| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hyeryeong Cho, Jaechul Li. The emerging role of gut hormones. Molecules and cells. 2024-10-19. PMID:39426686. |
the gut is traditionally recognized as the central organ for the digestion and absorption of nutrients, however it also functions as a significant endocrine organ, secreting a variety of hormones such as glucagon-like peptide 1 (glp-1), serotonin, somatostatin, and glucocorticoids. |
2024-10-19 |
2024-10-22 |
Not clear |
| Elisa Moser, Ayako Ura, Loreen Vogel, Katja Steiger, Carolin Mogler, Matthias Evert, Bruno Märkl, Klemens Scheidhauer, Marc Martignoni, Helmut Friess, Alexander von Werder, Ilaria Marinoni, Aurel Perren, Günter Klöppel, Atsuko Kasajim. ARX, PDX1, ISL1 and CDX2 expression distinguishes five subgroups of PanNETs with correlations to histology, hormone expression and outcome. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2024-08-15. PMID:39147030. |
185 pannets (non-functioning 165, functioning 20) resected between 1996 and 2023 were classified into five subgroups (a1, a2, b, c, d) by cluster analysis based on arx, pdx1, isl1 and cdx2 expression and correlated with trabecular vs. solid histology, expression of insulin, glucagon, pp, somatostatin, serotonin, gastrin, calcitonin, acth, daxx/atrx, men1 and alt status by fish, and disease-free survival (dfs). |
2024-08-15 |
2024-08-18 |
Not clear |
| Marianna Franchina, Federica Cavalcoli, Olga Falco, Marta La Milia, Alessandra Elvevi, Sara Massiron. Biochemical Markers for Neuroendocrine Tumors: Traditional Circulating Markers and Recent Development-A Comprehensive Review. Diagnostics (Basel, Switzerland). vol 14. issue 12. 2024-06-27. PMID:38928704. |
specific circulating markers such as serotonin and its metabolite 5-hydroxyindoleacetic acid (5-hiaa) and various gastrointestinal hormones such as gastrin, glucagon, somatostatin, and vasoactive intestinal peptide (vip) have a role in identifying functional nens. |
2024-06-27 |
2024-06-29 |
Not clear |
| Thomas G Hill, David J Hil. The Importance of Intra-Islet Communication in the Function and Plasticity of the Islets of Langerhans during Health and Diabetes. International journal of molecular sciences. vol 25. issue 7. 2024-04-13. PMID:38612880. |
this is mediated partly through circulatory feedback of the major secreted hormones, insulin and glucagon, but also by autocrine and paracrine actions within the islet by a range of other secreted products, including somatostatin, urocortin 3, serotonin, glucagon-like peptide-1, acetylcholine, and ghrelin. |
2024-04-13 |
2024-04-15 |
Not clear |
| Hui Yu, Huiqian Deng, Wei Zhou, Zhenling Lian. Effects of electroacupuncture combined with acupoint catgut embedding on gastrointestinal motility and gastrointestinal hormones in rats with functional dyspepsia. The Chinese journal of physiology. vol 66. issue 6. 2023-12-27. PMID:38149565. |
gastric emptying rate (ger) and intestinal propulsive ratio (ipr) were measured in each group, and serum gastrointestinal hormone (motilin [mtl], leptin, gastrin [gas], vasoactive intestinal peptide [vip], calcitonin gene-related peptide [cgrp], and somatostatin [ss]) levels, oxidative stress factors (superoxide dismutase [sod] and malondialdehyde [mda]) and 5-hydroxytryptamine (5-ht) levels were also measured. |
2023-12-27 |
2023-12-29 |
rat |
| Chrisanthi Zouli, Eleana Zisimopoulou, Alexandra Chrisoulido. Biomarkers in neuroendocrine neoplasms. Hellenic journal of nuclear medicine. vol 26 Suppl. 2023-09-02. PMID:37658563. |
functional nens can be divided into carcinoid tumors, with serotonin overproduction, and functional gep nen's (mostly located in pancreas) that may secrete insulin, vip, gastrin, glucagon or somatostatin. |
2023-09-02 |
2023-09-07 |
Not clear |
| Witold Żakowski, Piotr Zawistowsk. Neurochemistry of the mammillary body. Brain structure & function. 2023-06-28. PMID:37378855. |
the following groups of substances are reviewed: (1) classical neurotransmitters (glutamate and other excitatory transmitters, gamma-aminobutyric acid, acetylcholine, serotonin, and dopamine), (2) neuropeptides (enkephalins, substance p, cocaine- and amphetamine-regulated transcript, neurotensin, neuropeptide y, somatostatin, orexins, and galanin), and (3) other substances (calcium-binding proteins and calcium sensor proteins). |
2023-06-28 |
2023-08-14 |
rat |
| Dane H Tow, Catherine G Tran, Luis C Borbon, Maclain Ridder, Guiying Li, Courtney A Kaemmer, Ellen Abusada, Aswanth Harish Mahalingam, Anguraj Sadanandam, Chandrikha Chandrasekaran, Joseph Dillon, Douglas R Spitz, Dawn E Quelle, Carlos H F Chan, Andrew Bellizzi, James R Howe, Po Hien Ea. Inhibition of serotonin biosynthesis in neuroendocrine neoplasm suppresses tumor growth bioRxiv : the preprint server for biology. 2023-04-17. PMID:37066322. |
patients with high serotonin level may develop carcinoid syndrome, which can be treated with somatostatin analogues and the tph1 inhibitor telotristat ethyl in severe cases. |
2023-04-17 |
2023-08-14 |
Not clear |
| Hirofumi Watanabe, Fumiyoshi Fujishima, Michiaki Unno, Hironobu Sasano, Takashi Suzuk. Somatostatin receptor 2 in 10 different types of human non-neoplastic gastrointestinal neuroendocrine cells. Pathology, research and practice. vol 244. 2023-03-29. PMID:36989844. |
midgut nets, which often produce serotonin, are excellent targets for somatostatin analogs and are positive for sstr2. |
2023-03-29 |
2023-08-14 |
human |
| Anna-Sophia Liselott Beyer, Daniel Kaemmerer, Jörg Sänger, Amelie Lup. Co-Expression of Adaptor Protein FAM159B with Different Markers for Neuroendocrine Cells: An Immunocytochemical and Immunohistochemical Study. International journal of molecular sciences. vol 23. issue 21. 2022-11-11. PMID:36362289. |
the markers included prominent markers of neuroendocrine differentiation, such as chromogranin a (cga), neuron-specific enolase (nse), synaptophysin (syp), insulinoma-associated protein 1 (insm1), neural cell adhesion molecule 1 (ncam1), serotonin (5-ht), somatostatin-14/28 (sst), and several receptors that are typically expressed by neuroendocrine cells, such as dopamine receptor 2 (d2r), somatostatin receptor (sstr) 1, 2, 3, 4 and 5, and regulator of g-protein signalling 9 (rgs9). |
2022-11-11 |
2023-08-14 |
human |
| Bryan Wiederholt, Timothy Gengler, Jen Bendur. Anesthetic Management of Gastrointestinal Carcinoid Tumors: A Case Report. AANA journal. vol 90. issue 5. 2022-09-29. PMID:36173796. |
octreotide is a first-generation somatostatin analog that binds to somatostatin receptor 2 with high affinity, somatostatin receptor 3 and somatostatin receptor 5 with lower affinity, and suppresses the secretion of serotonin. |
2022-09-29 |
2023-08-14 |
Not clear |
| Surya P Nuguru, Sriker Rachakonda, Shravani Sripathi, Mashal I Khan, Naomi Patel, Roja T Med. Hypothyroidism and Depression: A Narrative Review. Cureus. vol 14. issue 8. 2022-08-25. PMID:36003348. |
studies have demonstrated that somatostatin and serotonin influence the hypothalamus-pituitary-thyroid axis, which links hypothyroidism to depression. |
2022-08-25 |
2023-08-14 |
Not clear |
| Ryo Ochi, Fumihiko Ueno, Mutsuki Sakuma, Hideaki Tani, Sakiko Tsugawa, Ariel Graff-Guerrero, Hiroyuki Uchida, Masaru Mimura, Shunji Oshima, Sachio Matsushita, Shinichiro Nakajim. Patterns of functional connectivity alterations induced by alcohol reflect somatostatin interneuron expression in the human cerebral cortex. Scientific reports. vol 12. issue 1. 2022-05-13. PMID:35550587. |
patterns of differences between conditions were related to regional genetic markers that express the primary gabaergic cortical interneuron subtypes (parvalbumin, somatostatin, and 5-hydroxytryptamine receptor 3a) obtained from the allen human brain atlas. |
2022-05-13 |
2023-08-13 |
human |
| Jason N. The Treatment of Psychotic Depression in a 64-Year-Old Patient With Carcinoid Syndrome. Cureus. vol 14. issue 4. 2022-05-09. PMID:35530836. |
the treatment of the neuropsychiatric manifestations of the disease is also complicated by the concurrent use of somatostatin analogues, which also affect total circulating serotonin levels, a neurotransmitter implicated in the aforementioned psychiatric disorders. |
2022-05-09 |
2023-08-13 |
Not clear |
| Thiago S Moreira, Cleyton R Sobrinho, Barbara Falquetto, Luiz M Oliveira, Janayna D Lima, Daniel K Mulkey, Ana C Takakur. The retrotrapezoid nucleus and the neuromodulation of breathing. Journal of neurophysiology. vol 125. issue 3. 2021-11-03. PMID:33427575. |
modulators such as acetylcholine, norepinephrine, histamine, serotonin (5-ht), adenosine triphosphate (atp), substance p, somatostatin, bombesin, orexin, and leptin can serve complementary or off-setting functions depending on the target cell type and signaling mechanisms engaged. |
2021-11-03 |
2023-08-13 |
Not clear |
| Roberto de Filippo, Benjamin R Rost, Alexander Stumpf, Claire Cooper, John J Tukker, Christoph Harms, Prateep Beed, Dietmar Schmit. Somatostatin interneurons activated by 5-HT eLife. vol 10. 2021-09-10. PMID:33789079. |
somatostatin interneurons activated by 5-ht serotonin (5-ht) is one of the major neuromodulators present in the mammalian brain and has been shown to play a role in multiple physiological processes. |
2021-09-10 |
2023-08-13 |
mouse |
| Akie Yanai, Md Nabiul Islam, Maki Hayashi-Okada, Mir Rubayet Jahan, Abu Md Mamun Tarif, Kanako Nozaki, Koh-Hei Masumoto, Koh Shinod. Immunohistochemical relationships of huntingtin-associated protein 1 with enteroendocrine cells in the pyloric mucosa of the rat stomach. Acta histochemica. vol 122. issue 8. 2021-08-30. PMID:33161374. |
in the present study, the expression of hap1 in pyloric stomach in adult male rats and its relationships with different chemical markers for eec [gastrin, marker of gastrin (g) cells; somatostatin, marker of delta (d) cells; 5-ht, marker of enterochromaffin (ec) cells; histamine, marker of enterochromaffin-like (ecl) cells] were examined employing single- or double-labelled immunohistochemistry and with light-, fluorescence- or electron-microscopy. |
2021-08-30 |
2023-08-13 |
rat |
| Elenia Cinelli, Donatella Mutolo, Tito Pantaleo, Fulvia Bongiann. Neural mechanisms underlying respiratory regulation within the preBötzinger complex of the rabbit. Respiratory physiology & neurobiology. vol 293. 2021-08-10. PMID:34224867. |
increases in respiratory frequency are induced by microinjections of neurokinins, somatostatin as well by serotonin (5-ht) through an action on 5-ht |
2021-08-10 |
2023-08-13 |
rabbit |
| Mohid S Khan, Thomas Walter, Amy Buchanan-Hughes, Emma Worthington, Lucie Keeber, Marion Feuilly, Enrique Grand. Differential diagnosis of diarrhoea in patients with neuroendocrine tumours: A systematic review. World journal of gastroenterology. vol 26. issue 30. 2021-05-14. PMID:32874063. |
somatostatin analogues or telotristat can be used to control symptoms of cs through inhibition of serotonin secretion. |
2021-05-14 |
2023-08-13 |
Not clear |
| Carolina Francelin, Luciana Peixoto Veneziani, Alessandro Dos Santos Farias, Daniella Arêas Mendes-da-Cruz, Wilson Savin. Neurotransmitters Modulate Intrathymic T-cell Development. Frontiers in cell and developmental biology. vol 9. 2021-05-02. PMID:33928093. |
evidence indicates that, among others, tecs also produce serotonin and dopamine, as well as somatostatin, substance p, vasoactive intestinal peptide (vip) and the typical pituitary neurohormones, oxytocin and arg-vasopressin. |
2021-05-02 |
2023-08-13 |
Not clear |