| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mélanie Druart, Marika Nosten-Bertrand, Stefanie Poll, Sophie Crux, Felix Nebeling, Célia Delhaye, Yaëlle Dubois, Manuel Mittag, Marion Leboyer, Ryad Tamouza, Martin Fuhrmann, Corentin Le Magueress. Elevated expression of complement C4 in the mouse prefrontal cortex causes schizophrenia-associated phenotypes. Molecular psychiatry. vol 26. issue 7. 2021-10-12. PMID:33837272. |
we found that functional gabaergic transmission was reduced in c4-oe mice, in line with diminished gaba release probability from parvalbumin interneurons, lower gad67 expression, and decreased intrinsic excitability in parvalbumin interneurons. |
2021-10-12 |
2023-08-13 |
mouse |
| Michael C Holter, Lauren T Hewitt, Kenji J Nishimura, Sara J Knowles, George R Bjorklund, Shiv Shah, Noah R Fry, Katherina P Rees, Tanya A Gupta, Carter W Daniels, Guohui Li, Steven Marsh, David Michael Treiman, Michael Foster Olive, Trent R Anderson, Federico Sanabria, William D Snider, Jason M Newber. Hyperactive MEK1 Signaling in Cortical GABAergic Neurons Promotes Embryonic Parvalbumin Neuron Loss and Defects in Behavioral Inhibition. Cerebral cortex (New York, N.Y. : 1991). vol 31. issue 6. 2021-10-11. PMID:33570093. |
hyperactive mek1 signaling in cortical gabaergic neurons promotes embryonic parvalbumin neuron loss and defects in behavioral inhibition. |
2021-10-11 |
2023-08-13 |
mouse |
| Antonello Pinna, Alessandro Colasant. The Neurometabolic Basis of Mood Instability: The Parvalbumin Interneuron Link-A Systematic Review and Meta-Analysis. Frontiers in pharmacology. vol 12. 2021-10-08. PMID:34616292. |
fast-spiking parvalbumin gabaergic interneurons modulate the activity of principal excitatory neurons through their inhibitory action determining precise neuronal excitation balance. |
2021-10-08 |
2023-08-13 |
Not clear |
| Meredith Lodge, Maria-Clemencia Hernandez, Jan M Schulz, Josef Bischofberge. Sparsification of AP firing in adult-born hippocampal granule cells via voltage-dependent α5-GABA Cell reports. vol 37. issue 1. 2021-10-05. PMID:34610304. |
here, we analyze gabaergic inputs in newborn hippocampal granule cells mediated by soma-targeting parvalbumin and dendrite-targeting somatostatin interneurons. |
2021-10-05 |
2023-08-13 |
Not clear |
| Laura Gennaccaro, Claudia Fuchs, Manuela Loi, Vincenzo Roncacè, Stefania Trazzi, Yassine Ait-Bali, Giuseppe Galvani, Anna Cecilia Berardi, Giorgio Medici, Marianna Tassinari, Elisa Ren, Roberto Rimondini, Maurizio Giustetto, Giorgio Aicardi, Elisabetta Cian. A GABA Neurobiology of disease. vol 153. 2021-08-20. PMID:33621640. |
interestingly, increased density of both gabaergic synaptic terminals and parvalbumin inhibitory interneurons was recently observed in the primary visual cortex of cdkl5 knockout (ko) mice, suggesting that excessive gabaergic transmission might contribute to the visual deficits characteristic of cdd. |
2021-08-20 |
2023-08-13 |
mouse |
| Joonhyuk Lee, Chloe L Stile, Annie R Bice, Zachary P Rosenthal, Ping Yan, Abraham Z Snyder, Jin-Moo Lee, Adam Q Baue. Opposed hemodynamic responses following increased excitation and parvalbumin-based inhibition. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 41. issue 4. 2021-07-16. PMID:33736512. |
parvalbumin interneurons are the largest subpopulation of gabaergic neurons in the brain, critical for brain development, plasticity, and long-distance excitatory neurotransmission. |
2021-07-16 |
2023-08-13 |
mouse |
| Olivier Dubanet, Arnaldo Ferreira Gomes Da Silva, Andreas Frick, Hajime Hirase, Anna Beyeler, Xavier Leinekuge. Probing the polarity of spontaneous perisomatic GABAergic synaptic transmission in the mouse CA3 circuit in vivo. Cell reports. vol 36. issue 2. 2021-07-14. PMID:34260906. |
we overcome this challenge by non-invasive extracellular recording of neuronal firing responses to optogenetically evoked and spontaneously occurring inhibitory perisomatic gabaergic field potentials, generated by individual parvalbumin interneurons on their target pyramidal cells. |
2021-07-14 |
2023-08-13 |
mouse |
| Lailun Nahar, Blake M Delacroix, Hyung W Na. The Role of Parvalbumin Interneurons in Neurotransmitter Balance and Neurological Disease. Frontiers in psychiatry. vol 12. 2021-07-06. PMID:34220586. |
parvalbumin fast-spiking interneurons (pv-fsi) are gabaergic cells that are only a small fraction of the brain's neuronal network, but manifest unique cellular and molecular properties that drastically influence the downstream effects on signaling and ultimately change cognitive behaviors. |
2021-07-06 |
2023-08-13 |
Not clear |
| Yucen Xia, Zhiqing Zhang, Weipeng Lin, Jinglan Yan, Chuan'an Zhu, Dongmin Yin, Su He, Yang Su, Nenggui Xu, Robert William Caldwell, Lin Yao, Yongjun Che. Modulating microglia activation prevents maternal immune activation induced schizophrenia-relevant behavior phenotypes via arginase 1 in the dentate gyrus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 11. 2021-06-23. PMID:32599605. |
we found fewer parvalbumin positive (pv+) cells and impaired gabaergic transmission in the dentate gyrus (dg), accompanied by schizophrenia-like behavior in the adult offspring. |
2021-06-23 |
2023-08-13 |
mouse |
| Justin N Siemian, Sarah Sarsfield, Yeka Apont. Glutamatergic fast-spiking parvalbumin neurons in the lateral hypothalamus: Electrophysiological properties to behavior. Physiology & behavior. vol 221. 2021-06-21. PMID:32289319. |
throughout the central nervous system, neurons expressing the calcium-binding protein parvalbumin have been typically classified as gabaergic with fast-spiking characteristics. |
2021-06-21 |
2023-08-13 |
Not clear |
| Nawshaba Nawreen, Evelin M Cotella, Rachel Morano, Parinaz Mahbod, Khushali S Dalal, Maureen Fitzgerald, Susan Martelle, Benjamin A Packard, Ana Franco-Villanueva, Rachel D Moloney, James P Herma. Chemogenetic Inhibition of Infralimbic Prefrontal Cortex GABAergic Parvalbumin Interneurons Attenuates the Impact of Chronic Stress in Male Mice. eNeuro. vol 7. issue 5. 2021-06-18. PMID:33055196. |
chemogenetic inhibition of infralimbic prefrontal cortex gabaergic parvalbumin interneurons attenuates the impact of chronic stress in male mice. |
2021-06-18 |
2023-08-13 |
mouse |
| Greg C Bristow, David M Thomson, Rebecca L Openshaw, Emma J Mitchell, Judith A Pratt, Neil Dawson, Brian J Morri. 16p11 Duplication Disrupts Hippocampal-Orbitofrontal-Amygdala Connectivity, Revealing a Neural Circuit Endophenotype for Schizophrenia. Cell reports. vol 31. issue 3. 2021-05-14. PMID:32320645. |
expression of schizophrenia-relevant gabaergic cell markers (parvalbumin and calbindin) is selectively decreased in orbitofrontal cortex, while somatostatin expression is decreased in lateral amygdala. |
2021-05-14 |
2023-08-13 |
mouse |
| Alexandre Mahrach, Guang Chen, Nuo Li, Carl van Vreeswijk, David Hanse. Mechanisms underlying the response of mouse cortical networks to optogenetic manipulation. eLife. vol 9. 2021-04-19. PMID:31951197. |
gabaergic interneurons can be subdivided into three subclasses: parvalbumin positive (pv), somatostatin positive (som) and serotonin positive neurons. |
2021-04-19 |
2023-08-13 |
mouse |
| Illke B Malungo, Nadine Gravett, Adhil Bhagwandin, Joshua G Davimes, Paul R Mange. A Preliminary Description of the Sleep-Related Neural Systems in the Brain of the Blue Wildebeest, Connochaetes taurinus. Anatomical record (Hoboken, N.J. : 2007). vol 303. issue 7. 2021-03-24. PMID:31513360. |
furthermore, the description and distribution of the gabaergic system, which was examined through immunostaining for the calcium binding proteins calbindin, calretinin, and parvalbumin, was also similar to that seen in other mammals. |
2021-03-24 |
2023-08-13 |
Not clear |
| Annarita Patrizi, Patricia N Awad, Bidisha Chattopadhyaya, Chloe Li, Graziella Di Cristo, Michela Fagiolin. Accelerated Hyper-Maturation of Parvalbumin Circuits in the Absence of MeCP2. Cerebral cortex (New York, N.Y. : 1991). vol 30. issue 1. 2021-03-22. PMID:31038696. |
cortical parvalbumin gabaergic interneurons (pv) make exuberant somatic connections onto pyramidal cells in the visual cortex of mecp2-deficient mice, which contributes to silencing neuronal cortical circuits. |
2021-03-22 |
2023-08-13 |
mouse |
| Yotam Sagi, Lucian Medrihan, Katia George, Miles Barney, Kathryn A McCabe, Paul Greengar. Emergence of 5-HT5A signaling in parvalbumin neurons mediates delayed antidepressant action. Molecular psychiatry. vol 25. issue 6. 2021-03-09. PMID:30804492. |
parvalbumin interneurons are a major class of gabaergic neurons, essential for dg function, and are involved in the pathophysiology of several neuropsychiatric disorders. |
2021-03-09 |
2023-08-13 |
mouse |
| John T Madden, Shannon M Thompson, Christy M Magcalas, Jennifer L Wagner, Derek A Hamilton, Daniel D Savage, Benjamin J Clark, Nathan S Pentkowsk. Moderate prenatal alcohol exposure reduces parvalbumin expressing GABAergic interneurons in the dorsal hippocampus of adult male and female rat offspring. Neuroscience letters. vol 718. 2021-03-01. PMID:31874217. |
moderate prenatal alcohol exposure reduces parvalbumin expressing gabaergic interneurons in the dorsal hippocampus of adult male and female rat offspring. |
2021-03-01 |
2023-08-13 |
rat |
| Chengcheng Zhang, Peiyan Ni, Yikang Liu, Yang Tian, Jinxue Wei, Bo Xiang, Liansheng Zhao, Xiaojing Li, Xiaohong Ma, Wei Deng, Wanjun Guo, Rongjun Ni, Yamin Zhang, Qiang Wang, Hailiang Huang, Nanyin Zhang, Tao L. GABAergic Abnormalities Associated with Sensorimotor Cortico-striatal Community Structural Deficits in ErbB4 Knockout Mice and First-Episode Treatment-Naïve Patients with Schizophrenia. Neuroscience bulletin. vol 36. issue 2. 2020-12-17. PMID:31388929. |
our study identified that erbb4 ablation in parvalbumin interneurons induced gabaergic dysregulation, providing valuable mechanistic insights into the sensorimotor cortico-striatal community structure deficits associated with schizophrenia. |
2020-12-17 |
2023-08-13 |
mouse |
| Corinna Höfling, Emira Shehabi, Peer-Hendrik Kuhn, Stefan F Lichtenthaler, Maike Hartlage-Rübsamen, Steffen Roßne. Cell Type-Specific Human APP Transgene Expression by Hippocampal Interneurons in the Tg2576 Mouse Model of Alzheimer's Disease. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:30853883. |
here, the expression of human app (happ) by gabaergic hippocampal interneurons immunoreactive for the calcium binding proteins parvalbumin, calbindin, calretinin, and for the peptide hormone somatostatin was analyzed in tg2576 mice by double immunofluorescent microscopy. |
2020-10-01 |
2023-08-13 |
mouse |
| Giulia Bonetto, Bruno Hivert, Laurence Goutebroze, Domna Karagogeos, Valérie Crépel, Catherine Faivre-Sarrail. Selective Axonal Expression of the Kv1 Channel Complex in Pre-myelinated GABAergic Hippocampal Neurons. Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:31164806. |
in the present study, we show that two subtypes of hippocampal gabaergic neurons, namely the somatostatin and parvalbumin positive cells, display a selective high expression of kv1 channels at the ais and all along the unmyelinated axons. |
2020-10-01 |
2023-08-13 |
mouse |