| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marco Pagliusi, Daniela Franco, Shannon Cole, Gessynger Morais-Silva, Ramesh Chandra, Megan E Fox, Sergio D Iñiguez, Cesar R Sartori, Mary Kay Lob. The BDNF-TrkB Pathway Acts Through Nucleus Accumbens D2 Expressing Neurons to Mediate Stress Susceptible Outcomes. Frontiers in psychiatry. vol 13. 2022-06-20. PMID:35722560. |
in stress outcomes, bdnf acting in the hippocampus has a stress resilience effect, and, inversely, in the nucleus accumbens (nac), bdnf acts as a stress susceptible molecule. |
2022-06-20 |
2023-08-14 |
mouse |
| Xiaojie Li, Bing Xie, Yun Lu, Hongyu Yang, Jian Wang, Feng Yu, Ludi Zhang, Bin Cong, Di Wen, Chunling M. Transcriptomic Analysis of Long Non-coding RNA-MicroRNA-mRNA Interactions in the Nucleus Accumbens Related to Morphine Addiction in Mice. Frontiers in psychiatry. vol 13. 2022-06-20. PMID:35722589. |
in this research, rna sequencing (rna-seq) was used to examine the expression profiles of lncrnas, mirnas and mrnas on the nucleus accumbens (nac) tissues of mice trained with morphine or saline conditioned place preference (cpp), with differential expression of 31 lncrnas, 393 mirnas, and 371 mrnas found. |
2022-06-20 |
2023-08-14 |
mouse |
| Li-Min Mao, Nirav Mathur, John Q Wan. Downregulation of surface AMPA receptor expression in the striatum following prolonged social isolation, a role of mGlu5 receptors. IBRO neuroscience reports. vol 13. 2022-06-17. PMID:35711245. |
in these depressed rats, surface levels of ampa receptors, mainly glua1 and glua3 subunits, were reduced in the nucleus accumbens (nac). |
2022-06-17 |
2023-08-14 |
rat |
| Li Zhu, Feifei Wu, Zhilan Yan, Lijun He, Shufei Wang, Haohao Hu, Eyleen L K Goh, Yingjie Zhu, Fanglin Guan, Teng Che. A novel microRNA, novel-m009C, regulates methamphetamine rewarding effects. Molecular psychiatry. 2022-06-17. PMID:35715487. |
its expression is consistently downregulated in the nucleus accumbens (nac) of mice when exposed to meth and cocaine, whereas significant alterations in novel-m009c expression were not observed in the nac of mice subjected to other rewarding and psychiatric stimuli, such as sucrose, morphine and mk-801. |
2022-06-17 |
2023-08-14 |
mouse |
| Sophia C Levis, Matthew T Birnie, Jessica L Bolton, Christina R Perrone, Johanna S Montesinos, Tallie Z Baram, Stephen V Mahle. Enduring disruption of reward and stress circuit activities by early-life adversity in male rats. Translational psychiatry. vol 12. issue 1. 2022-06-15. PMID:35705547. |
we probe potential circuit mechanisms in males by assessing opioid-associated neuronal activation in stress and reward circuit nodes including nucleus accumbens (nac), amygdala, medial prefrontal cortex (mpfc), and paraventricular thalamus. |
2022-06-15 |
2023-08-14 |
rat |
| Daniel A N Barbosa, Fiene Marie Kuijper, Jeffrey Duda, Allan R Wang, Samuel C D Cartmell, Sabir Saluja, Tricia Cunningham, Rajat S Shivacharan, Mahendra T Bhati, Debra L Safer, James D Lock, Robert C Malenka, Ricardo de Oliveira-Souza, Nolan R Williams, Murray Grossman, James C Gee, Jennifer A McNab, Cara Bohon, Casey H Halper. Aberrant impulse control circuitry in obesity. Molecular psychiatry. 2022-06-13. PMID:35697760. |
the ventromedial prefrontal cortex (vmpfc) to nucleus accumbens (nac) circuit has been implicated in impulsive reward-seeking. |
2022-06-13 |
2023-08-14 |
human |
| Cai-N Cheng, Shaw-Jye Wu, Andrew Chih Wei Huan. Environmental Enrichment Components Required to Reduce Methamphetamine-Induced Behavioral Sensitization in Mice: Examination of Behaviors and Neural Substrates. Journal of clinical medicine. vol 11. issue 11. 2022-06-10. PMID:35683439. |
the c-fos expression analysis showed that the medial prefrontal cortex (i.e., cingulate cortex 1 (cg1), prelimbic cortex (prl), and infralimbic cortex (il)), nucleus accumbens (nac), basolateral amygdala (bla), ventral tegmental area (vta), caudate-putamen (cpu), and hippocampus (i.e., ca1, ca3, and dentate gyrus (dg)) contributed to mamph-induced behavioral sensitization. |
2022-06-10 |
2023-08-14 |
mouse |
| Ryota Imai, Keita Mizuno, Yuji Omiya, Kazushige Mizoguchi, Yuko Maejima, Kenju Shimomur. The effects of ninjin'yoeito on the electrophysiological properties of dopamine neurons in the ventral tegmental area/substantia nigra pars compacta and medium spiny neurons in the nucleus accumbens. Aging. vol 14. issue undefined. 2022-06-06. PMID:35660668. |
the ventral tegmental area (vta), substantia nigra pars compacta (snpc) and nucleus accumbens (nac) are involved in the regulation of appetite and motivational behaviors. |
2022-06-06 |
2023-08-14 |
mouse |
| Xiayun Wan, Akifumi Eguchi, Youge Qu, Yong Yang, Lijia Chang, Jiajing Shan, Chisato Mori, Kenji Hashimot. Gut-microbiota-brain axis in the vulnerability to psychosis in adulthood after repeated cannabis exposure during adolescence. European archives of psychiatry and clinical neuroscience. 2022-06-06. PMID:35666299. |
repeated administration of win55,212-2 (2 mg/kg/day) during adolescence (p35-p45) significantly increased the expression of iba1 (ionized calcium-binding adapter molecule 1) in the medial prefrontal cortex (mpfc) and nucleus accumbens (nac) of adult mice after administration of lipopolysaccharide (lps: 0.5 mg/kg). |
2022-06-06 |
2023-08-14 |
mouse |
| Yu-Dan Ding, Xiao Chen, Zuo-Bing Chen, Le Li, Xue-Ying Li, Francisco Xavier Castellanos, Tong-Jian Bai, Qi-Jing Bo, Jun Cao, Zhi-Kai Chang, Guan-Mao Chen, Ning-Xuan Chen, Wei Chen, Chang Cheng, Yu-Qi Cheng, Xi-Long Cui, Jia Duan, Yi-Ru Fang, Qi-Yong Gong, Zheng-Hua Hou, Lan Hu, Li Kuang, Feng Li, Hui-Xian Li, Kai-Ming Li, Tao Li, Yan-Song Liu, Zhe-Ning Liu, Yi-Cheng Long, Bin Lu, Qing-Hua Luo, Hua-Qing Meng, Dai-Hui Peng, Hai-Tang Qiu, Jiang Qiu, Yue-Di Shen, Yu-Shu Shi, Tian-Mei Si, Yan-Qing Tang, Chuan-Yue Wang, Fei Wang, Kai Wang, Li Wang, Xiang Wang, Ying Wang, Yu-Wei Wang, Xiao-Ping Wu, Xin-Ran Wu, Chun-Ming Xie, Guang-Rong Xie, Hai-Yan Xie, Peng Xie, Xiu-Feng Xu, Hong Yang, Jian Yang, Jia-Shu Yao, Shu-Qiao Yao, Ying-Ying Yin, Yong-Gui Yuan, Yu-Feng Zang, Ai-Xia Zhang, Hong Zhang, Ke-Rang Zhang, Lei Zhang, Zhi-Jun Zhang, Jing-Ping Zhao, Ru-Bai Zhou, Yi-Ting Zhou, Jun-Juan Zhu, Zhi-Chen Zhu, Chao-Jie Zou, Xi-Nian Zuo, Chao-Gan Yan, Wen-Bin Gu. Reduced nucleus accumbens functional connectivity in reward network and default mode network in patients with recurrent major depressive disorder. Translational psychiatry. vol 12. issue 1. 2022-06-06. PMID:35668086. |
the nucleus accumbens (nac) is considered a hub of reward processing and a growing body of evidence has suggested its crucial role in the pathophysiology of major depressive disorder (mdd). |
2022-06-06 |
2023-08-14 |
Not clear |
| Sascha H Duttke, Patricia Montilla-Perez, Max W Chang, Hairi Li, Hao Chen, Lieselot L G Carrette, Giordano de Guglielmo, Olivier George, Abraham A Palmer, Christopher Benner, Francesca Teles. Glucocorticoid Receptor-Regulated Enhancers Play a Central Role in the Gene Regulatory Networks Underlying Drug Addiction. Frontiers in neuroscience. vol 16. 2022-06-02. PMID:35651629. |
we profiled initiating transcripts in two addiction-related brain regions, the prefrontal cortex (pfc) and the nucleus accumbens (nac), from rats that were never exposed to drugs or were subjected to prolonged abstinence after oxycodone or cocaine intravenous self-administration (ivsa). |
2022-06-02 |
2023-08-13 |
rat |
| Lisha Deng, Zheng Chu, Baijia Li, Peng Liu, Gang Lei, Liu Yang, Leile Zhang, Shaofu Li, Yiming Wang, Yonghui Dan. BDNF-AAV has protective effects on morphine-induced conditioned place preference through BDNF, TrkB, and CREB concentration changes in the VTA and NAc. Neuroscience letters. vol 782. 2022-06-02. PMID:35653819. |
western blot assays were used to determine the changes caused by bdnf, for example, changes in total bdnf, tropomyosin-related kinase receptor b (trkb), and camp response element binding protein (creb) in the ventral tegmental area (vta) and nucleus accumbens (nac). |
2022-06-02 |
2023-08-14 |
mouse |
| Weston Fleming, Junuk Lee, Brandy A Briones, Scott S Bolkan, Ilana B Witte. Cholinergic interneurons mediate cocaine extinction in male mice through plasticity across medium spiny neuron subtypes. Cell reports. vol 39. issue 9. 2022-06-01. PMID:35649378. |
cholinergic interneurons (chins) in the nucleus accumbens (nac) have been implicated in the extinction of drug associations, as well as related plasticity in medium spiny neurons (msns). |
2022-06-01 |
2023-08-13 |
mouse |
| Pei X Luo, Hannah Cortez Zakharenkov, Lisette Y Torres, Roberto A Rios, Bruno Gegenhuber, Alexis M Black, Christine K Xu, Vanessa A Minie, Amy M Tran, Jessica Tollkuhn, Brian C Traino. Oxytocin receptor behavioral effects and cell types in the bed nucleus of the stria terminalis. Hormones and behavior. vol 143. 2022-05-31. PMID:35636023. |
to gain insight into cell types that could be mediating this effect, we analyzed previously published single-cell rnaseq data from the bnst and nucleus accumbens (nac). |
2022-05-31 |
2023-08-13 |
mouse |
| Tomoyuki Ijiro, Atsushi Yaguchi, Ayaka Yokoyama, Sumiyoshi Kiguch. Rovatirelin ameliorates motor dysfunction in the cytosine arabinoside-induced rat model of spinocerebellar degeneration via acetylcholine and dopamine neurotransmission. Clinical and experimental pharmacology & physiology. 2022-05-31. PMID:35637550. |
moreover, rovatirelin significantly increased acetylcholine (ach) levels in the medial prefrontal cortex (mpfc) and dopamine (da) levels in the nucleus accumbens (nac) at ≥3 mg/kg and significantly increased da levels in the dorsal striatum at ≥10 mg/kg in normal rats. |
2022-05-31 |
2023-08-13 |
mouse |
| Xin Wang, Fei Li, Jun Zhu, Dayun Feng, Yingwu Shi, Liang Qu, Yang Li, Kang Guo, Yue Zhang, Qiang Wang, Naigeng Wang, Xuelian Wang, Shunnan G. Upregulation of Cell Division Cycle 20 Expression Alters the Morphology of Neuronal Dendritic Spines in the Nucleus Accumbens by Promoting FMRP Ubiquitination. Journal of neurochemistry. 2022-05-27. PMID:35621027. |
the nucleus accumbens (nac) is the key area of the reward circuit, but its heterogeneity has been poorly studied. |
2022-05-27 |
2023-08-13 |
rat |
| Bingqian Zhou, Yuan Chen, Ruiping Zheng, Yu Jiang, Shuying Li, Yarui Wei, MengZhe Zhang, XinYu Gao, Baohong Wen, Shaoqiang Han, Jingliang Chen. Alterations of Static and Dynamic Functional Connectivity of the Nucleus Accumbens in Patients With Major Depressive Disorder. Frontiers in psychiatry. vol 13. 2022-05-26. PMID:35615457. |
as an important node in the reward system, the resting-state functional connectivity of the nucleus accumbens (nac) is related to the etiology of mdd. |
2022-05-26 |
2023-08-13 |
Not clear |
| Bu-Fang Fan, Bo Hao, Yun-Da Dai, Li Xue, Yan-Wei Shi, Lu Liu, Shou-Min Xuan, Ning Yang, Xiao-Guang Wang, Hu Zha. Deficiency of Tet3 in nucleus accumbens enhances fear generalization and anxiety-like behaviors in mice. Brain pathology (Zurich, Switzerland). 2022-05-25. PMID:35612904. |
foot shock strength dependently induces fear generalization and tet3 expression in nucleus accumbens (nac) in mice. |
2022-05-25 |
2023-08-13 |
mouse |
| Na Zhao, Juan Yue, Zi-Jian Feng, Yang Qiao, Qiu Ge, Li-Xia Yuan, Jue Wang, Yu-Tao Xiang, Yu-Feng Zan. The Location Reliability of the Resting-State fMRI FC of Emotional Regions Towards rTMS Therapy. Neuroinformatics. 2022-05-24. PMID:35608748. |
resting-state magnetic resonance imaging (rs-fmri) studies indicated that the repetitive transcranial magnetic stimulation (rtms) exerts antidepression effect through the functional connectivity (fc) of the dlpfc with the subgenual anterior cingulate cortex (sgacc), pregneual acc (pgacc), or nucleus accumbens (nac). |
2022-05-24 |
2023-08-13 |
human |
| Viktor A Stratilov, Oleg V Vetrovoy, Ekaterina I Tyulkov. Prenatal Hypoxia Affects Nicotine Consumption and Withdrawal in Adult Rats via Impairment of the Glutamate System in the Brain. Molecular neurobiology. 2022-05-17. PMID:35581520. |
psh rats also demonstrated an increased level of phosphorylated darpp-32 protein (known as the relay for dopamine and glutamate signaling) at 34 threonine (pthr34darpp-32) in relation to its total amount in the nucleus accumbens of the striatum (nac). |
2022-05-17 |
2023-08-13 |
rat |