
monkey |
| Andras David Nagy, Ayaka Iwamoto, Misato Kawai, Ryosei Goda, Haruka Matsuo, Tsuyoshi Otsuka, Mao Nagasawa, Mitsuhiro Furuse, Shinobu Yasu. Melatonin adjusts the expression pattern of clock genes in the suprachiasmatic nucleus and induces antidepressant-like effect in a mouse model of seasonal affective disorder. Chronobiology international. vol 32. issue 4. 2016-02-16. PMID:25515595. |
melatonin treatments altered the expression of genes of serotonergic neurotransmission in the dorsal raphe (tph2, sert, vmat2 and 5ht1a) and serotonin contents in the amygdala. |
2016-02-16 |
2023-08-13 |
mouse |
| Ran Ye, Meagan A Quinlan, Hideki Iwamoto, Hsiao-Huei Wu, Noah H Green, Christopher S Jetter, Douglas G McMahon, Jeremy Veestra-VanderWeele, Pat Levitt, Randy D Blakel. Physical Interactions and Functional Relationships of Neuroligin 2 and Midbrain Serotonin Transporters. Frontiers in synaptic neuroscience. vol 7. 2016-01-21. PMID:26793096. |
dual color in situ hybridization confirmed co-expression of tph2 and nlgn2 mrna in the dorsal raphe, with immunocytochemical studies confirming sert:nlgn2 co-localization in raphe cell bodies but not axons. |
2016-01-21 |
2023-08-13 |
mouse |
| C L Bethea, K Coleman, K Phu, A P Reddy, A Ph. Relationships between androgens, serotonin gene expression and innervation in male macaques. Neuroscience. vol 274. 2015-10-15. PMID:24909896. |
tph2 and sert expression were significantly elevated in t- and dht + atd-treated groups over placebo- and flut + atd-treated groups in the dorsal raphe (p < 0.007). |
2015-10-15 |
2023-08-13 |
monkey |
| Meiju Zhu, Hongzhu Zhu, Ninghua Tan, Guangzhi Zeng, Zhigang Zeng, Hongbiao Chu, Hui Wang, Zhi Xia, Renle W. The effects of Acorus tatarinowii Schott on 5-HT concentrations, TPH2 and 5-HT1B expression in the dorsal raphe of exercised rats. Journal of ethnopharmacology. vol 158 Pt A. 2015-09-25. PMID:25456438. |
the effects of acorus tatarinowii schott on 5-ht concentrations, tph2 and 5-ht1b expression in the dorsal raphe of exercised rats. |
2015-09-25 |
2023-08-13 |
rat |
| Meiju Zhu, Hongzhu Zhu, Ninghua Tan, Guangzhi Zeng, Zhigang Zeng, Hongbiao Chu, Hui Wang, Zhi Xia, Renle W. The effects of Acorus tatarinowii Schott on 5-HT concentrations, TPH2 and 5-HT1B expression in the dorsal raphe of exercised rats. Journal of ethnopharmacology. vol 158 Pt A. 2015-09-25. PMID:25456438. |
in this study, the effects of acorus tatarinowii schott on treadmill running endurance, 5-ht concentrations, tph2, 5-ht1b expression in the dorsal raphe of exercised rats were investigated. |
2015-09-25 |
2023-08-13 |
rat |
| Helene Bach, Victoria Arango, Suham A Kassir, Tea Tsaava, Andrew J Dwork, J John Mann, Mark D Underwoo. Alcoholics have more tryptophan hydroxylase 2 mRNA and protein in the dorsal and median raphe nuclei. Alcoholism, clinical and experimental research. vol 38. issue 7. 2015-04-14. PMID:24942188. |
chronic alcohol use depletes brain serotonin (5-hydroxytryptamine [5-ht]), yet we previously found more tryptophan hydroxylase 2 (tph2), the rate-limiting biosynthetic enzyme for 5-ht, in the dorsal raphe nucleus (drn) of alcoholics. |
2015-04-14 |
2023-08-13 |
Not clear |
| C M Ragan, J S Lonstei. Differential postpartum sensitivity to the anxiety-modulating effects of offspring contact is associated with innate anxiety and brainstem levels of dopamine beta-hydroxylase in female laboratory rats. Neuroscience. vol 256. 2014-08-27. PMID:24161285. |
levels of dopamine β-hydroxylase (dbh, norepinephrine synthesizing enzyme) and tryptophan hydroxylase-2 (tph2, serotonin synthesizing enzyme) were measured in the brainstem and dorsal raphe, respectively. |
2014-08-27 |
2023-08-12 |
rat |
| C M Ragan, J S Lonstei. Differential postpartum sensitivity to the anxiety-modulating effects of offspring contact is associated with innate anxiety and brainstem levels of dopamine beta-hydroxylase in female laboratory rats. Neuroscience. vol 256. 2014-08-27. PMID:24161285. |
there was no relationship between females' anxiety and dorsal raphe tph2. |
2014-08-27 |
2023-08-12 |
rat |
| Ryoko Hiroi, Robert J Hand. Estrogen receptor-β regulates human tryptophan hydroxylase-2 through an estrogen response element in the 5' untranslated region. Journal of neurochemistry. vol 127. issue 4. 2014-01-06. PMID:24033289. |
in the dorsal raphe nucleus, 17β-estradiol (e2) increases the expression of the brain-specific, rate-limiting enzyme for serotonin biosynthesis, tryptophan hydroxylase-2 (tph2). |
2014-01-06 |
2023-08-12 |
human |