| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shane Horsefield, Hayden Burdett, Xiaoxiao Zhang, Mohammad K Manik, Yun Shi, Jian Chen, Tiancong Qi, Jonathan Gilley, Jhih-Siang Lai, Maxwell X Rank, Lachlan W Casey, Weixi Gu, Daniel J Ericsson, Gabriel Foley, Robert O Hughes, Todd Bosanac, Mark von Itzstein, John P Rathjen, Jeffrey D Nanson, Mikael Boden, Ian B Dry, Simon J Williams, Brian J Staskawicz, Michael P Coleman, Thomas Ve, Peter N Dodds, Bostjan Kob. NAD Science (New York, N.Y.). vol 365. issue 6455. 2020-02-14. PMID:31439792. |
nad sarm1 (sterile alpha and tir motif containing 1) is responsible for depletion of nicotinamide adenine dinucleotide in its oxidized form (nad |
2020-02-14 |
2023-08-13 |
Not clear |
| Kow Essuman, Daniel W Summers, Yo Sasaki, Xianrong Mao, Aldrin Kay Yuen Yim, Aaron DiAntonio, Jeffrey Milbrand. TIR Domain Proteins Are an Ancient Family of NAD Current biology : CB. vol 28. issue 3. 2019-07-03. PMID:29395922. |
in pursuing our work on axon degeneration [10], we made the surprising discovery that the tir domain of sarm1 (sterile alpha and tir motif containing 1), a tlr adaptor protein, has enzymatic activity [11]. |
2019-07-03 |
2023-08-13 |
Not clear |
| Owen M Peters, Elizabeth A Lewis, Jeannette M Osterloh, Alexandra Weiss, Johnny S Salameh, Jake Metterville, Robert H Brown, Marc R Freema. Loss of Sarm1 does not suppress motor neuron degeneration in the SOD1G93A mouse model of amyotrophic lateral sclerosis. Human molecular genetics. vol 27. issue 21. 2019-04-22. PMID:30010873. |
sterile alpha and tir motif containing 1 (sarm1) is an essential component of the prodegenerative pathway driving axon degeneration after axotomy and represents an appealing target for therapeutic intervention in neurological conditions involving axon loss. |
2019-04-22 |
2023-08-13 |
mouse |
| Hitoshi Murata, Cho Cho Khine, Akane Nishikawa, Ken-Ichi Yamamoto, Rie Kinoshita, Masakiyo Sakaguch. c-Jun N-terminal kinase (JNK)-mediated phosphorylation of SARM1 regulates NAD The Journal of biological chemistry. vol 293. issue 49. 2019-04-17. PMID:30333228. |
sterile alpha and toll/interleukin receptor motif-containing protein 1 (sarm1) has been attracting much attention as an important molecule for inducing axonal degeneration and neuronal cell death by causing loss of nad (nadh). |
2019-04-17 |
2023-08-13 |
Not clear |
| Kimberly A Fernandes, Katherine L Mitchell, Amit Patel, Olivia J Marola, Peter Shrager, Donald J Zack, Richard T Libby, Derek S Welsbi. Role of SARM1 and DR6 in retinal ganglion cell axonal and somal degeneration following axonal injury. Experimental eye research. vol 171. 2018-12-21. PMID:29526794. |
moreover, others have shown that activation of the dlk/jnk pathway contributes to distal axonal degeneration in some neuronal subtypes and that this activation is dependent on the adaptor protein, sterile alpha and tir motif containing 1 (sarm1). |
2018-12-21 |
2023-08-13 |
mouse |
| Zhen-Guo Pan, Xu-Sheng A. SARM1 deletion restrains NAFLD induced by high fat diet (HFD) through reducing inflammation, oxidative stress and lipid accumulation. Biochemical and biophysical research communications. vol 498. issue 3. 2018-04-30. PMID:29454967. |
sarm1 (sterile alpha and armadillo motif-containing protein 1) is the recently identified tir domain-containing cytosolic protein, which is involved in toll-like receptors (tlrs) signaling transduction. |
2018-04-30 |
2023-08-13 |
mouse |
| Daniel W Summers, Daniel A Gibson, Aaron DiAntonio, Jeffrey Milbrand. SARM1-specific motifs in the TIR domain enable NAD+ loss and regulate injury-induced SARM1 activation. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 41. 2018-01-30. PMID:27671644. |
sterile alpha and toll/interleukin receptor (tir) motif-containing protein 1 (sarm1) is an evolutionarily conserved executioner of this degeneration cascade, also known as wallerian degeneration; however, the mechanism of sarm1-dependent neuronal destruction is still obscure. |
2018-01-30 |
2023-08-13 |
Not clear |
| Stefanie Geisler, Ryan A Doan, Amy Strickland, Xin Huang, Jeffrey Milbrandt, Aaron DiAntoni. Prevention of vincristine-induced peripheral neuropathy by genetic deletion of SARM1 in mice. Brain : a journal of neurology. vol 139. issue Pt 12. 2017-05-10. PMID:27797810. |
recently, we and others discovered that genetic deletion of sarm1 (sterile alpha and tir motif containing protein 1) dramatically protects axons from degeneration after axotomy in mice. |
2017-05-10 |
2023-08-13 |
mouse |
| Nana Yan, Jianguo Su, Chunrong Yang, Youliang Rao, Xiaoli Feng, Quanyuan Wan, Chuzhao Le. Grass carp SARM1 and its two splice variants negatively regulate IFN-I response and promote cell death upon GCRV infection at different subcellular locations. Developmental and comparative immunology. vol 48. issue 1. 2015-08-04. PMID:25280626. |
sterile alpha and toll/il-1r motif containing 1 (sarm1) negatively regulates trif-dependent tlr signaling in mammals. |
2015-08-04 |
2023-08-13 |
Not clear |
| Josiah Gerdts, E J Brace, Yo Sasaki, Aaron DiAntonio, Jeffrey Milbrand. SARM1 activation triggers axon degeneration locally via NAD⁺ destruction. Science (New York, N.Y.). vol 348. issue 6233. 2015-06-23. PMID:25908823. |
sterile alpha and tir motif-containing 1 (sarm1) protein is an essential mediator of axon degeneration. |
2015-06-23 |
2023-08-13 |
mouse |
| Chia-Wen Lin, Yi-Ping Hsue. Sarm1, a neuronal inflammatory regulator, controls social interaction, associative memory and cognitive flexibility in mice. Brain, behavior, and immunity. vol 37. 2014-11-04. PMID:24321214. |
our prior study showed that sterile alpha and tir motif-containing 1 protein (sarm1) regulates neuronal morphogenesis through at least two pathways. |
2014-11-04 |
2023-08-12 |
mouse |
| Piyali Mukherjee, Tyson A Woods, Roger A Moore, Karin E Peterso. Activation of the innate signaling molecule MAVS by bunyavirus infection upregulates the adaptor protein SARM1, leading to neuronal death. Immunity. vol 38. issue 4. 2013-07-09. PMID:23499490. |
by using in vitro studies in primary neurons and in vivo studies in mice, we have shown that lacv infection induced the rna helicase, rig-i, and mitochondrial antiviral signaling protein (mavs) signaling pathway, resulting in upregulation of the sterile alpha and tir-containing motif 1 (sarm1), an adaptor molecule that we found to be directly involved in neuronal damage. |
2013-07-09 |
2023-08-12 |
mouse |
| Marc Dalo. Studies of SARM1 uncover similarities between immune and neuronal responses to danger. Science's STKE : signal transduction knowledge environment. vol 2007. issue 417. 2008-01-16. PMID:18089857. |
however, the physiological function of the fifth mammalian protein, sterile alpha and tir motif-containing 1 [sarm1, also known as myeloid differentiation marker 88-5 (myd88-5)], has remained elusive. |
2008-01-16 |
2023-08-12 |
mouse |
| Laurie L Molday, Winco W H Wu, Robert S Molda. Retinoschisin (RS1), the protein encoded by the X-linked retinoschisis gene, is anchored to the surface of retinal photoreceptor and bipolar cells through its interactions with a Na/K ATPase-SARM1 complex. The Journal of biological chemistry. vol 282. issue 45. 2007-12-12. PMID:17804407. |
instead, co-immunoprecipitation studies together with mass spectrometric-based proteomics and western blotting showed that retinoschisin is associated with a complex consisting of na/k atpase (alpha3, beta2 isoforms) and the sterile alpha and tir motif-containing protein sarm1. |
2007-12-12 |
2023-08-12 |
Not clear |