| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jie Shu, Fan Peng, Jing Li, Yuhang Liu, Xiaolan Li, Chengfu Yua. The Relationship between SNAP25 and Some Common Human Neurological Syndromes. Current pharmaceutical design. 2024-07-04. PMID:38963116. |
snap25 deficiency can lead to synaptic disorders and inhibit neurotransmitter release. |
2024-07-04 |
2024-07-10 |
human |
| Yongle Wu, Hai Ni. A Bioinformatics Study of Differentially Expressed Genes in Microarrays of Dorsal Root Ganglia from Rat Models of Neuropathic Pain. Medical science monitor : international medical journal of experimental and clinical research. vol 28. 2022-02-15. PMID:35165251. |
snap25 plays a role in synaptogenesis and the exocytotic release of neurotransmitters, and vamp2 participates in neurotransmitter release at a step between docking and fusion. |
2022-02-15 |
2023-08-13 |
rat |
| Julia Hesselbarth, Carla Schmid. Disorder-to-order transition of Synaptobrevin-2: Tracing the conformational diversity of a synaptic SNARE protein. Journal of structural biology. 2021-12-13. PMID:34902559. |
together with syntaxin-1a and snap25, it forms the core membrane fusion machinery that is responsible for neurotransmitter release and, therefore, signal transmission between neurons. |
2021-12-13 |
2023-08-13 |
Not clear |
| Cindy Périer, Vincent Martin, Sylvie Cornet, Christine Favre-Guilmard, Marie-Noelle Rocher, Julien Bindler, Stéphanie Wagner, Emile Andriambeloson, Brian Rudkin, Rudy Marty, Alban Vignaud, Matthew Beard, Stephane Lezmi, Mikhail Kaliniche. Recombinant botulinum neurotoxin serotype A1 in vivo characterization. Pharmacology research & perspectives. vol 9. issue 5. 2021-11-08. PMID:34632725. |
rbont/a1 inhibited motoneurons neurotransmitter release, which was robust, long-lasting, and accompanied by cleavage of snap25. |
2021-11-08 |
2023-08-13 |
mouse |
| Marta Nowacka-Chmielewska, Daniela Liśkiewicz, Arkadiusz Liśkiewicz, Łukasz Marczak, Anna Wojakowska, Jarosław Jerzy Barski, Andrzej Małeck. Cerebrocortical proteome profile of female rats subjected to the western diet and chronic social stress. Nutritional neuroscience. 2021-05-18. PMID:34000981. |
the down-regulation of proteins involved in neurotransmitter secretion (rph3a, snap25, syn1) as well as in learning and memory processes (map1a, snap25, tnr) were identified, while increased expression was detected for 14-3-3 protein gamma (ywhag) engaged in the modulation of the insulin-signaling cascade in the brain. |
2021-05-18 |
2023-08-13 |
human |
| Baris Alten, Qiangjun Zhou, Ok-Ho Shin, Luis Esquivies, Pei-Yi Lin, K Ian White, Rong Sun, Wendy K Chung, Lisa M Monteggia, Axel T Brunger, Ege T Kavalal. Role of Aberrant Spontaneous Neurotransmission in SNAP25-Associated Encephalopathies. Neuron. vol 109. issue 1. 2021-02-09. PMID:33147442. |
snare (soluble n-ethylmaleimide sensitive factor attachment protein receptor) complex, composed of synaptobrevin, syntaxin, and snap25, forms the essential fusion machinery for neurotransmitter release. |
2021-02-09 |
2023-08-13 |
Not clear |
| Baris Alten, Qiangjun Zhou, Ok-Ho Shin, Luis Esquivies, Pei-Yi Lin, K Ian White, Rong Sun, Wendy K Chung, Lisa M Monteggia, Axel T Brunger, Ege T Kavalal. Role of Aberrant Spontaneous Neurotransmission in SNAP25-Associated Encephalopathies. Neuron. vol 109. issue 1. 2021-02-09. PMID:33147442. |
here, we show that although structurally clustered mutations in snap25 give rise to related synaptic transmission phenotypes, specific alterations in spontaneous neurotransmitter release are a key factor to account for disease heterogeneity. |
2021-02-09 |
2023-08-13 |
Not clear |
| Roman Praschberger, Julie Jacquemyn, Patrik Verstreke. Molecule-to-Circuit Disease Mechanisms of a Synaptic SNAREopathy. Neuron. vol 109. issue 1. 2021-02-04. PMID:33412092. |
present a detailed investigation of disease-causing snap25 mutations based on structural analysis, neurotransmitter release, and emerging circuit properties. |
2021-02-04 |
2023-08-13 |
Not clear |
| Alfredo Ramos-Miguel, Vilte Barakauskas, Jehan Alamri, Masatoshi Miyauchi, Alasdair M Barr, Clare L Beasley, Gorazd Rosoklija, J John Mann, Andrew J Dwork, Annie Moradian, Gregg B Morin, William G Hone. The SNAP25 Interactome in Ventromedial Caudate in Schizophrenia Includes the Mitochondrial Protein ARF1. Neuroscience. vol 420. 2020-09-22. PMID:30610939. |
abnormalities of snap25 (synaptosome-associated protein 25) amount and protein-protein interactions occur in schizophrenia, and may contribute to abnormalities of neurotransmitter release in patients. |
2020-09-22 |
2023-08-13 |
Not clear |
| Dongmei Li, Ji Zheng, Mingyang Wang, Lu Feng, Zhili Ren, Yanyong Liu, Nan Yang, Pingping Zu. Changes of TSPO-mediated mitophagy signaling pathway in learned helplessness mice. Psychiatry research. vol 245. 2017-11-30. PMID:27543827. |
moreover, kifc2, relevant to the mitochondrial transport and snap25, relevant to neurotransmitter vesicle release, were also obviously down-regulated in the lh mice, which further rendered supportive evidence for the existing mitochondrial dysfunction in lh mice. |
2017-11-30 |
2023-08-13 |
mouse |
| Tristan D McClure-Begley, Irina Esterlis, Kathryn L Stone, TuKiet T Lam, Sharon R Grady, Christopher M Colangelo, Jon M Lindstrom, Michael J Marks, Marina R Picciott. Evaluation of the Nicotinic Acetylcholine Receptor-Associated Proteome at Baseline and Following Nicotine Exposure in Human and Mouse Cortex. eNeuro. vol 3. issue 4. 2017-10-25. PMID:27559543. |
we observed significant effects of nicotine exposure on the β2*-nachr-associated proteome in human and mouse cortex, particularly in the abundance of the nachr subunits themselves, as well as putative interacting proteins that make up core components of neuronal excitability (na/k atpase subunits), presynaptic neurotransmitter release (syntaxins, snap25, synaptotagmin), and a member of a known nachr protein chaperone family (14-3-3ζ). |
2017-10-25 |
2023-08-13 |
mouse |
| Antonio Lisboa, Rodolfo Melaré, Junia R B Franco, Carolina V Bis, Marta Gracia, Luis A Ponce-Soto, Sérgio Marangoni, Léa Rodrigues-Simioni, Maria Alice da Cruz-Höfling, Thalita Roch. Presynaptic Proteins as Markers of the Neurotoxic Activity of BmjeTX-I and BmjeTX-II Toxins from Bothrops marajoensis (Marajó Lancehead) Snake Venom. Biochemistry research international. vol 2016. 2016-09-16. PMID:27635261. |
considering that presynaptic toxins interfere into the machinery involved in neurotransmitter release (synaptophysin, synaptobrevin, and snap25 proteins), the main objective of this communication is to analyze, by immunofluorescence and western blotting, the expression of the synaptic proteins, synaptophysin, synaptobrevin, and snap25 and by myography, light, and transmission electron microscopy the pathology of motor nerve terminals and skeletal muscle fibres of chick biventer cervicis preparations (cbc) exposed in vitro to bmjetx-i and bmjetx-ii toxins from b. marajoensis venom. |
2016-09-16 |
2023-08-13 |
chicken |
| Antonio Lisboa, Rodolfo Melaré, Junia R B Franco, Carolina V Bis, Marta Gracia, Luis A Ponce-Soto, Sérgio Marangoni, Léa Rodrigues-Simioni, Maria Alice da Cruz-Höfling, Thalita Roch. Presynaptic Proteins as Markers of the Neurotoxic Activity of BmjeTX-I and BmjeTX-II Toxins from Bothrops marajoensis (Marajó Lancehead) Snake Venom. Biochemistry research international. vol 2016. 2016-09-16. PMID:27635261. |
the blockade resulted from interference on synaptophysin, synaptobrevin, and snap25 proteins leading to the conclusion that bmjetx-i and bmjetx-ii affected neurotransmitter release machinery by preventing the docking of synaptic vesicles to the axolemma of the nerve terminal. |
2016-09-16 |
2023-08-13 |
chicken |
| Shigeru Watanabe, Saori Yamamori, Shintaro Otsuka, Masanori Saito, Eiji Suzuki, Masakazu Kataoka, Hitoshi Miyaoka, Masami Takahash. Epileptogenesis and epileptic maturation in phosphorylation site-specific SNAP-25 mutant mice. Epilepsy research. vol 115. 2016-04-25. PMID:26220374. |
snap25(s187a/s187a) mouse is a knock-in mouse with a single amino acid substitution at a protein kinase c-dependent phosphorylation site of the synaptosomal-associated protein of 25 kda (snap-25), which is a target-soluble nsf attachment protein receptor (t-snare) protein essential for neurotransmitter release. |
2016-04-25 |
2023-08-13 |
mouse |
| Masafumi Shimojo, Julien Courchet, Simon Pieraut, Nina Torabi-Rander, Richard Sando, Franck Polleux, Anton Maximo. SNAREs Controlling Vesicular Release of BDNF and Development of Callosal Axons. Cell reports. vol 11. issue 7. 2016-03-22. PMID:25959820. |
at presynaptic active zones, exocytosis of neurotransmitter vesicles (svs) is driven by snare complexes that recruit syb2 and snap25. |
2016-03-22 |
2023-08-13 |
Not clear |
| Wei Wang, Fang Wang, Jia Liu, Wei Zhao, Qi Zhao, Mu He, Bao-Jiang Qian, Yang Xu, Ran Liu, Su-Juan Liu, Wei Liu, Jin Liu, Xin-Fu Zhou, Ting-Hua Wan. SNAP25 ameliorates sensory deficit in rats with spinal cord transection. Molecular neurobiology. vol 50. issue 2. 2015-09-11. PMID:24519330. |
synaptosomal-associated protein 25 (snap25) is a t-snare protein essential for exocytosis and neurotransmitter release, but its role in sensory functional recovery has not been determined. |
2015-09-11 |
2023-08-12 |
rat |
| Qingzhong Wang, Yanlin Wang, Weidong Ji, Guoquan Zhou, Kuanjun He, Zhiqiang Li, Jianhua Chen, Wenjin Li, Zujia Wen, Jiawei Shen, Yu Qiang, Jue Ji, Yujiong Wang, Yongyong Shi, Qizhong Yi, Yonggang Wan. SNAP25 is associated with schizophrenia and major depressive disorder in the Han Chinese population. The Journal of clinical psychiatry. vol 76. issue 1. 2015-03-24. PMID:25650683. |
synaptosomal-associated protein of 25 kda (snap25) is a member of the soluble n-ethylmaleimide-sensitive factor attachment receptor (snare) protein complex, which plays essential roles in the modulation of different voltage-gated calcium channels and neurotransmitter release. |
2015-03-24 |
2023-08-13 |
Not clear |
| P Manca, O Mameli, M A Caria, B Torrejón-Escribano, J Blas. Distribution of SNAP25, VAMP1 and VAMP2 in mature and developing deep cerebellar nuclei after estrogen administration. Neuroscience. vol 266. 2015-02-13. PMID:24534378. |
synaptosomal-associated protein of 25kda (snap25), vesicle-associated membrane protein 1 (vamp1) and 2 (vamp2) are components of soluble n-ethylmaleimide-sensitive fusion attachment protein receptors (snare) complex which is involved in synaptic vesicle exocytosis, a fundamental step in neurotransmitter release. |
2015-02-13 |
2023-08-12 |
rat |
| Mei Han, Xiao Xiao, Yan Yang, Ru-Yi Huang, Hong Cao, Zhi-Qi Zhao, Yu-Qiu Zhan. SIP30 is required for neuropathic pain-evoked aversion in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 2. 2014-03-03. PMID:24403136. |
sip30 (snap25 interacting protein of 30) is a snap25 interaction protein of 30 kda that functions in neurotransmitter release. |
2014-03-03 |
2023-08-12 |
rat |
| Ester Fernández-Salas, Joanne Wang, Yanira Molina, Jeremy B Nelson, Birgitte P S Jacky, K Roger Aok. Botulinum neurotoxin serotype A specific cell-based potency assay to replace the mouse bioassay. PloS one. vol 7. issue 11. 2013-05-22. PMID:23185348. |
botulinum neurotoxin serotype a (bont/a), a potent therapeutic used to treat various disorders, inhibits vesicular neurotransmitter exocytosis by cleaving snap25. |
2013-05-22 |
2023-08-12 |
mouse |