| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sylvana I S Rendeiro de Noronha, Lauro Angelo Gonçalves de Moraes, James E Hassell, Christopher E Stamper, Mathew R Arnold, Jared D Heinze, Christine L Foxx, Margaret M Lieb, Kristin E Cler, Bree L Karns, Sophia Jaekel, Kelsey M Loupy, Fernanda C S Silva, Deoclécio Alves Chianca-Jr, Christopher A Lowry, Rodrigo Cunha de Meneze. High-fat diet, microbiome-gut-brain axis signaling, and anxiety-like behavior in male rats. Biological research. vol 57. issue 1. 2024-05-05. PMID:38705984. |
we show that hfd intake decreased alpha diversity and altered the community composition of the gut microbiome in association with obesity, increased brainstem tph2, htr1a and slc6a4 mrna expression, including in the caudal part of the dorsomedial dorsal raphe nucleus (cdrd), a subregion previously associated with stress- and anxiety-related behavioral responses, and, finally, increased anxiety-related defensive behavioral responses. |
2024-05-05 |
2024-05-08 |
rat |
| Sylvana I S Rendeiro de Noronha, Lauro Angelo Gonçalves de Moraes, James E Hassell, Christopher E Stamper, Mathew R Arnold, Jared D Heinze, Christine L Foxx, Margaret M Lieb, Kristin E Cler, Bree L Karns, Sophia Jaekel, Kelsey M Loupy, Fernanda C S Silva, Deoclécio Alves Chianca-Jr, Christopher A Lowry, Rodrigo Cunha de Meneze. High-fat diet, microbiome-gut-brain axis signaling, and anxiety-like behavior in male rats. Biological research. vol 57. issue 1. 2024-05-05. PMID:38705984. |
we found that tph2, htr1a and slc6a4 mrna expression were increased in subregions of the dorsal raphe nucleus in the hfd, relative to control diet. |
2024-05-05 |
2024-05-08 |
rat |
| L Sophie Gullino, Cara Fuller, Poppy Dunn, Helen M Collins, Salah El Mestikawy, Trevor Shar. Evidence for a Role of 5-HT-glutamate Co-releasing Neurons in Acute Stress Mechanisms. ACS chemical neuroscience. 2024-02-20. PMID:38377469. |
acute, uncontrollable swim stress increased c-fos immunoreactivity in neurons co-expressing vglut3 and the 5-ht marker tryptophan hydroxylase 2 (tph2) in the dorsal raphe nucleus (drn). |
2024-02-20 |
2024-02-23 |
mouse |
| Sangwon Jang, Inah Park, Mijung Choi, Jihoon Kim, Seungeun Yeo, Sung-Oh Huh, Ji-Woong Choi, Cheil Moon, Han Kyoung Choe, Youngshik Choe, Kyungjin Ki. Impact of the circadian nuclear receptor REV-ERBα in dorsal raphe 5-HT neurons on social interaction behavior, especially social preference. Experimental & molecular medicine. 2023-08-03. PMID:37537215. |
to investigate whether the circadian nuclear receptor rev-erbα, a transcriptional repressor of the rate-limiting enzyme tryptophan hydroxylase 2 (tph2) gene in 5-ht biosynthesis, may affect social interaction behaviors, we generated a conditional knockout (cko) mouse by targeting rev-erbα in dorsal raphe (dr) 5-ht neurons (5-ht |
2023-08-03 |
2023-08-14 |
mouse |
| Pei He, Binjun He, Shu Li, Wen Chai, Wei Rao, Yu Zhu, Wenzhi Chen, Ping Zhang, Xiong Zhang, Haili Pan, Renshi X. Distribution Features and Potential Effects of Serotonin in the Cerebrum of SOD1 G93A Transgenic Mice. eNeuro. 2022-10-20. PMID:36265904. |
both 5-ht and tryptophan hydroxylase-2 (tph2) were mainly present in the limbic systems of the cerebrum, such as the glomerular layer of the olfactory bulb, nucleus accumbens, cingulate, fimbria of the hippocampus, mediodorsal thalamic nucleus, habenular nucleus, ventromedial hypothalamus nucleus, lateral hypothalamus area, dorsal raphe nucleus and piriform cortex. |
2022-10-20 |
2023-08-14 |
mouse |
| Pei He, Binjun He, Shu Li, Wen Chai, Wei Rao, Yu Zhu, Wenzhi Chen, Ping Zhang, Xiong Zhang, Haili Pan, Renshi X. Distribution Features and Potential Effects of Serotonin in the Cerebrum of SOD1 G93A Transgenic Mice. eNeuro. 2022-10-20. PMID:36265904. |
tph2 and 5-ht were expressed in cell bodies in the dorsal raphe nucleus and piriform cortex, while in other regions they were distributed as filaments and clump shapes in axons. |
2022-10-20 |
2023-08-14 |
mouse |
| Kento Igarashi, Toshiko Kuchiiwa, Satoshi Kuchiiwa, Haruki Iwai, Kazuo Tomita, Tomoaki Sat. Kamishoyosan (a Japanese traditional herbal formula), which effectively reduces the aggressive biting behavior of male and female mice, and potential regulation through increase of Tph1, Tph2, and Esr2 mRNA levels. Brain research. vol 1768. 2021-12-09. PMID:34260963. |
furthermore, gene expression of tryptophan hydroxylase (tph) 1 and tph2 were increased and 5-ht immunofluorescence was slightly increased in the dorsal raphe nucleus (drn) of isolation-reared mice administered with kss. |
2021-12-09 |
2023-08-13 |
mouse |
| Zeina S Malek, Louay M Labba. Photoperiod regulates the daily profiles of tryptophan hydroxylase-2 gene expression the raphe nuclei of rats. The International journal of neuroscience. vol 131. issue 12. 2021-11-10. PMID:32532168. |
we have assessed the daily expression of tph2 mrna in both median and dorsal raphe nuclei of rats housed either under long photoperiod (18 h light/6 h dark cycle, lp18:6) or short photoperiod (sp6:18). |
2021-11-10 |
2023-08-13 |
rat |
| Chen Li, Fantao Meng, Jacob C Garza, Jing Liu, Yun Lei, Sergei A Kirov, Ming Guo, Xin-Yun L. Modulation of depression-related behaviors by adiponectin AdipoR1 receptors in 5-HT neurons. Molecular psychiatry. vol 26. issue 8. 2021-11-02. PMID:31980728. |
here we show that adiponectin receptor 1 (adipor1) is expressed in the dorsal raphe nucleus (drn) and colocalized with tryptophan hydroxylase 2 (tph2), a marker of serotonin (5-ht) neurons. |
2021-11-02 |
2023-08-13 |
mouse |
| Aude Muzerelle, Mariano Soiza-Reilly, Cornelia Hainer, Pierre-Louis Ruet, Klaus-Peter Lesch, Michael Bader, Natalia Alenina, Sophie Scotto-Lomassese, Patricia Gaspa. Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival. Scientific reports. vol 11. issue 1. 2021-10-14. PMID:33727585. |
this nursing defect is due to acute rather constitutive 5-ht depletion, as it is reproduced by adult knockdown of tph2 in the dorsal raphe nucleus in mothers with a prior normal maternal experience. |
2021-10-14 |
2023-08-13 |
mouse |
| Luana Olegário da Silva, Raquel da Silva Aragão, Manuella da Luz Duarte Barros, Kelli Nogueira Ferraz-Pereira, Isabeli Lins Pinheiro, Lígia Cristina Monteiro Galind. Maternal exposure to high-fat diet modifies anxiety-like/depression-like behaviors and compounds of Serotonergic System in offspring: A preclinical systematic review. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 81. issue 5. 2021-08-06. PMID:33788300. |
maternal consumption of hfd was found to be associated with an inconsistent pattern of the expression of tph2 as well as reduced the immunoreactivity of 5-ht in the prefrontal cortex and increased 5-ht1a receptor expression in the dorsal raphe of offspring. |
2021-08-06 |
2023-08-13 |
Not clear |
| Hailan Liu, Chunmei Wang, Meng Yu, Yongjie Yang, Yang He, Hesong Liu, Chen Liang, Longlong Tu, Nan Zhang, Lina Wang, Julia Wang, Feng Liu, Fang Hu, Yong X. TPH2 in the Dorsal Raphe Nuclei Regulates Energy Balance in a Sex-Dependent Manner. Endocrinology. vol 162. issue 1. 2021-05-14. PMID:33034617. |
tph2 in the dorsal raphe nuclei regulates energy balance in a sex-dependent manner. |
2021-05-14 |
2023-08-13 |
mouse |
| Hailan Liu, Chunmei Wang, Meng Yu, Yongjie Yang, Yang He, Hesong Liu, Chen Liang, Longlong Tu, Nan Zhang, Lina Wang, Julia Wang, Feng Liu, Fang Hu, Yong X. TPH2 in the Dorsal Raphe Nuclei Regulates Energy Balance in a Sex-Dependent Manner. Endocrinology. vol 162. issue 1. 2021-05-14. PMID:33034617. |
abstractcentral 5-hydroxytryptamine (5-ht), which is primarily synthesized by tryptophan hydroxylase 2 (tph2) in the dorsal raphe nuclei (drn), plays a pivotal role in the regulation of food intake and body weight. |
2021-05-14 |
2023-08-13 |
mouse |
| Nina C Donner, Sofia M Davies, Stephanie D Fitz, Drake M Kienzle, Anantha Shekhar, Christopher A Lowr. Crh receptor priming in the bed nucleus of the stria terminalis (BNST) induces tph2 gene expression in the dorsomedial dorsal raphe nucleus and chronic anxiety. Progress in neuro-psychopharmacology & biological psychiatry. vol 96. 2021-01-04. PMID:31415826. |
crh receptor priming in the bed nucleus of the stria terminalis (bnst) induces tph2 gene expression in the dorsomedial dorsal raphe nucleus and chronic anxiety. |
2021-01-04 |
2023-08-13 |
rat |
| Nina C Donner, Sofia M Davies, Stephanie D Fitz, Drake M Kienzle, Anantha Shekhar, Christopher A Lowr. Crh receptor priming in the bed nucleus of the stria terminalis (BNST) induces tph2 gene expression in the dorsomedial dorsal raphe nucleus and chronic anxiety. Progress in neuro-psychopharmacology & biological psychiatry. vol 96. 2021-01-04. PMID:31415826. |
since the bnst projects heavily to the dorsal raphe nucleus (dr), the main source of brain serotonin, we here tested the hypothesis that such repeated, anxiety-inducing activation of crh receptors in the bnst alters the expression of serotonergic genes in the dr, including tph2, the gene encoding the rate-limiting enzyme for brain serotonin synthesis, and slc6a4, the gene encoding the serotonin transporter (sert). |
2021-01-04 |
2023-08-13 |
rat |
| Tadashi Takada, Naoki Yoneda, Tetsushi Hirano, Kanoko Onaru, Youhei Mantani, Toshifumi Yokoyama, Hiroshi Kitagawa, Yoshiaki Tabuchi, Collins Nimako, Mayumi Ishizuka, Yoshinori Ikenaka, Nobuhiko Hosh. Combined exposure to dinotefuran and chronic mild stress counteracts the change of the emotional and monoaminergic neuronal activity induced by either exposure singly despite corticosterone elevation in mice. The Journal of veterinary medical science. vol 82. issue 3. 2020-11-16. PMID:31983702. |
in addition, serotonin (5-ht) and tryptophan hydroxylase 2 (tph2) of the dorsal raphe nuclei (drn) and median raphe nuclei (mrn) and tyrosine hydroxylase (th) of the ventral tegmental area and substantia nigra (sn) were evaluated immunohistochemically. |
2020-11-16 |
2023-08-13 |
mouse |
| Nina C Donner, Kenneth H Kubala, James E Hassell, Margaret W Lieb, Kadi T Nguyen, Jared D Heinze, Robert C Drugan, Steven F Maier, Christopher A Lowr. Two models of inescapable stress increase Neurobiology of stress. vol 8. 2020-10-01. PMID:29520369. |
two models of inescapable stress increase expression of tph2, the rate-limiting enzyme for brain serotonin synthesis, is elevated in the dorsal raphe nucleus (dr) of depressed suicide victims. |
2020-10-01 |
2023-08-13 |
Not clear |
| Margaret W Lieb, Magdalena Weidner, Mathew R Arnold, Kelsey M Loupy, Kadi T Nguyen, James E Hassell, K'Loni S Schnabel, Raphael Kern, Heidi E W Day, Klaus-Peter Lesch, Jonas Waider, Christopher A Lowr. Effects of maternal separation on serotonergic systems in the dorsal and median raphe nuclei of adult male Tph2-deficient mice. Behavioural brain research. vol 373. 2020-09-14. PMID:31319134. |
for example, maternal separation increased slc6a4 mrna expression in the dorsal part of the dorsal raphe nucleus in tph2 heterozygous mice, but not in wild-type or knockout mice. |
2020-09-14 |
2023-08-13 |
mouse |
| Seong W Kang, Karen D Christensen, Douglas Aldridge, Wayne J Kuenze. Effects of light intensity and dual light intensity choice on plasma corticosterone, central serotonergic and dopaminergic activities in birds, Gallus gallus. General and comparative endocrinology. vol 285. 2020-03-13. PMID:31557469. |
tph2 expression in the dorsal raphe nucleus (drn) and caudal raphe nucleus (crn) of brainstem, and tph2 and th expression in ventral tegmental areas (vtn) of the midbrain were determined by qpcr. |
2020-03-13 |
2023-08-13 |
Not clear |
| Adrian M Russo, Adam J Lawther, Benjamin M Prior, Luke Isbel, W Gregory Somers, John A Lesku, Amanda L Richdale, Cheryl Dissanayake, Stephen Kent, Christopher A Lowry, Matthew W Hal. Social approach, anxiety, and altered tryptophan hydroxylase 2 activity in juvenile BALB/c and C57BL/6J mice. Behavioural brain research. vol 359. 2019-04-03. PMID:29935278. |
tryptophan hydroxylase 2 (tph2) activity was measured following injection of the aromatic amino acid decarboxylase (aadc)-inhibitor, nsd-1015, and subsequent hplc detection of 5-hydroxytryptophan (5-htp) within subregions of the dorsal raphe nucleus (dr) and median raphe nucleus (mnr). |
2019-04-03 |
2023-08-13 |
mouse |