| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shuang Jiang, Dayong Ren, Jianrui Li, Guangxin Yuan, Hongyu Li, Guangyu Xu, Xiao Han, Peige Du, Liping A. Effects of compound K on hyperglycemia and insulin resistance in rats with type 2 diabetes mellitus. Fitoterapia. vol 95. 2015-01-07. PMID:24613802. |
bodyweight, food-intake, fasting blood glucose (fbg), fasting serum insulin (fins), insulin sensitivity (isi), total glycerin (tg), total cholesterol (tc), as well as oral glucose tolerance test (ogtt) were evaluated in normal and diabetic rats. |
2015-01-07 |
2023-08-12 |
rat |
| Xingya Wang, Kali Chrysovergis, Justin Kosak, Thomas E Elin. Lower NLRP3 inflammasome activity in NAG-1 transgenic mice is linked to a resistance to obesity and increased insulin sensitivity. Obesity (Silver Spring, Md.). vol 22. issue 5. 2015-01-02. PMID:24124102. |
nag-1 tg mice are resistant to dietary- and genetic-induced obesity and have improved insulin sensitivity. |
2015-01-02 |
2023-08-12 |
mouse |
| Changrun Guo, Chunfeng Zhang, Lu Li, Zhenzhong Wang, Wei Xiao, Zhonglin Yan. Hypoglycemic and hypolipidemic effects of oxymatrine in high-fat diet and streptozotocin-induced diabetic rats. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 21. issue 6. 2015-01-02. PMID:24680614. |
the results demonstrated that oxymatrine could significantly decrease fasting blood glucose, glycosylated hemoglobin (ghb), food and water intake, non-esterified fatty acid (nefa), total cholesterol (tc), triglyceride (tg), low density lipoprotein cholesterol levels (ldl-c), and increase serum insulin, liver and muscle glycogen, high density lipoprotein cholesterol (hdl-c), glucagon-like peptide-1 (glp-1) and muscle glucose transporter-4 (glut-4) content in diabetic rats. |
2015-01-02 |
2023-08-12 |
rat |
| ShaoYi She, WeiJuan Liu, Tong Li, YingKai Hon. Effects of puerarin in STZ-induced diabetic rats by oxidative stress and the TGF-β1/Smad2 pathway. Food & function. vol 5. issue 5. 2014-12-19. PMID:24595557. |
rats were studied 30 days after the stz treatment, and the diabetes untreated model group presented significantly higher kidney index, blood glucose, triglyceride (tg), total cholesterol (tc), malondialdehyde (mda), interferon-γ (ifn-γ), and ifn-γ/il-4 levels, lower body weight, fasting blood insulin (fpi), il-4, superoxide dismutase (sod), catalase (cat), glutathione peroxidase (gsh-px) and nitric oxide (no) levels and worse renal function (higher blood urea nitrogen (bun), serum creatinine (scr), urine protein (up) levels and glomerular extracellular matrix (relative area)) compared with the normal control group (p < 0.05). |
2014-12-19 |
2023-08-12 |
rat |
| Ming Gu, Yu Zhang, Shengjie Fan, Xiaobo Ding, Guang Ji, Cheng Huan. Extracts of Rhizoma polygonati odorati prevent high-fat diet-induced metabolic disorders in C57BL/6 mice. PloS one. vol 8. issue 11. 2014-12-17. PMID:24312343. |
in the preventive experiment, the er blocked body weight gain, and lowered serum total cholesterol (tc), triglyceride (tg) and fasting blood glucose, improved glucose tolerance test (gtt) and insulin tolerance test (itt), reduced the levels of serum insulin and leptin, and increased serum adiponectin levels in mice fed with a high-fat diet significantly. |
2014-12-17 |
2023-08-12 |
mouse |
| Hassan Amouzad Mahdirejei, Sajedeh Fadaei Reyhan Abadei, Arshin Abbaspour Seidi, Negar Eshaghei Gorji, Hassan Rahmani Kafshgari, Mostafa Ebrahim Pour, Habib Bagheri Khalili, Farshad Hajeizad, Mohamad Khayer. Effects of an eight-week resistance training on plasma vaspin concentrations, metabolic parameters levels and physical fitness in patients with type 2 diabetes. Cell journal. vol 16. issue 3. 2014-12-16. PMID:24611142. |
waist-hip ratio (whr), glucose, insulin of plasma and insulin resistance [homeostasis model assessment of insulin resistance (homa-ir) score] were all significantly decreased, whereas levels of vaspin and plasma lipids [cholesterol, triglycerides (tg), high-density lipoprotein (hdl), low-density lipoprotein (ldl) and very low-density lipoproteins (vldl)] showed no significant changes in rt group as compared with the related values of control groups. |
2014-12-16 |
2023-08-12 |
human |
| Riccardo Torosantucci, Vera Brinks, Grzegorz Kijanka, Liem Andhyk Halim, Melody Sauerborn, Huub Schellekens, Wim Jiskoo. Development of a transgenic mouse model to study the immunogenicity of recombinant human insulin. Journal of pharmaceutical sciences. vol 103. issue 5. 2014-12-11. PMID:24619587. |
the aim of this work was to develop a transgenic (tg) balb/c mouse model for evaluating the immunogenicity of recombinant human insulin (insulin) formulations. |
2014-12-11 |
2023-08-12 |
mouse |
| Riccardo Torosantucci, Vera Brinks, Grzegorz Kijanka, Liem Andhyk Halim, Melody Sauerborn, Huub Schellekens, Wim Jiskoo. Development of a transgenic mouse model to study the immunogenicity of recombinant human insulin. Journal of pharmaceutical sciences. vol 103. issue 5. 2014-12-11. PMID:24619587. |
validation of the model was performed by measuring the antibody response against plain and particulate insulin in tg and nontransgenic (ntg) mice. |
2014-12-11 |
2023-08-12 |
mouse |
| Riccardo Torosantucci, Vera Brinks, Grzegorz Kijanka, Liem Andhyk Halim, Melody Sauerborn, Huub Schellekens, Wim Jiskoo. Development of a transgenic mouse model to study the immunogenicity of recombinant human insulin. Journal of pharmaceutical sciences. vol 103. issue 5. 2014-12-11. PMID:24619587. |
intraperitoneal administration of insulin (20 μg/dose, 12 doses over a period of 4 weeks) did not break the immune tolerance of the tg mice, whereas it did elicit antibodies in ntg mice. |
2014-12-11 |
2023-08-12 |
mouse |
| Riccardo Torosantucci, Vera Brinks, Grzegorz Kijanka, Liem Andhyk Halim, Melody Sauerborn, Huub Schellekens, Wim Jiskoo. Development of a transgenic mouse model to study the immunogenicity of recombinant human insulin. Journal of pharmaceutical sciences. vol 103. issue 5. 2014-12-11. PMID:24619587. |
the immune tolerance of tg mice could be circumvented, albeit at low titers, by administering insulin covalently bound to 50-nm polystyrene nanoparticles. |
2014-12-11 |
2023-08-12 |
mouse |
| Riccardo Torosantucci, Vera Brinks, Grzegorz Kijanka, Liem Andhyk Halim, Melody Sauerborn, Huub Schellekens, Wim Jiskoo. Development of a transgenic mouse model to study the immunogenicity of recombinant human insulin. Journal of pharmaceutical sciences. vol 103. issue 5. 2014-12-11. PMID:24619587. |
the tg mouse model was employed to compare the immunogenicity of oxidized aggregated insulin, oxidized nonaggregated insulin, and three commercially available formulations of insulin variants (i.e., levemir®, insulatard®, and actrapid®). |
2014-12-11 |
2023-08-12 |
mouse |
| Riccardo Torosantucci, Vera Brinks, Grzegorz Kijanka, Liem Andhyk Halim, Melody Sauerborn, Huub Schellekens, Wim Jiskoo. Development of a transgenic mouse model to study the immunogenicity of recombinant human insulin. Journal of pharmaceutical sciences. vol 103. issue 5. 2014-12-11. PMID:24619587. |
oxidized insulin, aggregated or nonaggregated, was moderately immunogenic in tg mice (50% and 33% responders, respectively), whereas the immunogenicity of the commercial formulations was low. |
2014-12-11 |
2023-08-12 |
mouse |
| Lingxiao Gong, Lingyun Gong, Ying Zhan. Intake of Tibetan hull-less barley is associated with a reduced risk of metabolic related syndrome in rats fed high-fat-sucrose diets. Nutrients. vol 6. issue 4. 2014-12-11. PMID:24763110. |
rats fed hfs-w had increased body weight, abdominal fat deposition, liver weight, liver fat deposition, triglyceride (tg), fasting blood glucose (fbg), serum fasting insulin (fins), and homeostasis model assessment of insulin resistance (homa-ir) scores, and decreased low-density lipoprotein cholesterol (ldl-c) levels compared to rats fed a basal diet (bd). |
2014-12-11 |
2023-08-13 |
rat |
| Matthias Kern, Joanna Kosacka, Nico Hesselbarth, Julia Brückner, John T Heiker, Gesine Flehmig, Ingrid Klöting, Peter Kovacs, Madlen Matz-Soja, Rolf Gebhardt, Knut Krohn, Susanne Sales, Kerstin Abshagen, Andrej Shevchenko, Michael Stumvoll, Matthias Blüher, Nora Klötin. Liver-restricted Repin1 deficiency improves whole-body insulin sensitivity, alters lipid metabolism, and causes secondary changes in adipose tissue in mice. Diabetes. vol 63. issue 10. 2014-11-18. PMID:24760138. |
hyperinsulinemic-euglycemic clamp studies revealed significantly improved whole-body insulin sensitivity in lrep1(-/-) mice, which may be due to significantly lower tg content in the liver. |
2014-11-18 |
2023-08-13 |
mouse |
| Yunlong Liu, Zhangzhao Gao, Qingtuo Guo, Tao Wang, Conger Lu, Ying Chen, Qing Sheng, Jian Chen, Zuoming Nie, Yaozhou Zhang, Wutong Wu, Zhengbing Lv, Jianhong Sh. Anti-diabetic effects of CTB-APSL fusion protein in type 2 diabetic mice. Marine drugs. vol 12. issue 3. 2014-11-12. PMID:24633252. |
the results demonstrated that the oral administration of ctb-apsl fusion protein can effectively reduce the levels of both fasting blood glucose (fbg) and glycosylated hemoglobin (ghb), promote insulin secretion and improve insulin resistance, significantly improve lipid metabolism, reduce triglycerides (tg), total cholesterol (tc) and low density lipoprotein (ldl) levels and increase high density lipoprotein (hdl) levels, as well as effectively improve the inflammatory response of type 2 diabetic mice through the reduction of the levels of inflammatory cytokines tumor necrosis factor-α (tnf-α) and interleukin-6 (il-6). |
2014-11-12 |
2023-08-12 |
mouse |
| Shin-Ichi Yokota, Kaai Nakamura, Midori Ando, Hiroyasu Kamei, Fumihiko Hakuno, Shin-Ichiro Takahashi, Shigenobu Shibat. Acetylcholinesterase (AChE) inhibition aggravates fasting-induced triglyceride accumulation in the mouse liver. FEBS open bio. vol 4. 2014-11-10. PMID:25383314. |
physostigmine promoted the 30 h fasting-induced increase in liver tg levels in a dose-dependent manner, accompanied by a significant fall in plasma insulin levels, without a fall in plasma tg. |
2014-11-10 |
2023-08-13 |
mouse |
| Shin-Ichi Yokota, Kaai Nakamura, Midori Ando, Hiroyasu Kamei, Fumihiko Hakuno, Shin-Ichiro Takahashi, Shigenobu Shibat. Acetylcholinesterase (AChE) inhibition aggravates fasting-induced triglyceride accumulation in the mouse liver. FEBS open bio. vol 4. 2014-11-10. PMID:25383314. |
the muscarinic receptor antagonist atropine blocked these effects of physostigmine on liver tg, serum insulin, and hepatic protein levels of srebp-1 and l-fabp. |
2014-11-10 |
2023-08-13 |
mouse |
| Yuhang Ma, Yufan Wang, Qianfang Huang, Qian Ren, Su Chen, Aifang Zhang, Li Zhao, Qin Zhen, Yongde Pen. Impaired β cell function in Chinese newly diagnosed type 2 diabetes mellitus with hyperlipidemia. Journal of diabetes research. vol 2014. 2014-10-28. PMID:24829924. |
multiple stepwise linear regression analysis showed that high fasting plasma glucose (fpg), decreased fasting insulin level (fins), and high triglyceride (tg) were independent risk factors of β cell dysfunction in newly diagnosed t2dm. |
2014-10-28 |
2023-08-13 |
human |
| Giuseppe Derosa, Pietro Dario Ragonesi, Elena Fogari, Arrigo Francesco Giuseppe Cicero, Lucio Bianchi, Aldo Bonaventura, Davide Romano, Pamela Maffiol. Sitagliptin added to previously taken antidiabetic agents on insulin resistance and lipid profile: a 2-year study evaluation. Fundamental & clinical pharmacology. vol 28. issue 2. 2014-10-27. PMID:23039403. |
we evaluated at the baseline and after 6, 12, 18, and 24 months the following parameters: body mass index, glycated hemoglobin (hba1c ), fasting plasma glucose (fpg), postprandial plasma glucose (ppg), fasting plasma insulin (fpi), homeostasis model assessment insulin resistance index (homa-ir), total cholesterol (tc), high-density lipoprotein cholesterol (hdl-c), low-density lipoprotein cholesterol (ldl-c), triglycerides (tg). |
2014-10-27 |
2023-08-12 |
Not clear |
| Maria Theresa E Montales, Stepan B Melnyk, Frank A Simmen, Rosalia C M Simme. Maternal metabolic perturbations elicited by high-fat diet promote Wnt-1-induced mammary tumor risk in adult female offspring via long-term effects on mammary and systemic phenotypes. Carcinogenesis. vol 35. issue 9. 2014-10-21. PMID:24832086. |
in human breast cancer mcf-7 cells, sera from maternal hfd-exposed tg offspring elicited changes in pten, bcl2 and il6 gene expression, mimicking in vivo exposure; increased cell viability and mammosphere formation and induced measures [insulin receptor substrate-1 (irs-1), irs-2] of insulin sensitivity. |
2014-10-21 |
2023-08-13 |
mouse |