| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Sato, O Ishikawa, Y Miyach. Distinct patterns of collagen gene expression are seen in normal and keloid fibroblasts grown in three-dimensional culture. The British journal of dermatology. vol 138. issue 6. 1998-10-08. PMID:9747353. |
in contrast, mrna levels remained high in keloid and hypertrophic scar fibroblasts. |
1998-10-08 |
2023-08-12 |
Not clear |
| M Sato, O Ishikawa, Y Miyach. Distinct patterns of collagen gene expression are seen in normal and keloid fibroblasts grown in three-dimensional culture. The British journal of dermatology. vol 138. issue 6. 1998-10-08. PMID:9747353. |
when we compared mrna expression in fibroblasts from the centre and the edge of hypertrophic scar, cells from the centre showed a persistently decreased level of collagenase mrna expression. |
1998-10-08 |
2023-08-12 |
Not clear |
| M Sato, O Ishikawa, Y Miyach. Distinct patterns of collagen gene expression are seen in normal and keloid fibroblasts grown in three-dimensional culture. The British journal of dermatology. vol 138. issue 6. 1998-10-08. PMID:9747353. |
fibroblasts from keloids and hypertrophic scar may have a defective system of down-regulation in extracellular matrix metabolism. |
1998-10-08 |
2023-08-12 |
Not clear |
| P G Scott, C M Dodd, A Ghahary, Y J Shen, E E Tredge. Fibroblasts from post-burn hypertrophic scar tissue synthesize less decorin than normal dermal fibroblasts. Clinical science (London, England : 1979). vol 94. issue 5. 1998-08-03. PMID:9682679. |
fibroblasts from post-burn hypertrophic scar tissue synthesize less decorin than normal dermal fibroblasts. |
1998-08-03 |
2023-08-12 |
Not clear |
| P G Scott, C M Dodd, A Ghahary, Y J Shen, E E Tredge. Fibroblasts from post-burn hypertrophic scar tissue synthesize less decorin than normal dermal fibroblasts. Clinical science (London, England : 1979). vol 94. issue 5. 1998-08-03. PMID:9682679. |
fibroblast cultures were established from biopsies of hypertrophic scar and normal dermis taken from nine patients recovering from second- and third-degree burns. |
1998-08-03 |
2023-08-12 |
Not clear |
| P G Scott, C M Dodd, A Ghahary, Y J Shen, E E Tredge. Fibroblasts from post-burn hypertrophic scar tissue synthesize less decorin than normal dermal fibroblasts. Clinical science (London, England : 1979). vol 94. issue 5. 1998-08-03. PMID:9682679. |
since transforming growth factor-beta 1 is implicated in various fibrotic conditions, including post-burn hypertrophic scar, its effect on decorin synthesis by these paired fibroblast cell strains was assessed. |
1998-08-03 |
2023-08-12 |
Not clear |
| P G Scott, C M Dodd, A Ghahary, Y J Shen, E E Tredge. Fibroblasts from post-burn hypertrophic scar tissue synthesize less decorin than normal dermal fibroblasts. Clinical science (London, England : 1979). vol 94. issue 5. 1998-08-03. PMID:9682679. |
production of decorin was lower in all cell strains of hypertrophic scar fibroblasts tested, compared with normal dermal fibroblasts cultured from the same patients (mean 49 +/- 23%; p < 0.001, n = 9). |
1998-08-03 |
2023-08-12 |
Not clear |
| P G Scott, C M Dodd, A Ghahary, Y J Shen, E E Tredge. Fibroblasts from post-burn hypertrophic scar tissue synthesize less decorin than normal dermal fibroblasts. Clinical science (London, England : 1979). vol 94. issue 5. 1998-08-03. PMID:9682679. |
treatment of confluent cultures with transforming growth factor-beta 1 for 3 days caused a reduction in both decorin protein and mrna in all six strains of hypertrophic scar fibroblasts tested and in five of six strains of normal dermal fibroblasts. |
1998-08-03 |
2023-08-12 |
Not clear |
| P G Scott, C M Dodd, A Ghahary, Y J Shen, E E Tredge. Fibroblasts from post-burn hypertrophic scar tissue synthesize less decorin than normal dermal fibroblasts. Clinical science (London, England : 1979). vol 94. issue 5. 1998-08-03. PMID:9682679. |
an increase in the length of the dermatan sulphate chain on decorin, a previously reported characteristic of this glycosaminoglycan in hypertrophic scar, was seen in all but two of the strains treated with transforming growth factor-beta 1. |
1998-08-03 |
2023-08-12 |
Not clear |
| P G Scott, C M Dodd, A Ghahary, Y J Shen, E E Tredge. Fibroblasts from post-burn hypertrophic scar tissue synthesize less decorin than normal dermal fibroblasts. Clinical science (London, England : 1979). vol 94. issue 5. 1998-08-03. PMID:9682679. |
the reduced capacity of fibroblasts in hypertrophic scar tissue to synthesize decorin may have implications for the development of the condition since this small proteoglycan is involved in tissue organization and may also play a role in modulating the activity in vivo of fibrogenic cytokines such as transforming growth factor-beta 1. |
1998-08-03 |
2023-08-12 |
Not clear |
| W L Garne. Epidermal regulation of dermal fibroblast activity. Plastic and reconstructive surgery. vol 102. issue 1. 1998-07-21. PMID:9655418. |
although the association between delayed burn wound healing and subsequent hypertrophic scar formation is well-established, the mechanism for this relationship is unknown. |
1998-07-21 |
2023-08-12 |
human |
| W L Garne. Epidermal regulation of dermal fibroblast activity. Plastic and reconstructive surgery. vol 102. issue 1. 1998-07-21. PMID:9655418. |
clinical strategies to decrease hypertrophic scar should include an attempt at early wound closure with skin grafting or the application of cultured epithelial autografts. |
1998-07-21 |
2023-08-12 |
human |
| C Castagnoli, C Trombotto, S Ondei, M Stella, M Calcagni, G Magliacani, S T Alasi. Characterization of T-cell subsets infiltrating post-burn hypertrophic scar tissues. Burns : journal of the International Society for Burn Injuries. vol 23. issue 7-8. 1998-07-17. PMID:9568325. |
characterization of t-cell subsets infiltrating post-burn hypertrophic scar tissues. |
1998-07-17 |
2023-08-12 |
Not clear |
| C Castagnoli, C Trombotto, S Ondei, M Stella, M Calcagni, G Magliacani, S T Alasi. Characterization of T-cell subsets infiltrating post-burn hypertrophic scar tissues. Burns : journal of the International Society for Burn Injuries. vol 23. issue 7-8. 1998-07-17. PMID:9568325. |
in this study, skin-infiltrating cells were characterized in both the active and remission phases of post-burn hypertrophic scar biopsies. |
1998-07-17 |
2023-08-12 |
Not clear |
| C Castagnoli, C Trombotto, S Ondei, M Stella, M Calcagni, G Magliacani, S T Alasi. Characterization of T-cell subsets infiltrating post-burn hypertrophic scar tissues. Burns : journal of the International Society for Burn Injuries. vol 23. issue 7-8. 1998-07-17. PMID:9568325. |
approximately 70 per cent of t lymphocytes present in the tissue involved in active phase hypertrophic scar samples were activated (positive with anti-hla-dr and il-2 receptor antibodies) which is significantly higher than remission phase hypertrophic and normotrophic scars, in which positivity was 40 and 38 per cent, respectively. |
1998-07-17 |
2023-08-12 |
Not clear |
| R J Wassermann, M Polo, P Smith, X Wang, F Ko, M C Robso. Differential production of apoptosis-modulating proteins in patients with hypertrophic burn scar. The Journal of surgical research. vol 75. issue 1. 1998-06-18. PMID:9614860. |
differential production of apoptosis-modulating proteins in patients with hypertrophic burn scar. |
1998-06-18 |
2023-08-12 |
Not clear |
| R J Wassermann, M Polo, P Smith, X Wang, F Ko, M C Robso. Differential production of apoptosis-modulating proteins in patients with hypertrophic burn scar. The Journal of surgical research. vol 75. issue 1. 1998-06-18. PMID:9614860. |
the following study was designed to quantify differential levels of the bcl-2 protooncogene and the fas cell surface receptor, two apoptosis-modulating proteins, in the peripheral blood mononuclear cell (pbmc) fractions of burn patients with hypertrophic scar versus those considered to have healed normally. |
1998-06-18 |
2023-08-12 |
Not clear |
| J Fan, J Wang, P D Spraggs, R E Nordströ. Rhomboid minigrafts in hair restoration surgery. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. vol 24. issue 5. 1998-06-10. PMID:9598015. |
this in turn can lead to piggybacking or insertion of two grafts per slit with the resultant effect of cyst formation, cobblestoning, and hypertrophic scar formation. |
1998-06-10 |
2023-08-12 |
Not clear |
| M Machesney, N Tidman, A Waseem, L Kirby, I Leig. Activated keratinocytes in the epidermis of hypertrophic scars. The American journal of pathology. vol 152. issue 5. 1998-06-02. PMID:9588880. |
hypertrophic scar epidermis was found to express the hyperproliferative keratins k6 and k16 in interfollicular epidermis in association with k17 and precocious expression of filaggrin. |
1998-06-02 |
2023-08-12 |
Not clear |
| M Machesney, N Tidman, A Waseem, L Kirby, I Leig. Activated keratinocytes in the epidermis of hypertrophic scars. The American journal of pathology. vol 152. issue 5. 1998-06-02. PMID:9588880. |
these results suggest the keratinocytes in hypertrophic scar epidermis have entered an alternative differentiation pathway and are expressing an activated phenotype. |
1998-06-02 |
2023-08-12 |
Not clear |