| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T S Rizzi, G Beunders, P Rizzu, E Sistermans, J W R Twisk, W van Mechelen, J B Deijen, H Meijers-Heijboer, M Verhage, P Heutink, D Posthum. Supporting the generalist genes hypothesis for intellectual ability/disability: the case of SNAP25. Genes, brain, and behavior. vol 11. issue 7. 2013-03-11. PMID:22762387. |
the gene product of snap25 is an important presynaptic plasma membrane protein, is known to be involved in regulating neurotransmitter release, and has been linked to memory and learning by its effect on long term potentiation in the hippocampus. |
2013-03-11 |
2023-08-12 |
Not clear |
| Rachele Cagliani, Stefania Riva, Cecilia Marino, Matteo Fumagalli, Maria Grazia D'Angelo, Valentina Riva, Giacomo P Comi, Uberto Pozzoli, Diego Forni, Mario Cáceres, Nereo Bresolin, Mario Clerici, Manuela Siron. Variants in SNAP25 are targets of natural selection and influence verbal performances in women. Cellular and molecular life sciences : CMLS. vol 69. issue 10. 2012-07-18. PMID:22193912. |
snap25 encodes a presynaptic protein with a role in regulation of neurotransmitter release. |
2012-07-18 |
2023-08-12 |
human |
| Mengfei Ho, Cheong-Hian Goh, Michael C Brothers, Shihua Wang, Ryan L Young, Yuxiang Ou, Juliana Nga-Man Lui, Marinos Kalafatis, Xiuwan Lan, Abigail E Wolf, Chad M Rienstra, Brenda A Wilso. Glycine insertion at protease cleavage site of SNAP25 resists cleavage but enhances affinity for botulinum neurotoxin serotype A. Protein science : a publication of the Protein Society. vol 21. issue 3. 2012-06-15. PMID:22170566. |
the light chain of botulinum neurotoxin a (bont/a-lc) is a zn-dependent protease that specifically cleaves snap25 of the snare complex, thereby impairing vesicle fusion and neurotransmitter release at neuromuscular junctions. |
2012-06-15 |
2023-08-12 |
Not clear |
| Noèlia Fernàndez-Castillo, Bru Cormand, Carlos Roncero, Cristina Sánchez-Mora, Lara Grau-Lopez, Begoña Gonzalvo, Laia Miquel, Roser Corominas, Josep Antoni Ramos-Quiroga, Miquel Casas, Marta Ribasé. Candidate pathway association study in cocaine dependence: the control of neurotransmitter release. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 13. issue 2. 2012-04-25. PMID:21426264. |
we examined the possible contribution to cocaine dependence of 16 genes involved in the cellular machinery that controls neurotransmitter release: genes encoding proteins of the snare complex (stx1a, snap25, vamp1 and vamp2), fusion control elements (syt1, syt2, cplx1, cplx2, cplx3 and cplx4) and regulatory elements (stxbp1, syp, snph, nsf, napa and rab3a). |
2012-04-25 |
2023-08-12 |
Not clear |
| B Etain, A Dumaine, F Mathieu, F Chevalier, C Henry, J-P Kahn, J Deshommes, F Bellivier, M Leboyer, S Jamai. A SNAP25 promoter variant is associated with early-onset bipolar disorder and a high expression level in brain. Molecular psychiatry. vol 15. issue 7. 2010-10-18. PMID:19125158. |
the synaptosomal-associated protein snap25 is a presynaptic plasma membrane protein essential for the triggering of vesicular fusion and neurotransmitter release, and for which abnormal protein levels have been reported in postmortem studies of bipolar patients. |
2010-10-18 |
2023-08-12 |
human |
| Angela S Pechenino, Karyn M Fric. The effects of acute 17beta-estradiol treatment on gene expression in the young female mouse hippocampus. Neurobiology of learning and memory. vol 91. issue 3. 2009-04-27. PMID:18938255. |
mrna expression changes in 5 of the genes were confirmed by real-time quantitative pcr analysis, and protein changes in these same genes were confirmed by western blot analysis: hsp70, a heat shock protein known to be estrogen responsive; igfbp2, an igf-i binding protein; actn4, an actin binding protein involved in protein trafficking; tubb2a, the major component of microtubules; and snap25, a synaptosome-specific protein required for neurotransmitter release. |
2009-04-27 |
2023-08-12 |
mouse |
| Kunihiro Kawashima, Taro Kishi, Masashi Ikeda, Tsuyoshi Kitajima, Yoshio Yamanouchi, Yoko Kinoshita, Nagahide Takahashi, Shinichi Saito, Kazutaka Ohi, Yuka Yasuda, Ryota Hashimoto, Masatoshi Takeda, Toshiya Inada, Norio Ozaki, Nakao Iwat. No association between tagging SNPs of SNARE complex genes (STX1A, VAMP2 and SNAP25) and schizophrenia in a Japanese population. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 147B. issue 7. 2008-11-17. PMID:18512733. |
the soluble n-ethylmaleimide-sensitive factor attachment protein receptor (snare) complex, which consists of syntaxin1a, vesicle-associated membrane protein 2 (vamp2) and synaptosomal-associated protein 25 kda (snap25), plays an important role in the neurotransmitter system, and is therefore an attractive place to search for candidate genes for schizophrenia. |
2008-11-17 |
2023-08-12 |
Not clear |
| Lisa G Riley, Basil D Roufogalis, George Q Li, Anthony S Weis. A radioassay for synaptic core complex assembly: screening of herbal extracts for effectors. Analytical biochemistry. vol 357. issue 1. 2006-12-08. PMID:16824472. |
synaptic core complex formation between syntaxin and synaptosome-associated protein of 25 kda (snap25) on the plasma membrane and synaptobrevin on the vesicle membrane is responsible for membrane fusion and neurotransmitter release. |
2006-12-08 |
2023-08-12 |
Not clear |
| Natsuko Kumamoto, Shinsuke Matsuzaki, Kiyoshi Inoue, Tsuyoshi Hattori, Shoko Shimizu, Ryota Hashimoto, Atsushi Yamatodani, Taiichi Katayama, Masaya Tohyam. Hyperactivation of midbrain dopaminergic system in schizophrenia could be attributed to the down-regulation of dysbindin. Biochemical and biophysical research communications. vol 345. issue 2. 2006-08-16. PMID:16701550. |
furthermore, suppression of dysbindin expression in pc12 cells resulted in an increase of the expression of snap25, which plays an important role in neurotransmitter release, and increased the release of dopamine. |
2006-08-16 |
2023-08-12 |
mouse |
| A Mizoguch. [Role of vesicle fusion mechanism and cell adhesion molecules in growth cone elongation and synaptogenesis]. Kaibogaku zasshi. Journal of anatomy. vol 74. issue 4. 1999-11-30. PMID:10496093. |
the cleavage of snap25, a protein involved in neurotransmitter release in synapse, resulted in inhibition of neurite elongation. |
1999-11-30 |
2023-08-12 |
Not clear |
| C Risinger, E Salaneck, C Söderberg, M Gates, J H Postlethwait, D Larhamma. Cloning of two loci for synapse protein Snap25 in zebrafish: comparison of paralogous linkage groups suggests loss of one locus in the mammalian lineage. Journal of neuroscience research. vol 54. issue 5. 1999-03-11. PMID:9843147. |
synaptosome-associated protein of 25 kda (snap25) is an intracellular protein that is defined as a target receptor for synapse vesicles prior to neurotransmitter release. |
1999-03-11 |
2023-08-12 |
human |