| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paweł Gut, Agata Czarnywojtek, Nadia Sawicka-Gutaj, Marek Ruchał. Assessment of serotonin concentration in patients with a small-intestine neuroendocrine neoplasm and carcinoid syndrome treated with somatostatin analogues. Polish archives of internal medicine. vol 130. issue 10. 2021-04-27. PMID:32643913. |
assessment of serotonin concentration in patients with a small-intestine neuroendocrine neoplasm and carcinoid syndrome treated with somatostatin analogues. |
2021-04-27 |
2023-08-13 |
Not clear |
| Alexandre Mahrach, Guang Chen, Nuo Li, Carl van Vreeswijk, David Hanse. Mechanisms underlying the response of mouse cortical networks to optogenetic manipulation. eLife. vol 9. 2021-04-19. PMID:31951197. |
gabaergic interneurons can be subdivided into three subclasses: parvalbumin positive (pv), somatostatin positive (som) and serotonin positive neurons. |
2021-04-19 |
2023-08-13 |
mouse |
| Cornelius J Fernandez, Mayuri Agarwal, Biju Pottakkat, Nisha Nigil Haroon, Annu Susan George, Joseph M Pappacha. Gastroenteropancreatic neuroendocrine neoplasms: A clinical snapshot. World journal of gastrointestinal surgery. vol 13. issue 3. 2021-04-03. PMID:33796213. |
specific neuroendocrine biomarkers that are used in the diagnosis of functional nens include insulin, glucagon, vasoactive intestinal polypeptide, gastrin, somatostatin, adrenocorticotropin, growth hormone releasing hormone, parathyroid hormone-related peptide, serotonin, histamine, and 5-hydroxy indole acetic acid (5-hiaa). |
2021-04-03 |
2023-08-13 |
human |
| Aura D Herrera-Martínez, Richard A Feelders, Rosanna Van den Dungen, Fadime Dogan-Oruc, Peter M van Koetsveld, Justo P Castaño, Wouter W de Herder, Leo J Hoflan. Effect of the Tryptophan Hydroxylase Inhibitor Telotristat on Growth and Serotonin Secretion in 2D and 3D Cultured Pancreatic Neuroendocrine Tumor Cells. Neuroendocrinology. vol 110. issue 5. 2021-02-15. PMID:31319410. |
the human pancreatic net cell lines bon-1/qgp-1 were used as 2d and 3d cultured models; somatostatin receptor and tph mrna expression, as well as the potential autocrine effect of serotonin on tumor cell proliferation using a 3d culture system were evaluated. |
2021-02-15 |
2023-08-13 |
human |
| Aura D Herrera-Martínez, Richard A Feelders, Rosanna Van den Dungen, Fadime Dogan-Oruc, Peter M van Koetsveld, Justo P Castaño, Wouter W de Herder, Leo J Hoflan. Effect of the Tryptophan Hydroxylase Inhibitor Telotristat on Growth and Serotonin Secretion in 2D and 3D Cultured Pancreatic Neuroendocrine Tumor Cells. Neuroendocrinology. vol 110. issue 5. 2021-02-15. PMID:31319410. |
these results suggest that telotristat is an effective drug for serotonin inhibition, but the effectiveness of its combination with sst2 (somatostatin receptor subtype 2)-preferring ssa should be evaluated in more detail. |
2021-02-15 |
2023-08-13 |
human |
| Jakub Pobłocki, Anna Jasińska, Anhelli Syrenicz, Elżbieta Andrysiak-Mamos, Małgorzata Szczuk. The Neuroendocrine Neoplasms of the Digestive Tract: Diagnosis, Treatment and Nutrition. Nutrients. vol 12. issue 5. 2021-02-11. PMID:32429294. |
different nuclear medicine procedures can also be used, like somatostatin analogues scintigraphy (srs) and 68ga-dota-peptide pet/ct, as well as biochemical methods to determine the level of general neuroendocrine markers, such as chromogranin a (cga), 5-hydroxyindolacetic acid (5-hiaa), synaptopfysin and cell type-specific peptide hormones, and neurotransmitters like gastrin, insulin, serotonin, and histamine. |
2021-02-11 |
2023-08-13 |
Not clear |
| Jakub Pobłocki, Anna Jasińska, Anhelli Syrenicz, Elżbieta Andrysiak-Mamos, Małgorzata Szczuk. The Neuroendocrine Neoplasms of the Digestive Tract: Diagnosis, Treatment and Nutrition. Nutrients. vol 12. issue 5. 2021-02-11. PMID:32429294. |
the treatment options for neuroendocrine neoplasms include surgery, somatostatin analogue therapy, radionuclide therapy, chemotherapy, molecular targeted therapies, alpha-interferon therapy, and inhibitors of serotonin production. |
2021-02-11 |
2023-08-13 |
Not clear |
| Carlo Capella, Cristina Riva, Guido Rindi, Fausto Sessa, Luciana Usellini, Annamaria Chiaravalli, Luciano Carnevali, Enrico Solci. Histopathology, hormone products, and clinicopathological profile of endocrine tumors of the upper small intestine: A study of 44 cases. Endocrine pathology. vol 2. issue 2. 2021-01-10. PMID:32138393. |
in addition to the main cell type, 30 tumors showed one or more, usually minor, cell populations producing somatostatin, serotonin, cholecystokinin, pancreatic polypeptide, insulin, neurotensin, or the alpha chain of human chorionic gonadotropin. |
2021-01-10 |
2023-08-13 |
human |
| Simon J Raphael, N Wilson Rodger, Doug Geddes B . Colocalization of pancreatic polypeptide and insulin in secretory granules of a pancreatic endocrine neoplasm. Endocrine pathology. vol 3. issue 3. 2021-01-10. PMID:32138396. |
immunohistochem-istry and immunoelectron microscopy showed all the tumors to be plurihormonal, each containing three or more of the following: insulin, glucagon, somatostatin, pancreatic polypep-tide, gastrin, and serotonin. |
2021-01-10 |
2023-08-13 |
Not clear |
| John A Maguire, Juan M Bilbao, Kaiman Kovacs, Lothar Resc. Hypothalamic neurocytoma with vasopressin immunoreactivity: Immunohistochemical and ultrastructural observations. Endocrine pathology. vol 3. issue 2. 2021-01-10. PMID:32138406. |
the neoplastic cells were immunoreactive for neuron-specific enolase (nse), synaptophysin, and vasopressin, and nonimmunoreactive for glial fibrillary acidic protein (gfap), vasoactive intestinal peptide (vip), bombesin, chromogranin, neurofilament, cytokeratins (high and low molecular weight), vimentin, s100 protein, somatostatin, β-endorphin, galactosamine, growth hormone-releasing hormone (grh), neurophysin, serotonin, adrenaline and noradrenaline, and corticotropin-releasing hormone (crh). |
2021-01-10 |
2023-08-13 |
Not clear |
| Ana Karen Sandoval-Talamantes, B A Gómez-González, D F Uriarte-Mayorga, M A Martínez-Guzman, Katia Alejandra Wheber-Hidalgo, Anabell Alvarado-Navarr. Neurotransmitters, neuropeptides and their receptors interact with immune response in healthy and psoriatic skin. Neuropeptides. vol 79. 2020-11-23. PMID:31902596. |
just as the immune system plays a fundamental role in psoriasis physiopathology, the nervous system maintains the inflammatory process through the neuropeptides and neurotransmitters synthesis, as histamine, serotonin, calcitonin gene-related peptide, nerve growth factor, vasoactive intestinal peptide, substance p, adenosine, glucagon-like peptide, somatostatin and pituitary adenylate cyclase polypeptide. |
2020-11-23 |
2023-08-13 |
Not clear |
| Zhenyang Ge, Zhijun Duan, Hang Yang, Shengai Zhang, Shuang Zhang, Lixia Wang, Dong Yang, Xiaoyu Sun, Zhifeng Zhang, Liping Su, Hong Zhu, Dongdong Zhou, Bojia Liu, Honggang Shi, Jun Yu, Hui Yang, Qingyong Chang, Nina Zhang, Dongsheng Wu, Jiande D Z Che. Home-Based Transcutaneous Neuromodulation Improved Constipation via Modulating Gastrointestinal Hormones and Bile Acids. Evidence-based complementary and alternative medicine : eCAM. vol 2018. 2020-10-01. PMID:29853946. |
plasma levels of serotonin (5-ht), motilin, somatostatin, and vasoactive intestinal peptide (vip) were measured by elisa and 12 individual bile acids assayed by liquid chromatography tandem mass spectrometry. |
2020-10-01 |
2023-08-13 |
Not clear |
| Eiichi Kumamot. Cellular Mechanisms for Antinociception Produced by Oxytocin and Orexins in the Rat Spinal Lamina II-Comparison with Those of Other Endogenous Pain Modulators. Pharmaceuticals (Basel, Switzerland). vol 12. issue 3. 2020-10-01. PMID:31527474. |
this review article will mention cellular mechanisms for antinociception produced by oxytocin, orexins a and b, and discuss similarity and difference in antinociceptive mechanisms among the hypothalamic neuropeptides and other endogenous pain modulators (opioids, nociceptin, adenosine, adenosine 5'-triphosphate (atp), noradrenaline, serotonin, dopamine, somatostatin, cannabinoids, galanin, substance p, bradykinin, neuropeptide y and acetylcholine) exhibiting a change in membrane potential, excitatory or inhibitory transmission in the spinal lamina ii neurons. |
2020-10-01 |
2023-08-13 |
rat |
| Vincent Larouche, Amit Akirov, Sameerah Alshehri, Shereen Ezza. Management of Small Bowel Neuroendocrine Tumors. Cancers. vol 11. issue 9. 2020-09-30. PMID:31540509. |
carcinoid syndrome, which is mostly managed by somatostatin analogue therapy and the serotonin antagonist telotristat etiprate for refractory diarrhea, as well as neuroendocrine carcinoma will be reviewed. |
2020-09-30 |
2023-08-13 |
Not clear |
| S Türk, K Çına. Regional and mucosal distributions of some intestinal immunoreactive endocrine cells in New Zealand white rabbit ( Iranian journal of veterinary research. vol 18. issue 4. 2020-09-29. PMID:29387099. |
regional and mucosal distributions of some intestinal immunoreactive endocrine cells in new zealand white rabbit ( the aim of this study was to detect the regional and mucosal distribution of endocrine cells that secrete gulcagon, somatostatin, chyholecystokinin-8 (cck-8), serotonin, secretin, substance p (sp) and histamine in the small and large intestine of new zealand white rabbit ( |
2020-09-29 |
2023-08-13 |
rabbit |
| Igor Rakoczy, Marzena Ocetek, Marzena Wiatr, Patrycja Zięba, Michał Panek, Piotr Kun. Non-necrotizing inflammatory granulomas (n-ngs) in the course of inflammatory bowel disease - immunology and clinical manifestation of intestinal and respiratory N-NGS. Wiadomosci lekarskie (Warsaw, Poland : 1960). vol 73. issue 7. 2020-08-11. PMID:32759453. |
the key functions of the immune response of the gastrointestinal tract are managed by the neuroendocrine regulatory system (nes) whose activities govern the production of various hormones including chromogranin/secretogranin, serotonin, vasoactive intestinal polypeptide (vip), neuropeptide y (npy), substance p, somatostatin or ghrelin. |
2020-08-11 |
2023-08-13 |
Not clear |
| Aura D Herrera-Martínez, Rosanna van den Dungen, Fadime Dogan-Oruc, Peter M van Koetsveld, Michael D Culler, Wouter W de Herder, Raúl M Luque, Richard A Feelders, Leo J Hoflan. Effects of novel somatostatin-dopamine chimeric drugs in 2D and 3D cell culture models of neuroendocrine tumors. Endocrine-related cancer. vol 26. issue 6. 2020-07-22. PMID:30939452. |
cell proliferation, somatostatin and dopamine receptor expression (ssts and d2r), apoptosis, lactate dehydrogenase, as well as serotonin and chromogranin a (cga) release were assessed. |
2020-07-22 |
2023-08-13 |
human |
| Johannes Hofland, Aura D Herrera-Martínez, Wouter T Zandee, Wouter W de Herde. Management of carcinoid syndrome: a systematic review and meta-analysis. Endocrine-related cancer. vol 26. issue 3. 2020-07-16. PMID:30608900. |
the serotonin synthesis inhibitor telotristat ethyl reduced bowel movements in 40% of patients with diarrhea refractory to somatostatin analogs. |
2020-07-16 |
2023-08-13 |
Not clear |
| Therese E Fazio Coles, Linda J Fothergill, Billie Hunne, Mehrdad Nikfarjam, Adam Testro, Brid Callaghan, Rachel M McQuade, John B Furnes. Quantitation and chemical coding of enteroendocrine cell populations in the human jejunum. Cell and tissue research. vol 379. issue 1. 2020-05-21. PMID:31478137. |
ten hormones (5-ht, cck, secretin, proglucagon-derived peptides, pyy, gip, somatostatin, neurotensin, ghrelin and motilin) were localised in eec of the human jejunum. |
2020-05-21 |
2023-08-13 |
mouse |
| Shozo Yamada, Lucia Stefaneanu, Kalman Kovacs, Tadashi Aiba, Yoshimasa Shishiba, Mitsuru Har. Intrasellar gangliocytoma with multiple immunoreactivities. Endocrine pathology. vol 1. issue 1. 2020-05-04. PMID:32357626. |
the tumor, removed by transsphenoidal surgery, exhibited immunoreactivities for vip and galanin in the cytoplasm of several nerve cells, a-subunit, somatostatin, and serotonin in the cytoplasm of few nerve cells. |
2020-05-04 |
2023-08-13 |
Not clear |