| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yihan Ye, Fuyong Son. SARM1 in the pathogenesis of immune-related disease. Toxicology research. vol 13. issue 6. 2024-12-12. PMID:39664502. |
sterile alpha and toll interleukin receptor motif-containing protein 1 (sarm1) are primarily expressed in the mammalian nervous system, with their presence in neurons being associated with mitochondrial aggregation. |
2024-12-12 |
2024-12-14 |
Not clear |
| Xuejin Zhang, Ting Li, Rong Zhang, Junfeng Li, Kaidi Wang, Jihong W. Downregulation of SARM1 Protects Retinal Ganglion Cell Axonal and Somal Degeneration Via JNK Activation in a Glaucomatous Model of Ocular Hypertension. Investigative ophthalmology & visual science. vol 65. issue 13. 2024-11-05. PMID:39499508. |
this study aimed to assess the expression of sterile alpha and tir motif containing protein 1 (sarm1) in both chronic and acute glaucomatous animal models and investigate the underlying sarm1-jnk signaling mechanism responsible for the protective effects of sarm1 downregulation on retinal ganglion cell (rgc) soma and axons in a chronic intraocular hypertension (coh) model. |
2024-11-05 |
2024-11-08 |
Not clear |
| Weifen Li, Wenhui Zhu, Junhao Chen, Tahir Ali, Shupeng L. SARM1 Deficiency Induced Depressive-like Behavior via AMPKα/p-eEF2 axis to Synapse Dysfunction. Neuropharmacology. 2024-11-03. PMID:39489288. |
sterile alpha and tir motif containing 1 (sarm1) are proteins implicated in various neurological processes; however, their role in depression remains unexplored. |
2024-11-03 |
2024-11-06 |
mouse |
| Christina Antoniou, Andrea Loreto, Jonathan Gilley, Elisa Merlini, Giuseppe Orsomando, Michael P Colema. Chronically Low NMNAT2 Expression Causes Sub-lethal SARM1 Activation and Altered Response to Nicotinamide Riboside in Axons. Molecular neurobiology. 2024-10-01. PMID:39352636. |
nicotinamide mononucleotide adenylyltransferase 2 (nmnat2) is an endogenous axon survival factor that maintains axon health by blocking activation of the downstream pro-degenerative protein sarm1 (sterile alpha and tir motif containing protein 1). |
2024-10-01 |
2024-10-03 |
mouse |
| Misaki Morishita, Shinji Matsud. SARM1 is essential for NMDA receptor-dependent endocytosis of AMPA receptors in hippocampal neurons. Neuroscience research. 2024-09-30. PMID:39349221. |
in this study, we showed that small interfering rna (sirna)-mediated knockdown of sterile alpha and toll/interleukin receptor motif containing 1 (sarm1) in cultured hippocampal neurons prevented the n-methyl-d-aspartate (nmda)-induced reduction in cell surface ampa receptors. |
2024-09-30 |
2024-10-03 |
Not clear |
| Samantha Y Tse-Kang, Khursheed A Wani, Nicholas D Peterson, Amanda Page, Fiachra Humphries, Read Pukkila-Worle. Intestinal immunity in C. elegans is activated by pathogen effector-triggered aggregation of the guard protein TIR-1 on lysosome-related organelles. Immunity. 2024-09-19. PMID:39299238. |
we discovered that the lone enzymatic tir-domain protein in the nematode c. elegans (tir-1, homolog of mammalian sterile alpha and tir motif-containing 1 [sarm1]) was strategically expressed on the membranes of a specific intracellular compartment called lysosome-related organelles. |
2024-09-19 |
2024-09-22 |
Not clear |
| Flora I Hinz, Carmela Louise M Villegas, Jasmine T Roberts, Heming Yao, Shreya Gaddam, Anton Delwig, Samantha A Green, Craig Fredrickson, Max Adrian, Raymond R Asuncion, Tommy K Cheung, Margaret Hayne, David H Hackos, Christopher M Rose, David Richmond, Casper C Hoogenraa. Context-Specific Stress Causes Compartmentalized SARM1 Activation and Local Degeneration in Cortical Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 44. issue 24. 2024-06-12. PMID:38692735. |
sterile alpha and tir motif containing 1 (sarm1) is an inducible nadase that localizes to mitochondria throughout neurons and senses metabolic changes that occur after injury. |
2024-06-12 |
2024-06-15 |
mouse |
| Huijuan Fan, Chun Song, Jingyu Zhan. Sarm1 Controls the MYD88-Mediated Inflammatory Responses in Inflammatory Bowel Disease via the Regulation of TRAF3 Recruitment. Immunological investigations. 2024-04-23. PMID:38651786. |
sterile alpha and tir motif-containing 1 (sarm1) is known as a negative regulator of inflammatory responses. |
2024-04-23 |
2024-04-26 |
Not clear |
| Jeremy Garb, Gil Amitai, Allen Lu, Gal Ofir, Alexander Brandis, Tevie Mehlman, Philip J Kranzusch, Rotem Sore. The SARM1 TIR domain produces glycocyclic ADPR molecules as minor products. PloS one. vol 19. issue 4. 2024-04-18. PMID:38635746. |
sterile alpha and tir motif-containing 1 (sarm1) is a protein involved in programmed death of injured axons. |
2024-04-18 |
2024-04-21 |
human |
| Moafaq S Alrawaili, Ahmad R Abuzinadah, Aysha A AlShareef, Emad A Hindi, Ahmed K Bamaga, Weam Alshora, Hashim Sind. Serum SARM1 Levels and Diabetic Peripheral Neuropathy in Type 2 Diabetes: Correlation with Clinical Neuropathy Scales and Nerve Conduction Studies and Impact of COVID-19 vaccination. Vaccines. vol 12. issue 2. 2024-02-24. PMID:38400192. |
recently, the gene for serum sterile alpha and toll/interleukin receptor motif-containing protein 1 (sarm1), which may contribute to the pathogenesis of wallerian degeneration, was discovered in mice models of peripheral neuropathy. |
2024-02-24 |
2024-02-26 |
mouse |
| Yan Guo, Zara Mehrabian, Jeffrey Milbrandt, Aaron DiAntonio, Steven L Bernstei. Synergistic Protection of Retinal Ganglion Cells (RGCs) by SARM1 Inactivation with CNTF in a Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy. Cells. vol 13. issue 3. 2024-02-09. PMID:38334594. |
we evaluated whether inhibiting sterile alpha and (toll/interleukin receptor (tir)) motif-containing 1 (sarm1) activity protects retinal ganglion cells (rgcs) following ischemic axonopathy (rodent nonarteritic anterior ischemic optic neuropathy: rnaion) by itself and combined with ciliary neurotrophic factor (cntf). |
2024-02-09 |
2024-02-11 |
rat |
| Olga Tarasiuk, Laura Molteni, Alessio Malacrida, Gabriella Nicolin. The Role of NMNAT2/SARM1 in Neuropathy Development. Biology. vol 13. issue 1. 2024-01-26. PMID:38275737. |
recent investigations into axon degeneration mechanisms have pinpointed nicotinamide mononucleotide adenylyltransferase 2 (nmnat2) and sterile alpha and tir motif-containing 1 protein (sarm1) as pivotal mediators of injury-induced axonal degeneration. |
2024-01-26 |
2024-01-28 |
Not clear |
| Takashi Miyamoto, Chaeyoung Kim, Johann Chow, Jason C Dugas, Jack DeGroot, Alex L Bagdasarian, Arun P Thottumkara, Martin Larhammar, Meredith Ek Calvert, Brian M Fox, Joseph W Lewcock, Lesley A Kan. SARM1 is responsible for calpain-dependent dendrite degeneration in mouse hippocampal neurons. The Journal of biological chemistry. 2024-01-10. PMID:38199568. |
sterile alpha and tir motif containing 1 (sarm1) is a critical regulator of axon degeneration that acts through hydrolysis of nad |
2024-01-10 |
2024-01-13 |
mouse |
| Sophia Barber, Veronica Gomez-Godinez, Joy Young, Abigail Wei, Sarah Chen, Anna Snissarenko, Sze Sze Chan, Chengbiao Wu, Linda Sh. Impacts of H Journal of biophotonics. 2024-01-08. PMID:38185916. |
sterile alpha and toll/interleukin receptor motif-containing protein 1 (sarm1) regulates several cell responses to axonal damage and has been implicated in promoting neuronal degeneration. |
2024-01-08 |
2024-01-10 |
Not clear |
| Katharine A Shanahan, Gavin M Davis, Ciara G Doran, Ryoichi Sugisawa, Gavin P Davey, Andrew G Bowi. SARM1 regulates NAD The Journal of biological chemistry. 2024-01-04. PMID:38176648. |
sarm1 regulates nad sterile alpha and heat/armadillo motif-containing protein (sarm1) was recently described as a nad |
2024-01-04 |
2024-01-07 |
Not clear |
| Elif O Dogan, James Bouley, Jianjun Zhong, Ashley L Harkins, Allison M Keeler, Daryl A Bosco, Robert H Brown, Nils Henninge. Genetic ablation of Sarm1 attenuates expression and mislocalization of phosphorylated TDP-43 after mouse repetitive traumatic brain injury. Acta neuropathologica communications. vol 11. issue 1. 2023-12-21. PMID:38124145. |
we sought to determine whether blocking the prodegenerative sarm1 (sterile alpha and tir motif containing 1) axon death pathway attenuates tdp-43 pathology after tbi. |
2023-12-21 |
2023-12-23 |
mouse |
| Janneke Doedée Icso, Paul Ryan Thompso. A phase transition reduces the threshold for nicotinamide mononucleotide-based activation of SARM1, an NAD(P) hydrolase, to physiologically relevant levels. The Journal of biological chemistry. vol 299. issue 11. 2023-11-06. PMID:37742918. |
activation of the nad(p)ase sterile alpha and toll-interleukin receptor motif containing protein 1 (sarm1) is critical for this process. |
2023-11-06 |
2023-11-08 |
Not clear |
| Hitoshi Murata, May Tha Zin Phoo, Toshiki Ochi, Nahoko Tomonobu, Ken-Ichi Yamamoto, Rie Kinoshita, Ikuko Miyazaki, Masahiro Nishibori, Masato Asanuma, Masakiyo Sakaguch. Phosphorylated SARM1 is involved in the pathological process of rotenone-induced neurodegeneration. Journal of biochemistry. 2023-09-19. PMID:37725528. |
sterile alpha and toll/interleukin receptor motif-containing protein 1 (sarm1) is a nad+ hydrolase that plays a key role in axonal degeneration and neuronal cell death. |
2023-09-19 |
2023-10-07 |
mouse |
| Hye Ran Kim, Hye Jin Lee, Yewon Jeon, So Young Jang, Yoon Kyoung Shin, Jean Ho Yun, Hye Ji Park, Hyongjong Koh, Kyung Eun Lee, Jung Eun Shin, Hwan Tae Par. Targeting SARM1 improves autophagic stress-induced axonal neuropathy. Autophagy. 2023-08-18. PMID:37561040. |
aav: adeno-associated virus; atf3: activating transcription factor 3; atg7: autophagy related 7; avil: advillin; cadpr: cyclic adp ribose; calc: calcitonin/calcitonin-related polypeptide; cmt: charcot-marie-tooth disease; cko: conditional knockout; deg: differentially expressed gene; drg: dorsal root ganglion; fe-sem: field emission scanning electron microscopy; if: immunofluorescence; ncv: nerve conduction velocity; pvalb: parvalbumin; rag: regeneration-associated gene; ros: reactive oxygen species; sarm1: sterile alpha and heat/armadillo motif containing 1; |
2023-08-18 |
2023-09-07 |
Not clear |
| Shuai Wang, Yiyu Yang, Zhigang Yu, Mingxue Song, Zhidan Liu, Shulin Shan, Hui Yong, Wenting Ni, Yalong Qiang, Cuiqin Zhang, Shu'e Wang, Xiulan Zhao, Fuyong Son. Mitophagy suppresses motor neuron necroptotic mitochondrial damage and alleviates necroptosis that converges to SARM1 in acrylamide-induced dying-back neuropathy. Journal of neurochemistry. 2023-06-23. PMID:37350308. |
sterile alpha and toll/interleukin 1 receptor motif-containing protein 1 (sarm1) is the central determinant of axonal degeneration and has crosstalk with different cell death programs to determine neuronal survival. |
2023-06-23 |
2023-08-14 |
Not clear |