| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Timothy J O'Neal, Marlaena N Nooney, Katie Thien, Susan M Ferguso. Chemogenetic modulation of accumbens direct or indirect pathways bidirectionally alters reinstatement of heroin-seeking in high- but not low-risk rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 8. 2021-06-23. PMID:31747681. |
relapse is often triggered by re-exposure to drug-associated cues, and though the neural substrates responsible for relapse in vulnerable individuals remains ambiguous, the nucleus accumbens (nac) has been shown to play a central role. |
2021-06-23 |
2023-08-13 |
rat |
| Alexia V Williams, Natalia Duque-Wilckens, Stephanie Ramos-Maciel, Katharine L Campi, Shanu K Bhela, Christine K Xu, Kenneth Jackson, Bice Chini, Patricia A Pesavento, Brian C Traino. Social approach and social vigilance are differentially regulated by oxytocin receptors in the nucleus accumbens. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 9. 2021-06-23. PMID:32198453. |
in the nucleus accumbens (nac) activation of oxytocin receptors (otr) promotes social approach (time spent near an unfamiliar individual). |
2021-06-23 |
2023-08-13 |
mouse |
| S Gallegos, L San Martin, A Araya, D M Lovinger, G E Homanics, L G Aguay. Reduced sedation and increased ethanol consumption in knock-in mice expressing an ethanol insensitive alpha 2 subunit of the glycine receptor. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 3. 2021-06-23. PMID:32357359. |
previous studies have shown the presence of several subunits of the inhibitory glycine receptor (glyr) in the reward system, specifically in medium spiny neurons (msns) of the nucleus accumbens (nac). |
2021-06-23 |
2023-08-13 |
mouse |
| Nichol M L Wong, James L Findon, Robert H Wichers, Vincent Giampietro, Vladimira Stoencheva, Clodagh M Murphy, Sarah Blainey, Christine Ecker, Declan G Murphy, Grainne M McAlonan, Eileen Dal. Serotonin differentially modulates the temporal dynamics of the limbic response to facial emotions in male adults with and without autism spectrum disorder (ASD): a randomised placebo-controlled single-dose crossover trial. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 13. 2021-06-23. PMID:32388538. |
the biological basis of this is poorly understood but may include neurochemically mediated differences in the responsivity of key 'limbic' regions (including amygdala, ventromedial prefrontal cortex (vmpfc) and nucleus accumbens (nac)). |
2021-06-23 |
2023-08-13 |
human |
| Di Liu, Qian-Qian Tang, Di Wang, Su-Pei Song, Xiao-Na Yang, Su-Wan Hu, Zhi-Yong Wang, Zheng Xu, He Liu, Jun-Xia Yang, Sarah E Montgomery, Hongxing Zhang, Ming-Hu Han, Hai-Lei Ding, Jun-Li Ca. Mesocortical BDNF signaling mediates antidepressive-like effects of lithium. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 9. 2021-06-23. PMID:32428928. |
here, we demonstrated that the ventral tegmental area (vta) dopamine (da) neurons that project to the medial prefrontal cortex (mpfc), but not to nucleus accumbens (nac), contributed to the antidepressive-like effects of lithium. |
2021-06-23 |
2023-08-13 |
mouse |
| Yannick Fotio, Anna Maria Borruto, Federica Benvenuti, Gregory Demopulos, George Gaitanaris, Marisa Roberto, Roberto Ciccociopp. Activation of peroxisome proliferator-activated receptor γ reduces alcohol drinking and seeking by modulating multiple mesocorticolimbic regions in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 2. 2021-06-23. PMID:32610339. |
microinjections of pioglitazone in the ventral tegmental area (vta), central amygdala (cea), and nucleus accumbens (nac) shell had no such effect. |
2021-06-23 |
2023-08-13 |
rat |
| Yanaira Alonso-Caraballo, Tracy L Fetterly, Emily T Jorgensen, Allison M Nieto, Travis E Brown, Carrie R Ferrari. Sex specific effects of "junk-food" diet on calcium permeable AMPA receptors and silent synapses in the nucleus accumbens core. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 3. 2021-06-23. PMID:32731252. |
cp-ampars in the nucleus accumbens (nac) mediate cue-triggered motivation for food and cocaine. |
2021-06-23 |
2023-08-13 |
rat |
| Christina A Markunas, Stephen A Semick, Bryan C Quach, Ran Tao, Amy Deep-Soboslay, Megan U Carnes, Laura J Bierut, Thomas M Hyde, Joel E Kleinman, Eric O Johnson, Andrew E Jaffe, Dana B Hancoc. Genome-wide DNA methylation differences in nucleus accumbens of smokers vs. nonsmokers. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 3. 2021-06-23. PMID:32731254. |
we report the first epigenome-wide association study (ewas) of smoking in human postmortem brain, focusing on nucleus accumbens (nac) as a key brain region in developing and reinforcing addiction. |
2021-06-23 |
2023-08-13 |
human |
| Adina S Fischer, Bailey Holt-Gosselin, Scott L Fleming, Laura M Hack, Tali M Ball, Alan F Schatzberg, Leanne M William. Intrinsic reward circuit connectivity profiles underlying symptom and quality of life outcomes following antidepressant medication: a report from the iSPOT-D trial. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 4. 2021-06-23. PMID:33230268. |
we quantified functional connectivity (fc) of reward neurocircuitry using nucleus accumbens (nac) seed regions of interest, and then characterized how changes in fc relate to symptom response (primary outcome) and qol response (secondary outcome). |
2021-06-23 |
2023-08-13 |
Not clear |
| Jerome A J Becker, Lucie P Pellissier, Yannick Corde, Thibaut Laboute, Audrey Léauté, Jorge Gandía, Julie Le Merre. Facilitating mGluR4 activity reverses the long-term deleterious consequences of chronic morphine exposure in male mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 7. 2021-06-23. PMID:33349673. |
transcriptional regulation of marker genes of medium spiny neurons (msns) allowed best discriminating between 4-week morphine and cocaine abstinence in the nucleus accumbens (nac). |
2021-06-23 |
2023-08-13 |
mouse |
| Hope Kronman, Angélica Torres-Berrío, Simone Sidoli, Orna Issler, Arthur Godino, Aarthi Ramakrishnan, Philipp Mews, Casey K Lardner, Eric M Parise, Deena M Walker, Yentl Y van der Zee, Caleb J Browne, Brittany F Boyce, Rachael Neve, Benjamin A Garcia, Li Shen, Catherine J Peña, Eric J Nestle. Long-term behavioral and cell-type-specific molecular effects of early life stress are mediated by H3K79me2 dynamics in medium spiny neurons. Nature neuroscience. vol 24. issue 5. 2021-06-22. PMID:33723435. |
animals susceptible to chronic social defeat stress (csds) exhibit depression-related behaviors, with aberrant transcription across several limbic brain regions, most notably in the nucleus accumbens (nac). |
2021-06-22 |
2023-08-13 |
mouse |
| Mary K Estes, Jasric J Bland, Kenya K Ector, Melissa J Puppa, Douglas W Powell, Deranda B Leste. A high fat western diet attenuates phasic dopamine release. Neuroscience letters. vol 756. 2021-06-22. PMID:33979702. |
natural rewards, such as food and social interaction, as well as drugs of abuse elicit increased mesolimbic dopamine release in the nucleus accumbens (nac). |
2021-06-22 |
2023-08-13 |
mouse |
| Kaili Du, Zhuoyi Wang, Huimin Zhang, Yaofang Zhang, Hongliang Su, Zhiwen Wei, Chao Zhang, Keming Yun, Bin Con. Levo-tetrahydropalmatine attenuates the acquisition of fentanyl-induced conditioned place preference and the changes in ERK and CREB phosphorylation expression in mice. Neuroscience letters. vol 756. 2021-06-22. PMID:34029649. |
western blot assays were used to dissect the accompanying changes in the phosphorylation of extracellular signal-regulated kinase (erk) and camp response element binding protein (creb) in related brain regions, including the hippocampus (hip), caudate putamen (cpu), prefrontal cortex (pfc), and nucleus accumbens (nac), which may mediate the effects of l-thp on fentanyl-induced cpp. |
2021-06-22 |
2023-08-13 |
mouse |
| Elena Alvarez-Salas, Aldo González, Maria Isabel Amaya, Patricia de Gortar. Accumbal TRH is downstream of the effects of isolation stress on hedonic food intake in rats. Nutritional neuroscience. vol 24. issue 7. 2021-06-21. PMID:31438781. |
nucleus accumbens (nac) is part of the mesocorticolimbic system and participates in processing rewarding characteristics of food modulating palatable food intake, mainly when glucocorticoids are elevated. |
2021-06-21 |
2023-08-13 |
rat |
| Kenneth D Car. Homeostatic regulation of reward via synaptic insertion of calcium-permeable AMPA receptors in nucleus accumbens. Physiology & behavior. vol 219. 2021-06-21. PMID:32092445. |
the main findings are that fr decreases basal dopamine (da) transmission, upregulates signaling downstream of the d1 da receptor (d1r), and triggers synaptic incorporation of calcium-permeable ampa receptors (cp-ampars) in the nucleus accumbens (nac). |
2021-06-21 |
2023-08-13 |
human |
| Keenan T Hope, Isobel A Hawes, Eric N Moca, Antonello Bonci, Lindsay M De Bias. Maturation of the microglial population varies across mesolimbic nuclei. The European journal of neuroscience. vol 52. issue 7. 2021-06-21. PMID:32281691. |
we found that microglial density peaks in the ventral tegmental area (vta) and nucleus accumbens (nac) during the third postnatal week, driven by a burst of microglial proliferation. |
2021-06-21 |
2023-08-13 |
mouse |
| Loreto San Martin, Scarlet Gallegos, Anibal Araya, Nicol Romero, Giovanni Morelli, Joris Comhair, Robert J Harvey, Jean-Michel Rigo, Bert Brone, Luis G Aguay. Ethanol consumption and sedation are altered in mice lacking the glycine receptor α2 subunit. British journal of pharmacology. vol 177. issue 17. 2021-06-21. PMID:32436225. |
like other drugs of abuse, ethanol affects dopamine levels in the nucleus accumbens (nac), an important region of the mesolimbic system, causing a reinforcing effect. |
2021-06-21 |
2023-08-13 |
mouse |
| Carrie R Ferrari. Why did I eat that? Contributions of individual differences in incentive motivation and nucleus accumbens plasticity to obesity. Physiology & behavior. vol 227. 2021-06-21. PMID:32777311. |
the ability to seek out and find food relies in large part on activation on mesocorticolimbic regions including the nucleus accumbens (nac). |
2021-06-21 |
2023-08-13 |
Not clear |
| Samantha R Eck, Debra A Bangasse. The effects of early life stress on motivated behaviors: A role for gonadal hormones. Neuroscience and biobehavioral reviews. vol 119. 2021-06-21. PMID:33022296. |
motivated behaviors are controlled by the mesocorticolimbic dopamine (da) system, consisting of projections from the ventral tegmental area (vta) to the nucleus accumbens (nac) and prefrontal cortex (pfc), with input from structures including the medial preoptic area (mpoa). |
2021-06-21 |
2023-08-13 |
Not clear |
| Benjamin L Thompson, Marlene Oscar-Berman, Gary B Kapla. Opioid-induced structural and functional plasticity of medium-spiny neurons in the nucleus accumbens. Neuroscience and biobehavioral reviews. vol 120. 2021-06-21. PMID:33152423. |
in particular, structural and functional alterations in the dendritic spines of medium spiny neurons (msns) within the nucleus accumbens (nac) and its dopaminergic projections from the ventral tegmental area (vta) are believed to facilitate these behavioral sequelae. |
2021-06-21 |
2023-08-13 |
Not clear |